GB2595140B - Flupentixol/melitracen pharmaceutical composition and preparation thereof - Google Patents

Flupentixol/melitracen pharmaceutical composition and preparation thereof Download PDF

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Publication number
GB2595140B
GB2595140B GB2111477.2A GB202111477A GB2595140B GB 2595140 B GB2595140 B GB 2595140B GB 202111477 A GB202111477 A GB 202111477A GB 2595140 B GB2595140 B GB 2595140B
Authority
GB
United Kingdom
Prior art keywords
flupentixol
preparation
pharmaceutical composition
melitracen pharmaceutical
melitracen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
GB2111477.2A
Other versions
GB2595140A (en
Inventor
BU Shui
Chen Yunwan
Yang Yudong
Hu Gongyun
Wang Duantong
Zheng Weiguo
Xu Ligui
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Guangdong Scient Finder Pharmaceutical Tech Co Ltd
Hainan Huineng Pharmaceutical Co Ltd
Original Assignee
Guangdong Scient Finder Pharmaceutical Tech Co Ltd
Hainan Huineng Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Guangdong Scient Finder Pharmaceutical Tech Co Ltd, Hainan Huineng Pharmaceutical Co Ltd filed Critical Guangdong Scient Finder Pharmaceutical Tech Co Ltd
Publication of GB2595140A publication Critical patent/GB2595140A/en
Application granted granted Critical
Publication of GB2595140B publication Critical patent/GB2595140B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
GB2111477.2A 2019-01-10 2019-12-13 Flupentixol/melitracen pharmaceutical composition and preparation thereof Active GB2595140B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201910024441.8A CN109674754B (en) 2019-01-10 2019-01-10 Flupentixol and melitracen pharmaceutical composition and preparation thereof
PCT/CN2019/125211 WO2020143394A1 (en) 2019-01-10 2019-12-13 Flupentixol/melitracen pharmaceutical composition and preparation thereof

Publications (2)

Publication Number Publication Date
GB2595140A GB2595140A (en) 2021-11-17
GB2595140B true GB2595140B (en) 2023-06-14

Family

ID=66192951

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2111477.2A Active GB2595140B (en) 2019-01-10 2019-12-13 Flupentixol/melitracen pharmaceutical composition and preparation thereof

Country Status (3)

Country Link
CN (1) CN109674754B (en)
GB (1) GB2595140B (en)
WO (1) WO2020143394A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109771386B (en) * 2019-01-10 2021-10-08 广东赛烽医药科技有限公司 Flupentixol melitracen tablet and preparation method thereof
CN109674754B (en) * 2019-01-10 2021-10-08 广东赛烽医药科技有限公司 Flupentixol and melitracen pharmaceutical composition and preparation thereof
CN112300119B (en) * 2019-08-02 2024-04-16 苏州恩华生物医药科技有限公司 Metliquxin and flupentixol eutectic and preparation method thereof

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2374450A1 (en) * 2010-04-06 2011-10-12 H. Lundbeck A/S Flupentixol compositions
CN104288153A (en) * 2014-09-19 2015-01-21 四川海思科制药有限公司 Flupentixol and melitracen pharmaceutical composition and preparation method thereof
CN105663062A (en) * 2016-02-17 2016-06-15 南京卓泰医药科技有限公司 Flupentixol and melitracen medicine composition and preparation method thereof
CN108362792A (en) * 2018-01-31 2018-08-03 成都倍特药业有限公司 A kind of detection method of flupentixol and melitracen compound medicine impurity, new recognizable impurity and safer compound medicine
CN108498470A (en) * 2017-02-24 2018-09-07 重庆圣华曦药业股份有限公司 A kind of flupentixol and melitracen pharmaceutical composition and preparation method thereof
CN109674754A (en) * 2019-01-10 2019-04-26 广东赛烽医药科技有限公司 A kind of flupentixol and melitracen pharmaceutical composition and its preparation
CN109771386A (en) * 2019-01-10 2019-05-21 广东赛烽医药科技有限公司 A kind of Flupentixol and Melitracen Tablets agent and preparation method thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101912397B (en) * 2010-04-30 2013-03-27 H.隆德贝克有限公司 Flupentixol composition
GB201015079D0 (en) * 2010-09-10 2010-10-27 Helperby Therapeutics Ltd Novel use
CN103877088A (en) * 2012-12-19 2014-06-25 H.隆德贝克有限公司 Melitracen pharmaceutical composition with high security

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2374450A1 (en) * 2010-04-06 2011-10-12 H. Lundbeck A/S Flupentixol compositions
CN104288153A (en) * 2014-09-19 2015-01-21 四川海思科制药有限公司 Flupentixol and melitracen pharmaceutical composition and preparation method thereof
CN105663062A (en) * 2016-02-17 2016-06-15 南京卓泰医药科技有限公司 Flupentixol and melitracen medicine composition and preparation method thereof
CN108498470A (en) * 2017-02-24 2018-09-07 重庆圣华曦药业股份有限公司 A kind of flupentixol and melitracen pharmaceutical composition and preparation method thereof
CN108362792A (en) * 2018-01-31 2018-08-03 成都倍特药业有限公司 A kind of detection method of flupentixol and melitracen compound medicine impurity, new recognizable impurity and safer compound medicine
CN109674754A (en) * 2019-01-10 2019-04-26 广东赛烽医药科技有限公司 A kind of flupentixol and melitracen pharmaceutical composition and its preparation
CN109771386A (en) * 2019-01-10 2019-05-21 广东赛烽医药科技有限公司 A kind of Flupentixol and Melitracen Tablets agent and preparation method thereof

Also Published As

Publication number Publication date
WO2020143394A1 (en) 2020-07-16
CN109674754B (en) 2021-10-08
GB2595140A (en) 2021-11-17
CN109674754A (en) 2019-04-26

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