GB583378A - Improvements in or relating to the degradation of dextrane - Google Patents

Improvements in or relating to the degradation of dextrane

Info

Publication number
GB583378A
GB583378A GB13104/44A GB1310444A GB583378A GB 583378 A GB583378 A GB 583378A GB 13104/44 A GB13104/44 A GB 13104/44A GB 1310444 A GB1310444 A GB 1310444A GB 583378 A GB583378 A GB 583378A
Authority
GB
United Kingdom
Prior art keywords
dextrane
product
degradation
hydrolysis
concentration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB13104/44A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Health AB
Original Assignee
Pharmacia AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia AB filed Critical Pharmacia AB
Publication of GB583378A publication Critical patent/GB583378A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0021—Dextran, i.e. (alpha-1,4)-D-glucan; Derivatives thereof, e.g. Sephadex, i.e. crosslinked dextran

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • External Artificial Organs (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

Partially depolymerised dextrane is prepared by subjecting at least partially water soluble microbiologically produced dextranes to an acid hydrolytic treatment under controlled conditions of time temperature and acidity so that only partial breaking down of the starting material takes place. The product is isolated by any method known to be capable of separating as hydrolysis or degradation product from the hydrolysis or degradation reaction medium. The conditions of reaction are adjusted so that products are obtained which are completely water soluble and which at a concentration of 0.7 per cent in aqueous solution have a sedimentation constant of from 1.5 X 10-13 to 20 X 10-13 and a diffusion constant of from 0.2 X 107 to 8 X 107, and the relative viscosity of which at a concentration of 4 per cent in aqueous solution shows a value of from 1.5 to 15. The preferred reaction conditions comprise a treatment with dilute hydrochloric acid at temperatures of 30 DEG C.-150 DEG C. for less than 24 hours followed by dialysis of the solution. In examples a microbiologically produced dextrane is hydrolysed with dilute hydrochloric acid for varying periods, the product neutralised and precipitated with alcohol. It is then re-dissolved in water and dialysed in a cellophane bag against distilled water. The products are used as injection or infusion fluids either alone or in combination with other physiologically active salts.
GB13104/44A 1943-07-17 1944-07-10 Improvements in or relating to the degradation of dextrane Expired GB583378A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE583378X 1943-07-17

Publications (1)

Publication Number Publication Date
GB583378A true GB583378A (en) 1946-12-17

Family

ID=20312462

Family Applications (1)

Application Number Title Priority Date Filing Date
GB13104/44A Expired GB583378A (en) 1943-07-17 1944-07-10 Improvements in or relating to the degradation of dextrane

Country Status (1)

Country Link
GB (1) GB583378A (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE844586C (en) * 1950-05-26 1952-07-21 Gerhard Dr-Ing Nehlsen Device for the automatic limitation of the approach path of rolling stands
US2644815A (en) * 1948-10-15 1953-07-07 Pharmacia Ab Process for producing dextran products having substantially uniform molecular size for pharmaceutical and therapeutic preparations
US2708174A (en) * 1952-11-15 1955-05-10 Commercial Solvents Corp Clinical dextran composition
US2719147A (en) * 1951-04-24 1955-09-27 Ivan A Wolff Thermal modification of dextran
US2727838A (en) * 1952-11-15 1955-12-20 Commercial Solvents Corp Process for hydrolyzing dextran
US2789066A (en) * 1953-10-14 1957-04-16 Ohio Commw Eng Co Method for hydrolyzing dextran

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2644815A (en) * 1948-10-15 1953-07-07 Pharmacia Ab Process for producing dextran products having substantially uniform molecular size for pharmaceutical and therapeutic preparations
DE844586C (en) * 1950-05-26 1952-07-21 Gerhard Dr-Ing Nehlsen Device for the automatic limitation of the approach path of rolling stands
US2719147A (en) * 1951-04-24 1955-09-27 Ivan A Wolff Thermal modification of dextran
US2708174A (en) * 1952-11-15 1955-05-10 Commercial Solvents Corp Clinical dextran composition
US2727838A (en) * 1952-11-15 1955-12-20 Commercial Solvents Corp Process for hydrolyzing dextran
US2789066A (en) * 1953-10-14 1957-04-16 Ohio Commw Eng Co Method for hydrolyzing dextran

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