GB515671A - Process for the manufacture of highly concentrated aqueous solutions of germ-gland hormones and their derivatives - Google Patents

Process for the manufacture of highly concentrated aqueous solutions of germ-gland hormones and their derivatives

Info

Publication number
GB515671A
GB515671A GB6582/38A GB658238A GB515671A GB 515671 A GB515671 A GB 515671A GB 6582/38 A GB6582/38 A GB 6582/38A GB 658238 A GB658238 A GB 658238A GB 515671 A GB515671 A GB 515671A
Authority
GB
United Kingdom
Prior art keywords
hormone
acids
oestradiol
salts
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB6582/38A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Bayer Schering Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Schering Pharma AG filed Critical Bayer Schering Pharma AG
Publication of GB515671A publication Critical patent/GB515671A/en
Expired legal-status Critical Current

Links

Landscapes

  • Steroid Compounds (AREA)

Abstract

515,671. Hormone solutions. SCHERING AKT.-GES. March 2, 1938, Nos. 6582 and 6583. Void. Convention dates March 2, 1937, and Oct. 25, 1937. [Class 81(i)] Concentrated aqueous solutions of germgland hoxmones and their derivatives or of suprarenal cortex hormone, suitable for injection, are obtained with the use, as solution promoters, of hydrotropic substances such as bile acids or their salts, or keto-sulphonic acids of sterols or other steroids or their salts. Examples of the hormones are dihydrofollide hormone (oestradiol), androsterone, androstandiol, testosterone, corpus luteum hormone, follicle hormone hydrate (oestriol), oestrone, oestradiol palmitate, oestradiol benzoate, and progesterone. Hydrotropic substances referred to are the following acids and their alkali salts : cholesterone - 3 - sulphonic acid - 6, sulphonic acids of other sterol ketones, of unsaturated oxo-bile acids or of oxo-cholenic acids and their lower homologues, sodium taurocholate, desoxycholic acid, and glycocholic acid. According to numerous examples the hormone is in each case boiled with an aqueous solution of the hydrotropic substance, in some cases with addition of acetone which is evaporated off.
GB6582/38A 1937-03-02 1937-03-02 Process for the manufacture of highly concentrated aqueous solutions of germ-gland hormones and their derivatives Expired GB515671A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE515671X 1937-03-02

Publications (1)

Publication Number Publication Date
GB515671A true GB515671A (en) 1939-12-11

Family

ID=6549047

Family Applications (1)

Application Number Title Priority Date Filing Date
GB6582/38A Expired GB515671A (en) 1937-03-02 1937-03-02 Process for the manufacture of highly concentrated aqueous solutions of germ-gland hormones and their derivatives

Country Status (1)

Country Link
GB (1) GB515671A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2557052A (en) * 1947-10-24 1951-06-12 Upjohn Co Progesterone suspensions
US2675342A (en) * 1950-09-30 1954-04-13 Schering Corp Supersaturated oil solutions of steroid hormones
US2687981A (en) * 1949-02-18 1954-08-31 Organon Steroidal composition and method of preparing same

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2557052A (en) * 1947-10-24 1951-06-12 Upjohn Co Progesterone suspensions
US2687981A (en) * 1949-02-18 1954-08-31 Organon Steroidal composition and method of preparing same
US2675342A (en) * 1950-09-30 1954-04-13 Schering Corp Supersaturated oil solutions of steroid hormones

Similar Documents

Publication Publication Date Title
Saez et al. Further in vivo studies in male pseudohermaphroditism with gynecomastia due to a testicular 17-ketosteroid reductase defect (compared to a case of testicular feminization)
Raspé Schering Symposium on Endocrinology, Berlin, May 26 to 27, 1967: Advances in the Biosciences
Short Steroids present in the follicular fluid of the mare
HUGGINS et al. Promotion of growth of preputial glands by steroids and the pituitary growth hormone
Lindner et al. Steroids in the ovarian lymph and blood of conscious ewes
Weissmann et al. Hemolysis and augmentation of hemolysis by neutral steroids and bile acids
Mikhail et al. Steroids in human ovarian vein blood
GB515671A (en) Process for the manufacture of highly concentrated aqueous solutions of germ-gland hormones and their derivatives
Grosser et al. Acetylation of cortisol by neonatal rat brain in vitro
Lanthier et al. THE IN VITRO BIOSYNTHESIS OF ANDROGENIC STEROIDS BY HUMAN NORMAL AND» STEIN-LEVENTHAL TYPE «OVARIAN SLICES
Kaiser In vitro stimulation of steroidosynthesis in the human ovary by human FSH and LH
Constantinides et al. Estriol and prednisolone in rabbit atherosclerosis
Flint et al. Control of placental endocrine function; role of enzyme activation in the onset of labour
Khan et al. Selective stimulation of luteal androgen biosynthesis by luteinizing hormone: comparison of hormonal regulation of P45017α activity in corpora lutea and follicles
Kellie The extraction and hydrolysis of steroid monoglucuronides
Valensi et al. Feminizing Leydig cell tumor: endocrine and incubation studies
Meijs-Roelofs et al. Sexual maturation and the adrenal glands
Lamers et al. Role of sex steroid hormones in the normal and glucocorticosteroid hormone-induced evolution of carbamoylphosphate synthase (ammonia) and arginase activity in rat liver ontogenesis
Folkerd et al. The action of dexamethasone and prolactin on aromatase activity in human adipose tissue
Mango et al. Effects of Dehydroepiandrosterone and 16 α-Hydroxydehydroepiandrosterone on the Reduction of Glucose to Glucitol by the Human Placenta
GB555445A (en) Hormone preparations
Zmigrod et al. Metabolism of progesterone by the rat ovary: Formation of 3β-hydroxy-5α-pregnan-20-one by ovarian microsomes
Dixon et al. In vitro production of testosterone sulfate from progesterone-4-14C in an adrenal tumor
HANSEN et al. Studies of the Zimmermann reaction: factors affecting the color intensity; relation of molecular structure to color production
Billiar et al. Metabolic clearance rate and production rate of 20α-hydroxypregn-4-en-3-one in the menstrual cycle