GB2570955A - Delievery of physiologically acceptable lubricant - Google Patents
Delievery of physiologically acceptable lubricant Download PDFInfo
- Publication number
- GB2570955A GB2570955A GB1811987.5A GB201811987A GB2570955A GB 2570955 A GB2570955 A GB 2570955A GB 201811987 A GB201811987 A GB 201811987A GB 2570955 A GB2570955 A GB 2570955A
- Authority
- GB
- United Kingdom
- Prior art keywords
- package
- capsule
- lubricant
- outer protective
- exposure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/009—Sachets, pouches characterised by the material or function of the envelope
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1611—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Inorganic Chemistry (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Medicinal Preparation (AREA)
Abstract
A package for delivery of a physiologically acceptable lubricant comprises a solid lubricant precursor that on exposure to moisture forms the physiologically acceptable lubricant, housed in a capsule capable of disintegration on exposure to moisture at a temperature in the range 35°C - 45°C and encapsulated by an outer protective membrane inhibiting exposure of the capsule to moisture. In some embodiments, the inner capsule may be in the form of a sachet or bag. Preferably the capsule is made from poly vinyl alcohol (PVA). In an embodiment, the capsule disintegrates within 15 seconds of exposure to water at 25℃. The lubricant precursor preferably comprises powdered sucrose, poly(ethylene oxide) and fumed silica. In some embodiments the outer membrane is compostable. For use the capsules are removed from the outer membrane and placed in the required position, preferably in the vagina of an animal.
Description
The present invention relates to the delivery of physiologically acceptable lubricants.
BACKGROUND
The typical approach for lubricating the vaginal passage of an animal in preparation for parturition, or other veterinary procedure, is for a veterinary physician to directly apply a lubricant into vaginal passage, to provide lubrication by hand; or by hose and funnel if administering large volumes of liquid lubricant which are often required
The established approach to assist animals during obstetrical procedures is for a lubricant to be applied directly to the operator’s hand(s) which are then inserted into the animal where the lubricant is applied. Many lubricants are oil-based, but oil-based lubricants are undesirable in obstetrical procedures due to potentially adverse effects to the animal. Water based veterinary lubricants are commonly used and readily available . They are inexpensive and cause less intraabdominal irritation to the animal if a caesarean section is required (following unsuccessful delivery per vagina) “Water based” lubricants are available ready to use in gel form; or as dry powdered lubricant precursors that dissolve in contact with body fluids to provide the lubricant effect. The powder form can either be dissolved in a bucket of water to then funnel into the animal or applied by hand at the relevant points of friction where extra lubrication is required. This does form a very slippery surface (more than the ready to use gel) and can help in difficult situations (hence used more commonly by vets when called in emergency situations - but can be used by farmers too).
Unlike oil-based lubricants, water-based lubricants are absorbed and/or evaporated which means that they do not leave the animal in a lubricated state following the obstetrical procedure. Therefore, physiologically acceptable water-based lubricants are strongly preferred by veterinary professionals performing obstetrical procedures.
However, powdered lubricant precursors can spill causing wastage, and furthermore can cover the vets hands in lubricant before they have started work, making handling tools difficult. This approach also has the drawback of not being targeted as it may be required, in some circumstances, to lubricate a particular area of the vaginal passage. Further, powdered lubricant precursors typically come in containers from which a desired quantity is used, but unused powdered lubricant precursors in the container can be contaminated.
Therefore, there is a need for a means for manually delivering a physiologically acceptable lubricant to the vaginal passage of an animal in an easy to apply, simple and targeted way that minimises wastage and contamination of unused powdered lubricant precursor.
SUMMARY OF THE INVENTION
A package for delivery of a physiologically acceptable lubricant, comprising:
a) a solid lubricant precursor that on exposure to moisture forms the physiologically acceptable lubricant;
housed in
b) a capsule capable of disintegration on exposure to moisture at a temperature in the range 35°C - 45°C;
encapsulated by
c) an outer protective membrane inhibiting exposure of the capsule to moisture.
By “capsule” is meant a container or envelope of suitable form for holding the solid lubricant precursor.
BRIEF DESCRIPTION OF THE DRAWINGS
FIG. 1 schematically depicts a lubricant precursor housed in a capsule, wherein said capsule is encapsulated by an outer protective membrane.
