GB2612021B - Chimeric protein and expression system - Google Patents

Chimeric protein and expression system Download PDF

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Publication number
GB2612021B
GB2612021B GB2114216.1A GB202114216A GB2612021B GB 2612021 B GB2612021 B GB 2612021B GB 202114216 A GB202114216 A GB 202114216A GB 2612021 B GB2612021 B GB 2612021B
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GB
United Kingdom
Prior art keywords
expression system
chimeric protein
chimeric
protein
expression
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
GB2114216.1A
Other languages
English (en)
Other versions
GB2612021A (en
GB202114216D0 (en
Inventor
Egan Ronan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Endocryne Ltd
Original Assignee
Endocryne Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Endocryne Ltd filed Critical Endocryne Ltd
Priority to GB2114216.1A priority Critical patent/GB2612021B/en
Publication of GB202114216D0 publication Critical patent/GB202114216D0/en
Priority to EP22805919.2A priority patent/EP4413123A1/en
Priority to CA3233224A priority patent/CA3233224A1/en
Priority to JP2024521249A priority patent/JP2024537248A/ja
Priority to PCT/GB2022/052514 priority patent/WO2023057750A1/en
Publication of GB2612021A publication Critical patent/GB2612021A/en
Application granted granted Critical
Publication of GB2612021B publication Critical patent/GB2612021B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/13—Transferases (2.) transferring sulfur containing groups (2.8)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
    • C07K14/395—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts from Saccharomyces
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y208/00—Transferases transferring sulfur-containing groups (2.8)
    • C12Y208/01—Sulfurtransferases (2.8.1)
    • C12Y208/01008—Lipoyl synthase (2.8.1.8)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
GB2114216.1A 2021-10-04 2021-10-04 Chimeric protein and expression system Active GB2612021B (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
GB2114216.1A GB2612021B (en) 2021-10-04 2021-10-04 Chimeric protein and expression system
EP22805919.2A EP4413123A1 (en) 2021-10-04 2022-10-04 Chimeric protein and expression system
CA3233224A CA3233224A1 (en) 2021-10-04 2022-10-04 Chimeric protein and expression system
JP2024521249A JP2024537248A (ja) 2021-10-04 2022-10-04 キメラタンパク質及び発現系
PCT/GB2022/052514 WO2023057750A1 (en) 2021-10-04 2022-10-04 Chimeric protein and expression system

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2114216.1A GB2612021B (en) 2021-10-04 2021-10-04 Chimeric protein and expression system

Publications (3)

Publication Number Publication Date
GB202114216D0 GB202114216D0 (en) 2021-11-17
GB2612021A GB2612021A (en) 2023-04-26
GB2612021B true GB2612021B (en) 2024-09-04

Family

ID=78497810

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2114216.1A Active GB2612021B (en) 2021-10-04 2021-10-04 Chimeric protein and expression system

Country Status (5)

Country Link
EP (1) EP4413123A1 (https=)
JP (1) JP2024537248A (https=)
CA (1) CA3233224A1 (https=)
GB (1) GB2612021B (https=)
WO (1) WO2023057750A1 (https=)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11692016B2 (en) * 2012-03-09 2023-07-04 Vestaron Corporation High gene expression yeast strain

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
eLife, Vol.5, 2016, Uzarska, M. et al., "Mitochondrial Bol1 and Bol3 function...", Article No.: e16673 *
Mol. Cell. Biochem., Vol.317, 2008, Zhou Yu-Bo, et al., "hBolA, novel non-classical secreted proteins...", pp.61-68 *

Also Published As

Publication number Publication date
GB2612021A (en) 2023-04-26
WO2023057750A1 (en) 2023-04-13
GB202114216D0 (en) 2021-11-17
JP2024537248A (ja) 2024-10-10
CA3233224A1 (en) 2023-04-13
EP4413123A1 (en) 2024-08-14

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