GB811624A - A novel substituted thioxanthene, a process for its production and novel acid salts thereof - Google Patents

A novel substituted thioxanthene, a process for its production and novel acid salts thereof

Info

Publication number
GB811624A
GB811624A GB3461457A GB3461457A GB811624A GB 811624 A GB811624 A GB 811624A GB 3461457 A GB3461457 A GB 3461457A GB 3461457 A GB3461457 A GB 3461457A GB 811624 A GB811624 A GB 811624A
Authority
GB
United Kingdom
Prior art keywords
thioxanthene
salts
compound
acid salts
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3461457A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wander AG
Original Assignee
Wander AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wander AG filed Critical Wander AG
Publication of GB811624A publication Critical patent/GB811624A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

The invention comprises the compound 9-(11-methylpiperidino - 31 - methyl) thioxanthene and its acid salts, e.g. its salts with hydrochloric, sulphuric, phosphoric, acetic, maleic, tartaric and citric acids. The thioxanthene compound may be prepared by metallizing thioxanthene in the 9-position by reaction with an alkali metal-transferring compound, such as sodamide or an aryl sodium, particularly phenyl or tolyl sodium, or an aryl or alkyl lithium, and reacting the metal thioxanthene simultaneously or subsequently with a halogen acid ester or an aryl sulphonic acid ester of N-methylpiperidino-3-methanol. The reaction is carried out in an inert solvent, e.g. benzene, toluene, dioxan or anisole. Aryl sulphonic acid esters mentioned are benzene- and p-toluene-sulphonic acid esters. In an example, thioxanthene is reacted with phenyl sodium and the product reacted with N-methyl-3-chloromethyl-piperidine. The compound of the invention and its acid salts are useful therapeutically (see Group VI). U.S.A. Specifications 2,368,006, 2,676,971 and German Specification 815,346 are referred to.ALSO:A medicine comprises a therapeutic dose of 9 - (11 - methylpiperidino - 31 - methyl) - thioxanthene and its acid salts. The compounds are stated to have anti-Parkinson effects. Water-soluble acid salts specified are salts with hydrochloric, sulphuric, phosphoric, acetic, maleic, tartaric and citric acids; these salts are also satisfactory for perenteral therapy. U.S.A. Specifications 2,368,006, 2,676,971 and German Specification 815,346 are referred to.
GB3461457A 1956-11-06 1957-11-06 A novel substituted thioxanthene, a process for its production and novel acid salts thereof Expired GB811624A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH3927756 1956-11-06

Publications (1)

Publication Number Publication Date
GB811624A true GB811624A (en) 1959-04-08

Family

ID=49786075

Family Applications (3)

Application Number Title Priority Date Filing Date
GB3461457A Expired GB811624A (en) 1956-11-06 1957-11-06 A novel substituted thioxanthene, a process for its production and novel acid salts thereof
GB2752758A Expired GB835867A (en) 1956-11-06 1958-08-27 New thioxanthene derivatives and a process for their preparation
GB4009659A Expired GB911633A (en) 1956-11-06 1959-11-25 Thioxanthene derivatives and a process for their production

Family Applications After (2)

Application Number Title Priority Date Filing Date
GB2752758A Expired GB835867A (en) 1956-11-06 1958-08-27 New thioxanthene derivatives and a process for their preparation
GB4009659A Expired GB911633A (en) 1956-11-06 1959-11-25 Thioxanthene derivatives and a process for their production

Country Status (3)

Country Link
CH (2) CH354442A (en)
DE (1) DE1203779B (en)
GB (3) GB811624A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3236854A (en) * 1961-09-08 1966-02-22 Rhone Poulenc Sa Azathioxanthene derivatives

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2368006A (en) * 1943-10-07 1945-01-23 Searle & Co Heterocyclic tertiary amines
DE815346C (en) * 1949-03-31 1951-10-01 Rhone Poulenc Sa Process for the preparation of (Diaethylamino-2'-propyl-1 ') -10-thioxanthene

Also Published As

Publication number Publication date
DE1203779B (en) 1965-10-28
GB911633A (en) 1962-11-28
GB835867A (en) 1960-05-25
CH354442A (en) 1961-05-31
CH358419A (en) 1961-11-30

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