GB2601200A - Nasal disinfection composition - Google Patents

Nasal disinfection composition Download PDF

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GB2601200A
GB2601200A GB2019544.2A GB202019544A GB2601200A GB 2601200 A GB2601200 A GB 2601200A GB 202019544 A GB202019544 A GB 202019544A GB 2601200 A GB2601200 A GB 2601200A
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peg
esters
dimethicone
oil
nasal
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Ian Jeremy Brain Archibald
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Otolaryngology (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Emergency Medicine (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)

Abstract

A nasal disinfection composition comprising an alkali salt of a fatty acid is provided. Preferably the fatty acid is a triglyceride derived from coconut oil, olive oil or palm oil, and the alkali salt is preferably a sodium or potassium salt. The composition may also comprise an alcohol, and/or antiviral agent and/or antibacterial agent. Preferably the composition further comprises gelatin, pectin and carboxymethylcellulose wherein each of the gelatin, pectin and carboxymethylcellulose are all at 0.1 to 33.33 % w/v. The composition may also comprise at least one polyethylene glycol, and/or ethyl lauroyl arginate, and/or methyl cellulose. The composition may be in the form of a liquid spray, viscous liquid, or powder. The nasal disinfection as herein defined is preferably instilled into the nose, nasopharynx, and upper airway to temporarily reduce viral load and thus reduced the risk of transmission, particularly reduce the viral load and transmission of SARS-CoV-2.

Description

Nasal Disinfection Composition The present application relates to a nasal disinfection composition. More particularly, the application relates to a nasal disinfection composition comprising an alkali salt of a fatty acid. 5 The SARS-CoV-2 pandemic has highlighted the urgent need for new types of protection against viral infection. Many countries have had to implement measures such as social distancing and travel restrictions in order to control the spread of the virus. These measures have in turn led to significant economic downturns which have contributed to exacerbating the global crisis.
The SARS-CoV-2 virus has been shown to replicate efficiently in the upper airways during its incubation period. During this prodromal stage, asymptomatic individuals release large amounts of virus from infected cells. It has also been shown that nasal swabs have yielded higher viral loads than throat swabs in symptomatic and asymptomatic individuals (Sungnak W., Becavin C. et al, 2020, SARS-CoV-2, Nature Med 26, 681-687). It is therefore clear that the nasal epithelium is a key portal for the initial infection and transmission.
The importance of the nasal cavity in the spread of SARS-CoV-2 throughout the body has also been demonstrated in Hou et al., 2020, Cell 182, 429-446. In this study, a gradient of infectivity was shown from the nose to the distal respiratory tract High-sensitivity RNA in situ mapping revealed the highest angiotensin-converting enzyme 2 (IACE2) expression in the nose with decreasing expression throughout the lower respiratory tract., paralleled by a striking gradient of SARS-CoV-2 infection in proximal (high) versus distal (low) pulmonary epithelial cultures.
Physical barriers in the form of facernasks and faceshield that cover the nasal cavity have proven effective in reducing the spread of SARS-CoV-2. Face coverings have however proven to have limitations One such issue is the discomfort of wearing a mask, particularly for long periods of time. In the case of fabric masks, it is common to see people wearing them incorrectly with the mask pulled down to expose the nose for this very reason. This renders the mask highly ineffective in providing a bather to infection. Other common issues with face coverings are that they reduce the quality of social interactions and have to be removed when eating and drinking.
Other common place measures to prevent infection include hand washing and the use of hand sanitizers. While a useful preventative measure to control virus spread, they are not necessarily always available when they are needed and they do not target the source of viral load.
The case for the need to target the source of viral load is illustrated in the studies of Dexter F et al., 2020, Anesth Analg 131(1), 37-42 and Loftus RW et al., 2018, Am J Infect Control 46, 1134-1141. Nasal disinfection was achieved in these studies using preprocedural chlorhexidine wipes, 2 doses of nasal povidone-iodine within 1 hour of incision, and a chlorhexidine mouth rinse.
Further studies have also shown the benefits to preventing infection by performing nasal disinfection, for example Cegolon, L et al., 2020, International journal of hygiene and environmental health, vol. 230 113605 and Frank Set al., 2020 Otolaryngol Head Neck Surg, doi:10.1001.
Nasal introduction of potential anti-viral treatments has also recently been shown in several studies. For example, a Columbia University study used ferrets to demonstrate that nasal sprays could be used to introduce lipoproteins that prevented thc spread of SARS-CoV-2. A further study from Stanford University demonstrated that antibodies harvested from egg yolks from chickens which had been immunised with the SARS-CoV-2 surface protein could be introduced using a nasal spray in order to protect against SARS-CoV-2 infection.
In yet a further study, Nasus Pliartna claims that its product Taffix is effective against coronavirus. The power is inhaled into the nose and comprises a combination of ingredients including methyl cellulose and citric acid. The Taffix acts by creating an acidic environment in the nasal cavity which is advise to the survival of the virus.
The University Hospital of Wales has also conducted an in vitro trail using mouthwash and found it to be highly effective against coronavirus. 0.07% cetypyridinium chloride (CPC) was found to kill the virus within 30 seconds. This study indicates that CPC containing mouthwash may be useful in preventing the virus from infecting tissue in the mouth and throat such that it is prevented from entering the lungs. These types of mouthwash often contain surfactants, ethanol, and ethyl laurol arginate, which have been shown to be safe to use in humans.
