GB2563531B - Heterodimers and purification thereof - Google Patents
Heterodimers and purification thereof Download PDFInfo
- Publication number
- GB2563531B GB2563531B GB1814284.4A GB201814284A GB2563531B GB 2563531 B GB2563531 B GB 2563531B GB 201814284 A GB201814284 A GB 201814284A GB 2563531 B GB2563531 B GB 2563531B
- Authority
- GB
- United Kingdom
- Prior art keywords
- heterodimers
- purification
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Mycology (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB1602156.0A GB201602156D0 (en) | 2016-02-05 | 2016-02-05 | Heterodimers and purification thereof |
PCT/GB2017/050257 WO2017134440A2 (en) | 2016-02-05 | 2017-02-02 | Heterodimers and purification thereof |
Publications (3)
Publication Number | Publication Date |
---|---|
GB201814284D0 GB201814284D0 (en) | 2018-10-17 |
GB2563531A GB2563531A (en) | 2018-12-19 |
GB2563531B true GB2563531B (en) | 2020-05-13 |
Family
ID=55641913
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GBGB1602156.0A Ceased GB201602156D0 (en) | 2016-02-05 | 2016-02-05 | Heterodimers and purification thereof |
GB1814284.4A Active GB2563531B (en) | 2016-02-05 | 2017-02-02 | Heterodimers and purification thereof |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GBGB1602156.0A Ceased GB201602156D0 (en) | 2016-02-05 | 2016-02-05 | Heterodimers and purification thereof |
Country Status (2)
Country | Link |
---|---|
GB (2) | GB201602156D0 (en) |
WO (1) | WO2017134440A2 (en) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2018191438A1 (en) | 2017-04-11 | 2018-10-18 | Inhibrx, Inc. | Multispecific polypeptide constructs having constrained cd3 binding and methods of using the same |
KR20210006913A (en) | 2018-04-11 | 2021-01-19 | 인히브릭스, 인크. | Multispecific polypeptide constructs with limited CD3 binding and related methods and uses |
CN112789294A (en) | 2018-07-24 | 2021-05-11 | 印希比股份有限公司 | Multispecific polypeptide constructs containing constrained CD3 binding domains and receptor binding regions and methods of use thereof |
SG11202101369XA (en) * | 2018-08-17 | 2021-03-30 | Regeneron Pharma | Method and chromatography system for determining amount and purity of a multimeric protein |
CA3115089A1 (en) | 2018-10-11 | 2020-04-16 | Inhibrx, Inc. | Dll3 single domain antibodies and therapeutic compositions thereof |
WO2020077257A1 (en) | 2018-10-11 | 2020-04-16 | Inhibrx, Inc. | Pd-1 single domain antibodies and therapeutic compositions thereof |
CN113166261A (en) | 2018-10-11 | 2021-07-23 | 印希比股份有限公司 | B7H3 single domain antibodies and therapeutic compositions thereof |
US20210340273A1 (en) | 2018-10-11 | 2021-11-04 | Inhlbrx, inc. | 5t4 single domain antibodies and therapeutic compositions thereof |
AU2019384790A1 (en) | 2018-11-21 | 2021-03-18 | Regeneron Pharmaceuticals, Inc. | Anti-staphylococcus antibodies and uses thereof |
MA56205A (en) | 2019-06-11 | 2022-04-20 | Regeneron Pharma | ANTI-PCRV ANTIBODIES WHICH BIND TO PCRV, COMPOSITIONS COMPRISING ANTI-PCRV ANTIBODIES, AND METHODS OF USE THEREOF |
WO2020252260A1 (en) * | 2019-06-13 | 2020-12-17 | Regeneron Pharmaceuticals, Inc. | Methods for removing undesired components during multistage chromatographic processes |
BR112022014667A2 (en) | 2020-01-29 | 2022-09-20 | Inhibrx Inc | CD28 SINGLE DOMAIN ANTIBODIES AND MULTIVALENT AND MULTISPECIFIC CONSTRUCTS THEREOF |
WO2024102948A1 (en) | 2022-11-11 | 2024-05-16 | Celgene Corporation | Fc receptor-homolog 5 (fcrh5) specific binding molecules and bispecific t-cell engaging antibodies including same and related methods |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010151792A1 (en) * | 2009-06-26 | 2010-12-29 | Regeneron Pharmaceuticals, Inc. | Readily isolated bispecific antibodies with native immunoglobulin format |
WO2011078332A1 (en) * | 2009-12-25 | 2011-06-30 | 中外製薬株式会社 | Polypeptide modification method for purifying polypeptide multimers |
WO2014049003A1 (en) * | 2012-09-25 | 2014-04-03 | Glenmark Pharmaceuticals S.A. | Purification of hetero-dimeric immunoglobulins |
