GB824375A - Respiration-stimulant substances from blood - Google Patents

Respiration-stimulant substances from blood

Info

Publication number
GB824375A
GB824375A GB3811456A GB3811456A GB824375A GB 824375 A GB824375 A GB 824375A GB 3811456 A GB3811456 A GB 3811456A GB 3811456 A GB3811456 A GB 3811456A GB 824375 A GB824375 A GB 824375A
Authority
GB
Grant status
Application
Patent type
Prior art keywords
blood
dialysis
preferably
carbon atoms
deproteination
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3811456A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Solco Basel AG
Original Assignee
Solco Basel AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14Blood; Artificial blood

Abstract

A process for the preparation of a respiration-stimulating active substance comprises subjecting the blood of slaughter-animals to dialysis to effect substantially complete deproteination and to effect complete removal of protein particles having a molecular weight in excess of approximately 3000 therefrom and concentrating the dialysate thereby obtained to a dry content of 10-60 mg/ml., preferably at least 30 mg/ml. The dialysis is preferably effected in a tube of "Cellophane" (Registered Trade Mark) employing as solvents water or dilute alcohol. Prior to dialysis the blood may be subjected to a preliminary deproteination by fractional precipitation with alcohols, e.g. straight or branched chain aliphatic alcohols containing from 1-6 carbon atoms or acid such as trichloracetic acid or preferably perchloric acid. The concentrated dialysate may be purified by precipitation with aliphatic ketones or alcohols containing from 1-6 carbon atoms, acetone being a particularly useful precipitant, or by extraction with a water-immiscible or partly immiscible solvent such as aliphatic alcohols with 3-8 carbon atoms, e.g. butanol, or aliphatic ethers with 2-12 carbon atoms and both resulting phases worked up. Preferably the blood is subjected to a pretreatment before dialysis or before the preliminary deproteination preceding dialysis, such as haemolysis, treatment with acetone, spray-drying, defibrination, peptic and/or tryptic digestion. The crude concentrate and/or purified concentrate may be evaporated to dryness, dissolved in distilled water and sterile filtered and freeze-dried under sterile conditions. Phenol and cresol may be added as preservatives. The crude concentrate after sterile filtration can be applied directly. The blood used is preferably that of young slaughter-animals and may come from animals which have been put into a condition of altered activity by mechanical or chemical treatment or by irradiation. Blood-cells and plasma may be separated and worked up separately.
GB3811456A 1955-12-13 1956-12-13 Respiration-stimulant substances from blood Expired GB824375A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE824375X 1955-12-13

Publications (1)

Publication Number Publication Date
GB824375A true true GB824375A (en) 1959-11-25

Family

ID=6747263

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3811456A Expired GB824375A (en) 1955-12-13 1956-12-13 Respiration-stimulant substances from blood

Country Status (1)

Country Link
GB (1) GB824375A (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2022429A1 (en) * 1968-11-02 1970-07-31 Ist Naz Chim Biolog
DE3042999A1 (en) * 1980-11-14 1982-07-22 Solco Basel Ag Skin cosmetic compsn. contg. calves blood extract - prepd. by dialysis against water, concn. and inorganic salt extn. by silica gel treatment
FR2527079A1 (en) * 1982-05-21 1983-11-25 Solco Basel Ag Method for obtaining, from calf's blood, active substances accelerant cellular respiration
EP0645135A1 (en) 1993-09-29 1995-03-29 Solco Basel AG Sunscreen composition containing hemodialysate
WO2002067957A1 (en) * 2001-02-28 2002-09-06 Biopure Corporation Use of defibrinated blood for manufacture of a hemoglobin-based oxygen carrier
US7001715B2 (en) 2002-02-28 2006-02-21 Biopure Corporation Purification of red blood cells by separation and diafiltration

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2022429A1 (en) * 1968-11-02 1970-07-31 Ist Naz Chim Biolog
DE3042999A1 (en) * 1980-11-14 1982-07-22 Solco Basel Ag Skin cosmetic compsn. contg. calves blood extract - prepd. by dialysis against water, concn. and inorganic salt extn. by silica gel treatment
FR2527079A1 (en) * 1982-05-21 1983-11-25 Solco Basel Ag Method for obtaining, from calf's blood, active substances accelerant cellular respiration
EP0095170A2 (en) * 1982-05-21 1983-11-30 Solco Basel AG Process for obtaining cellular respiration stimulation-active substances from calves' blood
GB2130088A (en) * 1982-05-21 1984-05-31 Solco Basel Ag Cell stimulating agents
EP0095170A3 (en) * 1982-05-21 1984-06-06 Solco Basel Ag Process for obtaining cellular respiration stimulation-active substances from calves' blood
US5486353A (en) * 1993-09-29 1996-01-23 Solco Basel Ag Antisun product
EP0645135A1 (en) 1993-09-29 1995-03-29 Solco Basel AG Sunscreen composition containing hemodialysate
WO2002067957A1 (en) * 2001-02-28 2002-09-06 Biopure Corporation Use of defibrinated blood for manufacture of a hemoglobin-based oxygen carrier
US6518010B2 (en) 2001-02-28 2003-02-11 Biopure Corporation Use of defibrinated blood for manufacture of a hemoglobin-based oxygen carrier
US6986984B2 (en) 2001-02-28 2006-01-17 Biopure Corporation Use of defibrinated blood for manufacture of a hemoglobin-based oxygen carrier
US7553613B2 (en) 2001-02-28 2009-06-30 Biopure Corporation Use of defibrinated blood for manufacture of hemoglobin-based oxygen carrier
US7001715B2 (en) 2002-02-28 2006-02-21 Biopure Corporation Purification of red blood cells by separation and diafiltration

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