The above-mentioned studies are not without their problems. For example in the Frank et al study the povidone-iodine used to disinfect the nasal cavity could cause a potential toxic reaction and lead to systemic adsorption. The other studies also describe some potentially toxic compounds and others either ineffective or potentially expensive compounds which would make the treatments inaccessible to many, especially those living in developing countries.
The present invention seeks to mitigate at least the above-mentioned disadvantages and provide a cheap, effective, and widely available alternative.
According to a first aspect of the invention, there is provided a nasal disinfection composition comprising an alkali salt of a fatty acid. Alkali salt of a fatty acid are more commonly referred to as soaps and are a simple, low-cost disinfectant which can be instilled into the nose, nasopharynx and upper airway to temporarily reduce viral load and thus reduce the risk of transmission. Soap has a long history of being efficacious in breaking down the lipid membrane of viruses, being harmless on systemic adsorption, and being non-irritant on mucous membranes.
In one embodiment, the invention is a nasal disinfection composition comprising an alkali salt of a fatty acid. In another embodiment, the invention is a nasal disinfection composition consisting of an alkali salt of a fatly acid. In this embodiment, the only active ingredient is the alkali salt of a fatty acid.
Preferably, the fatty acid is a triglyceride. More preferably, the triglyceride is derived from a seed oil, vegetable oil, or animal fat. Even more preferably, the triglyceride is derived from coconut oil, olive oil, or palm oil.
Preferably, the alkali is a sodium or potassium salt. More preferably, the alkali used to make the alkali salt of a fatty acid is NaOH or KOH.
Preferably, the composition may further comprise alcohol or an anti-viral agent and/or an antibacterial agent. These additional components of the composition may enhance the ability to prevent the spread of infection.
According to a second aspect of the invention, there is provided a method of preventing viral infection comprising the step of inhaling a nasal disinfection composition compiising an alkali sal( of a fatty acid.
Exemplary embodiments of the invention will now be described.
The present invention is a nasal disinfection composition comprising an alkali salt of a fatty acid. The nasal disinfection composition can be introduced to the nasal cavity as a spray, a viscous liquid or gel, or as a powder. In the embodiment in which the nasal disinfection composition is a spray, it may be introduced to the nasal cavity using one of the many nasal aspirators commercial available of which the skilled person would be well aware. In the embodiment in which the nasal disinfection composition is a viscous liquid or gel or as a powder, the nasal disinfection composition may be introduced into the nasal cavity digitally using a users fingers or by use of an applicator or by inhaling/snorting the composition.
Alkali salts of a fatty acid, commonly known as soap, disrupt the lipid membrane forming the membrane around viral particles. The fatty membrane of SARS-CoV-2 contains virus proteins, holds and protects the RNA. The membrane needs to be sufficiently stable to protect the RNA from the surrounding environment, but not so stable that it cannot break open inside the host cell to release the RNA.
This balance between structural stability and the ability to release RNA is essential for transmission and replication of the virus, but also renders the membrane susceptible to being destroyed by soap or detergent. Soap dissolves the fat membrane and the virus falls apart and becomes inactive.
Disinfectants, or liquids, wipes, gels and creams containing alcohol have a similar effect but are not quite as good as normal soap. Apart from alcohol and soap, the "antibacterial agents" in these products don't affect the virus structure as effectively as soap alone.
Soaps are a type of surfactant and usually made from water-soluble Na or K salts of fatty acids. The basic ingredients of Soap are: 1. triglycerides (e.g. oils and fats); and 2. a strong alkali (e.g. KOH or NaOH).
Commonly used types of soap are sodium stearate, sodium hwreth sulphate, Castille soap, and d-Panthenol. The seed oils give softer but milder soaps. Soap made from pure olive oil, sometimes called Castile soap or Marseille soap, is reputed for its particular mildness. The term "Castile" is also sometimes applied to soaps from a mixture of oils, but a high percentage of olive oil.
In one embodiment, the fatty acid is a triglyceride. In another embodiment, the triglyceride is derived from a seed oil, vegetable oil, or animal fat. In yet another embodiment, the triglyceride is derived from coconut oil, olive oil, or palm oil.
Soaps, surfactants, and detergents may all be used as part of the nasal disinfectant composition and, provided they are non-toxic and non-irritants, each may be used alone or in combination. Examples of possible soaps, surfactants, and detergents are sodium lauryl sulphate, sodium dodccyl sulphate, polysorbate 20, cetyltrimethylammonium bromide, cetylpyridinium chloride, polysorbate, poloxamer, span 20, cetrimide, benzalkonium chloride, tween 80, polyoxyethylene alkyl ether, polyoxyethylene monoalkyl carboxylate, sorbitan monolaurate 20, polyoxyethylene-2-oley1 ether, polyoxyethylene sorbitan monoester, transcutol P. Brij 36 T, polyoxyethylene alkyl ethers, polyoxyethylene nonylphenol, span 80, span 85, pluronicF127, sorbitan monopalmitate, polozamer, sorbitan monolaurate, poloxamer 182 and sodium palrnitate (15 C chain). In one preferred embodiment, the nasal disinfection composition may comprise ethyl lauroyl arginate, also known as E243.
The nasal disinfection composition acts by inhaling a nasal disinfection composition comprising an alkali salt of a fatly acid. Once the disinfection composition has entered the nasal cavity it will dissolve the lipid membrane of the virus present at the time of inhalation.
