GB2503672A - Apparatus for minimising the effect of joule-thomson cooling - Google Patents

Apparatus for minimising the effect of joule-thomson cooling Download PDF

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Publication number
GB2503672A
GB2503672A GB1211767.7A GB201211767A GB2503672A GB 2503672 A GB2503672 A GB 2503672A GB 201211767 A GB201211767 A GB 201211767A GB 2503672 A GB2503672 A GB 2503672A
Authority
GB
United Kingdom
Prior art keywords
opening
stages
series
joule
pressure drop
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB1211767.7A
Other versions
GB201211767D0 (en
Inventor
Mirza Najam Ali Beg
Mir Mahmood Sarshar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Caltec Ltd
Original Assignee
Caltec Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Caltec Ltd filed Critical Caltec Ltd
Priority to GB1211767.7A priority Critical patent/GB2503672A/en
Publication of GB201211767D0 publication Critical patent/GB201211767D0/en
Priority to US14/412,333 priority patent/US20150184806A1/en
Priority to PCT/GB2013/051689 priority patent/WO2014006370A1/en
Publication of GB2503672A publication Critical patent/GB2503672A/en
Priority to NO20150022A priority patent/NO20150022A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16LPIPES; JOINTS OR FITTINGS FOR PIPES; SUPPORTS FOR PIPES, CABLES OR PROTECTIVE TUBING; MEANS FOR THERMAL INSULATION IN GENERAL
    • F16L9/00Rigid pipes
    • F16L9/22Pipes composed of a plurality of segments
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16LPIPES; JOINTS OR FITTINGS FOR PIPES; SUPPORTS FOR PIPES, CABLES OR PROTECTIVE TUBING; MEANS FOR THERMAL INSULATION IN GENERAL
    • F16L55/00Devices or appurtenances for use in, or in connection with, pipes or pipe systems
    • F16L55/02Energy absorbers; Noise absorbers
    • F16L55/027Throttle passages
    • EFIXED CONSTRUCTIONS
    • E21EARTH DRILLING; MINING
    • E21BEARTH DRILLING, e.g. DEEP DRILLING; OBTAINING OIL, GAS, WATER, SOLUBLE OR MELTABLE MATERIALS OR A SLURRY OF MINERALS FROM WELLS
    • E21B34/00Valve arrangements for boreholes or wells
    • E21B34/02Valve arrangements for boreholes or wells in well heads
    • E21B34/025Chokes or valves in wellheads and sub-sea wellheads for variably regulating fluid flow
    • EFIXED CONSTRUCTIONS
    • E21EARTH DRILLING; MINING
    • E21BEARTH DRILLING, e.g. DEEP DRILLING; OBTAINING OIL, GAS, WATER, SOLUBLE OR MELTABLE MATERIALS OR A SLURRY OF MINERALS FROM WELLS
    • E21B36/00Heating, cooling, insulating arrangements for boreholes or wells, e.g. for use in permafrost zones
    • EFIXED CONSTRUCTIONS
    • E21EARTH DRILLING; MINING
    • E21BEARTH DRILLING, e.g. DEEP DRILLING; OBTAINING OIL, GAS, WATER, SOLUBLE OR MELTABLE MATERIALS OR A SLURRY OF MINERALS FROM WELLS
    • E21B41/00Equipment or details not covered by groups E21B15/00 - E21B40/00
    • E21B41/005Waste disposal systems
    • E21B41/0071Adaptation of flares, e.g. arrangements of flares in offshore installations
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F15FLUID-PRESSURE ACTUATORS; HYDRAULICS OR PNEUMATICS IN GENERAL
    • F15DFLUID DYNAMICS, i.e. METHODS OR MEANS FOR INFLUENCING THE FLOW OF GASES OR LIQUIDS
    • F15D1/00Influencing flow of fluids
    • F15D1/02Influencing flow of fluids in pipes or conduits
    • F15D1/025Influencing flow of fluids in pipes or conduits by means of orifice or throttle elements
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16LPIPES; JOINTS OR FITTINGS FOR PIPES; SUPPORTS FOR PIPES, CABLES OR PROTECTIVE TUBING; MEANS FOR THERMAL INSULATION IN GENERAL
    • F16L55/00Devices or appurtenances for use in, or in connection with, pipes or pipe systems
    • F16L55/02Energy absorbers; Noise absorbers
    • F16L55/027Throttle passages
    • F16L55/02709Throttle passages in the form of perforated plates
    • F16L55/02718Throttle passages in the form of perforated plates placed transversely
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16LPIPES; JOINTS OR FITTINGS FOR PIPES; SUPPORTS FOR PIPES, CABLES OR PROTECTIVE TUBING; MEANS FOR THERMAL INSULATION IN GENERAL
    • F16L9/00Rigid pipes
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17DPIPE-LINE SYSTEMS; PIPE-LINES
    • F17D1/00Pipe-line systems
    • F17D1/02Pipe-line systems for gases or vapours
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17DPIPE-LINE SYSTEMS; PIPE-LINES
    • F17D1/00Pipe-line systems
    • F17D1/02Pipe-line systems for gases or vapours
    • F17D1/04Pipe-line systems for gases or vapours for distribution of gas
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17DPIPE-LINE SYSTEMS; PIPE-LINES
    • F17D1/00Pipe-line systems
    • F17D1/20Arrangements or systems of devices for influencing or altering dynamic characteristics of the systems, e.g. for damping pulsations caused by opening or closing of valves
    • GPHYSICS
    • G05CONTROLLING; REGULATING
    • G05DSYSTEMS FOR CONTROLLING OR REGULATING NON-ELECTRIC VARIABLES
    • G05D16/00Control of fluid pressure
    • G05D16/02Modifications to reduce the effects of instability, e.g. due to vibrations, friction, abnormal temperature, overloading or unbalance
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00Fluid handling
    • Y10T137/0318Processes
    • Y10T137/0324With control of flow by a condition or characteristic of a fluid
    • Y10T137/0379By fluid pressure

