GB2505352A - Anti-nerve growth factor antibodies and methods of preparing and using the same - Google Patents

Anti-nerve growth factor antibodies and methods of preparing and using the same Download PDF

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Publication number
GB2505352A
GB2505352A GB1320045.6A GB201320045A GB2505352A GB 2505352 A GB2505352 A GB 2505352A GB 201320045 A GB201320045 A GB 201320045A GB 2505352 A GB2505352 A GB 2505352A
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United Kingdom
Prior art keywords
canine
preparing
methods
growth factor
same
Prior art date
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Application number
GB1320045.6A
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GB201320045D0 (en
GB2505352B (en
Inventor
David Gearing
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NVIP Pty Ltd
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NVIP Pty Ltd
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Publication date
Priority claimed from GBGB1114858.2A external-priority patent/GB201114858D0/en
Application filed by NVIP Pty Ltd filed Critical NVIP Pty Ltd
Priority to GB1517547.4A priority Critical patent/GB2528401A/en
Publication of GB201320045D0 publication Critical patent/GB201320045D0/en
Publication of GB2505352A publication Critical patent/GB2505352A/en
Application granted granted Critical
Publication of GB2505352B publication Critical patent/GB2505352B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • C07K16/467—Igs with modifications in the FR-residues only
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered

Abstract

A method of preparing an antibody suitable for use in a canine is provided. Also provided are caninised antibodies which specifically bind to canine neuronal growth factor (NGF) and neutralise the ability of canine NGF to bind to the p75 or TrkA canine NGF receptor. The invention extends to nucleic acids encoding same and to methods of treating pain and arthritis in a canine using said antibodies and/or nucleic acids.
GB1320045.6A 2011-05-06 2012-05-08 Anti-nerve growth factor antibodies and methods of preparing and using the same Active GB2505352B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB1517547.4A GB2528401A (en) 2011-05-06 2012-05-08 Anti-nerve growth factor antibodies and methods of preparing and using the same

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161483481P 2011-05-06 2011-05-06
GBGB1114858.2A GB201114858D0 (en) 2011-08-29 2011-08-29 Anti-nerve growth factor antibodies and methods of using the same
US201161531439P 2011-09-06 2011-09-06
PCT/GB2012/051002 WO2012153121A1 (en) 2011-05-06 2012-05-08 Anti-nerve growth factor antibodies and methods of preparing and using the same

Publications (3)

Publication Number Publication Date
GB201320045D0 GB201320045D0 (en) 2013-12-25
GB2505352A true GB2505352A (en) 2014-02-26
GB2505352B GB2505352B (en) 2016-01-27

Family

ID=49818570

Family Applications (2)

Application Number Title Priority Date Filing Date
GB1320045.6A Active GB2505352B (en) 2011-05-06 2012-05-08 Anti-nerve growth factor antibodies and methods of preparing and using the same
GB1320053.0A Active GB2504889C (en) 2011-05-06 2012-05-08 Therapeutic canine immunoglobulins and methods of using the same

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB1320053.0A Active GB2504889C (en) 2011-05-06 2012-05-08 Therapeutic canine immunoglobulins and methods of using the same

Country Status (1)

Country Link
GB (2) GB2505352B (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003060080A2 (en) * 2001-12-21 2003-07-24 Idexx Laboratories, Inc. Canine immunoglobulin variable domains, caninized antibodies, and methods for making and using them
WO2005061540A2 (en) * 2003-12-24 2005-07-07 Lay Line Genomics S.P.A. Method for the humanization of antibodies and humanized antibodies thereby obtained
WO2012024650A2 (en) * 2010-08-19 2012-02-23 Abbott Laboratories Anti-ngf antibodies and their use

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001253282A1 (en) * 2000-04-07 2001-10-23 Heska Corporation Compositions and methods related to canine igg and canine il-13 receptors
US8569460B2 (en) * 2009-03-25 2013-10-29 Vet Therapeutics, Inc. Antibody constant domain regions and uses thereof
WO2010117448A2 (en) * 2009-04-05 2010-10-14 Provenance Biopharmaceuticals Corp. Chimeric immunocytokines and methods of use thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003060080A2 (en) * 2001-12-21 2003-07-24 Idexx Laboratories, Inc. Canine immunoglobulin variable domains, caninized antibodies, and methods for making and using them
WO2005061540A2 (en) * 2003-12-24 2005-07-07 Lay Line Genomics S.P.A. Method for the humanization of antibodies and humanized antibodies thereby obtained
WO2012024650A2 (en) * 2010-08-19 2012-02-23 Abbott Laboratories Anti-ngf antibodies and their use

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ABE T ET AL: "Protective role of nerve growth factor against postischemic dysfunction of sympathetic coronary innervation.", CIRCULATION 7 JAN 1997 LNKD-PUBMED: 8994439, vol. 95, no. 1, 7 January 1997 (1997-01-07), pages 213-220, XP002679817, ISSN: 0009-7322 the whole document *
COVACEUSZACH S ET AL: "Dissecting NGF Interactions with TrkA and p75 Receptors by Structural and Functional Studies of an Anti-NGF Neutralizing Antibody", JOURNAL OF MOLECULAR BIOLOGY, ACADEMIC PRESS, UNITED KINGDOM, vol. 381, no. 4,12 September 2008 (2008-09-12), pages 881-896, XP023611489,IS *
DATABASE Geneseq [Online] 8 September 2005 (2005-09-08), "Humanized alpha D11 antibody heavy chain variable region SEQ ID NO 17.", XP002679816, retrieved from EBI accession no. GSP:AEB12537Database accession no. AEB12537 sequence *
PELAT THIBAUT ET AL: "Non-human primate immune libraries combined with germline humanization: an (almost) new,and powerful approach for the isolation of therapeutic antibodies", MABS., vol.1, no.4, 1July 2009 (2009-07-01), pages 377-381, XP009135983, paragraph [0006] *

Also Published As

Publication number Publication date
GB2504889C (en) 2015-08-26
GB201320045D0 (en) 2013-12-25
GB2505352B (en) 2016-01-27
GB2504889A (en) 2014-02-12
GB201320053D0 (en) 2013-12-25
GB2504889B (en) 2015-07-15

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732E Amendments to the register in respect of changes of name or changes affecting rights (sect. 32/1977)

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732E Amendments to the register in respect of changes of name or changes affecting rights (sect. 32/1977)

Free format text: REGISTERED BETWEEN 20220609 AND 20220615