GB714664A - Process for the manufacture of pure nicotinic acid - Google Patents
Process for the manufacture of pure nicotinic acidInfo
- Publication number
- GB714664A GB714664A GB24615/52A GB2461552A GB714664A GB 714664 A GB714664 A GB 714664A GB 24615/52 A GB24615/52 A GB 24615/52A GB 2461552 A GB2461552 A GB 2461552A GB 714664 A GB714664 A GB 714664A
- Authority
- GB
- United Kingdom
- Prior art keywords
- nicotinic acid
- acid
- diphenyl
- mixture
- pure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
Abstract
A process for the manufacture of pure nicotinic acid comprises subjecting a mixture of a nicotinic acid-containing composition with an inert solvent to azeotropic distillation and separating the pure nicotinic acid by crystallization from the mixture of nicotinic acid and the inert solvent which thereby distils over. Suitable solvents are tetrahydronaphthalene, diphenyl, diphenyl ether or mixtures thereof. The nicotinic acid composition may be impure nicotinic acid formed in situ by thermal treatment of a compound capable of being thereby transformed into nicotinic acid, e.g. dicarboxylic acids, such as quinolinic or isocinchomeronic acid. Examples describe (1) the distillation of a mixture of nicotinic acid, diphenyl and diphenyl ether; (2) and (3) the production of nicotinic acid by heating quinolinic acid and isocinchromeronic acid, mixed with diphenyl and diphenyl ether to 130 DEG C. and 210 DEG to 230 DEG C. respectively, followed by azeotropic distillation.ALSO:A process for the manufacture of pure nicotinic acid comprises subjecting a mixture containing nicotinic acid to azeotropic distillation with an inert solvent and separating the pure nicotinic acid by crystallization from the mixture of nicotinic acid and the inert solvent which distils over. Suitable solvents are tetrahydronaphthalene, diphenyl, diphenyl ether or mixtures thereof. The nicotinic acid composition may be impure nicotinic acid formed by thermal treatment of a compound capable of being transformed into nicotinic acid, e.g dicarboxylic acids such as quinolinic or isoinchomeronic acid. Examples describe (1) the distillation of a mixture of nicotinic acid, diphenyl and diphenyl ether; (2) and (3) the production of nicotinic acid by heating quinolinic acid and iso-cinchomeronic acid, mixed with diphenyl and diphenyl ether to 130 DEG C. and 210 DEG to 230 DEG C. respectively, followed by azeotropic distillation.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH714664X | 1951-10-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB714664A true GB714664A (en) | 1954-09-01 |
Family
ID=4531015
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB24615/52A Expired GB714664A (en) | 1951-10-04 | 1952-10-01 | Process for the manufacture of pure nicotinic acid |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB714664A (en) |
-
1952
- 1952-10-01 GB GB24615/52A patent/GB714664A/en not_active Expired
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