Abstract

The apparatus consists of modular stages (A, B, C) arranged in series, each stage including a main chamber 2 and a nozzle opening 5. In practice, a fluid passing through the opening S is 5 subject to a pressure drop as it enters a main chamber of a subsequent stage in the series. This multi-stage pressure drop avoids a sharp drop in temperature, as would occur if the total pressure drop was achieved in one stage, that may cause hydrates to form in an oil/gas pipeline.

Description

APPARATUS FOR MINIMISING THE EFFECT OF JOULE-THOMSON COOLING
The present invention relates to an apparatus for minimising the effect of Joule-Thomson cooling, especially in the oil and gas extraction industry.
The Joule-Thomson effect is a well known thermodynamic phenomenon related to the drop in the temperature of any gas as its pressure drops and its volume expands: the bigger the drop in pressure of the gas, the bigger the drop in temperature of gas. This property has been used successfully in applications such as refrigeration. It is also well known in the oil and gas industry that if water is present with produced gas, a physical bonding takes place between the molecules of water and light hydrocarbon gas molecules, such as ethane, methane and propane at a particular pressure and temperature. This physical bonding forms snow like particles known as hydrates which, when formed, accumulate at various points along their flow path or at points which have a restriction such as valves or flanged connecting points. The accumulation of hydrates can potentially block the passage of fluids completely.
The formation of hydrates is dependent on the combined temperature and pressure of the system. At higher pressures, hydrates form at higher temperatures, compared to low pressure cases when hydrates may form at a much lower temperature. In such cases hydrate inhibitors such as methanol or MEG (Glycol) are injected to change the temperature at which hydrates can form. This is analogous to adding anti-freeze to the cooling water of a vehicle radiator to prevent water turning into ice at sub-zero temperatures during winter.
In the oil and gas industry when a producing well is shut in for some time, the shut-in wellhead pressure increases significantly. At the time the operator re-opens the well, a sudden drop in the pressure of gas across the choke valve or the wing valve of the well may cause a Joule-Thomson cooling effect. The significant drop in the temperature of produced hydrocarbons could lead to formation of hydrates. There are also safety cases where the produced gas is released to atmosphere or a flare system, and in such cases the low temperatures generated could lead to hydrates forming within the blow down system.
Operators are therefore keen to have a system which prevents low temperatures being generated during the blow down or opening of the wells without having to inject vast quantities of hydrate suppressants.
The present invention seeks to provide a system which minimises the Joule-Thomson effect or the level by which the temperature of the mixture may drop as the pressure of gas drops across a valve, and thus prevents formation of hydrates in such cases.
In a broad aspect of the invention there is provided an apparatus for minimising the effect of Joule-Thomson cooling, comprised of a plurality of stages arranged in series, each stage including a main chamber and an opening where, in use, a fluid passing through the main chamber is subject to a pressure drop as it exits the opening into a main chamber of a subsequent stage in the series.
Preferably the pressure drop between stages generates sonic flow through the opening of each stage. Preferably the pressure drops by a factor of approximately 1.5 to 2.5, most preferably 1.8-2.0.
Preferably the opening is incorporated in a nozzle. The diameter of the opening may be varied between stages or be adjustable to match the expected flow rate of gas at the operating pressure and temperature and to create the pressure ratio between each stage Preferably the main chamber is in the form of a cylindrical bore or pipe section. In one form of the invention the opening is provided in a disc section that abuts the pipe section such that, in practice, a plurality of alternating pipe sections and disc sections can be stacked in series to build the apparatus.
The stages may also be modular components, each including a main chamber and opening, that fit together to provide the series of stages communicating there between via the opening(s).
It will be apparent that the apparatus or system for implementation in an oil or gas line to reduce the effect of Joule-Thomson cooling according to the invention consists of a number of similar components which help to drop the pressure of gas at several stages. At each stage, the pressure may drop by a factor close to two in order to maintain a sonic velocity across the nozzle of each stage. The total pressure drop ratio across the total system (multiple stages) can be high and may vary from typically 4 to 1, to as high as 70 to 1 or higher. The number of the stages can therefore vary depending on the ratio of the high pressure gas to that of the downstream gas pressure. So, if the high pressure to downstream pressure ratio is 16, the system staged pressure drop will be from 16 to 8, 8 to 4,4 to 2 and finally 2 to 1.
An approximate 2 to 1 pressure ratio between each stage does not need to be exactly 2 and in some cases it could be higher depending on the composition of gas, the original temperature and high pressure to discharge pressure ratio. A pressure drop ratio of 1.8 to 1 has proven to generate sonic flow through the nozzle of each stage.