-
2016
- 2016-02-05 GB GBGB1602156.0A patent/GB201602156D0/en not_active Ceased
-
2017
- 2017-02-02 GB GB1814284.4A patent/GB2563531B/en active Active
- 2017-02-02 WO PCT/GB2017/050257 patent/WO2017134440A2/en active Application Filing
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010151792A1 (en) * | 2009-06-26 | 2010-12-29 | Regeneron Pharmaceuticals, Inc. | Readily isolated bispecific antibodies with native immunoglobulin format |
WO2011078332A1 (en) * | 2009-12-25 | 2011-06-30 | 中外製薬株式会社 | Polypeptide modification method for purifying polypeptide multimers |
WO2014049003A1 (en) * | 2012-09-25 | 2014-04-03 | Glenmark Pharmaceuticals S.A. | Purification of hetero-dimeric immunoglobulins |
Non-Patent Citations (4)
Title |
---|
IRINA S. MOREIRA ET AL: 'Unraveling the Importance of Protein-Protein Interaction: Application of a Computational Alanine-Scanning Mutagenesis to the Study of the IgGl Streptococcal Protein G (C2 Fragment) Complex',THE JOURNAL OF PHYSICAL CHEMISTRY B, vol. 110, no. 22, 1 June 2006 * |
JENDEBERG L ET AL: "Engineering of Fcl and Fc3 from human immunoglobulin G toanalyse subclass specificity for staphylococcal protein A", JOURNAL OF IMMUNOLOGICAL METHODS, ELSEVIER SCIENCE PUBLISHERS B.V.,AMSTERDAM, NL,vol. 201, no. l,14 February 1997 (1997-02-14), pages25-34, XP * |
K N POTTER, YUCHENG LI, J DONALD CAPRA2F3, E, C DOMAINS, E: "Staphylococcal protein A simultaneously interacts with framework region 1, complementarity-determining region 2, and framework region 3 on human VH3-encoded Igs", JOURNAL OF IMMUNOLOGY (BALTIMORE, MD. : 1950), AM ASSOC IMMNOL, UNITED STATES, 1 October 1996 (1996-10-01), UNITED STATES, pages 2982, XP055098543, Retrieved from the Internet <URL:http://www.ncbi.nlm.nih.gov/pubmed/8816406> * |
SAUER-ERIKSSON, A.E. KLEYWEGT, G.J. UHLEN, M. JONES, T.A.: "Crystal structure of the C2 fragment of streptococcal protein G in complex with the Fc domain of human IgG", STRUCTURE, ELSEVIER, AMSTERDAM, NL, vol. 3, no. 3, 1 March 1995 (1995-03-01), AMSTERDAM, NL, pages 265 - 278, XP004587842, ISSN: 0969-2126, DOI: 10.1016/S0969-2126(01)00157-5 * |
Also Published As
Publication number | Publication date |
---|---|
WO2017134440A2 (en) | 2017-08-10 |
WO2017134440A3 (en) | 2017-10-19 |
GB201602156D0 (en) | 2016-03-23 |
GB201814284D0 (en) | 2018-10-17 |
GB2563531A (en) | 2018-12-19 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
GB2563531B (en) | Heterodimers and purification thereof | |
IL261442A (en) | Tgfb1-binding immunoglobulins and use thereof | |
HK1243741A1 (en) | Tnfrsf-binding agents and uses thereof | |
IL255577B (en) | Tigit-binding agents and uses thereof | |
HK1256419A1 (en) | Acetamide thienotriazolodiazepines and uses thereof | |
IL262926A (en) | Mic-1 compounds and use thereof | |
HK1252227A1 (en) | Fastening system and use thereof | |
SG11201706029VA (en) | Anti-senescence compounds and uses thereof | |
HK1246780A1 (en) | Aza-pyridone compounds and uses thereof | |
ZA201705456B (en) | Benzoxaborole compounds and uses thereof | |
IL254241A0 (en) | Etv2 and uses thereof | |
IL264473A (en) | Gpr156 variants and uses thereof | |
IL253800B (en) | Trans-2-octenal ans use thereof | |
IL253459A0 (en) | Isoergoline compounds and uses thereof | |
GB201718875D0 (en) | Autophagy-inhibiting compounds and uses thereof | |
IL264751A (en) | Purification systems and methods | |
GB201614224D0 (en) | Compounds and uses thereof | |
IL265617B (en) | 1-phenylpropanone compounds and use thereof | |
GB2545167B (en) | Cloches and use thereof | |
GB201613134D0 (en) | Novel compounds and their use | |
GB201514770D0 (en) | Compounds and their use | |
GB201513318D0 (en) | Novel compounds and their use | |
GB201500278D0 (en) | Novel combination and use | |
GB201503258D0 (en) | Rehydration and purification device |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
732E | Amendments to the register in respect of changes of name or changes affecting rights (sect. 32/1977) |
Free format text: REGISTERED BETWEEN 20190103 AND 20190109 |