FIG. 2 schematically depicts a plurality of capsules, each housing a lubricant precursor, encapsulated by an outer protective membrane.
DETAILED DESCRIPTION
The invention provides a package for delivery of a physiologically acceptable lubricant, comprising:
a) a solid lubricant precursor 10 that on exposure to moisture forms the physiologically acceptable lubricant [described below under “Lubricant precursor];
housed in
b) a capsule 20 capable of disintegration on exposure to moisture at a temperature in the range 35°C - 45°C [described below under “Capsule”];;
encapsulated by
c) an outer protective membrane 30 inhibiting exposure of the capsule 20 to moisture [described below under “Outer protective membrane];.
Lubricant precursor
The vaginal passage of an animal is “wet and warm”. The body temperatures of most domestic animals range between approximately 35°C and 45°C. Most mammals would not go above 40°C if healthy [with different species having different ranges of body temperature and with typical ranges of 37-39°C for most domestic animals]. Any lubricant precursor 10 (as shown in Figs. 1-3) that is physiologically acceptable and soluble in such conditions may be used.
While powder form lubricant precursors may be preferred in normal use (as providing rapid dissolution), tabletted precursors may provide some advantage in handling properties in some applications.
A suitable type of lubricant precursor 10 comprises a mixture of poly(ethylene) oxide, sucrose, and silica [e.g. “J-Lube Lubricant Powder” by Jorgensens Laboratories]. Other materials that can be used in this application may include, for example, methyl cellulose or carboxymethyl cellulose if the vaginal temperature is appropriate.
Capsule
The capsule 20 (as shown in Figs. 1-3) must be capable of disintegration on exposure to the physiological conditions of being “wet and warm” [temperature in the range 35°C - 45°C], while being physiologically acceptable. A physiologically acceptable material may be regarded as any material that does not cause any harm to the animal to which the lubricant is being delivered. Materials that disintegrate on exposure to moisture at a temperature below 40°C will be usable for most domestic mammals. Materials that disintegrate on exposure to moisture at a temperature below 35°C will be usable for all domestic animals. However materials that disintegrate when dry on exposure to temperatures below 35°C would require refrigerated storage.
Solid or gel capsules may be used, but a convenient way is for the capsule 20 to be in membrane form, e.g. as a bag or sachet.
The capsule 20 must disintegrate sufficiently to release the lubricant precursor when used, and this disintegration may be by at least partially dissolving, at least partially melting, or otherwise degrading once it has been inserted into the animal.
The capsule 20 may comprise materials that simply melt at temperature, but a problem with such materials is that the capsules may need to be refrigerated to avoid temperature excursions in storage degrading the capsule 20.
Preferably therefore, the capsule 20 is of a material that dissolves at least in part on exposure to moisture at a temperature in the range 35°C - 45°C.
Bio-soluble polymers can provide such materials. The most commonly known bio-soluble polymer is polyvinyl alcohol (PVOH or PVA) but other bio-soluble polymers [e.g. copolymers with PVOH/PVA] may provide suitable materials.
PVOH/PVA can be used to form thin membranes and has heat sealing and adhesive properties which make it ideal for forming a sealed bag or sachet of the capsule 20 or inner membrane to encapsulate a lubricant precursor 10. Physiologically acceptable adhesives should desirably be used.
The thickness and type of PVOH/PVA is preferably chosen such that the capsule 20 does not start to dissolve by making contact with wet fingers. Selection of a PVOH/PVA that needs a water temperature of at least 25 °C to dissolve fully is beneficial
The relationship between capsule membrane thickness and dissolution time is linear, however disintegration time is not necessarily linear with the membrane thickness. Dissolution refers to the act of the membrane going into the solution (such as a cow’s vaginal fluid or water). Disintegration refers to the extent or rate at which the membrane breaks up into smaller constituent parts.
For example, a 25 pm thick PVOH/PVA membrane takes 90 seconds to dissolve and 2 seconds to disintegrate at 25°C, and a 35 pm thick PVOH/PVA membrane takes 100 seconds to dissolve and 3 seconds to disintegrate at 25°C.
Both dissolution and disintegration times will be faster at the animal’s internal body temperature, e.g. a healthy cow has a normal core body temperature around 38.6°C so the dissolution time and disintegration time for 25 pm thick membrane will be shorter than at 25 °C.