The present invention will be hereinafter described with reference to the accompanying drawings, wherein:-Figure 1 illustrates a side section view according to a first embodiment of the invention; Figure 2 illustrates a side section view according to a second embodiment of the invention; Figure 3 illustrates a side section view according to a third embodiment of the invention; Figure 4 illustrates an end and side section view according to a fourth embodiment of the invention; and Figure 5 illustrates a schematic view of an oil production line incorporating an apparatus of the invention.
As previously mentioned, the present invention involves the provision of a series of pressure reducing stages 3 in a production line. In order to simplify and standardise the system each component of the system would preferably have similar general configurations which can be pushed inside a pipe section S in tandem/series as shown in Figure 1.
At each stage 3, the pressure drop across the nozzle S of the section can allow the pressure to drop by, say, a factor of two, to generate sonic flow. The flow after passing through a nozzle opening 5 of the first unit A then passes through a short chamber (the length of the opening 5) within which a shock wave may be generated. The flow then enters a main chamber 2 of second unit B and within the length of the second unit/chamber; it expands, reducing its velocity.
This process is repeated as the flow passes through each unit A to D (and further units if necessary). It is believed that by dropping the pressure of gas in several stages in the manner described according to the invention, the final and total temperature drop across the system would be much less than that predicted if the pressure of gas dropped through a single stage, which would occur in cases where there is a pressure drops across a choke valve or a control valve.
The proposed multi-stage system does not prevent a drop in the temperature of gas but will reduce the J-T effect and will limit the temperature drop to a value which is outside the hydrate formation band at the given pressure.
Key features of the apparatus with reference to the Figures are as follows: -A cylindrical body 3 which has a known diameter and a length preferably equal to at least twice the internal diameter.
-A nozzles at the downstream end of the first unit A to cause the first pressure drop stage. This nozzle may be part of a disc shaped section 4 as shown in Figure 1.
Alternatively, it may be part of the body of a section 3 tapered to form the end nozzle, as shown in Figure 2.
-Each unit is preferably isolated by seal ring 6 so that there is no escape of gas or pressure from one unit to the next unit by routes other than the nozzle of each unit.
-Figure 2 shows a variation in the configuration of each single unit section 3 by having a receiving end 7 to allow the seal between two consecutive units to be effective.
-The number of units within each system is dependent on the ratio of the pressure at the inlet and the outlet of the system as desired or dictated by the operating conditions of the downstream pipeline or process system.
-A control valve or an adjustable choke valve may be included downstream of the system to provide added flexibility for the last stage of system and final pressure drop, orfor tuning the system.
-The nozzle or orifice 5 for each unit may have a different dimension so that it allows the same mass of gas to pass through at the prevailing pressure and temperature. In order to make each unit as similar as possible for ease of fabrication the section carrying the nozzle may be a separate disc as in Figure 1, or the nozzle end can be a separate machined part screwed to the end of the unit through threaded joint 18, as shown in Figure 2.
-As a variation to the system and to achieve a better performance, meaning less temperature drop across the system for the same level of pressure drop, each or selected unit stages can be fed gas from a previous stage via pipe work 9 and inlet and outlet P1 and P2 as shown in Figure 3. A valve 10 allows the pressure from a previous stage to drop to that of the next stage and also to regulate the flow through parallel line 9. Valves 11 and 12 enable individual control of inlets to respective stages C and B. -Alternatively, or in addition, gas or liquids from a separate source can be introduced into each unit via line 17 and valve 14 as shown in Figure 3. As also shown in Figure 3, seals 16 enable the isolation of each section and flow of gas through port holes 15.
The impact of introducing gas or liquids from a source to each stage is to help with further recovery of temperature orto minimise temperature loss through each unit.
-The end result when such a system is used is that the pressure Pt from the inlet point can drop significantly to its outlet point P2, but the temperature loss across the system will be significantly less than that achieved by dropping the pressure across a valve or a choke valve. By doing so, as the temperature of the gas will not drop significantly, the outlet temperature will be above the hydrate formation range and thus there will be no need to introduce hydrate inhibitors such as methanol.
-As a further extension of the illustrated systems shown in Figures ito 3, according to Figure 4 the disc 4 which carries the nozzle 5 may contain more than one nozzle. The multi-nozzle assembly shown in figure 4 helps to split the flow into a number of smaller nozzles which also has the benefit of modifying the design for different applications where the flow rate of gas will be different. In such cases some of the nozzles can be blocked off to match the relevant flow rate of gas.
Figure 5 shows the general arrangement of the system at a wellhead which allows the J-T cooling control spool piece of the invention to be brought into the stream during start up of the well or to bypass it during the normal mode of production.

