GB856414A - Anti-allergic and anti-viral substances prepared from bacterial cultures - Google Patents
Anti-allergic and anti-viral substances prepared from bacterial culturesInfo
- Publication number
- GB856414A GB856414A GB7815/57A GB781557A GB856414A GB 856414 A GB856414 A GB 856414A GB 7815/57 A GB7815/57 A GB 7815/57A GB 781557 A GB781557 A GB 781557A GB 856414 A GB856414 A GB 856414A
- Authority
- GB
- United Kingdom
- Prior art keywords
- ethanol
- test
- products
- bacteria
- proteus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 230000000840 anti-viral effect Effects 0.000 title abstract 3
- 239000000126 substance Substances 0.000 title abstract 3
- 230000003266 anti-allergic effect Effects 0.000 title abstract 2
- 230000001580 bacterial effect Effects 0.000 title abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 12
- 241000894006 Bacteria Species 0.000 abstract 4
- 239000007864 aqueous solution Substances 0.000 abstract 4
- 239000000243 solution Substances 0.000 abstract 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 4
- 239000000463 material Substances 0.000 abstract 3
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 abstract 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 2
- 241000588769 Proteus <enterobacteria> Species 0.000 abstract 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 2
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 abstract 2
- 238000000502 dialysis Methods 0.000 abstract 2
- 239000008103 glucose Substances 0.000 abstract 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 abstract 2
- LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 abstract 2
- CYDQOEWLBCCFJZ-UHFFFAOYSA-N 4-(4-fluorophenyl)oxane-4-carboxylic acid Chemical compound C=1C=C(F)C=CC=1C1(C(=O)O)CCOCC1 CYDQOEWLBCCFJZ-UHFFFAOYSA-N 0.000 abstract 1
- 229920000298 Cellophane Polymers 0.000 abstract 1
- 229920002307 Dextran Polymers 0.000 abstract 1
- 239000001828 Gelatine Substances 0.000 abstract 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 abstract 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 abstract 1
- 241000588770 Proteus mirabilis Species 0.000 abstract 1
- 241000588767 Proteus vulgaris Species 0.000 abstract 1
- 229920002472 Starch Polymers 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 230000010933 acylation Effects 0.000 abstract 1
- 238000005917 acylation reaction Methods 0.000 abstract 1
- 238000007792 addition Methods 0.000 abstract 1
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 abstract 1
- 229910052921 ammonium sulfate Inorganic materials 0.000 abstract 1
- 239000001166 ammonium sulphate Substances 0.000 abstract 1
- 235000011130 ammonium sulphate Nutrition 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 235000019445 benzyl alcohol Nutrition 0.000 abstract 1
- 150000003938 benzyl alcohols Chemical class 0.000 abstract 1
- 239000000872 buffer Substances 0.000 abstract 1
- 239000002775 capsule Substances 0.000 abstract 1
- 239000000969 carrier Substances 0.000 abstract 1
- 238000005119 centrifugation Methods 0.000 abstract 1
- 239000006071 cream Substances 0.000 abstract 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-M dihydrogenphosphate Chemical compound OP(O)([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-M 0.000 abstract 1
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 abstract 1
- 239000008298 dragée Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003995 emulsifying agent Substances 0.000 abstract 1
- 239000000839 emulsion Substances 0.000 abstract 1
- 238000000605 extraction Methods 0.000 abstract 1
- 229920000159 gelatin Polymers 0.000 abstract 1
- 235000019322 gelatine Nutrition 0.000 abstract 1
- 239000008101 lactose Substances 0.000 abstract 1
- 235000019359 magnesium stearate Nutrition 0.000 abstract 1
- AAIXGPLMFDSDPW-UHFFFAOYSA-K magnesium;potassium;chloride;sulfate Chemical compound [Mg+2].[K]Cl.[O-]S([O-])(=O)=O AAIXGPLMFDSDPW-UHFFFAOYSA-K 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
- 235000015097 nutrients Nutrition 0.000 abstract 1
- 239000002674 ointment Substances 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 239000011049 pearl Substances 0.000 abstract 1
- 235000019271 petrolatum Nutrition 0.000 abstract 1
- 239000003208 petroleum Substances 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 239000011574 phosphorus Substances 0.000 abstract 1
- 229910052698 phosphorus Inorganic materials 0.000 abstract 1
- 229920001515 polyalkylene glycol Polymers 0.000 abstract 1
- 229910000160 potassium phosphate Inorganic materials 0.000 abstract 1
- 235000011009 potassium phosphates Nutrition 0.000 abstract 1
- 238000001556 precipitation Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
