GB651913A - Purification of ª‡-aminocarboxylic acids - Google Patents

Purification of ª‡-aminocarboxylic acids

Info

Publication number
GB651913A
GB651913A GB15775/48A GB1577548A GB651913A GB 651913 A GB651913 A GB 651913A GB 15775/48 A GB15775/48 A GB 15775/48A GB 1577548 A GB1577548 A GB 1577548A GB 651913 A GB651913 A GB 651913A
Authority
GB
United Kingdom
Prior art keywords
glycine
product
aqueous solution
leucine
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB15775/48A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Imperial Chemical Industries Ltd
Original Assignee
Imperial Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imperial Chemical Industries Ltd filed Critical Imperial Chemical Industries Ltd
Priority to GB15775/48A priority Critical patent/GB651913A/en
Publication of GB651913A publication Critical patent/GB651913A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/38—Separation; Purification; Stabilisation; Use of additives
    • C07C227/40—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/08—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

New compounds are obtained by reacting sodium or potassium carbonate with an a -amino carboxylic acid in an aqueous medium and isolating the product. Suitable a -amino carboxylic acids are glycine, alanine, valine, leucine, phenylalanine, cysteine, methionine, tyrosine, proline, glutamic acid, lysine and histidine. The product from glycine and sodium carbonate probably has the formula <FORM:0651913/IV (b)/1> The reaction product may be isolated from the reaction mixture by cooling a hot concentrated aqueous solution or by the addition of methanol to a concentrated aqueous solution at room temperature. The new compounds are useful as intermediates in the synthesis of N-anhydrocarboxy-a -amino acid and of valuable polymeric materials. The a -amino acids may be regenerated in a purified form from the new compounds, e.g. by acidification of an aqueous solution thereof followed by crystallization and filtration; or the reaction product may be converted by treatment with barium hydroxide into the corresponding barium product which may be boiled in aqueous solution to regenerate the amino acid. In the examples: (1) sodium carbonate is reacted with (a) glycine, (b) l-leucine, (c) dl-alanine, (d) a -amino-isobutyric acid, (e) phenyl alanine; and (2) the reaction product of (a) sodium carbonate and glycine is treated with saturated aqueous barium hydroxide solution; pure glycine is obtained by boiling an aqueous solution of the barium product; and (b) Na2CO3 and l-leucine is warmed with water, and hydrogen chloride and more water are then added; the mixture is heated and on cooling purified l-leucine separates. Specification 651,914 is referred to.
GB15775/48A 1948-06-11 1948-06-11 Purification of ª‡-aminocarboxylic acids Expired GB651913A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB15775/48A GB651913A (en) 1948-06-11 1948-06-11 Purification of ª‡-aminocarboxylic acids

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB15775/48A GB651913A (en) 1948-06-11 1948-06-11 Purification of ª‡-aminocarboxylic acids

Publications (1)

Publication Number Publication Date
GB651913A true GB651913A (en) 1951-04-11

Family

ID=10065257

Family Applications (1)

Application Number Title Priority Date Filing Date
GB15775/48A Expired GB651913A (en) 1948-06-11 1948-06-11 Purification of ª‡-aminocarboxylic acids

Country Status (1)

Country Link
GB (1) GB651913A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000035804A1 (en) 1998-12-16 2000-06-22 Herm. Sprenger Gmbh & Co. Kg Snaffle bit with two side rings and a shackle
US7775023B2 (en) 2004-07-30 2010-08-17 Herm. Sprenger Gmbh & Co. Kg Snaffle bit with two side members and a shackle and method of manufacturing same

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000035804A1 (en) 1998-12-16 2000-06-22 Herm. Sprenger Gmbh & Co. Kg Snaffle bit with two side rings and a shackle
US7775023B2 (en) 2004-07-30 2010-08-17 Herm. Sprenger Gmbh & Co. Kg Snaffle bit with two side members and a shackle and method of manufacturing same

Similar Documents

Publication Publication Date Title
Okura et al. The structure of elastatinal, an elastase inhibitor of microbial origin
PAUL et al. Some side reactions of nitro-L-arginine
GB651913A (en) Purification of ª‡-aminocarboxylic acids
CA1104156A (en) Analogues of bestatin
Benoiton et al. Studies on diastereoisomeric α-amino acids and corresponding α-hydroxy acids. X. The preparation of β-hydroxy-β-methylaspartic acid
US3030380A (en) Process for preparing optically active amino acids from protein hydrolysates
CA1055046A (en) Preparation of .epsilon.(.gamma.glutamyl)-lysine
Kashima et al. Amino alcohols as C-terminal protecting groups in peptide synthesis
SU670213A3 (en) Method of producing optically active amino acids
Chosho et al. The Reactions of N-Substituted Thioamides with α-Halonitriles
Gaudry Study on the synthesis of valine by the Strecker method
Izumi et al. Asymmetric Hydrogenation of C= O Double Bond with Modified Raney Nickel. XII
US4370495A (en) Process for the preparation of α-[4-(4-chlorobenzoylaminoethyl)-phenoxy]-isobutyric acid
US3845110A (en) Process for the recovery of n-acyl-d-methionine and n-acyl-l-methionine
JPH0259828B2 (en)
GB1038913A (en) A process for producing n-carboxy anhydrides of alpha-amino acids
US4350628A (en) Preparation of dehydropeptides
US3627782A (en) Synthesis of gramine salt of nitroacetate esters
JPS6035356B2 (en) Method for producing pyroglutamyl peptide
GB628413A (en) Improvements in or relating to ethylene cyanohydrin and method of producing same
JP2000501387A (en) Method for producing N-acetyl-D, L-α-aminocarboxylic acid
SU517585A1 (en) Method for producing substituted aromatic amino acid esters
JPS6112899B2 (en)
ES2205069T3 (en) PROCEDURE FOR THE RACEMIZATION OF ACIDS N-ACETIL-D (L) -ALFA-AMINOCARBOXILIC.
SU598871A1 (en) Method of preparing hydrochloride of methylaminoacetopyrocatechol