GB693990A - Improvements in or relating to methods of preparing cyclopentanophenanthrene derivatives - Google Patents
Improvements in or relating to methods of preparing cyclopentanophenanthrene derivativesInfo
- Publication number
- GB693990A GB693990A GB30914/50A GB3091450A GB693990A GB 693990 A GB693990 A GB 693990A GB 30914/50 A GB30914/50 A GB 30914/50A GB 3091450 A GB3091450 A GB 3091450A GB 693990 A GB693990 A GB 693990A
- Authority
- GB
- United Kingdom
- Prior art keywords
- hydroxy
- groups
- bromo
- reacting
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
17a - Hydroxy - 20 - oxo - 21 - acyloxyallopregnane compounds are manufactured by reacting a 21 - halogen - 17a - hydroxy - 20 - oxoallopregnane compound with an alkali metal salt of a fatty acid containing fewer than 6 carbon atoms in the molecule, in an inert organic solvent for the starting material. The starting materials may be otherwise unsubstituted or may contain further substituents, e.g. hydroxy, etherified hydroxy, acyloxy or keto groups or corresponding thio groups, especially keto or a -or b -hydroxy groups, or groups convertible thereto, in the 3-position. Preferably a 21-bromo or 21-iodo compound is heated with sodium or potassium acetate or propionate in an aliphatic ketone in which the two aliphatic groups attached to the carbonyl group each contain fewer than 6 carbon atoms (e.g. acetone). Examples describe the preparation of 3b -acetoxy - 17a : 21 - dihydroxy - and 3b : 21 - diacetoxy - 17 - a - hydroxyallopregnan - 20 - one, and 17a - hydroxy - 21 - acetoxyallopregnane - 3 : 20 - dione. Specification 685,331 is referred to. 21 - Bromo - and 21 - iodo - 17a - hydroxy - 20-oxoallopregnanes are obtainable by brominating the corresponding allopregnane compounds, and, if desired, reacting the resulting 21-bromo-derivative with an alkali metal iodide, e.g. sodium iodide.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US693990XA | 1950-01-23 | 1950-01-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB693990A true GB693990A (en) | 1953-07-08 |
Family
ID=22088735
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB30914/50A Expired GB693990A (en) | 1950-01-23 | 1950-12-19 | Improvements in or relating to methods of preparing cyclopentanophenanthrene derivatives |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB693990A (en) |
-
1950
- 1950-12-19 GB GB30914/50A patent/GB693990A/en not_active Expired
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