- 229940007042 proteus vulgaris Drugs 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
- 239000011780 sodium chloride Substances 0.000 abstract 1
- 239000001540 sodium lactate Substances 0.000 abstract 1
- 235000011088 sodium lactate Nutrition 0.000 abstract 1
- 229940005581 sodium lactate Drugs 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 239000002195 soluble material Substances 0.000 abstract 1
- 241000894007 species Species 0.000 abstract 1
- 239000003381 stabilizer Substances 0.000 abstract 1
- 235000019698 starch Nutrition 0.000 abstract 1
- 150000003456 sulfonamides Chemical class 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
- 230000002195 synergetic effect Effects 0.000 abstract 1
- 239000003826 tablet Substances 0.000 abstract 1
- 239000000454 talc Substances 0.000 abstract 1
- 229910052623 talc Inorganic materials 0.000 abstract 1
- 235000012222 talc Nutrition 0.000 abstract 1
- 230000000699 topical effect Effects 0.000 abstract 1
- 235000015112 vegetable and seed oil Nutrition 0.000 abstract 1
- 239000008158 vegetable oil Substances 0.000 abstract 1
- 238000009736 wetting Methods 0.000 abstract 1
- 239000000080 wetting agent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Mycology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention relates to bacterial culture products having antiviral properties and obtained from the culture solutions of bacteria of the genus proteus freed from bacteria material, said products being of so high a molecular weight that they are not dialysable in aqueous solution through "Cellophane" (Registered Trade Mark) and being soluble in ethanol to such an extent that they are not precipitated from their aqueous solutions by adding ethanol up to a content of 75%, said products being characterized by a phosphorus content of below 1,7% and a sugar value of below 20% by leaving the leucocyte emigration in the leucocyte emigration test (LE-test-described) unchanged at concentrations of 10-9 and less and by being inactive in the antilipemia test (AL-test-described) at doses smaller than 50g /kg, and their acylation products. Specified are the acetyl, propyl and benzoyl derivatives. Typical species of Proteus are Proteus mirabilis and Proteus vulgaris. The cultivation is aerobic preferably submerged using nutrient media known to be suitable for the growth of these microorganisms, a fully synthetic medium (e.g. glucose, ammonium sulphate, primary potassium phosphate, potassium chloride magnesium sulphate and sodium lactate in water of pH 7,4-7,5) being preferred. The bacteria cell material is separated from the culture solution, e.g. by centrifugation and the culture solution adjusted to apH6,5 is dialysed against water. Inactive material is precipitated by adding 3 volumes of ethanol to the clarified aqueous solution remaining after dialysis, and the ethanol soluble material after removal of ethanol is dialysed. The non-dialysable solid residue can be further purified by further dialysis against water, precipitation with ethanol and extraction with chloroform or petroleum ether.ALSO:Anti-allergic, anti-viral substances having a synergistic action with sulphonamides and obtained as a 75% aqueous alcohol-soluble, non-dialysable (aqueous solution) isolate of the clarified broth in which have been cultured bacteria of the genus Protens, (see Group IV(b)), or the acyl derivatives thereof especially the acetyl derivative, are mixed with a carrier to provide pharmaceutical preparations for topical, enteral or parenteral administration. Specified carriers are water, polyalkylene glycols, gelatine, lactose, dextranes, starches, magnesium stearate, talc, vegetable oils, benzyl alcohols, gums, petroleum jelly and chlolesterol. Optional additions are stabilizing agents, wetting or emulsifying agents, substances for regulating the asmotic pressure e.g. sodium chloride and glucose, buffers e.g. sodium mono- and dihydrogen phosphate and other drugs. The preparations may be in the form of salves, creams, tablets, dragees, capsules, pearls, solutions suspensions or emulsions.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH856414X | 1956-03-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB856414A true GB856414A (en) | 1960-12-14 |
Family
ID=4542721
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB7815/57A Expired GB856414A (en) | 1956-03-08 | 1957-03-08 | Anti-allergic and anti-viral substances prepared from bacterial cultures |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB856414A (en) |
-
1957
- 1957-03-08 GB GB7815/57A patent/GB856414A/en not_active Expired
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