However, disinfection composition with persist in the nasal cavity long after use and provide a barrier to prevent virus from infecting the nasal cavity, which has been shown to be a key point of entry for SARS-CoV-2 infection.
Introduction of the alkali salt of a fatty acid composition into the nasal cavity may be introduced into the nasal cavity as a spray. Using a spray to introduce the nasal disinfection composition is advantageous as it is quick, effective at distributing the product throughout the nasal cavity evenly, and a means of introduction to the nasal cavity that is commonly used.
In one embodiment, the composition may be dried or lyophilised into a powder. In another embodiment, the composition may be a viscous liquid or gel. In these embodiments, the composition may be introduced into the nasal cavity by applicator or by inhaling/snorting the composition. The composition would dissolve in the aqueous environment of the mucous membranes of the nasal cavity. In the embodiment in which the composition is a power, this embodiment of the present invention may be advantageous as some aspirators for liquids can be bulky and take up more space than a powder.
In one embodiment, the nasal disinfection composition comprises polyethylene glycol (PEG). 10 In another embodiment, PEG may be used to modify one or more compound/drug through pegilation in order to modify that compound/drug for the purpose of slowing down the elimination of the compound/drug from the nasal cavity of the body. Prolonging the presence of the nasal disinfection composition may be beneficial to enhancing the use of the composition.
In one embodiment, the nasal disinfection composition comprises methyl cellulose. Methyl cellulose may be used as a carrier which is combined with an alkali salt of a fatty acid. In a preferred embodiment, methyl cellulose may be combined in the composition with the surfactant ethyl lauroyl arginate.
In one preferred embodiment, the PEG is PEG hydrogenated castor oil. The PEG hydrogenated castor oil may be PEG-40 hydrogenated castor oil and PEG-60 hydrogenated castor oil. In a further embodiment, the PEG may be selected from a group consisting of 25 PEG-2 COCAMINE, PEG-2 DIMEADOWFOAMA MIDOETHYLMONIU M METHOSULFATE, PEG-2 DISTEARATE, PEG-2 HYDROGENATED TALLOW AMINE, GALACTENE, PEG-2 OLEAMINE, PEG-2 OLEATE, PEG-2 SOYAMINE, PEG-2 STEARATE, PEG-2 TALLOW AMINE, Cola@ Mate OPA-30. ISOXAL -5, PEG-3 DICAPRYLATE/CAPRATE, PPG-5-LAURETH-5; PEG-3 DISTEARATE, MAGNESIUM PEG-3 COCAMIDE SULFATE, ALCORAMNOSAN, PEG-4, PEG-4 DIREPTANOATE, PEG-4 LAURATE, PEG-4 OLEATE, PEG-4 OLIVATE, PEG-4 POLYGLYCERYL-2 STEARATE, PEG-4 RAPESEEDAMIDE, ISOXAL-12, PEG-4 STEARATE, PEG-5 CASTOR OIL, PEG-5 COCAMINE, PEG-5 OLEAMMONIUM METHOSULFATE, PEG-5 OLEATE, PPG-5-LAURETH-5, PEG-5 STEARATE, PEG-5 STEARYL AMMONIUM LACTATE, DIHYDROXYPROPYL PEG-5 LINOLEAMMONIUM CHLORIDE, PEG-6, PEG-6 CAPRYLIC/CAPRIC GLYCERIDES, PEG-6 DIOLEATE, PEG-6 OLEAMINE, PEG-6 OLEATE, PEG-6 SORB1TAN OLEATE, PEG-6 SORB1TAN STEARATE, PEG-6 STEARATE, ALMOND OIL PEG-6 ESTERS, HYDROGENATED PALM/PALM KERNEL OIL PEG-6 ESTERS, PEG-7 AMODIMETHICONE, PEG-7 GLYCERYL COCOATE. PEG-7 GLYCERYL SOYATE, PEG-7 HYDROGENATED CASTOR OIL, PEG-7 OLIVATE. AMMONIUM DIMETHICONE PEG-7 SULFATE, DIMETHICONE PEG-7 AVOCADOATE, DIMETHICONE PEG-7 COCOATE, DIMETHICONE PEG-7 ISOSTEARATE, DIMETHICONE PEG-7 OLIVATE. DIMETHICONE PEG-7 PHOSPHATE, DIMETHICONE