GB768007A - A new antibiotic cycloserine and method of preparing the same - Google Patents
A new antibiotic cycloserine and method of preparing the sameInfo
- Publication number
- GB768007A GB768007A GB815/55A GB81555A GB768007A GB 768007 A GB768007 A GB 768007A GB 815/55 A GB815/55 A GB 815/55A GB 81555 A GB81555 A GB 81555A GB 768007 A GB768007 A GB 768007A
- Authority
- GB
- United Kingdom
- Prior art keywords
- cycloserine
- per cent
- silver salt
- soluble
- silver
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
<PICT:0768007/IV(b)/1> A new antibiotic, cycloserine, is produced by cultivating Streptomyces orchidaceus (described) NRRL-2454 in an aqueous nutrient medium under submerged aerobic conditions at a temperature of 20 DEG to 30 DEG C., and preferably 20 DEG C., for 1 to 5 days. The medium contains (a) a source of carbohydrate such as glucose (preferred), sucrose, lactose, maltose, starch and glycerol; (b) a source of nitrogen, e.g. soybean products (preferred), alfalfa meal, amino acid cake, milk solids, whey nutrient, dried wheat slop, ground wheat, casein, a bone albumenoid material and enzymalic digest of lactalbumia; (c) calcium carbonate; (d) antifoaming agent. Cycloserine is recovered from the clarified broth by adsorption on (a) strongly basic anion exchange resins, e.g. "Amberlites" (Registered Trade Mark) IRA-400 and IRA-410 and Dowex-2 and elution with anions other than OH, e.g. chloride, sulphate, acetate and formate; (b) strongly acid cation exchange resins, e.g. Amberlite IR-120. The elute is decolorized with carbon and the cycloserine precipitated as the silver salt by the addition of a soluble silver salt, e.g. silver nitrate. The silver cycloserine is decomposed with aqueous acid and the cycloserine recovered by freeze drying or the addition of a water-miscible non-solvent, e.g. acetone. Cycloserine is a broad spectrum antibiotic useful in animal and poultry feed supplements; it is soluble in water, slightly soluble in glycols, isopropyl alcohol, methanol, ethanol, dioxane, 1-butanol and acetone; insoluble in hexane, benzene, chloroform, ether and petroleum ether; it contains 6 per cent hydrogen, 35.49 per cent carbon, 26.55 per cent nitrogen and 31.96 per cent oxygen; molecular weight 102; characteristic ultra-violet absorption at a wavelength of 224 microns; <FORM:0768007/IV(b)/1> , C=5.0 per cent, L=2.0 dm. 2N sodium hydroxide solution; gives a green colour with cupric ion in aqueous solution; gives a reddish brown with iron in aqueous solution; meltingpoint 155-157 DEG C.; exhibit characteristic absorption in infra red at 6.15, 6.55, 6.65, 7.20, 7.40, 7.50, 7.85, 8.20, 8.60, 8.80, 9.00, 9.40, 10.65, 10.90, 11.30, 11.40, 12.05, 12.50 and 13.25 microns: forms silver salt.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US768007XA | 1954-04-21 | 1954-04-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB768007A true GB768007A (en) | 1957-02-13 |
Family
ID=22134259
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB815/55A Expired GB768007A (en) | 1954-04-21 | 1955-01-11 | A new antibiotic cycloserine and method of preparing the same |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB768007A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3124590A (en) * | 1964-03-10 | Recovery of cycloserine | ||
CN114163393A (en) * | 2020-09-10 | 2022-03-11 | 浙江海正药业股份有限公司 | Cycloserine crystal form and preparation method thereof |
-
1955
- 1955-01-11 GB GB815/55A patent/GB768007A/en not_active Expired
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3124590A (en) * | 1964-03-10 | Recovery of cycloserine | ||
CN114163393A (en) * | 2020-09-10 | 2022-03-11 | 浙江海正药业股份有限公司 | Cycloserine crystal form and preparation method thereof |
WO2022052969A1 (en) * | 2020-09-10 | 2022-03-17 | 浙江海正药业股份有限公司 | Cycloserine crystal form and preparation method therefor |
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