In order for the lubricant precursor 10 to escape the capsule 20, the capsule 20 must at least be partially disintegrated.
There are three main factors to consider with regards to dissolution time: (i) the temperature of the liquid that the membrane is immersed in, (ii) the type of material used to make the membrane and (iii) the thickness of the membrane.
A controlled dissolution time of the capsule 20 may be advantageous as any obstetrical procedure has to be done fairly rapidly and efficiently to reduce risk to both dam and offspring, hence the need for a relatively quick precursor 10 release and adequate lubrication time i.e. the time from the capsule 20 having been inserted to the lubricant precursor 10 effectively reducing friction at the targeted location. A capsule 20 with too short a dissolution time may not allow the veterinarian to sufficiently target the area that requires lubrication as it may cause the capsule 20 to dissolve prior to being correctly positioned.
The optimum size and shape of the capsule 20 depends on the animal concerned and the dose of lubricant precursor to be delivered but a precursor dose in the range lOg - lOOg might be typical, with a 20 g dose in, for example, a 5cm x 5cm sachet being a convenient size which should allow easy handling and placement. One such sachet would be enough for preparing a ewe for parturition, for example, and two or three might be required for a cow .
Outer protective membrane
As the capsule 20 is designed to disintegrate on exposure to moisture at a temperature below 45 °C, it needs to be protected against dissolving, disintegrating and/or melting (depending on the material of the capsule 20 and the surrounding conditions) prior to insertion into the animal. An outer protective membrane 30 (as shown in Figs. 1-3) provides this function. The outer protective membrane 30 is removed or discarded prior to the insertion of the capsule 20 into the animal.
The outer protective membrane 30 should inhibit, and ideally prevent, moisture from reaching the capsule 20, and hence the lubricant precursor 10.
The outer protective membrane 30 may comprise a biodegradable and/or compostable material.
An example of such a material is Bio-Flex® FX 1130 produced by FKuR Kunststoff GmbH and is a biodegradable and compostable compound which can be used for blown fdm extrusion to produce bags. Bio-Flex® is impermeable so an outer protective membrane 30 comprising Bio-Flex® will not allow an encapsulated capsule 20 (e.g. a soluble capsule) to dissolve.
Multiple capsules
Optionally, the outer protective membrane 30 may encapsulate two or more capsules 20.
This may be useful in situations where several “doses” of lubricant may be required. The capsule 20 may comprise a first capsule and a second capsule, both encapsulated by the outer protective membrane 30. The first and second capsules may be of the same thickness (i.e. same dissolution and/or disintegration time) or they may have different thicknesses with respect to one another (i.e. different dissolution times and/or disintegration times). For example, a first capsule encapsulated by the outer protective membrane 30 may be a first soluble capsule, and a second capsule encapsulated by the outer protective membrane 30 may be a second soluble capsule whereby the first soluble capsule has a thickness greater than the second soluble capsule such that the first soluble capsule requires more time to dissolve and/or disintegrate than the second soluble capsule.
Weakness/ridged edges
To improve efficient removal of the capsule 20 from the outer protective membrane 30 (and also to reduce any “wrap-rage”), the outer protective membrane 30 may comprise at least one weakness line for assisting removal of the outer protective membrane 30 to expose the at least one capsule 20. Optionally, or additionally, the at least one weakness line may comprise at least one perforation and/or tab which protrudes the outer protective membrane external surface for gripping and making it easier to remove the outer protective membrane 30. Optionally, or additionally, the outer protective membrane 30 may comprise at least one ridged edge. A ridged edge, similar to that of the ridged edges commonly used on confectionary wrappers, permits quick and simple removal of the outer protective membrane 30.
It is stressed that the present invention can be used for any procedure which requires the lubrication of an animal’s internal parts.
Example
Packages were prepared comprising:- • 24 grams of lubricant precursor 10 in the form of a powder [“J-Lube Lubricant Powder” by Jorgensens Laboratories] housed in • a capsule 20 consisting of adhesively sealed (cyanoacrylate glue) 5x5cm envelope comprising a 25 pm thickness] film of PVOH/PVA encapsulated by • a 6cm x 6cm envelope comprising a <110 pm thickness] film of compostable polymer [Bio-Flex® FX 1130 produced by FKuR Kunststoff GmbH]. A weakness line was provided to enable easy removal of the capsule.
