GB2522283A - Traditional chinese medicine composition for the treatment of diabetes - Google Patents

Traditional chinese medicine composition for the treatment of diabetes Download PDF

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Publication number
GB2522283A
GB2522283A GB1403996.0A GB201403996A GB2522283A GB 2522283 A GB2522283 A GB 2522283A GB 201403996 A GB201403996 A GB 201403996A GB 2522283 A GB2522283 A GB 2522283A
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GB
United Kingdom
Prior art keywords
chinese medicine
traditional chinese
medicine composition
motherwort
musk
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Application number
GB1403996.0A
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GB201403996D0 (en
Inventor
Xiangsheng Kong
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ZHUHAI HAI BIN PHARMACEUTICAL BIOTECHNOLOGY CO Ltd
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ZHUHAI HAI BIN PHARMACEUTICAL BIOTECHNOLOGY CO Ltd
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Publication of GB201403996D0 publication Critical patent/GB201403996D0/en
Publication of GB2522283A publication Critical patent/GB2522283A/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/533—Leonurus (motherwort)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236—Ligusticum (licorice-root)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/148—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with compounds of unknown constitution, e.g. material from plants or animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Abstract

A traditional Chinese medicine composition for treating diabetes comprises extracts from: musk; motherwort, clove and xanthium (cocklebur). Preferably the composition comprises musk 50-500g; chuanxiong 50-500g, motherwort 50-500g, clove 10-80g and cocklebur (xanthium) 10-80g. A process for making the traditional Chinese medicine comprising using supercritical carbon dioxide extraction of essential oil extracts from: musk, motherwort, cloves and xanthium, followed by steam distillation thereof, adding borneol and a suitable matrix substance, is also provided.

