GB2528526B - Method of generating ions of high mass to charge ratio by charge reduction - Google Patents

Method of generating ions of high mass to charge ratio by charge reduction

Info

Publication number
GB2528526B
GB2528526B GB1504933.1A GB201504933A GB2528526B GB 2528526 B GB2528526 B GB 2528526B GB 201504933 A GB201504933 A GB 201504933A GB 2528526 B GB2528526 B GB 2528526B
Authority
GB
United Kingdom
Prior art keywords
charge
high mass
generating ions
reduction
charge ratio
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
GB1504933.1A
Other versions
GB2528526A (en
GB201504933D0 (en
Inventor
Mark Brown Jeffery
Paul Williams Jonathan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Micromass UK Ltd
Original Assignee
Micromass UK Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB201405216A external-priority patent/GB201405216D0/en
Priority claimed from GB201405661A external-priority patent/GB201405661D0/en
Application filed by Micromass UK Ltd filed Critical Micromass UK Ltd
Publication of GB201504933D0 publication Critical patent/GB201504933D0/en
Publication of GB2528526A publication Critical patent/GB2528526A/en
Application granted granted Critical
Publication of GB2528526B publication Critical patent/GB2528526B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • H01J49/0045—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction
    • H01J49/0077—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction specific reactions other than fragmentation
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/0027—Methods for using particle spectrometers
    • H01J49/0031—Step by step routines describing the use of the apparatus
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • H01J49/0045—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • H01J49/0045—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction
    • H01J49/0072—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction by ion/ion reaction, e.g. electron transfer dissociation, proton transfer dissociation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
GB1504933.1A 2014-03-24 2015-03-24 Method of generating ions of high mass to charge ratio by charge reduction Active GB2528526B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB201405216A GB201405216D0 (en) 2014-03-24 2014-03-24 Method of generating ions of high M/Z by charge reduction
GB201405661A GB201405661D0 (en) 2014-03-28 2014-03-28 Method of generating ions of highm/z by charge reduction

Publications (3)

Publication Number Publication Date
GB201504933D0 GB201504933D0 (en) 2015-05-06
GB2528526A GB2528526A (en) 2016-01-27
GB2528526B true GB2528526B (en) 2018-10-03

Family

ID=53052291

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1504933.1A Active GB2528526B (en) 2014-03-24 2015-03-24 Method of generating ions of high mass to charge ratio by charge reduction

Country Status (1)

Country Link
GB (1) GB2528526B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020044160A1 (en) * 2018-08-29 2020-03-05 Dh Technologies Development Pte. Ltd. Method for top down proteomics using exd and ptr

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006107831A2 (en) * 2005-04-04 2006-10-12 Craig Whitehouse Atmospheric pressure ion source for mass spectrometry
US20070102634A1 (en) * 2005-11-10 2007-05-10 Frey Brian L Electrospray ionization ion source with tunable charge reduction
GB2443066A (en) * 2006-10-18 2008-04-23 Bruker Daltonik Gmbh An anion source for electron transfer dissociation and deprotonation
WO2009147411A2 (en) * 2008-06-05 2009-12-10 Micromass Uk Limited Method of charge reduction of electron transfer dissociation product ions
US20100252731A1 (en) * 2009-04-06 2010-10-07 Ut-Battelle, Llc Real-time airborne particle analyzer
US20110057098A1 (en) * 2009-09-08 2011-03-10 Life Technologies Corporation And Mds Analytical Technologies Targeted ion parking for quantitation

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006107831A2 (en) * 2005-04-04 2006-10-12 Craig Whitehouse Atmospheric pressure ion source for mass spectrometry
US20070102634A1 (en) * 2005-11-10 2007-05-10 Frey Brian L Electrospray ionization ion source with tunable charge reduction
GB2443066A (en) * 2006-10-18 2008-04-23 Bruker Daltonik Gmbh An anion source for electron transfer dissociation and deprotonation
WO2009147411A2 (en) * 2008-06-05 2009-12-10 Micromass Uk Limited Method of charge reduction of electron transfer dissociation product ions
US20100252731A1 (en) * 2009-04-06 2010-10-07 Ut-Battelle, Llc Real-time airborne particle analyzer
US20110057098A1 (en) * 2009-09-08 2011-03-10 Life Technologies Corporation And Mds Analytical Technologies Targeted ion parking for quantitation

Also Published As

Publication number Publication date
GB2528526A (en) 2016-01-27
GB201504933D0 (en) 2015-05-06

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