GB2614972B - Stable composition of chloral hydrate - Google Patents

Stable composition of chloral hydrate Download PDF

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Publication number
GB2614972B
GB2614972B GB2301765.0A GB202301765A GB2614972B GB 2614972 B GB2614972 B GB 2614972B GB 202301765 A GB202301765 A GB 202301765A GB 2614972 B GB2614972 B GB 2614972B
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GB
United Kingdom
Prior art keywords
stable composition
chloral hydrate
chloral
hydrate
stable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
GB2301765.0A
Other versions
GB2614972A (en
Inventor
Mcquillian James
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Atnahs Pharma UK Ltd
Original Assignee
Atnahs Pharma UK Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Atnahs Pharma UK Ltd filed Critical Atnahs Pharma UK Ltd
Publication of GB2614972A publication Critical patent/GB2614972A/en
Application granted granted Critical
Publication of GB2614972B publication Critical patent/GB2614972B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/11—Aldehydes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Anesthesiology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Medicinal Preparation (AREA)
GB2301765.0A 2022-07-18 2023-02-08 Stable composition of chloral hydrate Active GB2614972B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2210518.3A GB2617419B (en) 2022-07-18 2022-07-18 Stable composition of chloral hydrate

Publications (2)

Publication Number Publication Date
GB2614972A GB2614972A (en) 2023-07-26
GB2614972B true GB2614972B (en) 2024-02-07

Family

ID=84540117

Family Applications (2)

Application Number Title Priority Date Filing Date
GB2210518.3A Active GB2617419B (en) 2022-07-18 2022-07-18 Stable composition of chloral hydrate
GB2301765.0A Active GB2614972B (en) 2022-07-18 2023-02-08 Stable composition of chloral hydrate

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GB2210518.3A Active GB2617419B (en) 2022-07-18 2022-07-18 Stable composition of chloral hydrate

Country Status (2)

Country Link
GB (2) GB2617419B (en)
WO (1) WO2023139294A1 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1421144A (en) * 1971-12-29 1976-01-14 Squibb & Sons Inc One piece gelatin capsules containing chloral hydrate

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102004049015A1 (en) * 2004-10-05 2006-04-06 G. Pohl-Boskamp Gmbh & Co. Kg Use of acids to stabilize chloral hydrate, especially in pharmaceutical compositions for filling gelatin capsules
WO2019158043A1 (en) 2018-02-13 2019-08-22 特丰制药有限公司 Stable chloral hydrate solution, preparation method thereof, and use thereof
CN112656758A (en) 2020-12-03 2021-04-16 成都施贝康生物医药科技有限公司 Stable chloral hydrate syrup, preparation method, quality control method and application thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1421144A (en) * 1971-12-29 1976-01-14 Squibb & Sons Inc One piece gelatin capsules containing chloral hydrate

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
Farmacia hospitalaria, vol. 37, no. 1, 2013, Bustos-Fierro et al., "Stability evaluation of 7 % chloral hydrate syrup contained in mono and multi-dose bottles under room and refrigeration conditions.", pages 4-9; Available from http://www.grupoaulamedica.com/fh/pdf/96.pdf *
Malaysian Journal of Pharmacy, vol. 4, no. 1, 2018, Thean et al., "Stability of Extemporaneously Compounded Chloral Hydrate Oral Solution"; Available from https://mjpharm.org/stability-of-extemporaneously-compounded-chloral-hydrate-oral-solution/ *
Marlborough Pharmaceutical Ltd, May 2022, "Chloral Hydrate 143 mg/5mL Oral Solution", medicines.org.uk. [online], Available from https://www.medicines.org.uk/emc/product/8136/smpc [Accessed 8 March 2023] *
Marlborough Pharmaceuticals Ltd, August 2021, "Chloral Hydrate 500 mg/5ml Oral Solution", medicines.org.uk, [online], Available from https://www.medicines.org.uk/emc/product/13223/smpc [Accessed 8 March 2023] *
Pharmazie, vol. 73, no. 4, 2018, Uriel et al., "Stability of regularly prescribed oral liquids formulated with SyrSpend® SF", pages 196-201; Available from https://www.ingentaconnect.com/content/govi/pharmaz/2018/00000073/00000004/art00003;jsessionid=a7acdr1b3jrmi.x-ic-live-03 *
Yakugaku Zasshi, vol. 119, no. 5, Kakehi et al., "Examination of the stability of chloral hydrate and its preparation by capillary electrophoresis", p. 410-416. *

Also Published As

Publication number Publication date
GB2614972A (en) 2023-07-26
GB2617419B (en) 2024-07-10
WO2023139294A1 (en) 2023-07-27
GB202210518D0 (en) 2022-08-31
GB2617419A (en) 2023-10-11

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