GB552808A - - Google Patents
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- Publication number
- GB552808A GB552808A GB552808DA GB552808A GB 552808 A GB552808 A GB 552808A GB 552808D A GB552808D A GB 552808DA GB 552808 A GB552808 A GB 552808A
- Authority
- GB
- United Kingdom
- Prior art keywords
- malonic acid
- ethoxypentene
- oxo
- oct
- reacting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
552,808. Pyridine derivatives. HOFFMANNLA ROCHE & CO. AKT.-GES., F. July 29, 1941, Nos. 9627, 9628, 9629 and 9630. Convention dates, Sept. 25, 1940, Oct. 4, 1940, Oct. 31, 1940 and Nov. 1, 1940. [Class 2 (iii)] 2 - Methyl - 4 - ethoxymethyl - 6 - hydroxypyridines having a carbalkoxy, carboxyamide or nitrile group in the 5-position, are prepared by reacting 2-amino-4-oxo-5-ethoxypentene-2 with malonic acid dinitrile, malonic acid alkyl esters, malonic acid diamide or cyanacetamide, preferably in presence of a solvent. The products are intermediates for the synthesis of Vitamin B6. The 2-amino-4-oxo-5-ethoxypentene-2 is prepared by reacting ethoxyacetylacetone with ammonium chloride in aqueous solution or with aqueous ammonia, and may be used without isolation. Examples are given of the interaction of the pentene with (1) malonic acid dinitrile in the cold or cyanoacetamide under heat to give the 5-cyano product, (2) malonic acid diethyl ester in the presence of sodium ethylate to form the 5-carboxylic acid ethyl ester, (3) malonic acid diamide to produce the 5-carboxylic acid amide. Specification 534,916 is referred to.
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB552808A true GB552808A (en) |
Family
ID=1748679
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB552808D Active GB552808A (en) |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB552808A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2532055A (en) * | 1945-04-03 | 1950-11-28 | Wyeth Corp | Pyridone derivatives |
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0
- GB GB552808D patent/GB552808A/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2532055A (en) * | 1945-04-03 | 1950-11-28 | Wyeth Corp | Pyridone derivatives |
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