PEG-7 PHTHALATE, DIMETHICONE PEG-7 SUCCINATE, OLIVE OIL PEG-7 ESTERS, SODIUM PEG-7 OLIVE OIL CARBOXYLATE, STEARDIMONIUM HYDROXYPROPYL PEG-7 DIMETHICONE PHOSPHATE CHLORIDE, PEG-8. PEG-8 BEESWAX, XALIFIN -15. XALIFIN 15 N-P, IDRORAMNOSAN, PEG-8 DIISOSTEARATE, PEG-8 DILAURATE, DIMETHICONE PEG-8 AVOCADOATE, PEG-8 DIOLEATE. PEG-8 DISTEARATE. PEG-8 DODECENYLSUCCIN ATE, PEG-8 GLYCERYL LAURATE. ISOXAL -E, PEG-8 LAURATE, PEG-8 OLEATE,PEG-8 METHYL ETHER TRIETHOXYSILANE, PEG-8 STEARATE, 5M3340P. APRICOT KERNEL OIL PEG-8 ESTERS. ARGAN OIL PEG-8 ESTERS, AVOCADO OIL PEG-8 ESTERS, Viatenza® Cupuacu PE8, Viatenza® Baobab PE8, BERTHOLLETIA EXCELSA SEED OIL PEG-8 ESTERS, BITTER CHERRY SEED OIL PEG-8 ESTERS, BORAGE SEED OIL POLYGLYCERYL-6 ESTERS, Viatenza® Buriti PE8, Viatenza® Cocoa PE8, Silamine® C-300, DIMETHICONE PEG-8 BEESWAX, DIMETHICONE PEG-8 LANOLATE, DLMETHICONE PEG-8 MEADOWFOAMATE, SilsoftTM Surface, DIMETHICONE PEG-8 SUCC1NATE, DISODIUM PEG-8 PALM GLYCERIDES SULEOSUCCINATE. GRAPE SEED OIL PEG-8 ESTERS, HAZEL SEED OIL PEG-8 ESTERS, Viatenza® Hemp PE8, Viatenza® Mafura PE8, Viatenza® Mongongo PE8, MACADAMIA TERNIFOLLA SEED OIL PEG-8 ESTERS, OLIVE OIL PEG-8 ESTERS, ORBIGNYA OLEIFERA SEED OIL PEG-8 ESTERS, PUMPKIN SEED OIL PEG-8 ESTERS, ROSA RUB IGINOSA SEED OIL PEG-8 ESTERS, SAFFLOWER SEED OIL PEG-8 ESTERS, SCLEROCARYA BIRREA SEED OIL PEG-8 ESTERS, SESAME SEED OIL PEG-8 ESTERS, SHEA BUTTER PEG-8 ESTERS, SOYBEAN OIL PEG-8 ESTERS, SUNFLOWER SEED OIL PEG-8 ESTERS, SWEET ALMOND OIL PEG-8 ESTERS, WATERMELON SEED 0Th PEG-8 ESTERS, WHEAT GERM OIL PEG-8 ESTERS, Viatenza® Ximenia PE8, PEG-9 CASTOR OIL, PEG-9 ISOSTEARATE, PEG-9 LAURATE, BrijTM L9, PEG-9 STEARATE, CETYL PEG/PPG-10/1 DIMETHICONE, ISOXAL -11, ISOXAL -11 P-F, PEG-10 DIMETHICONE, PEG-10 LAURATE, PEG-10 OLEAMINE, PEG-10 OLEATE, PEG-10 POLYGLYCERYL-2 LAURATE, PPG-5-LAURETH-5. PEG-10 SORBITAN LAURATE, PEG-10 STEARATE, PEG-10 SUNFLOWER GLYCERIDES, VegeshineTM Q10, DIMETHICONE PEG-10 PHOSPHATE, LAURYL PEG-I0 METHYL ETHER DIMETHICONE, PEG-11 METHYL ETHER DIMETHICONE, PEG-12, Sabopeg 600; Pluracare0 E 600; Pluracare® E 600 NF; Jeechem 600, PEG-12 DILAURATE. PEG-12 DIMETHICONE, PEG-12 DIOLEATE, PEG-12 DISTEARATE. PEG-12 DITALLATE, PEG-12 LAURATE, PEG-12 OLEATE. PEG-12 STEARATE, PEG-14 DIMETHICONE, HETOXAMATE MI-14. PEG-14 OLEATE, PEG-14 STEARATE, PEG-15 CASTOR OIL, PEG-15 COCAMINE, PEG-15 COCOMONIUM CHLORIDE, PEG-15 COCOMONIUM METHOSULFATE, PEG-15 GLYCERYL ISOSTEARATE, PEG-15 GLYCERYL LAURATE, PEG-15 GLYCERYL STEARATE, PEG-15 HYDROGENATED TALLOW AMINE, Jeemate 600 ML, HETOXAMATE MA -15, PEG-15 TALLOW AMINE, PEG-16, MULSIFAN CAO 16, PEG-16 HYDROGENATED CASTOR OIL, PEG-16 MACADAMIA GLYCERIDES, PEG-20, PEG-20 ALMOND GLYCERIDES, PEG-20 GLYCERYL LAURATE, PEG-20 GLYCERYL OLEATE, PEG-20 GLYCERYL STEARATE; PPG-5-LAURETH-5, PEG-20 HYDROGENATED LANOLIN, PEG-20 METHYL GLUCOSE SESQUISTEARATE, PEG-20 OLEAMINE, PEG-20 OLEATE. PEG-20 SORBITAN ISOSTEARATE, PEG-20 STEARATE, BIS-PEG-20 DIMETHICONE, TRIBEHENIN PEG-20 ESTERS, Jeemate 1000-ML, Jccmatc 1000-0C, Jecmatc 1000-DPS, Sabopal NS 22, LAURETH-23. FM-2501; Cosmethicone@ SF-230, PEG-24 HYDROGENATED LANOLIN, PEG-25 HYDROGENATED CASTOR OIL, PEG-25 OLEAMINE, PEG-25 PABA, PEG-25 STEARATE, Sabopal NS 25, GLYCERETH-26, PEG-27 LANOLIN, PEG-29 CASTOR OIL, MULSIFAN CAO 30, PEG-30 CASTOR OIL, PEG-30 DIPOLYHYDROXYST EARATE, PEG-30 GLYCERYL COCOATE, PEG-30 GLYCERYL COCOATE, PEG-30 