Such packages were used in assisting calving and lambing, and enabled the lubricant precursor 10 to be delivered where required without spillage of the lubricant precursor 10.
Claims (13)
1. A package for delivery of a physiologically acceptable lubricant, comprising:
a) a solid lubricant precursor that on exposure to moisture forms the physiologically acceptable lubricant;
housed in
b) a capsule capable of disintegration on exposure to moisture at a temperature in the range 35°C - 45°C;
encapsulated by
c) an outer protective membrane inhibiting exposure of the capsule to moisture.
2. A package as claimed in Claim 0, wherein the capsule is soluble at least in part at a temperature below 40°C.
3. A package as claimed in Claim 0 or Claim 2, wherein the capsule is in the form of an inner membrane.
4. A package as claimed in Claim 3, wherein the inner membrane is a sachet or bag.
5. A package as claimed in any of Claims 0 to 4, wherein the capsule comprises at least in part a bio-soluble polymer.
6. A package as claimed in Claim 5, wherein the bio-soluble polymer is a heat sealable polymer.
7. A package as claimed in Claims 5 or Claim 6, wherein the biosoluble polymer comprises polyvinyl alcohol.
8. A package as claimed in any of Claims 0 to 7, wherein the capsule disintegrates within 15 seconds of exposure to water at a temperature of 25 °C or above.
9. A package as claimed in any of Claims 0 to 8, wherein the lubricant precursor comprises a mixture of powdered sucrose, polyethylene oxide), and fumed silica.
10. A package as claimed in any of Claims 0 to 9, wherein the outer protective membrane is compostable.
11. A package as claimed in any of Claims 0 to 10, wherein the outer protective membrane comprises at least one weakness line.
12. A package as claimed in any of Claims 0 to 11, wherein the outer protective membrane comprises two or more capsules.
13. A method of delivering lubricant to an animal, comprising removing the outer protective membrane from a package as claimed any of Claims 1 to 12 and placing at least one of the capsules in required position.
24 04 19
13. A method of delivering lubricant to an animal, comprising removing the outer protective membrane from a package as claimed any of Claims 0 to 12 and placing at least one of the capsules in required position.
The amendments to the claims are as follows;
24 04 19
Claims
1. A package for delivery of a physiologically acceptable lubricant, comprising:
a) a solid lubricant precursor that on exposure to moisture forms the physiologically acceptable lubricant;
housed in
b) a capsule capable of disintegration on exposure to moisture at a temperature in the range 35°C - 45°C;
encapsulated by
c) an outer protective membrane inhibiting exposure of the capsule to moisture.
2. A package as claimed in Claim 1, wherein the capsule is soluble at least in part at a temperature below 40°C.
3. A package as claimed in Claim 1 or Claim 2, wherein the capsule is in the form of an inner membrane.
4. A package as claimed in Claim 3, wherein the inner membrane is a sachet or bag.
5. A package as claimed in any of Claims 1 to 4, wherein the capsule comprises at least in part a bio-soluble polymer.
6. A package as claimed in Claim 5, wherein the bio-soluble polymer is a heat sealable polymer.
7. A package as claimed in Claims 5 or Claim 6, wherein the biosoluble polymer comprises polyvinyl alcohol.
8. A package as claimed in any of Claims 1 to 7, wherein the capsule disintegrates within 15 seconds of exposure to water at a temperature of 25 °C or above.
9. A package as claimed in any of Claims 1 to 8, wherein the lubricant precursor comprises a mixture of powdered sucrose, poly(ethylene oxide), and fumed silica.
10. A package as claimed in any of Claims 1 to 9, wherein the outer protective membrane is compostable.
11. A package as claimed in any of Claims 1 to 10, wherein the outer protective membrane comprises at least one weakness line.
