GB2550750A - Anthelmintic compounds - Google Patents

Anthelmintic compounds

Info

Publication number
GB2550750A
GB2550750A GB1712632.7A GB201712632A GB2550750A GB 2550750 A GB2550750 A GB 2550750A GB 201712632 A GB201712632 A GB 201712632A GB 2550750 A GB2550750 A GB 2550750A
Authority
GB
United Kingdom
Prior art keywords
sempervirol
anthelmintic compounds
compounds
fascioliasis
diterpenoids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB1712632.7A
Other versions
GB201712632D0 (en
Inventor
Francis Hoffmann Karl
James Nash Robert
Peak Emily
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aberystwyth University
Original Assignee
Aberystwyth University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aberystwyth University filed Critical Aberystwyth University
Publication of GB201712632D0 publication Critical patent/GB201712632D0/en
Publication of GB2550750A publication Critical patent/GB2550750A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics

Abstract

The present invention relates to compounds, in particular derivatives of the diterpenoids sempervirol and 7‐keto‐sempervirol, and their use in therapy, including in pharmaceutical compositions and combinations, especially in the treatment and/or prophylaxis of the tropical diseases schistosomiasis and/or fascioliasis, for example in humans or in non‐human land mammals such as sheep, cattle, other ruminants, or goats.
GB1712632.7A 2014-12-19 2015-12-18 Anthelmintic compounds Withdrawn GB2550750A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB201422846 2014-12-19
PCT/GB2015/054078 WO2016097759A1 (en) 2014-12-19 2015-12-18 Anthelmintic compounds

Publications (2)

Publication Number Publication Date
GB201712632D0 GB201712632D0 (en) 2017-09-20
GB2550750A true GB2550750A (en) 2017-11-29

Family

ID=55025253

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1712632.7A Withdrawn GB2550750A (en) 2014-12-19 2015-12-18 Anthelmintic compounds

Country Status (2)

Country Link
GB (1) GB2550750A (en)
WO (1) WO2016097759A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201700692D0 (en) * 2017-01-16 2017-03-01 Salvensis Novel compounds and their use in the treatment of schistosomiasis
GB201811695D0 (en) * 2018-07-17 2018-08-29 Salvensis Compounds for use in the treatment of fascioliasis

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0806203A2 (en) * 1996-05-06 1997-11-12 Eli Lilly And Company Anti-viral compositions
CN1727319A (en) * 2005-07-28 2006-02-01 浙江大学 Device in category of substitution tricyclo-diterpene-orthodiphenol, preparation method and application
US20080125491A1 (en) * 2003-03-17 2008-05-29 Arena Pharmaceuticals, Inc. Human G Protein-Coupled Receptor and Modulators Thereof for the Treatment of Cell Death-Related Disorders
US20100009927A1 (en) * 2008-07-14 2010-01-14 Herbalscience Group Llc Anti-Inflammatory and Anti-Allergy Extracts from Nettle

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4282253A (en) 1979-11-14 1981-08-04 The United States Of America As Represented By The Secretary Of The Army Topical prophylaxis against schistosomiasis

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0806203A2 (en) * 1996-05-06 1997-11-12 Eli Lilly And Company Anti-viral compositions
US20080125491A1 (en) * 2003-03-17 2008-05-29 Arena Pharmaceuticals, Inc. Human G Protein-Coupled Receptor and Modulators Thereof for the Treatment of Cell Death-Related Disorders
CN1727319A (en) * 2005-07-28 2006-02-01 浙江大学 Device in category of substitution tricyclo-diterpene-orthodiphenol, preparation method and application
US20100009927A1 (en) * 2008-07-14 2010-01-14 Herbalscience Group Llc Anti-Inflammatory and Anti-Allergy Extracts from Nettle

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
J Edwards et al, "The Diterpenoid 7-Keto-Sempervirol, Derived from Lycium chinense, Displays Anthelmintic Activity against both Schistosoma mansoni and Fasciola hepatica(pdf) | Paperity", PLOS Neglected Tropical Diseases, (20150301), URL: http://paperity.org/p/60966523/the-diterpenoid-7-keto *
KAI WANG; XIANXIAN LIU; XIANGHUI YI; HENGSHAN WANG; YE ZHANG; YINGMING PAN: "Synthesis and metal ion binding activity of methyl 12-amino-13-nitro-7-oxo dehydrodeisopropylabietate derivatives", MEDICINAL CHEMISTRY RESEARCH, BIRKHÄUSER-VERLAG, BOSTON, vol. 21, no. 9, 18 August 2011 (2011-08-18), Boston, pages 2494 - 2500, XP035092226, ISSN: 1554-8120, DOI: 10.1007/s00044-011-9766-2 *
SHIGEO MURAKOSHI ET AL, "Appearance of Three-moulters from Larvae of the Silkworm, Bombyx mori L., by Oral Administration of Abietic Acid Derivatives", NIHON-ÃYÃ-DÃBUTSÃ-KONCHÃ-GAKKAI-SHI = JAPANESE JOURNAL OF APPLIED ENTOMOLOGY AND ZOOLOGY, JP, (19750101), vol. 19, no. 4, doi:10.1303/jjaez.19.267 *
Wei He ET AL, "BI OORGANI C & MEDI CI NAL CHEMI STRY LETTERS NOVEL CYTOKINE RELEASE INHIBITORS. PART IV: ANALOGS OF PODOCARPIC ACID", Pergamon Bioorganic & Medicinal Chemistry Letters, (19990101), pages 469 - 474, URL: http://www.sciencedirect.com/science/article/pii/S0960894X99000232/pdf?md5=7ba8 *

Also Published As

Publication number Publication date
GB201712632D0 (en) 2017-09-20
WO2016097759A1 (en) 2016-06-23

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Legal Events

Date Code Title Description
WAP Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1)