GB2618473A - Apparatus and method for cryo-preservation during transport and storage of items and/or substances - Google Patents
Apparatus and method for cryo-preservation during transport and storage of items and/or substances Download PDFInfo
- Publication number
- GB2618473A GB2618473A GB2312500.8A GB202312500A GB2618473A GB 2618473 A GB2618473 A GB 2618473A GB 202312500 A GB202312500 A GB 202312500A GB 2618473 A GB2618473 A GB 2618473A
- Authority
- GB
- United Kingdom
- Prior art keywords
- create
- chamber
- heat exchanger
- ambient air
- environment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 title claims abstract 8
- 238000005138 cryopreservation Methods 0.000 title claims 2
- 239000000126 substance Substances 0.000 title 1
- 238000005057 refrigeration Methods 0.000 claims abstract 13
- 238000001816 cooling Methods 0.000 claims abstract 12
- 239000012080 ambient air Substances 0.000 claims abstract 10
- 239000003570 air Substances 0.000 claims abstract 7
- 239000002826 coolant Substances 0.000 claims abstract 6
- 239000000203 mixture Substances 0.000 claims 5
- 239000003507 refrigerant Substances 0.000 claims 5
- 239000007789 gas Substances 0.000 claims 3
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 claims 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- XPDWGBQVDMORPB-UHFFFAOYSA-N Fluoroform Chemical compound FC(F)F XPDWGBQVDMORPB-UHFFFAOYSA-N 0.000 claims 2
- RWRIWBAIICGTTQ-UHFFFAOYSA-N difluoromethane Chemical compound FCF RWRIWBAIICGTTQ-UHFFFAOYSA-N 0.000 claims 2
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 claims 2
- 230000001172 regenerating effect Effects 0.000 claims 2
- LDTMPQQAWUMPKS-OWOJBTEDSA-N (e)-1-chloro-3,3,3-trifluoroprop-1-ene Chemical compound FC(F)(F)\C=C\Cl LDTMPQQAWUMPKS-OWOJBTEDSA-N 0.000 claims 1
- OTMSDBZUPAUEDD-UHFFFAOYSA-N Ethane Chemical compound CC OTMSDBZUPAUEDD-UHFFFAOYSA-N 0.000 claims 1
- 229910052786 argon Inorganic materials 0.000 claims 1
- 238000009932 biopreservation Methods 0.000 claims 1
- 230000006835 compression Effects 0.000 claims 1
- 238000007906 compression Methods 0.000 claims 1
- 238000012864 cross contamination Methods 0.000 claims 1
- 238000007791 dehumidification Methods 0.000 claims 1
- 239000002274 desiccant Substances 0.000 claims 1
- 238000001704 evaporation Methods 0.000 claims 1
- 230000008020 evaporation Effects 0.000 claims 1
- 230000009477 glass transition Effects 0.000 claims 1
- -1 hydro fluoro ole fin Chemical class 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- JRZJOMJEPLMPRA-UHFFFAOYSA-N olefin Natural products CCCCCCCC=C JRZJOMJEPLMPRA-UHFFFAOYSA-N 0.000 claims 1
- 238000011084 recovery Methods 0.000 claims 1
- 230000001954 sterilising effect Effects 0.000 claims 1
- TXEYQDLBPFQVAA-UHFFFAOYSA-N tetrafluoromethane Chemical compound FC(F)(F)F TXEYQDLBPFQVAA-UHFFFAOYSA-N 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Classifications
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25B—REFRIGERATION MACHINES, PLANTS OR SYSTEMS; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS
- F25B7/00—Compression machines, plants or systems, with cascade operation, i.e. with two or more circuits, the heat from the condenser of one circuit being absorbed by the evaporator of the next circuit
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25B—REFRIGERATION MACHINES, PLANTS OR SYSTEMS; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS
- F25B49/00—Arrangement or mounting of control or safety devices
- F25B49/02—Arrangement or mounting of control or safety devices for compression type machines, plants or systems
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25B—REFRIGERATION MACHINES, PLANTS OR SYSTEMS; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS
- F25B2600/00—Control issues
- F25B2600/25—Control of valves
Landscapes
- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Mechanical Engineering (AREA)
- Thermal Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Devices That Are Associated With Refrigeration Equipment (AREA)
Abstract
The invention relates to apparatus and a method for the creation and provision of a cryogenic cooling environment for at least a predetermined period of time within a predefined volume in a first chamber with a heat exchanger. The apparatus may include a second chamber with a heat exchanger and means for utilising ambient air, refrigeration apparatus to cool said ambient air to or below a predetermined temperature to create the cryogenic cooling environment in at least the second chamber at or below -110 degrees Celsius. The apparatus includes a compressor and control means for control of the operation of the apparatus to create an initial controlled ambient air cool down stage to create cooled air followed by the use of a vapour cycle refrigeration system in which the said cooled air is used as the means to create the cooling medium for said volume. There is also provided a method for allowing an intervention in the operation of a refrigeration system for creating a cryogenic storage environment which allows the system to regain a substantially ambient temperature condition to allow said intervention relatively quickly.
