GB643268A - Improved process for the preparation of prolonged effect insulin products - Google Patents

Improved process for the preparation of prolonged effect insulin products

Info

Publication number
GB643268A
GB643268A GB34626/45A GB3462645A GB643268A GB 643268 A GB643268 A GB 643268A GB 34626/45 A GB34626/45 A GB 34626/45A GB 3462645 A GB3462645 A GB 3462645A GB 643268 A GB643268 A GB 643268A
Authority
GB
United Kingdom
Prior art keywords
insulin
preparation
salmiridine
protein
addition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB34626/45A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nordisk Insulinlaboratorium
Original Assignee
Nordisk Insulinlaboratorium
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nordisk Insulinlaboratorium filed Critical Nordisk Insulinlaboratorium
Publication of GB643268A publication Critical patent/GB643268A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

A crystalline insulin preparation having a prolonged therapeutic effect comprises insulin, a zinc salt, an alkaline protein or protein split product, and a phenol or phenol derivative mixed together in aqueous medium in approximately isophanous conditions (i.e. such that after the removal of the insulin complex from preparations of the above type, the addition of insulin to one portion of the residual liquor and of alkaline protein to the other, produces the same degree of opalescence in both portions) at a pH of 6-8, preferably in the presence of a buffer such as sodium phosphate or acetate. Crystallization is improved in the presence of inorganic salts such as sodium chloride, which may be added to produce an isotonic preparation. Alternatively, an excess of such salt may be used and isotonicity produced by the addition of e.g. glucose. Specified proteins are salmiridine, clupeine, scombrine, sturine, thynnine, cyprinine, cyclopterine, a split product of salmiridine and thymus histone. Suitable phenols are o-, m-, p-cresol; m-, p-, chlorophenol; m-, p-nitrophenol and resorcin.
GB34626/45A 1944-04-04 1945-12-20 Improved process for the preparation of prolonged effect insulin products Expired GB643268A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK643268X 1944-04-04

Publications (1)

Publication Number Publication Date
GB643268A true GB643268A (en) 1950-09-15

Family

ID=8151959

Family Applications (1)

Application Number Title Priority Date Filing Date
GB34626/45A Expired GB643268A (en) 1944-04-04 1945-12-20 Improved process for the preparation of prolonged effect insulin products

Country Status (2)

Country Link
GB (1) GB643268A (en)
MY (1) MY5300087A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE948279C (en) * 1951-03-02 1956-08-30 Novo Terapeutisk Labor As Process for the production of insulin crystals with an increased metal content
DE1044360B (en) * 1953-08-19 1958-11-20 Roskilde Medical Company Ltd R Process for the production of zinc insulin with an increased zinc content
EP1585771A1 (en) * 2002-12-31 2005-10-19 Altus Pharmaceuticals Inc. Complexes of protein crystals and ionic polymers
US9376479B2 (en) 2002-12-31 2016-06-28 Anjinomoto Althea, Inc. Human growth hormone crystals and methods for preparing them

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE948279C (en) * 1951-03-02 1956-08-30 Novo Terapeutisk Labor As Process for the production of insulin crystals with an increased metal content
DE1044360B (en) * 1953-08-19 1958-11-20 Roskilde Medical Company Ltd R Process for the production of zinc insulin with an increased zinc content
EP1585771A1 (en) * 2002-12-31 2005-10-19 Altus Pharmaceuticals Inc. Complexes of protein crystals and ionic polymers
EP1585771A4 (en) * 2002-12-31 2006-11-29 Altus Pharmaceuticals Inc Complexes of protein crystals and ionic polymers
AU2003300126B2 (en) * 2002-12-31 2010-04-01 Altus Pharmaceuticals Inc. Complexes of protein crystals and ionic polymers
US9376479B2 (en) 2002-12-31 2016-06-28 Anjinomoto Althea, Inc. Human growth hormone crystals and methods for preparing them

Also Published As

Publication number Publication date
MY5300087A (en) 1953-12-31

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