Description

Traditional Chinese medicine composition for the treatment of diabetes.
Field
This invention relates to the field of medicine. In particular the invention relates to a pharmaceutical composition for the treatment of diabetes and to a method for the preparation thereof.
Background of the Invention
Traditional Chinese medicine may be used to treat diabetes and its secondary effects. According to modern medical research, diabetes often results in islet capillary fibrosis, increased blood viscosity, erythrocyte aggregation, enhanced platelet adhesion and aggregation of the vessel wall enhancement, coagulation factors, fibrinogen and other blood stasis increased pathological changes. Clinical symptoms include numbness, dark purple tongue lips, tongue side petechiae or ecchymosis, sublingual vein stasis slow pulse, astringent characteristics, such as blood stasis syndrome. Therefore, the incidence of bleeding is important in this disease pathogenesis, but also where the key lies to obtain long-term efficacy of a treatment. Especially in secondary effects of diabetes, mostly lower extremity vascular disease, blood blockage, and peripheral dystrophy.
Summary
The technical problem to be solved by the present invention is to provide a treatment of diabetes which has a significant effect and provides a treatment process which is short and has a high cure rate.
The object of the present invention is achieved by the following technical solution. The invention provides a traditional Chinese medicine (TCM) composition for treating diabetes, characterized in that it comprises extracts from the following active ingredients: musk ( Latin name: Moschus), Chuan Xiong ( Latin name: Rhizorna Chuanxiong), motherwort ( Latin name Leonurus japonicus Houtt), cloves ( Latin name: Syringa ob/ata) and cocklebur ( Latin name anthium sibiricum).
The composition may comprise the following weight ratio of active ingredients: musk SOg-500g, SOg-500g Chuanxiong motherwort SOg-SOOg, 1 Og-80g cloves, cocklebur 1 Og-80g.
Preferably the composition comprises the active ingredients in the following amounts: Musk 200g, Chuanxiong 200g, motherwort 1 SOg, 60g cloves and cocklebur 60g.
Another object of the present invention to provide a method for preparing a composition comprising said traditional Chinese medicine composition.
The active ingredients of the composition according to the invention may be added to a pharmaceutically acceptable carrier. Suitable carriers include diluents, excipients, fillers, binders, wetting agents, disintegrating agents, absorption accelerators, surfactants, adsorption carriers and lubricants, for example. The skilled person will appreciate that the carrier can be selected depending on the desired preparation form or end use.
The composition according to the invention can be prepared in any suitable dosage form. For example, the composition can be further processed into dosage forms including oral tablets, capsules, granules and a variety of formulations and injections. Such dosage forms can be prepared according to conventional methods in the art of pharmacy.
Detailed Description
The present invention provides a composition for the treatment of diabetes and describes the effect of the treatment of diabetes. The following experiments demonstrate pharmacodynamics and toxicology of the composition according to the invention.
The invention is described in more detail below by way of example. The examples are illustrative of embodiments of the invention and are not to be considered to limit the scope of the invention.
Example I
Musk (accurately weighed) 200g, Chuanxiong 200g, motherwort 150g, cloves 60g, and 60g cocklebur were rinsed with deionized water 3200m1 deionized water was added. The mixture was heated to extract one hour after the release of the extract; then add 2400m1 of deionized water, heated after one hour extraction, the extract discharged 2400m1 of deionized water was further added, heated 0.5 hours after the extraction, the extract discharged. After three combined extracts were filtered, concentrated to 600 ml, and then added at a concentration of 95 % by volume of ethanol containing 60% alcohol, 24 hours the precipitate was filtered; the filtrate was recovered to 400 ml, was added at a concentration of 95% ethanol containing alcohol an amount of 80% precipitation, filtration, recovery of ethanol and concentrated to 400g, to provide a herbal extract composition.
Example 2
Take 250m1 injection preparation of Example 1 extract composition lOg, plus the amount of water for injection to dissolve sodium chloride 2.25g, adjust the volume with water for injection to 1 25m1, adding the right amount of carbon injection, boil for 15 minutes, let cool, filter. However, the filtrate was added to adjust the amount of water for injection to 250 ml of pH adjustment, followed by filtration, filling, sterilization, packaging.
Example 3
According to 1985 World Health Organization (WHO) diagnostic criteria for diabetes type 1 or 2 diabetes may be diagnosed by outpatient observation. A total of 177 cases, according to sex, age and duration divided into two groups cases, 52 cases in the control group. Observed 125 cases, male 89 cases, female 36 cases; the oldest 75 and the youngest 29 years old, average 51 years; longest duration of 19 years, the shortest one month, an average of 3.5 years. Of which 68 cases with hyperlipidemia, coronary heart disease in 19 cases, 18 cases of hypertension, gout, three cases; five cases of cerebrovascular disease complicated by diabetes, diabetic foot two cases; TCM is 78 cases of deficiency and blood stasis, qi stasis cloud 33 cases, 14 cases of kidney blood stasis. The control group 52 cases, 36 males and 16 females;, the oldest 74 and the youngest 30 years old, average 53 years; duration of up to 18 years and the shortest 1.5 months, an average of three years. 20 patients with hyperlipidemia, coronary heart disease in 5 cases, 8 cases of hypertension, gout, one case complicated by diabetes and cerebrovascular disease in 2 cases, 2 cases of diabetic peripheral neuropathy, diabetic foot one case. Two groups of gender, age, duration of comparison there was no significant statistical difference (P> 0.05).
Strict control of blood glucose control, blood sugar is maintained at or close to normal levels, vitamin 312500Lg intramuscular injection, oral nutritional vitamins BllOmg nerve, 65422 Injection 20mg in 0.9% sodium chloride injection in 250m1, 1 day, intravenous drip.
Treatment group received two injections 250m1 cases daily, intravenous drip 1.2.3 2 treatment groups were two weeks as a course of treatment after a statistical effect.
Determination of the efficacy According to Chinese medicine efficacy standards Society of Diabetes diabetes mellitus) Third Conference Professional Committee ( May 1992 Shandong) efficacy standards, combined with the TCM Syndrome Diagnostic efficacy of the standard developed [1]: marked symptoms should disappear; fasting blood glucose c6.lmmol/ L, 2h postprandial blood glucose <8.3mmol/ L. should be effective for the disappearance of symptoms; fasting blood glucose <8.3mmol I L, 2h postprandial blood glucose <11.1 mmol I L. Invalid symptoms and laboratory tests for the change, or exacerbations. 3.2 The outcome of the observation group 125 cases, 92 cases markedly effective in 25 cases, 8 cases, markedly effective rate 73.6%, the total efficiency of 93.6%. The control group was 52 cases; 15 cases markedly effective, 20 cases significant efficiency 28.9%, the total efficiency of 61.6%. Observed compared with the control group, the statistical treatment, significant efficiency and total efficiency were significant differences (P <0.01). The observation group 65 cases were followed up markedly, including five cases in five years, 15 cases of 3 years, 45 cases a year without recurrence.
From the above experimental results, the pharmaceutical composition prepared by a medicine for diabetes, the present invention has a significant therapeutic effect.
Example 4
Taken in accordance with the weight ratio of musk 500g, Chuanxiong 500g, Motheiwort 50g, cloves lOg, cocklebur lOg, polyethylene glycol -4000 5g, Polysorbate -80 0.5g. After preparing raw materials, prescription drugs or using supercritical carbon dioxide extraction of essential oil was extracted by steam distillation, adding borneol, accessories matrix, to make drops or pills
Example 5
Taken in accordance with the weight ratio of musk 50g, ChuanXiong 50g, motherwort SOOg, cloves Sag, cocklebur 80g, polysorbate -80 3.5 g. After preparing raw materials, taking prescription drugs or using supercritical carbon dioxide extraction of essential oil was extracted by steam distillation, adding borneol, accessories matrix, to make a gel.
Example 6
Taken in accordance with the weight ratio Shichangpu musk 300g, Ghuanxiong 300g, motherwort 150g, cloves 50g, cocklebur 50g, polysorbate - 1.74g. After preparing raw materials, prescription medicine with supercritical carbon dioxide extraction or steam distillation extraction of volatile oil, add borneol, accessories matrix, to make a particulate.
The words comprises/comprising when used in this specification are to specify the presence of stated features, integers, steps or components but does not preclude the presence or addition of one or more other features, integers, steps, components or groups thereof.