Claims (22)
- Claims1 Apparatus for the creation and provision of a cryogenic cooling environment for at least a predetermined period of time within a predefined volume in a first chamber with a heat exchanger, said apparatus including a second chamber with a heat exchanger and means for utilising ambient air, refrigeration apparatus to cool said ambient air to or below a predetermined temperature to create the cryogenic cooling environment in at least the second chamber at or below -110 degrees Celsius and wherein the apparatus includes a compressor and control means for control of the operation of the apparatus to create an initial controlled ambient air cool down stage to create cooled air followed by the use of a vapour cycle refrigeration system in which the said cooled air is used as the means to create the cooling medium for said volume.
- 2 Apparatus according to claim 1 wherein the refrigeration apparatus utilises a reduced TEWI gas charge.
- 3 Apparatus according to any of the preceding claims wherein the said volume is defined in the first chamber in the form of a container in which one or more products which are to be cooled are placed.
- 4 Apparatus according to any of the preceding claims wherein the said chambers are transportable or is part of a transportable apparatus.
- 5 Apparatus according to any of claims 1-3 wherein the chamber is provided as part of a bio storage facility within a building.
- 6 Apparatus according to any of the preceding claims wherein said apparatus includes means for sterilising the cooling medium to prevent cross contamination of materials.
- 7 Apparatus according to any of the preceding claims wherein the said cryogenic cooling environment is provided at a temperature of less than -132 degrees Celsius.
- 8 Apparatus according to any of the preceding claims wherein the cooling medium has temperature less than the glass transition point of water.
- 9 Apparatus according to any of the preceding claims wherein the vapour cycle refrigeration system creates direct cooling by evaporation of one or more mixed refrigerants using one or more air heat exchanger surfaces at an elevated internal pressure.
- 10 Apparatus according to claim 9 wherein the said one or more heat exchanger surfaces cool the ambient air to a temperature colder than -90 degrees Celsius, to enable cryo-preservation in the cooling medium environment.
- 11 Apparatus according to any of the claims 9 or 10 wherein the refrigerant mixture includes a hydro fluoro ole fin (HFO) and/or hydrohaloalkene (I II IO/ 1 II Ac) as refrigerants.
- 12 Apparatus according to claim 11 wherein trans-l-chloro-3,3,3-trifluoropropene is used.
- 13 Apparatus according to any of the preceding claims wherein the refrigerant mixture includes difluoromethane when below or at its lower flammability limit in order to achieve an Al classification.
- 14 Apparatus according to any of the preceding claims wherein the apparatus utilises a cryogen of mixed and variable composition which changes phase wholly inside the system and is recirculated. 18
- 15 Apparatus according to any of the preceding claims wherein regenerative cooling is used to provide recovery of energy as heat at a temperature above 35 degrees Celsius.
- 16 Apparatus according to any of the preceding claims wherein the said controlled cooldown of the said volume is achieved by combining regenerative desiccant dehumidification and forced airflow with bio preservation.
- 17 Apparatus according to any of the preceding claims wherein a compression cooling procedure is used utilising a mixture of gasses within said heat exchanger.
- 18 Apparatus according to claim 17 wherein the refrigerant cooling blend within the heat exchangers contains at least two of; trifluoromethane, tetrafluoromethane, methane, argon, nitrogen and/ or ethane.
- 19. Apparatus according to any of the preceding claims wherein the heat exchangers are evaporators.
