GB651913A - Purification of ª-aminocarboxylic acids - Google Patents
Purification of ª-aminocarboxylic acidsInfo
- Publication number
- GB651913A GB651913A GB15775/48A GB1577548A GB651913A GB 651913 A GB651913 A GB 651913A GB 15775/48 A GB15775/48 A GB 15775/48A GB 1577548 A GB1577548 A GB 1577548A GB 651913 A GB651913 A GB 651913A
- Authority
- GB
- United Kingdom
- Prior art keywords
- glycine
- product
- aqueous solution
- leucine
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/38—Separation; Purification; Stabilisation; Use of additives
- C07C227/40—Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
- C07C229/08—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
New compounds are obtained by reacting sodium or potassium carbonate with an a -amino carboxylic acid in an aqueous medium and isolating the product. Suitable a -amino carboxylic acids are glycine, alanine, valine, leucine, phenylalanine, cysteine, methionine, tyrosine, proline, glutamic acid, lysine and histidine. The product from glycine and sodium carbonate probably has the formula <FORM:0651913/IV (b)/1> The reaction product may be isolated from the reaction mixture by cooling a hot concentrated aqueous solution or by the addition of methanol to a concentrated aqueous solution at room temperature. The new compounds are useful as intermediates in the synthesis of N-anhydrocarboxy-a -amino acid and of valuable polymeric materials. The a -amino acids may be regenerated in a purified form from the new compounds, e.g. by acidification of an aqueous solution thereof followed by crystallization and filtration; or the reaction product may be converted by treatment with barium hydroxide into the corresponding barium product which may be boiled in aqueous solution to regenerate the amino acid. In the examples: (1) sodium carbonate is reacted with (a) glycine, (b) l-leucine, (c) dl-alanine, (d) a -amino-isobutyric acid, (e) phenyl alanine; and (2) the reaction product of (a) sodium carbonate and glycine is treated with saturated aqueous barium hydroxide solution; pure glycine is obtained by boiling an aqueous solution of the barium product; and (b) Na2CO3 and l-leucine is warmed with water, and hydrogen chloride and more water are then added; the mixture is heated and on cooling purified l-leucine separates. Specification 651,914 is referred to.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB15775/48A GB651913A (en) | 1948-06-11 | 1948-06-11 | Purification of ª-aminocarboxylic acids |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB15775/48A GB651913A (en) | 1948-06-11 | 1948-06-11 | Purification of ª-aminocarboxylic acids |
Publications (1)
Publication Number | Publication Date |
---|---|
GB651913A true GB651913A (en) | 1951-04-11 |
Family
ID=10065257
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB15775/48A Expired GB651913A (en) | 1948-06-11 | 1948-06-11 | Purification of ª-aminocarboxylic acids |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB651913A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000035804A1 (en) | 1998-12-16 | 2000-06-22 | Herm. Sprenger Gmbh & Co. Kg | Snaffle bit with two side rings and a shackle |
US7775023B2 (en) | 2004-07-30 | 2010-08-17 | Herm. Sprenger Gmbh & Co. Kg | Snaffle bit with two side members and a shackle and method of manufacturing same |
-
1948
- 1948-06-11 GB GB15775/48A patent/GB651913A/en not_active Expired
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000035804A1 (en) | 1998-12-16 | 2000-06-22 | Herm. Sprenger Gmbh & Co. Kg | Snaffle bit with two side rings and a shackle |
US7775023B2 (en) | 2004-07-30 | 2010-08-17 | Herm. Sprenger Gmbh & Co. Kg | Snaffle bit with two side members and a shackle and method of manufacturing same |
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