Claims (7)

  1. Claims 1. A traditional Chinese medicine composition for treating diabetes, characterized in that it comprises extracts from the following active ingredients: musk root, motherwort, cloves and Xanthium.
  2. 2. A traditional Chinese medicine composition according to claim 1, wherein the weight ratio of active ingredients is: musk 50g-500g, chuanxiong 50g-500g, motherwort 50g-500g, clove 10g-80g, and cocklebur lOg-BOg.
  3. 3. A traditional Chinese medicine composition according to claim 2, wherein the weight ratio of the active ingredients is: musk 200g, chuanxiong 200g, motherwort 1 50g, 60g cloves, and cocklebur 60g.
  4. 4. A traditional Chinese medicine composition according to any one of claims 1-3, characterized in that it can be combined with one or more pharmaceutically acceptable carriers to prepare a desired dosage form.
  5. 5. A traditional Chinese medicine composition according to claim 4, wherein the pharmaceutically acceptable carrier comprises diluent, excipient, fillers, binders, wetting agents, disintegrating agents, absorption accelerators, surfactants, lubricants or adsorption carrier.
  6. 6. A process for making a traditional Chinese medicine composition according to any of claims 1 to 5, comprising using supercritical carbon dioxide extraction of essential oil extracts from the following active ingredients: musk root, motherwort, cloves and Xanthium, followed by steam distillation thereof, adding borneol and a suitable matrix substance.
  7. 7. Use of a traditional Chinese medicine composition according to any one of claims 1 to 5 for the treatment of diabetes or diabetes symptoms.
GB1403996.0A 2014-01-16 2014-03-06 Traditional chinese medicine composition for the treatment of diabetes Withdrawn GB2522283A (en)

Applications Claiming Priority (1)

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GB (1) GB2522283A (en)
IE (1) IE20140059A1 (en)
NL (1) NL2012393C2 (en)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104784237A (en) * 2015-04-08 2015-07-22 吉林农业大学 Application of Italian cocklebur in preparation of alpha-glucosidase inhibitor
CN106075209A (en) * 2016-07-12 2016-11-09 佛山杰致信息科技有限公司 A kind of compositions treating diabetes
KR102220820B1 (en) * 2018-10-22 2021-02-26 주식회사 한웅 mixture containing musk rat musk having anti-diabetic activity and preparation thereof
CN111454774A (en) * 2020-04-26 2020-07-28 五邑大学 Method for extracting plant essential oil with hypoglycemic activity

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3922263A (en) * 1974-12-16 1975-11-25 Univ Mississippi Hypoglycemic compound and method of preparing
CN101766705A (en) * 2006-03-27 2010-07-07 深圳市生物谷科技有限公司 Medicinal combination containing borneol and musk
CN102948892A (en) * 2011-08-30 2013-03-06 王新建 Leonurus heterophyllus sweet blood glucose reducing beverage and preparing method thereof

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JP3471076B2 (en) * 1994-05-21 2003-11-25 株式会社資生堂 Hypnotic perfume composition
JPH0923849A (en) * 1995-07-14 1997-01-28 Moritani Kenko Shokuhin Kk Health food for quiet sleep
CN1278737C (en) * 2003-12-17 2006-10-11 昆明紫健生物技术有限公司 Compound medicinal formulation with bioactivity
CN101766699B (en) * 2006-03-27 2011-08-03 深圳市金沙江投资有限公司 Medicinal combination containing musk
CN101549096A (en) * 2009-04-19 2009-10-07 丁家轩 Chinese medicine particles for treating diabetes

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3922263A (en) * 1974-12-16 1975-11-25 Univ Mississippi Hypoglycemic compound and method of preparing
CN101766705A (en) * 2006-03-27 2010-07-07 深圳市生物谷科技有限公司 Medicinal combination containing borneol and musk
CN102948892A (en) * 2011-08-30 2013-03-06 王新建 Leonurus heterophyllus sweet blood glucose reducing beverage and preparing method thereof

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Food Chemistry, vol. 122, No. 4, 2010, pages 1116-1121 *
Journal of Natural Medicines, vol. 66, No. 2, 2012, pages 394-399 *
Journal of Zhejiang University. Medical Sciences, vol. 42, No. 6, 2013, pages 632-637 *

Also Published As

Publication number Publication date
CN103720765B (en) 2017-01-11
IE20140059A1 (en) 2014-07-16
CN103720765A (en) 2014-04-16
GB201403996D0 (en) 2014-04-23
NL2012393C2 (en) 2015-07-20

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