GLYCERYL SOYATE, PEG-30 GLYCERYL STEARATE, PEG-30 LANOLIN, PEG-30 OLEAMINE, PEG-30 TALLOW AMINE, Sympatens PEG-1500 G; RenexTM PEG 1500; Jeechem 1450; Sabopeg 1500; Pluracare0 E 1450 N NF, PEG-32, SUNFLOWER SEED OIL PEG-32 ESTERS. PEG-35 CASTOR OIL. PEG-35 SOY GLYCERIDES, PEG-36 CASTOR OIL, PEG-40, PEG-40 CASTOR OIL, PEG-40 HYDROGENATED CASTOR OIL; PPG-5-LAURETH-5. PEG-40 LANOLIN, PEG-40 SORBITAN PERISOSTEARATE. PEG-40 SORBITAN PEROLEATE, PEG-40 STEARATE. PEG-42 BABASSU GLYCERIDES. PEG-45 PALM KERNEL GLYCERIDES, PEG-45 STEARATE, PEG-50 HYDROGENATED CASTOR OIL, PEG-50 LANOLIN, PEG-50 SHEA BUTTER, PEG-50 STEARATE, PEG-54 CASTOR OIL, Hetoxanaine T-50, PEG-55 STEARATE, PEG-60, PEG-60 ALMOND GLYCERIDES, PEG-60 CASTOR OIL. PEG-60 CORN GLYCERIDES, PEG-60 EVENING PRIMROSE GLYCERIDES, PEG-60 HYDROGENATED CASTOR OIL, PPG-5-LAURETH-5, PEG-60 LANOLIN, CrovolTM Maracuja, PEG-75, PEG-75 LANOLIN, PEG-75 MEADOWFOAM OIL, PEG-75 SHEA BUTTER GLYCERIDES, PEG-78 GLYCERYL COCOATE. PEG-80 GLYCERYL COCOATE, PEG-80 SORBITAN LAURATE, PEG-90, PEG-90 DIISOSTEARATE, PEG-100 STEARATE, Apricot Kernel Glycerides, PEG-120 METHYL GLUCOSE DIOLEATE, PEG-150, PEG-150 DISTEARATE. PEG-150 PENTAERYTHRITYL TETRASTEARATE, PEG-150 POLYGLYCERYL-2 TRISTEARATE, PEG-150 STEARATE, PEG-175 DIISOSTEARATE, PEG-180. PEG-200 CASTOR OIL. Siniu'sot 220, PEG-200 HYDROGENATED GLYCERYL PALMATE, PEG-4, PEG-220, PEG-240, PEG-6, PEG-400, PEG-8, PEG-450, PEG-12, PEG-800, PEG-150, PEG-20, PEG-40, PEG-32, PEG-60, PEG-75, PEG-90, PEG-180, PEG-220. PEG-240. PEG-350, PEG-8(10, PEG-2M, PEG-5M, PEG-7M. PEG-9M, PEG-14M, PEG-20M, PEG-23M, PEG-45M, PEG-65M, PEG-90M, PEG-115M, PEG-160M, CETYL PEG/PPG-10/1 DIMETHICONE, CETYL PEG/PPG-7/3 DIMETHICONE, DIM ETHICONE PEG/PPG-7/4 PHOSPHATE, HYDROLYZED WHEAT PROTEIN/PEG20 ACETATE COPOLYMER, JOJOBA OIL PEG-150 ESTERS, JOJOBA WAX PEG-120 ESTERS, JOJOBA WAX PEG-80 ESTERS, LAURYL PEG/PPG-18/18 METHICONE, POLYURETHANE-34. SeraSol() SC 89, PEG/PPG-15/15 DIMETHICONE. PEG/PPG-15/5 DIMETHICONE, UconTM 75-H-450, PEG/PPG-18/18 DIMETHICONE, PEG/PPG-20/15 DIM ETHICONE, PEG/PPG-25/25 DIMETHICONE, PEG/PPG-6/2 GLYCERYL COCOATE. PEG/PPG-6/4 DIMETHICONE. PURE THIXC) 1450. AXIOM ACT-33A. PPG12-PEG-65 LANOLIN OIL. PPG-5-LAURETH-5, Wax PEG-3 Beeswax, PEG-2, PEG-7, PEG-9. PEG-10. PEG-12, PEG-14, PEG-16, PEG-18, PEG-20. PEG-32, PEG-33, PEG-40, 5 PEG-45, PEG-55, PEG-60, PEG-75, PEG-80, PEG-90, PEG-100, PEG-135, PEG-150, PEG-180, PEG-200. PEG-220, PEG-240. PEG-350. PEG-400, PEG-500. PEG-800, PEG-2M, PEG-5M, PEG-7M, PEG-9M, PEG-14M, PEG-20M, PEG-23M, PEG-25M, PEG-45M, PEG-65M, PEG-90M, PEG-115M, PEG-160M, PEG-180M, POLVOXYETHYLENE), CARBOWAX, GoLYTELY, GlycoLax, Fortrans. TriLyte, Colyte, Halflytely, Macrogol, 10 MiraLAX, MoviPrep, PEG/PPG-17/6 copolymer. PEG-20 glyceryl triisostearatc, and PegosperseTM 200 DL.
The nasal disinfection composition described herein would be an effective preventative measure for most respiratory viral infections and may also be a useful preventative measure against certain bacterial infections associated with the nasal cavity. The skilled person would appreciate the wide range of applications for the present invention beyond the particular examples set out above.

Claims (18)

  1. CLAIMS1. A nasal disinfection composition comprising an alkali salt of a fatty acid.
  2. 2. The nasal disinfection composition of claim 1, wherein the fatty acid is a triglyceride.