Claims (22)

  1. CLAIMS: 1. An apparatus for installation in a pipeline to minimise the effect of Joule-Thomson cooling, comprising a plurality of stages arranged in series, each stage including a main chamber and an opening wherein, in use, a fluid passing through the opening is subject to a pressure drop as it enters a main chamber of a subsequent stage in the series.
  2. 2. The apparatus of claim 1 wherein the pressure drop between stages generates sonic flow through the opening.
  3. 3. The apparatus of claim 1 or 2 wherein the length of a main chamber is at least twice its internal diameter.
  4. 4. The apparatus of any preceding claim wherein the cross sectional area of subsequent openings varies across the plurality of stages or is adjustable.
  5. 5. The apparatus of any preceding claim wherein the opening is a nozzle.
  6. 6. The apparatus of any preceding claim wherein the opening is formed in a disc or plate abutting or located across a pipe section.
  7. 7. The apparatus of any preceding claim wherein there are multiple openings.
  8. 8. The apparatus of any preceding claim wherein the pressure drops between stages by a factor of approximately 1.5 to 2.5, most preferably 1.8-2.0.
  9. 9. The apparatus of any preceding claim wherein the main chamber is in the form of a cylindrical bore or pipe section.
  10. 10. The apparatus of any preceding claim wherein the stages are a plurality of modular components, each including a main chamber and opening, that fit together to provide the series of stages communicating there-between via the opening(s).
  11. 11. The apparatus of claim 10 wherein at least one of the modular components includes a tapered or conical end toward the opening.
  12. 12. The apparatus of claim 11 wherein the modular component includes a receiving end to receive a tapered or conical end of an adjacent component.
  13. 13. The apparatus of any preceding claim including gaskets or appropriate seals to prevent unwanted leaking of fluid between stages or around the pipeline.
  14. 14. A modular component for use in an apparatus to minimise the effect of Joule-Thomson cooling, including a chamber with an opening end including a tapered or conical portion and a receiving end for receiving the opening end of another modular component.
  15. 15. A method of minimising the effect of Joule-Thomson cooling in a pipeline, wherein a plurality of stages arranged in series are provided in the pipeline, each stage including a main bore or pipe section and an opening at a downstream end of the bore/pipe section wherein, in use, a fluid passing through the opening is subject to a pressure drop as it enters the bore/pipe section of a subsequent stage in the series.
  16. 16. The method of claim 15 wherein the opening is provided in a plate or disc arranged abutting and/or across the bore/pipe section.
  17. 17. The method of claim 16 wherein there is a plurality of openings in the plate or disc and/or the size of the opening(s) is varied between subsequent stages.
  18. 18. The method of any of claims 15 to 17 wherein the pressure drop ratio between stages is approximately 1.5 to 2.5.
  19. 19. The method of claim 18 wherein the pressure drop and/or dimensions of bore/openings of stages is selected to achieve sonic flow.
  20. 20. The method of any of claims 15 to 19 wherein a plurality of alternating pipe sections and plate/disc sections is stacked in series to build an apparatus.
  21. 21. An apparatus for installation in a pipeline to minimise the effect of Joule-Thomson cooling substantially as herein described with reference to the accompanying drawings.
  22. 22. A method of minimising the effect of Joule-Thompson cooling in a pipeline substantially as herein described with reference to the accompanying drawings.
GB1211767.7A 2012-07-03 2012-07-03 Apparatus for minimising the effect of joule-thomson cooling Withdrawn GB2503672A (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
GB1211767.7A GB2503672A (en) 2012-07-03 2012-07-03 Apparatus for minimising the effect of joule-thomson cooling
US14/412,333 US20150184806A1 (en) 2012-07-03 2013-06-26 Apparatus and method for reducing the effect of joule-thomson cooling
PCT/GB2013/051689 WO2014006370A1 (en) 2012-07-03 2013-06-26 Apparatus and method for reducing the effect of joule-thomson cooling
NO20150022A NO20150022A1 (en) 2012-07-03 2015-01-06 Apparatus and method for reducing the effect of Joule-Thomson Cooling

