GB668114A - New substance serving as generator for vitamin d2 or calciferol - Google Patents

New substance serving as generator for vitamin d2 or calciferol

Info

Publication number
GB668114A
GB668114A GB1111/50A GB111150A GB668114A GB 668114 A GB668114 A GB 668114A GB 1111/50 A GB1111/50 A GB 1111/50A GB 111150 A GB111150 A GB 111150A GB 668114 A GB668114 A GB 668114A
Authority
GB
United Kingdom
Prior art keywords
vitamin
ergosterol
benzene
exceeding
degrees
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1111/50A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Usines Chimiques des Laboratoires Francais
Original Assignee
Roussel Uclaf SA
Usines Chimiques des Laboratoires Francais
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA, Usines Chimiques des Laboratoires Francais filed Critical Roussel Uclaf SA
Publication of GB668114A publication Critical patent/GB668114A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14—All rings being cycloaliphatic
    • C07C2602/24—All rings being cycloaliphatic the ring system containing nine carbon atoms, e.g. perhydroindane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Steroid Compounds (AREA)

Abstract

The invention comprises a new chemical compound designated precalciferol which is isomeric with calciferol and capable of being converted there into without the action of light further characterized by having an optical notation of +43 degrees in benzene (e=1 per cent) and by forming a 3 : 5-dinitrobenzoate crystallizing in fine very pale yellow needles of m.p. 103-104 DEG C. and having an optical notation of +30 degrees in benzene and +45 degrees in chloroform and its esters. These substances are obtained from ergosterol by preparing the resinous irradiation product from ergosterol in the usual manner, separating out the excess of ergosterol, esterifying the resinous product of radiation, preferably with 3 : 5-dinitrobenzoyl chloride at a temperature not exceeding 25 DEG C. at all stages of the preparation, separating by chromatography the less strongly adsorbed fraction, crystallizing this fraction with the use of a mixture of solvents or a solvent such as lignoin, and recrystallizing the product thus obtained from a mixture of solvents or a solvent such as methylethyl ketone and alcohol in order to isolate the ester of precalciferol, and if the free unesterified substance is desired, saponifying the ester with alkali at a temperature not exceeding 15 DEG C. Vitamin D2 may be obtained from the products by heating to a moderate temperature, preferably not exceeding 80 DEG C. in the presence of a solvent such as benzene, and then separating Vitamin D2.
GB1111/50A 1949-01-21 1950-01-16 New substance serving as generator for vitamin d2 or calciferol Expired GB668114A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR668114X 1949-01-21

Publications (1)

Publication Number Publication Date
GB668114A true GB668114A (en) 1952-03-12

Family

ID=9014813

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1111/50A Expired GB668114A (en) 1949-01-21 1950-01-16 New substance serving as generator for vitamin d2 or calciferol

Country Status (1)

Country Link
GB (1) GB668114A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0603726A2 (en) * 1992-12-21 1994-06-29 Bristol-Myers Squibb Company Nutritional compositions containing vitamin d esters

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0603726A2 (en) * 1992-12-21 1994-06-29 Bristol-Myers Squibb Company Nutritional compositions containing vitamin d esters
EP0603726B1 (en) * 1992-12-21 2002-04-17 Bristol-Myers Squibb Company Nutritional compositions containing vitamin d esters

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