GB811624A - A novel substituted thioxanthene, a process for its production and novel acid salts thereof - Google Patents
A novel substituted thioxanthene, a process for its production and novel acid salts thereofInfo
- Publication number
- GB811624A GB811624A GB3461457A GB3461457A GB811624A GB 811624 A GB811624 A GB 811624A GB 3461457 A GB3461457 A GB 3461457A GB 3461457 A GB3461457 A GB 3461457A GB 811624 A GB811624 A GB 811624A
- Authority
- GB
- United Kingdom
- Prior art keywords
- thioxanthene
- salts
- compound
- acid salts
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
The invention comprises the compound 9-(11-methylpiperidino - 31 - methyl) thioxanthene and its acid salts, e.g. its salts with hydrochloric, sulphuric, phosphoric, acetic, maleic, tartaric and citric acids. The thioxanthene compound may be prepared by metallizing thioxanthene in the 9-position by reaction with an alkali metal-transferring compound, such as sodamide or an aryl sodium, particularly phenyl or tolyl sodium, or an aryl or alkyl lithium, and reacting the metal thioxanthene simultaneously or subsequently with a halogen acid ester or an aryl sulphonic acid ester of N-methylpiperidino-3-methanol. The reaction is carried out in an inert solvent, e.g. benzene, toluene, dioxan or anisole. Aryl sulphonic acid esters mentioned are benzene- and p-toluene-sulphonic acid esters. In an example, thioxanthene is reacted with phenyl sodium and the product reacted with N-methyl-3-chloromethyl-piperidine. The compound of the invention and its acid salts are useful therapeutically (see Group VI). U.S.A. Specifications 2,368,006, 2,676,971 and German Specification 815,346 are referred to.ALSO:A medicine comprises a therapeutic dose of 9 - (11 - methylpiperidino - 31 - methyl) - thioxanthene and its acid salts. The compounds are stated to have anti-Parkinson effects. Water-soluble acid salts specified are salts with hydrochloric, sulphuric, phosphoric, acetic, maleic, tartaric and citric acids; these salts are also satisfactory for perenteral therapy. U.S.A. Specifications 2,368,006, 2,676,971 and German Specification 815,346 are referred to.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH3927756 | 1956-11-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB811624A true GB811624A (en) | 1959-04-08 |
Family
ID=49786075
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB3461457A Expired GB811624A (en) | 1956-11-06 | 1957-11-06 | A novel substituted thioxanthene, a process for its production and novel acid salts thereof |
GB2752758A Expired GB835867A (en) | 1956-11-06 | 1958-08-27 | New thioxanthene derivatives and a process for their preparation |
GB4009659A Expired GB911633A (en) | 1956-11-06 | 1959-11-25 | Thioxanthene derivatives and a process for their production |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB2752758A Expired GB835867A (en) | 1956-11-06 | 1958-08-27 | New thioxanthene derivatives and a process for their preparation |
GB4009659A Expired GB911633A (en) | 1956-11-06 | 1959-11-25 | Thioxanthene derivatives and a process for their production |
Country Status (3)
Country | Link |
---|---|
CH (2) | CH354442A (en) |
DE (1) | DE1203779B (en) |
GB (3) | GB811624A (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3236854A (en) * | 1961-09-08 | 1966-02-22 | Rhone Poulenc Sa | Azathioxanthene derivatives |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2368006A (en) * | 1943-10-07 | 1945-01-23 | Searle & Co | Heterocyclic tertiary amines |
DE815346C (en) * | 1949-03-31 | 1951-10-01 | Rhone Poulenc Sa | Process for the preparation of (Diaethylamino-2'-propyl-1 ') -10-thioxanthene |
-
1956
- 1956-11-06 CH CH354442D patent/CH354442A/en unknown
- 1956-11-19 DE DE1956W0020128 patent/DE1203779B/en active Pending
-
1957
- 1957-11-06 GB GB3461457A patent/GB811624A/en not_active Expired
-
1958
- 1958-08-18 CH CH358419D patent/CH358419A/en unknown
- 1958-08-27 GB GB2752758A patent/GB835867A/en not_active Expired
-
1959
- 1959-11-25 GB GB4009659A patent/GB911633A/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
DE1203779B (en) | 1965-10-28 |
GB911633A (en) | 1962-11-28 |
GB835867A (en) | 1960-05-25 |
CH354442A (en) | 1961-05-31 |
CH358419A (en) | 1961-11-30 |
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