GB300040A - Improvements in the production of pure ª‡-hydroxycarboxylic acids - Google Patents
Improvements in the production of pure ª‡-hydroxycarboxylic acidsInfo
- Publication number
- GB300040A GB300040A GB3512327A GB3512327A GB300040A GB 300040 A GB300040 A GB 300040A GB 3512327 A GB3512327 A GB 3512327A GB 3512327 A GB3512327 A GB 3512327A GB 300040 A GB300040 A GB 300040A
- Authority
- GB
- United Kingdom
- Prior art keywords
- acid
- nitrile
- dioxane
- saponification
- hydroxycarboxylic acids
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/08—Preparation of carboxylic acids or their salts, halides or anhydrides from nitriles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
300,040. Johnson, J. Y., (I. G. Farbenindustrie Akt.-Ges.). Dec. 28, 1927. Cyanhydrins;a-hydroxycarboxylic acids.-The manufacture of a-hydroxycarboxylic acids bv the acid saponification of the corresponding nitrile is performed with a sufficient amount of water in the presence of an inert organic solvent or organic solvent mixture which is capable of dissolving the reagents and the reaction products, except the resulting ammonium salt. Suitable organic solvents are dioxane, ethyl ether, tetrachlorethane, chloroform. The nitriles may be prepared (by reaction of hydrocyanic acid with the correspond - ing aldehyde or ketone) in the inert, solvent afterwards required in the saponification, the water necessary for the saponification being added before or after the nitrile synthesis. In one example, acetaldehyde is led into a cooled mixture of dioxane, caustic soda solution, water, and hydrocyanic acid; the nitrile of lactic acid is formed and, when the reaction is complete, hydrogen chloride is led in to saponify the nitrile. The deposited ammonium chloride is filtered off and the dioxane is removed from the filtrate by distillation. In other examples, conducted similarly, benzaldehyde and propionaldehyde are used instead of acetaldehyde and the products are mandelic acid and a-hydroxybutyric acid respectively.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB3512327A GB300040A (en) | 1927-12-28 | 1927-12-28 | Improvements in the production of pure ª‡-hydroxycarboxylic acids |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB3512327A GB300040A (en) | 1927-12-28 | 1927-12-28 | Improvements in the production of pure ª‡-hydroxycarboxylic acids |
Publications (1)
Publication Number | Publication Date |
---|---|
GB300040A true GB300040A (en) | 1928-11-08 |
Family
ID=10374096
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB3512327A Expired GB300040A (en) | 1927-12-28 | 1927-12-28 | Improvements in the production of pure ª‡-hydroxycarboxylic acids |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB300040A (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2500018A (en) * | 1946-09-20 | 1950-03-07 | Frederick C Bersworth | Method of forming anhydrous solid phase alkali metal salts of glycolonitrile |
US3284495A (en) * | 1962-04-26 | 1966-11-08 | Knapsack Ag | Process for the continuous manufacture, purification, and isolation of lactic acid |
EP0293752A2 (en) * | 1987-06-02 | 1988-12-07 | Desitin Arzneimittel GmbH | Process for preparing E-2-propyl-2-pentenoic acid and its physiologically compatible salts |
-
1927
- 1927-12-28 GB GB3512327A patent/GB300040A/en not_active Expired
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2500018A (en) * | 1946-09-20 | 1950-03-07 | Frederick C Bersworth | Method of forming anhydrous solid phase alkali metal salts of glycolonitrile |
US3284495A (en) * | 1962-04-26 | 1966-11-08 | Knapsack Ag | Process for the continuous manufacture, purification, and isolation of lactic acid |
EP0293752A2 (en) * | 1987-06-02 | 1988-12-07 | Desitin Arzneimittel GmbH | Process for preparing E-2-propyl-2-pentenoic acid and its physiologically compatible salts |
EP0293752A3 (en) * | 1987-06-02 | 1990-09-05 | Desitin Arzneimittel GmbH | Process for preparing e-2-propyl-2-pentenoic acid and its physiologically compatible salts |
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