GB489623A - Improvements in high vacuum distillation of materials containing sterols and related compounds - Google Patents
Improvements in high vacuum distillation of materials containing sterols and related compoundsInfo
- Publication number
- GB489623A GB489623A GB2624/37A GB262437A GB489623A GB 489623 A GB489623 A GB 489623A GB 2624/37 A GB2624/37 A GB 2624/37A GB 262437 A GB262437 A GB 262437A GB 489623 A GB489623 A GB 489623A
- Authority
- GB
- United Kingdom
- Prior art keywords
- oil
- sterols
- cholesterol
- oils
- saponins
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Steroid Compounds (AREA)
Abstract
Raw material containing a compound having a cholane nucleus such as sterols, saponins and bile acids, is subjected to short-path high-vacuum distillation to separate the substance therefrom, the compound then being purified. The raw materials specified comprise animal oils and waxes, such as whale oil, faecal fats and oils and chinese wax; vegetable oils, such as soya bean oil, cotton-seed oil, wheat germ oil and calabar bean oil; and fungoid growths, such as ergot of rye, each of which groups are sources of zoösterols, phytosterols and mycosterols respectively. Particular sterols which may thus be isolated comprise cholesterols, cinchol, coprosterol, stigmasterol, sitosterol, and ergosterol. Other sterols such as cinchocerotin, quebrachol and rhamnol, saponins, such as digitonin, and bile acids, such as cholanic acid may also be separated from the raw materials containing them. In a preferred apparatus the distilling surface comprises an internally-heated hollow vertical dome with a spirally - corrugated surface. The distance between distilling and condensing surfaces may vary between ,25 inch and 10 feet and the degree of vacuum correspondingly between 8 microns and ,01 micron of mercury. Temperatures may range between 70 and 325 DEG C. In an example, clarified whale oil was distilled at temperatures of 90 to 220 DEG C. and pressures of ,001 to ,003 mm. of mercury. A first fraction containing free acids, squalene and other volatiles was withdrawn, and at 120-160 DEG C. a mixture of cholesterol and cholesteryl esters distilled over. The cholesterol was extracted with acetoacetic ester and recrystallized. Purification may comprise saponification of the fraction followed by solvent extraction and distillation of the latter. Specification 487,697 is referred to.ALSO:Raw material containing a compound having a cholane nucleus such as sterols, saponins, and bile acids is subjected to short path high vacuum distillation to separate the substance therefrom, the compound then being purified. The raw materials specified comprise animal oils and waxes such as whale oil, faecal fats and oils and chinese wax; vegetable oils, such as soya bean oil, cotton-seed oil, wheat germ oil and calabar bean oil; and fungoid growths, such as ergot of rye, each of which groups are sources of zoösterols, phytosterols and mycosterols respectively. Particular sterols which may thus be isolated comprise cholesterol, cinchol, coprosterol, stigmasterol, sitosterol and ergosterol. Other sterols such as cinchocerotin, quebrachol and rhamnol, saponins, such as digitonin, and bile acids such as chelanic acid may also be separated from the raw materials containing them. The distance between distilling and condensing surfaces may vary between ,25 inches and 10 feet and the degree of vacuum correspondingly between 8 microns and ,01 microns of mercury. Temperatures may range between 70 and 325 DEG C. In an example, clarified whale oil was distilled at temperatures of 90 to 220 DEG C. and pressures of ,001 to ,003 millimetres of mercury. A first fraction containing free acids, squalene and other volatiles was withdrawn, and at 120-160 DEG C. a mixture of cholesterol and cholesteryl esters distilled over. The cholesterol was extracted with acetoacetic ester and recrystallized. Purification may comprise saponification of the fraction followed by solvent extraction and distillation of the latter. Specification 487,697 is referred to.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US489623XA | 1936-02-06 | 1936-02-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB489623A true GB489623A (en) | 1938-07-29 |
Family
ID=21957365
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB2624/37A Expired GB489623A (en) | 1936-02-06 | 1937-01-29 | Improvements in high vacuum distillation of materials containing sterols and related compounds |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB489623A (en) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7632530B2 (en) | 2005-11-08 | 2009-12-15 | Council Of Scientific And Industrial Research | Process for the preparation of high purity phytosterols |
WO2016096989A1 (en) * | 2014-12-19 | 2016-06-23 | Dsm Ip Assets B.V. | Method of extracting cholesterol from fish oil residue |
US10190074B1 (en) | 2018-02-14 | 2019-01-29 | Golden Omega S.A. | Composition comprising cholesterol |
US10196583B1 (en) | 2018-02-14 | 2019-02-05 | Alejandro Markovits Rojas | Fish oil cholesterol |
US10196586B1 (en) | 2018-02-14 | 2019-02-05 | Golden Omega S.A. | Feed ingredient |
WO2022069923A1 (en) | 2020-09-30 | 2022-04-07 | Naturmega S.A. | Method for obtaining cholesterol present in fish oil |
-
1937
- 1937-01-29 GB GB2624/37A patent/GB489623A/en not_active Expired
Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7632530B2 (en) | 2005-11-08 | 2009-12-15 | Council Of Scientific And Industrial Research | Process for the preparation of high purity phytosterols |
WO2016096989A1 (en) * | 2014-12-19 | 2016-06-23 | Dsm Ip Assets B.V. | Method of extracting cholesterol from fish oil residue |
WO2019159027A1 (en) | 2018-02-14 | 2019-08-22 | Golden Omega S.A. | Feed ingredient |
US10196583B1 (en) | 2018-02-14 | 2019-02-05 | Alejandro Markovits Rojas | Fish oil cholesterol |
US10196586B1 (en) | 2018-02-14 | 2019-02-05 | Golden Omega S.A. | Feed ingredient |
WO2019159028A1 (en) | 2018-02-14 | 2019-08-22 | Golden Omega S.A. | Composition comprising cholesterol |
US10190074B1 (en) | 2018-02-14 | 2019-01-29 | Golden Omega S.A. | Composition comprising cholesterol |
CN110150474A (en) * | 2018-02-14 | 2019-08-23 | 金欧米茄公司 | Feed ingredient |
CN110150473A (en) * | 2018-02-14 | 2019-08-23 | 金欧米茄公司 | Include cholesteric composition |
EP3666867A1 (en) | 2018-02-14 | 2020-06-17 | Alejandro Markovits Rojas | Fish oil cholesterol |
CN110150474B (en) * | 2018-02-14 | 2022-12-09 | 金欧米茄公司 | Feed ingredient |
CN110150473B (en) * | 2018-02-14 | 2022-12-13 | 金欧米茄公司 | Composition comprising cholesterol |
WO2022069923A1 (en) | 2020-09-30 | 2022-04-07 | Naturmega S.A. | Method for obtaining cholesterol present in fish oil |
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