GB792978A - Improvements in or relating to streptomycin salts - Google Patents

Abstract

The invention relates to a salt of streptomycin and a phosphorylated inositol, especially one containing three molecules of streptomycin per molecule of phytic acid. The salt may be hydrated or anhydrous. Where free acid groups are available for further salt formation, non-toxic metal ions such as sodium, potassium, ammonium, calcium and magnesium may be present. The phytic acid (inositol hexaphosphoric acid) may be replaced by other inositol phosphoric acids such as the tri- and tetraphosphoric acid. It is preferred to react a water-soluble phytate, e.g. sodium phytate, with a water-soluble salt of streptomycin, e.g. streptomycin sulphate, in aqueous solution at a pH of 7 to 8, preferably after a preliminary treatment with carbon. Streptomycin phytate is therapeutically active, non-toxic and relatively insoluble in water. It is used medicinally (see Group VI) and in the recovery of streptomycin from aqueous solution.ALSO:A therapeutic preparation in the form of a powder, tablet, capsule or aqueous or oily suspension for oral or parenteral use, comprises a salt of streptomycin and a phosphorylated inositol, e.g. streptomycin phytate (see Group IV (b)) with or without the addition of other medicaments. An edible oil such as coconut oil or an injectable oil such as peanut oil, as such or gelled with aluminium monostearate, forms the vehicle for the oily suspensions. Optional ingredients are (a) suspending agents such as sodium carboxymethyl cellulose, methyl cellulose, polyvinyl alcohol, polyvinyl pyrrolidone, gum tragacanth, gelatine, pectin, alginates, dextrans, gum karaya, lecithin, polyoxyalkylene derivatives, glyceryl monostearate, inositol phosphoric acids and their non-toxic salts; (b) buffers such as sodium citrate or sodium phosphate; (c) preservatives, e.g. phenol, cresol, alkyl esters of p-hydroxy benzoic acid; (d) other pharmaceutical adjuvants. The particle size of the streptomycin phylate may be varied. Specified other medicaments are anti-histamines, sulpha drugs, vitamins, lipotropic agents, stimulants, analgesics, laxatives, sedatives and antibiotics such as potassium benzyl penicillin. The streptomycin phylate particles may be coated with a suspending agent such as lecithin.