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Expired
Application number
GB2899338A
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Imperial Chemical Industries Ltd
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Imperial Chemical Industries Ltd
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Application filed by Imperial Chemical Industries LtdfiledCriticalImperial Chemical Industries Ltd
Priority to GB2899338ApriorityCriticalpatent/GB519894A/en
Publication of GB519894ApublicationCriticalpatent/GB519894A/en
Organic Low-Molecular-Weight Compounds And Preparation Thereof
(AREA)
Abstract
519,894. #-(4-Hydroxy-3-methoxyphenyl)- isopropylamine. ROBINSON, -R., LOWE, A., and IMPERIAL CHEMICAL INDUSTRIES, Ltd. Oct. 6, 1938, No. 28993. [Class 2 (iii)] #-Methyl-#-(4-aralkyloxy-3-methoxyphenyl glycidic acid esters are made by condensing an aralkyl ether, preferably the benzyl ether, of 4- hydroxy-3-methoxybenzaldehyde with an #- halogeno-propionic ester, preferably ethyl- #- bromo-propionate. The esters may be saponified to form the corresponding glycidic acids, which are converted, by heating, into 4-aralkyloxy- 3-methoxyphenylacetones. The latter on treatment with hydroxylamine hydrochloride yield the. corresponding oximes, which are converted into #-(4-aralkyloxy - 3 - methoxy)-isopropylamines on reduction. The latter, when heated, with hydrochloric acid in glacial acetic acid, lose the aralkyl group and yield (#-(4-hydroxy-3- methoxyphenyl)-isopropylamine, which as such or in the form of its salts is a medicinal agent. An example is given. The Provisional Specification describes the application of the process to the production of #-hydroxyphenyl-isopropylamines in general.
GB2899338A1938-10-061938-10-06Manufacture of new amines and their salts
ExpiredGB519894A
(en)