12. A package as claimed in any of Claims 1 to 11, wherein the outer protective membrane encapsulates two or more capsules.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1811987.5A GB2570955B (en) | 2018-07-23 | 2018-07-23 | Delivery of physiologically acceptable lubricant |
| PCT/GB2019/052012 WO2020021239A1 (en) | 2018-07-23 | 2019-07-18 | Delivery of physiologically acceptable lubricant |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1811987.5A GB2570955B (en) | 2018-07-23 | 2018-07-23 | Delivery of physiologically acceptable lubricant |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| GB201811987D0 GB201811987D0 (en) | 2018-09-05 |
| GB2570955A true GB2570955A (en) | 2019-08-14 |
| GB2570955B GB2570955B (en) | 2020-07-15 |
Family
ID=63364363
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1811987.5A Active GB2570955B (en) | 2018-07-23 | 2018-07-23 | Delivery of physiologically acceptable lubricant |
Country Status (2)
| Country | Link |
|---|---|
| GB (1) | GB2570955B (en) |
| WO (1) | WO2020021239A1 (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3927196A (en) * | 1971-07-02 | 1975-12-16 | American Home Prod | Soluble capsules |
| US4278633A (en) * | 1978-12-20 | 1981-07-14 | Stanley Drug Products, Inc. | Method of treating a water soluble capsule |
| JP3726570B2 (en) * | 1999-07-27 | 2005-12-14 | 不二製油株式会社 | Soft capsule manufacturing method and coating or lubricant |
| GB2417231A (en) * | 2004-08-19 | 2006-02-22 | Lrc Products | Lubricant-containing capsules |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070281008A1 (en) * | 2006-06-05 | 2007-12-06 | Lin Shun Y | Personal lubricant compositions and kits for providing personal lubrication |
| US20090155354A1 (en) * | 2007-12-14 | 2009-06-18 | Mclean Barbara Wanamaker | Dispensing encapsulated liquids into body cavities |
-
2018
- 2018-07-23 GB GB1811987.5A patent/GB2570955B/en active Active
-
2019
- 2019-07-18 WO PCT/GB2019/052012 patent/WO2020021239A1/en active Application Filing
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3927196A (en) * | 1971-07-02 | 1975-12-16 | American Home Prod | Soluble capsules |
| US4278633A (en) * | 1978-12-20 | 1981-07-14 | Stanley Drug Products, Inc. | Method of treating a water soluble capsule |
| JP3726570B2 (en) * | 1999-07-27 | 2005-12-14 | 不二製油株式会社 | Soft capsule manufacturing method and coating or lubricant |
| GB2417231A (en) * | 2004-08-19 | 2006-02-22 | Lrc Products | Lubricant-containing capsules |
Also Published As
| Publication number | Publication date |
|---|---|
| GB2570955B (en) | 2020-07-15 |
| WO2020021239A1 (en) | 2020-01-30 |
| GB201811987D0 (en) | 2018-09-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN107207122B (en) | Individually sealed antiseptic applicator | |
| EP1014866B1 (en) | Sterile syringe package | |
| EP3721910B1 (en) | Radiation activated gels that release fluids and assemblies containing the same | |
| EP1500383A2 (en) | Hemostatic cleansing swab | |
| JP2017512086A (en) | System and method for providing an antimicrobial dispensing applicator | |
| US7919453B2 (en) | Dosage cap assembly for an applicator | |
| GB2417231A (en) | Lubricant-containing capsules | |
| GB2570955A (en) | Delievery of physiologically acceptable lubricant | |
| CA3041921A1 (en) | Hemostatic nose plugs | |
| KR20100134782A (en) | Condom with localized active agent | |
| US20140294952A1 (en) | Dissolvable medication admisistration bag and method of using the same | |
| WO2001041666A1 (en) | Sterile syringe package | |
| US20140031768A1 (en) | Liquid dispensing container | |
| EP1242127B1 (en) | Antiseptic tampon and preparation method | |
| US8747346B2 (en) | Hemostatic agent applicator for survical procedures | |
| JP2004001784A (en) | Kit for disinfectant | |
| GB2371036A (en) | Sterile pack containing medical device and lubricant | |
| JP2007182445A (en) | Apparatus for preventing leakage of humor from dead body | |
| US8196745B2 (en) | Suppository delivery device | |
| US7731030B2 (en) | Suppository delivery device | |
| CN215193765U (en) | Instant medicine bag | |
| JP4228159B2 (en) | Packaging material to prevent blocking | |
| EP2574335A1 (en) | Manufacturing method of patch preparation | |
| JP2013532034A (en) | Release agent in containers | |
| JP2005245874A (en) | Pressure sensitive adhesive sheet for hair removal |