  3. 3. The nasal disinfection composition of claim 1 or claim 2, wherein the alkali is a sodium or potassium salt.
  4. 4. The nasal disinfection composition of claim 2, wherein the triglyccride is derived from a seed oil, vegetable oil, or animal fat.
  5. 5. The nasal disinfection composition of claim 4, wherein the triglyccride is derived from coconut oil, olive oil, or palm oil.
  6. 6. The nasal disinfection composition of any preceding claims, wherein the alkali used to make the alkali salt of a fatty acid is NaOH or KOH.
  7. 7. The nasal disinfection composition of any preceding claims, wherein the composition further comprises alcohol.
  8. 8. The nasal disinfection composition of any preceding claims, wherein the composition further comprises an anti-viral agent and/or an antibacterial agent.
  9. 9. The nasal disinfection composition of any preceding claims, wherein the nasal composition further comprises gelatin, pectin and carboxymethylcellulosc.
  10. 10. The nasal disinfection composition according to claim 9, wherein each of the gelatin, pectin and carboxymethythellulose are all at 0.1 to 33.33 % w/v.
  11. 11. The nasal disinfection composition according to claim 9, wherein each of the gelatin, pectin and carboxymethylcellulose are all at 16.7% w/v.
  12. 12. The nasal disinfection composition according to any preceding claim, wherein the composition is in the form of a liquid spray or a viscous liquid or a powder.
  13. 13. The nasal disinfection composition according to any preceding claim, further comprising at least one polyethylene glycol. 15 14. The nasal disinfection composition according to claim 13, wherein the at least one polyethylene glycol is selected from a group consisting of PEG-2 COCAMINE, PEG-2 DIM EA DOW FOAM A M IDOETHY LMON IU M M ETHOS ULEATE, PEG-2 DISTEARATE, PEG-2 HYDROGENATED TALLOW AMINE, GALACTENE, PEG-2 OLEAMINE, PEG-2 OLEATE, PEG-2 SOYAMINE, PEG-2 STEARATE, PEG-2 TALLOW AMINE, Cola@ Male OPA-30, ISOXAL -5, PEG-3 DICAPRYLATE/CAPRATE, PPG-5-LAURETH-5; PEG-3 DISTEARATE, MAGNESIUM PEG-3 COCAMIDE SULFATE, ALCORAMNOSAN, PEG-4, PEG-4 DIHEPTANOATE, PEG-4 LAURATE, PEG-4 OLEATE, PEG-4 OLIVATE, PEG-4 POLYGLYCERYL-2 STEARATE, PEG-4 RAPESEEDAMIDE, ISOXAL-12, PEG-4 STEARATE, PEG-5 CASTOR Olt. PEG-5 COCAMINE, PEG-5 OLEAMMONIUM METHOSULFATE, PEG-5 OLEATE, PPG-5-LAURETH-5. PEG-5 STEARATE, PEG-5 STEARYL AMMONIUM LACTATE, DIHYDROXYPROPYL PEG-5 LINOLEAMMONIUM CHLORIDE, PEG-6, PEG-6 CAPRYLIC/CAPRIC GLYCERIDES, PEG-6 DIOLEATE, PEG-6 OLEAMINE PEG-6 OLEATE, PEG-6 SORBITAN OLEATE, PEG-6 SORBITAN STEARATE, PEG-6 STEARATE ALMOND OIL PEG-6 ESTERS, HYDROGENATED PALM/PALM KERNEL OIL PEG-6 ESTERS, PEG-7 AMODIMETHICONE, PEG-7 GLYCERYL COCOATE, PEG-7 GLYCERYL SOYATE, PEG-7 HYDROGENATED CASTOR OIL, PEG-7 OLIVATE AMMONIUM DIMETHICONE PEG-7 SULFATE, DIMETHICONE PEG-7 AVOCADOATE, DIMETHICONE PEG-7 COCOATE, DIMETHICONE PEG-7 ISOSTEARATE, DIMETHICONE PEG-7 OLIVATE, DIMETHICONE PEG-7 PHOSPHATE, DIMETHICONE PEG-7 PHTHALATE, DIMETHICONE PEG-7 SUCCINATE OLIVE OIL PEG-7 ESTERS, SODIUM PEG-7 OLIVE OIL CARBOXYLATE, STEARDIMONIUM HYDROXYPROPYL PEG-7 DIMETHICONE PHOSPHATE CHLORIDE, PEG-8, PEG-8 BEESWAX, XALIFIN -15. XALIEIN 15 N-P, IDRORAMNOSAN, PEG-8 DIISOSTEARATE, PEG-8 DILAURATE, DIMETHICONE PEG-8 AVOCADOATE, PEG-8 DIOLEATE, PEG-8 DISTEARATE, PEG-8 