GB809165A - New pharmaceutical compositions - Google Patents

New pharmaceutical compositions

Info

Publication number
GB809165A
GB809165A GB1854856A GB1854856A GB809165A GB 809165 A GB809165 A GB 809165A GB 1854856 A GB1854856 A GB 1854856A GB 1854856 A GB1854856 A GB 1854856A GB 809165 A GB809165 A GB 809165A
Authority
GB
United Kingdom
Prior art keywords
aqueous
amino
stearate
stands
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1854856A
Inventor
Stanley Birtwell
William Glynne Moss Jones
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Imperial Chemical Industries Ltd
Original Assignee
Imperial Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imperial Chemical Industries Ltd filed Critical Imperial Chemical Industries Ltd
Priority to GB1854856A priority Critical patent/GB809165A/en
Publication of GB809165A publication Critical patent/GB809165A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/16—Compounds containing any of the groups, e.g. aminoguanidine
    • C07C281/18—Compounds containing any of the groups, e.g. aminoguanidine the other nitrogen atom being further doubly-bound to a carbon atom, e.g. guanylhydrazones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Pharmaceutical compositions useful for oral parenteral or topical administration in the treatment of allergic conditions, e.g. asthma, hay fever and inflammatory diseases, comprise at least one amino-guanidine derivative of the formula: <FORM:0809165/VI/1> wherein of the substituents A and B, one stands for a phenyl, a naphthyl or tetrahydronaphthyl radical which may optionally bear substituents and the other stands for hydrogen or for an alkyl radical, R, R1 and R11 stand for hydrogen or for alkyl radicals and wherein R111 stands for hydrogen, an alkyl radical or an aralkyl radical, or a salt thereof, in admixture with non-toxic pharmaceutically acceptable diluents or carriers therefor. Examples of the active ingredients are: N1-amino-N2-p-chlorophenylguanidine, N1 - amino - N2 - p - methoxyphenylguanidine and N1-amino-N2-phenylguanidine, and the monohydrochloride, stearate and salicylate salts thereof. The compositions may take the form of coated or uncoated tablets containing conventional adjuvants or ion-exchange resins on which have been absorbed the active constituents; oral syrups and elixirs formulated from sweetened aqueous media; oral suspensions in sweetened aqueous media containing suspending and dispersing agents; capsules containing the active ingredient and a solid diluent; injectable preparations, e.g. aqueous solutions, dispersible powders and suspensions in aqueous and oily media; topical preparations, e.g. creams, ointment and lotions. Adjuvants used in formulating the above preparations include, calcium carbonate, maize starch, alginic acid, magnesium stearate, "Amberlie" (Registered Trade Mark) IR-120, aqueous glycerin containing saccharin, aqueous alcohol containing sucrose, methyl and propyl parabens, sodium carboxy methylcellulose, sodium alginate, polyvinylpyrrolidone, lecithin, polyoxyethylene stearate, heptadeca-ethyleneoxycetanal and related compounds, polyoxyethylene sorbitol hexa-oleate and related compounds, polyoxyethylene sorbitan mono-oleate and related compounds, chlorocresol, arachis oil in the presence of a gelling agent, e.g. aluminium stearate, liquid paraffin, paraffin wax, animal and vegetable oils, e.g. lanolin, fatty alcohols or acids, e.g. cetyl alcohol, stearic or oleic acids and their salts, glycol, sorbital, polyethylene glycols, calamine and zinc oxide. Specification 800,869, [Group IV (b)], is referred to.
GB1854856A 1956-06-15 1956-06-15 New pharmaceutical compositions Expired GB809165A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB1854856A GB809165A (en) 1956-06-15 1956-06-15 New pharmaceutical compositions

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1854856A GB809165A (en) 1956-06-15 1956-06-15 New pharmaceutical compositions

Publications (1)

Publication Number Publication Date
GB809165A true GB809165A (en) 1959-02-18

Family

ID=10114321

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1854856A Expired GB809165A (en) 1956-06-15 1956-06-15 New pharmaceutical compositions

Country Status (1)

Country Link
GB (1) GB809165A (en)

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4163800A (en) * 1977-08-17 1979-08-07 The Procter & Gamble Company Topical composition and treatment of skin lesions therewith
US4978684A (en) * 1987-11-13 1990-12-18 The Rockefeller University Method and agents for preventing staining of teeth
US4983604A (en) * 1987-11-13 1991-01-08 The Rockefeller University Inhibitors of nonenzymatic cross-linking
US5096703A (en) * 1984-03-19 1992-03-17 The Rockefeller University Method and agents for preventing staining of teeth
US5140048A (en) * 1984-03-19 1992-08-18 The Rockefeller University Inhibitors of nonenzymatic cross-linking
US5468777A (en) * 1984-03-19 1995-11-21 The Rockefeller University Method and agents for preventing and reversing the staining of teeth
US5612332A (en) * 1984-03-19 1997-03-18 Alteon Inc. Di- and triaminoguanidines, and methods of use
US5850840A (en) * 1995-11-15 1998-12-22 Alteon Inc. Methods for measurement and treatment predicated on the presence of advanced glycosylation endproducts in tobacco and its combustion byproducts
US5852009A (en) * 1984-03-19 1998-12-22 The Rockefeller University Compositions, including pharmaceutical compositions, for inhibiting the advanced glycosylation of proteins, and therapeutic methods based thereon
US5877217A (en) * 1995-12-26 1999-03-02 Alteon Inc. N-acylaminoalkyl-hydrazinecarboximidamides
US6110968A (en) * 1995-12-26 2000-08-29 The Picower Institute For Medical Research Methods for treatment predicated on the presence of advanced glycosylation endproducts in tobacco and its combustion byproducts

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4163800A (en) * 1977-08-17 1979-08-07 The Procter & Gamble Company Topical composition and treatment of skin lesions therewith
US5096703A (en) * 1984-03-19 1992-03-17 The Rockefeller University Method and agents for preventing staining of teeth
US5140048A (en) * 1984-03-19 1992-08-18 The Rockefeller University Inhibitors of nonenzymatic cross-linking
US5468777A (en) * 1984-03-19 1995-11-21 The Rockefeller University Method and agents for preventing and reversing the staining of teeth
US5612332A (en) * 1984-03-19 1997-03-18 Alteon Inc. Di- and triaminoguanidines, and methods of use
US5852009A (en) * 1984-03-19 1998-12-22 The Rockefeller University Compositions, including pharmaceutical compositions, for inhibiting the advanced glycosylation of proteins, and therapeutic methods based thereon
US6114323A (en) * 1984-03-19 2000-09-05 The Rockefeller University Methods for inhibiting the advanced glycosylation of proteins
US4978684A (en) * 1987-11-13 1990-12-18 The Rockefeller University Method and agents for preventing staining of teeth
US4983604A (en) * 1987-11-13 1991-01-08 The Rockefeller University Inhibitors of nonenzymatic cross-linking
US5850840A (en) * 1995-11-15 1998-12-22 Alteon Inc. Methods for measurement and treatment predicated on the presence of advanced glycosylation endproducts in tobacco and its combustion byproducts
US5877217A (en) * 1995-12-26 1999-03-02 Alteon Inc. N-acylaminoalkyl-hydrazinecarboximidamides
US6110968A (en) * 1995-12-26 2000-08-29 The Picower Institute For Medical Research Methods for treatment predicated on the presence of advanced glycosylation endproducts in tobacco and its combustion byproducts

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