- 20 Apparatus for the creation and provision of a cryogenic cooling environment for at least a predetermined period of time within a predefined volume, said apparatus including a chamber in which the cryogenic cooling environment is created. Said chamber including a heat exchanger, a means for utilising ambient air, refrigeration apparatus to cool said ambient air to or below a predetermined temperature to create the cryogenic cooling environment in at least the second chamber at or below -110 degrees Celsius and wherein the apparatus includes a compressor and control means for control of the operation of the apparatus to create an initial controlled ambient air cool down stage to create cooled air followed by the use of a vapour cycle refrigeration system in which the said cooled air is used as the means to create the cooling medium for said volume. 19
- 21. A method for allowing an intervention in the operation of a refrigeration system for creating a cryogenic storage environment, wherein said method including steps to allow the system to regain a substantially ambient temperature condition to allow said intervention by injecting a flow of hot gas into a high pressure side of the refrigeration system at a location after the location of an autocascade refrigeration system and controlling system pressures and temperatures to allow the work done by a compressor of the system to heat the refrigeration process to near ambient temperatures.
- 22. A method according to claim 21 wherein the return flow of the injected gas may pass either directly through or bypass the heat exchanger of the chamber.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB2100707.5A GB202100707D0 (en) | 2021-01-19 | 2021-01-19 | Apparatus and method for cryo-preservation during transport and storage of items and/or substances |
| PCT/GB2022/050142 WO2022157489A1 (en) | 2021-01-19 | 2022-01-19 | Apparatus and method for cryo-preservation during transport and storage of items and/or substances |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| GB202312500D0 GB202312500D0 (en) | 2023-09-27 |
| GB2618473A true GB2618473A (en) | 2023-11-08 |
Family
ID=74679063
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GBGB2100707.5A Ceased GB202100707D0 (en) | 2021-01-19 | 2021-01-19 | Apparatus and method for cryo-preservation during transport and storage of items and/or substances |
| GB2312500.8A Pending GB2618473A (en) | 2021-01-19 | 2022-01-19 | Apparatus and method for cryo-preservation during transport and storage of items and/or substances |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GBGB2100707.5A Ceased GB202100707D0 (en) | 2021-01-19 | 2021-01-19 | Apparatus and method for cryo-preservation during transport and storage of items and/or substances |
Country Status (2)
| Country | Link |
|---|---|
| GB (2) | GB202100707D0 (en) |
| WO (1) | WO2022157489A1 (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060075775A1 (en) * | 2004-10-07 | 2006-04-13 | Mikhail Boiarski | Efficient heat exchanger for refrigeration process |
| US20100147017A1 (en) * | 2006-05-15 | 2010-06-17 | Sanyo Electric Co., Ltd. | Refrigeration apparatus |
| CN212253209U (en) * | 2020-03-23 | 2020-12-29 | 青岛海尔智能技术研发有限公司 | Cascade compression refrigeration system and refrigeration equipment with same |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103250012B (en) * | 2011-03-18 | 2016-02-17 | 东芝开利株式会社 | binary refrigeration cycle device |
| GB201211208D0 (en) | 2012-06-25 | 2012-08-08 | Stenhouse James T | Materials and methods to improve energy efficiency and enable ultra fast recovery after defrost cycle in cascade refrigeration systems |
| CN106715635B (en) * | 2014-09-23 | 2020-09-15 | 科慕埃弗西有限公司 | (2E) Use of (E) -1,1,1,4,5,5, 5-heptafluoro-4- (trifluoromethyl) pent-2-ene in high temperature heat pumps |
| KR20190126476A (en) * | 2018-05-02 | 2019-11-12 | 주식회사 위니아대우 | Refrigerator |
-
2021
- 2021-01-19 GB GBGB2100707.5A patent/GB202100707D0/en not_active Ceased
-
2022
- 2022-01-19 WO PCT/GB2022/050142 patent/WO2022157489A1/en active Application Filing
- 2022-01-19 GB GB2312500.8A patent/GB2618473A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060075775A1 (en) * | 2004-10-07 | 2006-04-13 | Mikhail Boiarski | Efficient heat exchanger for refrigeration process |
| US20100147017A1 (en) * | 2006-05-15 | 2010-06-17 | Sanyo Electric Co., Ltd. | Refrigeration apparatus |
| CN212253209U (en) * | 2020-03-23 | 2020-12-29 | 青岛海尔智能技术研发有限公司 | Cascade compression refrigeration system and refrigeration equipment with same |
Also Published As
| Publication number | Publication date |
|---|---|
| GB202312500D0 (en) | 2023-09-27 |
| GB202100707D0 (en) | 2021-03-03 |
| WO2022157489A1 (en) | 2022-07-28 |
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