DODECENYLSUCCIN ATE, PEG-8 GLYCERYL LAURATE, ISOXAL -E, PEG-8 LAURATE, PEG-8 OLEATE,PEG-8 METHYL ETHER TRIETHOXYSILANE, PEG-8 STEARATE, 5M3340P, APRICOT KERNEL OIL PEG-8 ESTERS, ARGAN OIL PEG-8 ESTERS, AVOCADO OIL PEG-8 ESTERS, Vialenta0 Cupuacu PE8, Viatenza0 Baobab PE8, BERTHOLLETIA EXCELSA SEED OIL PEG-8 ESTERS, BITTER CHERRY SEED OIL PEG-8 ESTERS, BORAGE SEED OIL POLYGLYCERYL-6 ESTERS, Viatenza0 Buriti PE8, Viatenza0 Cocoa PE8, Silaminc® C-300, DIMETHICONE PEG-8 BEESWAX, DIMETHICONE PEG-8 LANOLATE, DIMETHICONE PEG-8 MEADOWFOAMATE, Silsoftim Surface, DIMETHICONE PEG-8 SUCCINATE, DISODIUM PEG-8 PALM GLYCERIDES SULFOSUCCINATE. GRAPE SEED OIL PEG-8 ESTERS, HAZEL SEED OIL PEG-8 ESTERS, Viatenza® Hemp PE8, Viatenza® Mafura PE8, Viatenza® Mongongo PE8, MACADAMIA TERNIFOLIA SEED OIL PEG-8 ESTERS, OLIVE OIL PEG-8 ESTERS, ORBIGNYA OLEIFERA SEED OIL PEG-8 ESTERS, PUMPKIN SEED OIL PEG-8 ESTERS, ROSA RUB IGINOSA SEED OIL PEG-8 ESTERS, SAFFLOWER SEED OIL PEG-8 ESTERS, SCLEROCARYA BIRREA SEED OIL PEG-8 ESTERS, SESAME SEED OIL PEG-8 ESTERS, SHEA BUTTER PEG-8 ESTERS, SOYBEAN OIL PEG-8 ESTERS, SUNFLOWER SEED OIL PEG-8 ESTERS, SWEET ALMOND OIL PEG-8 ESTERS, WATERMELON SEED Olt PEG-8 ESTERS, WHEAT GERM OIL PEG-8 ESTERS, Viatenza® Ximenia PE8, PEG-9 CASTOR OIL, PEG-9 ISOSTEARATE, PEG-9 LAURATE, Brij'M L9, PEG-9 STEARATE, CETYL PEG/PPG-10/1 DIMETHICONE, ISOXAL -II, ISOXAL -11 P-F. PEG-10 DIMETHICONE, PEG-10 LAURATE PEG-10 OLEAMINE, PEG-10 OLEATE, PEG-10 POLYGLYCERYL-2 LAURATE, PPG-5-LAURETH-5, PEG-10 SORBITAN LAURATE, PEG-10 STEARATE, PEG-10 SUNFLOWER GLYCERIDES, VegeshineTm Q10, DIMETHICONE PEG-10 PHOSPHATE, LAURYL PEG-10 METHYL ETHER DIMETHICONE, PEG-11 METHYL ETHER DIMETHICONE, PEG-fl, Sabopeg 600; Pluracare0 E 600; Pluracare0 E 600 NF; Jeechem 600, PEG-12 DILAURATE, PEG-12 DIMETHICONE, PEG-12 DIOLEATE, PEG-12 DISTEARATE, PEG-12 DITALLATE, PEG-12 LAURATE, PEG-12 OLEATE, PEG-12 STEARATE, PEG-I4 DIMETHICONE, HETOXAMATE MI -14, PEG-I4 OLEATE, PEG-14 STEARATE, PEG-15 CASTOR OIL, PEG-15 COCAMINE, PEG-15 COCOMONIUM CHLORIDE, PEG-15 COCOMONIUM METHOSULFATE, PEG-15 GLYCERYL ISOSTEARATE, PEG-15 GLYCERYL LAURATE, PEG-15 GLYCERYL STEARATE, PEG-15 HYDROGENATED TALLOW AMINE, Jeemate 600 ML, HETOXAMATE MA - 15, PEG-15 TALLOW AMINE, PEG-16, MULSIFAN CAO 16, PEG-16 HYDROGENATED CASTOR OIL. PEG-16 MACADAMIA GLYCERIDES, PEG-20, PEG-20 ALMOND GLYCERIDES, PEG-20 GLYCERYL LAURATE, PEG-20 GLYCERYL OLEATE, PEG-20 GLYCERYL STEARATE; PPG-5-LAURETH-5, PEG-20 HYDROGENATED LANOLIN, PEG-20 METHYL GLUCOSE SESQUISTEARATE, PEG-20 OLEAMINE, PEG-20 OLEATE. PEG-20 SORB ITAN ISOSTEARATE, PEG-20 STEARATE, BIS-PEG-20 DIMETHICONE, TRIBEHENIN PEG-20 ESTERS, Jeemate 1000-ML, Jeemate 1000-0C, Jeemate 1000-DPS, Sabopal NS 22, LAURETH-23, FM-2501: Cosmethicone® SF-230, PEG-24 HYDROGENATED LANOLIN. PEG-25 HYDROGENATED CASTOR OIL, PEG-25 OLEAMINE, PEG-25 PABA, PEG-25 STEARATE, Sabopal NS 25, GLYCERETH-26, PEG-27 LANOLIN, PEG-29 CASTOR OIL, MULSIFAN CAO 30, PEG-30 CASTOR OIL, PEG-30 DIPOLYHYDROXYST EARATE, PEG-30 GLYCERYL COCOATE, PEG-30 GLYCERYL COCOATE, PEG-30 GLYCERYL SOYATE, PEG-30 GLYCERYL STEARATE, PEG-30 LANOLIN, PEG-30 OLEAMINE, PEG-30 TALLOW AMINE, Sympatctic PEG-1500 G; RenexTm PEG 1500; Jeechem 1450; Sabopeg 1500; Pluracaree E 1450 N NF, PEG-32, SUNFLOWER SEED OIL PEG-32 ESTERS, PEG-35 CASTOR OIL, PEG-35 SOY