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1211767.7A GB2503672A (en) 2012-07-03 2012-07-03 Apparatus for minimising the effect of joule-thomson cooling

Publications (2)

Publication Number Publication Date
GB201211767D0 GB201211767D0 (en) 2012-08-15
GB2503672A true GB2503672A (en) 2014-01-08

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Family Applications (1)

Application Number Title Priority Date Filing Date
GB1211767.7A Withdrawn GB2503672A (en) 2012-07-03 2012-07-03 Apparatus for minimising the effect of joule-thomson cooling

Country Status (4)

Country Link
US (1) US20150184806A1 (en)
GB (1) GB2503672A (en)
NO (1) NO20150022A1 (en)
WO (1) WO2014006370A1 (en)

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CN110541993A (en) * 2019-01-29 2019-12-06 深圳海油工程水下技术有限公司 Pressure-reducing and flow-limiting device for pre-debugging water injection of underwater pipeline
CN111006091A (en) * 2019-12-24 2020-04-14 江阴市节流装置厂有限公司 Baffle type pressure reducing device
US20220299146A1 (en) * 2021-03-19 2022-09-22 Akron Brass Company Fluid monitor elbow

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US10138716B2 (en) * 2016-05-18 2018-11-27 Baker Hughes, A Ge Company, Llc Modular nozzle inflow control device with autonomy and flow bias
CN105840945A (en) * 2016-05-31 2016-08-10 成都国光电子仪表有限责任公司 Throttle orifice
CN110080718B (en) * 2018-01-25 2021-08-31 中国石油天然气股份有限公司 Glib and production tree
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CN110068182A (en) * 2019-05-29 2019-07-30 天津商业大学 Atomizer formula current divider and refrigeration system
US11919014B2 (en) * 2020-02-13 2024-03-05 Sonny's HFI Holdings, LLC. Nozzle assembly
US11633703B2 (en) 2020-04-10 2023-04-25 Sonny's Hfi Holdings, Llc Insert assembly for foaming device
KR102351321B1 (en) * 2020-10-19 2022-01-14 주식회사 성원에스티씨 Flow control valve device
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Publication number Priority date Publication date Assignee Title
CN110541993A (en) * 2019-01-29 2019-12-06 深圳海油工程水下技术有限公司 Pressure-reducing and flow-limiting device for pre-debugging water injection of underwater pipeline
CN111006091A (en) * 2019-12-24 2020-04-14 江阴市节流装置厂有限公司 Baffle type pressure reducing device
CN111006091B (en) * 2019-12-24 2021-11-02 江阴市节流装置厂有限公司 Baffle type pressure reducing device
US20220299146A1 (en) * 2021-03-19 2022-09-22 Akron Brass Company Fluid monitor elbow

Also Published As

Publication number Publication date
NO20150022A1 (en) 2015-01-06
US20150184806A1 (en) 2015-07-02
GB201211767D0 (en) 2012-08-15
WO2014006370A1 (en) 2014-01-09

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