GLYCERIDES, PEG-36 CASTOR OIL, PEG-40, PEG-40 CASTOR OIL, PEG-40 HYDROGENATED CASTOR OIL; PPG-5-LAURETH-5. PEG-40 LANOLIN, PEG-40 SORBITAN PERISOSTEARATE. PEG-40 SORBTTAN PEROLEATE, PEG-40 STEARATE, PEG-42 BABASSU GLYCERIDES, PEG-45 PALM KERNEL GLYCERIDES, PEG-45 STEARATE, PEG-50 HYDROGENATED CASTOR OIL, PEG-50 LANOLIN, PEG-50 SHEA BUTTER, PEG-50 STEARATE, PEG-54 CASTOR OIL, Hetoxamine T-50, PEG-55 STEARATE, PEG-60, PEG-60 ALMOND GLYCERIDES, PEG-60 CASTOR OIL, PEG-60 CORN GLYCERIDES, PEG-60 EVENING PRIMROSE GLYCERIDES, PEG-60 HYDROGENATED CASTOR OIL, PPG-5-LAURETH-5, PEG-60 LANOLIN, Crovol I m Maracuja, PEG-75, PEG-75 LANOLIN. PEG-75 MEADOWFOAM OIL, PEG-75 SHEA BUTTER GLYCERIDES. PEG-78 GLYCERYL COCOATE, PEG-80 GLYCERYL COCOATE, PEG-80 SORBYTAN LAURATE, PEG-90, PEG-90 DIISOSTEARATE, PEG-100 STEARATE, Apricot Kernel Glycerides, PEG-120 METHYL GLUCOSE DIOLEATE, PEG-150, PEG-150 DISTEARATE, PEG-150 PENTAERYTHRITYL TETRASTEARATE, PEG-150 POLYGLYCERYL-2 TRISTEARATE, PEG-150 STEARATE, PEG-175 DIISOSTEARATE, PEG-180, PEG-200 CASTOR OIL, Simulsol 220, PEG-200 HYDROGENATED GLYCERYL PALMATE, PEG-4, PEG-220, PEG-240, PEG-6, PEG-400, PEG-8, PEG-450, PEG-12, PEG-800, PEG-150, PEG-20, PEG-40, PEG-32, PEG-60, PEG-75, PEG-90, PEG-180, PEG-220, PEG-240, PEG-350, PEG-800, PEG-2M, PEG-5M, PEG-7M, PEG-9M, PEG-14M, PEG-20M, PEG-23M, PEG-45M, PEG-65M, PEG-90M, PEG-115M, PEG-160M, CETYL PEG/PPG-10n DIMETHICONE, CETYL PEG/PPG-7/3 DIMETHICONE, DIMETHICONE PEG/PPG-7/4 PHOSPHATE, HYDROLYZED WHEAT PROTEIN/PEG- 20 ACETATE COPOLYMER, JOJOBA OIL PEG-150 ESTERS, JOJOBA WAX PEG-120 ESTERS, JOJOBA WAX PEG-80 ESTERS, LAURYL PEG/PPG-18/18 METHICONE, POLYURETHANE-34, SeraSol® SC 89, PEG/PPG-15/15 DIMETHICONE, PEG/PPG-15/5 DIM ETHICONE, Ucon 75-H-450, PEG/PPG-18/18 DIMETHICONE, PEG/PPG-20/15 DIMETHICONE, PEG/PPG-25/25 DIMETHICONE, PEG/PPG-6/2 GLYCERYL COCOATE, PEG/PPG-6/4 DIMETHICONE, PURE THIXC) 1450, AXIOM ACT-33A, PPG12-PEG-65 LANOLIN OIL, PPG-5-LAURETH-S, Wax PEG-3 Beeswax, PEG-2, PEG-7, PEG-9, PEG-10, PEG-12, PEG-
  14. 14, PEG-16, PEG-18, PEG-20, PEG-32, PEG-33, PEG-40, PEG-45, PEG-55, PEG-60, PEG-75, PEG-80, PEG-90, PEG-100, PEG-135, PEG-150, PEG-180, PEG-200, PEG-220, PEG-240, PEG-350, PEG-400, PEG-500, PEG-800, PEG-2M, PEG-5M, PEG-7M, PEG-9M, PEG-14M, PEG-20M, PEG-23M, PEG-25M, PEG-45M, PEG-65M, PEG-90M, PEG-115M, PEG-160M, PEG-180M, POLY(OXYETHYLENE), CARBOWAX. GoLYTELY, GlycoLax, Fortrans, TriLyte. Colyte. Halflytely, Macrogol, MiraLAX, MoviPrep, PEG/PPG-17/6 copolymer, PEG-20 glyceryl triisostearate, and PegosperseTM 200 DL
  15. 15. The nasal disinfection composition according to claim 13, wherein the at least one polyethylene glycol is PEG hydrogenated castor oil.
  16. 16. The nasal disinfection composition according to any preceding claim, wherein the composition comprises ethyl lauroyl arginate.
  17. 17. The nasal disinfection composition according to any preceding claim, wherein the composition comprises methyl cellulose.
  18. 18. A method of preventing viral infection comprising the step of inhaling a nasal disinfection composition comprising an alkali salt of a fatty acid.
GB2019544.2A 2020-11-20 2020-12-10 Nasal disinfection composition Pending GB2601200A (en)

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Citations (2)

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