GB2500092A - Small volume syringe for ophthalmic solution - Google Patents
Small volume syringe for ophthalmic solution Download PDFInfo
- Publication number
- GB2500092A GB2500092A GB1301368.5A GB201301368A GB2500092A GB 2500092 A GB2500092 A GB 2500092A GB 201301368 A GB201301368 A GB 201301368A GB 2500092 A GB2500092 A GB 2500092A
- Authority
- GB
- United Kingdom
- Prior art keywords
- syringe
- filled syringe
- filled
- less
- syringe according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002997 ophthalmic solution Substances 0.000 title claims abstract description 18
- 229940054534 ophthalmic solution Drugs 0.000 title claims abstract description 17
- 229940071643 prefilled syringe Drugs 0.000 claims abstract description 93
- 239000005557 antagonist Substances 0.000 claims abstract description 63
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims abstract description 61
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims abstract description 61
- 239000000243 solution Substances 0.000 claims abstract description 21
- 239000002245 particle Substances 0.000 claims abstract description 14
- 239000012530 fluid Substances 0.000 claims abstract description 10
- 239000011521 glass Substances 0.000 claims abstract description 4
- 229920002545 silicone oil Polymers 0.000 claims description 51
- 238000000034 method Methods 0.000 claims description 21
- 208000004644 retinal vein occlusion Diseases 0.000 claims description 20
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims description 18
- 230000036512 infertility Effects 0.000 claims description 13
- 108010081667 aflibercept Proteins 0.000 claims description 12
- 206010060823 Choroidal neovascularisation Diseases 0.000 claims description 10
- 206010012688 Diabetic retinal oedema Diseases 0.000 claims description 10
- 206010073286 Pathologic myopia Diseases 0.000 claims description 10
- 201000011190 diabetic macular edema Diseases 0.000 claims description 10
- 238000002347 injection Methods 0.000 claims description 10
- 239000007924 injection Substances 0.000 claims description 10
- 230000037452 priming Effects 0.000 claims description 10
- 239000011248 coating agent Substances 0.000 claims description 9
- 238000000576 coating method Methods 0.000 claims description 9
- 229960002833 aflibercept Drugs 0.000 claims description 7
- 229960003876 ranibizumab Drugs 0.000 claims description 7
- 206010012689 Diabetic retinopathy Diseases 0.000 claims description 5
- 208000001344 Macular Edema Diseases 0.000 claims description 5
- 206010025415 Macular oedema Diseases 0.000 claims description 5
- 208000022873 Ocular disease Diseases 0.000 claims description 5
- 206010038934 Retinopathy proliferative Diseases 0.000 claims description 5
- 201000010230 macular retinal edema Diseases 0.000 claims description 5
- 208000000208 Wet Macular Degeneration Diseases 0.000 claims description 4
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- 238000002560 therapeutic procedure Methods 0.000 claims description 3
- 239000003921 oil Substances 0.000 abstract description 3
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 abstract 1
- 229910052710 silicon Inorganic materials 0.000 abstract 1
- 239000010703 silicon Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 description 16
- 238000004659 sterilization and disinfection Methods 0.000 description 15
- 125000003275 alpha amino acid group Chemical group 0.000 description 8
- 102000004169 proteins and genes Human genes 0.000 description 8
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- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 7
- 239000007789 gas Substances 0.000 description 6
- 238000007789 sealing Methods 0.000 description 6
- 238000013461 design Methods 0.000 description 5
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- BJHCYTJNPVGSBZ-YXSASFKJSA-N 1-[4-[6-amino-5-[(Z)-methoxyiminomethyl]pyrimidin-4-yl]oxy-2-chlorophenyl]-3-ethylurea Chemical compound CCNC(=O)Nc1ccc(Oc2ncnc(N)c2\C=N/OC)cc1Cl BJHCYTJNPVGSBZ-YXSASFKJSA-N 0.000 description 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 2
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- 102000003886 Glycoproteins Human genes 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 102000016549 Vascular Endothelial Growth Factor Receptor-2 Human genes 0.000 description 2
- 102100033177 Vascular endothelial growth factor receptor 2 Human genes 0.000 description 2
- 229960000397 bevacizumab Drugs 0.000 description 2
- 102000023732 binding proteins Human genes 0.000 description 2
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- 238000004590 computer program Methods 0.000 description 2
- 229940051306 eylea Drugs 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000000314 lubricant Substances 0.000 description 2
- 229940076783 lucentis Drugs 0.000 description 2
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- 229920001184 polypeptide Polymers 0.000 description 2
- 108091008601 sVEGFR Proteins 0.000 description 2
- 238000010845 search algorithm Methods 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- PXFBZOLANLWPMH-UHFFFAOYSA-N 16-Epiaffinine Natural products C1C(C2=CC=CC=C2N2)=C2C(=O)CC2C(=CC)CN(C)C1C2CO PXFBZOLANLWPMH-UHFFFAOYSA-N 0.000 description 1
- 101100381481 Caenorhabditis elegans baz-2 gene Proteins 0.000 description 1
- 229920000089 Cyclic olefin copolymer Polymers 0.000 description 1
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- 238000004566 IR spectroscopy Methods 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 102000001708 Protein Isoforms Human genes 0.000 description 1
- 108010029485 Protein Isoforms Proteins 0.000 description 1
- 101100372762 Rattus norvegicus Flt1 gene Proteins 0.000 description 1
- 108010073925 Vascular Endothelial Growth Factor B Proteins 0.000 description 1
- 102000009521 Vascular Endothelial Growth Factor B Human genes 0.000 description 1
- 208000034699 Vitreous floaters Diseases 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 206010064930 age-related macular degeneration Diseases 0.000 description 1
- 230000029936 alkylation Effects 0.000 description 1
- 238000005804 alkylation reaction Methods 0.000 description 1
- 125000000539 amino acid group Chemical group 0.000 description 1
- 108010089411 angiocal protein Proteins 0.000 description 1
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- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 229940120638 avastin Drugs 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000001010 compromised effect Effects 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
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- 238000012217 deletion Methods 0.000 description 1
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- 239000000539 dimer Substances 0.000 description 1
- 230000004438 eyesight Effects 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 102000058223 human VEGFA Human genes 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 229940102223 injectable solution Drugs 0.000 description 1
- 230000004410 intraocular pressure Effects 0.000 description 1
- 108020001756 ligand binding domains Proteins 0.000 description 1
- 208000002780 macular degeneration Diseases 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
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- 230000006320 pegylation Effects 0.000 description 1
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- 238000012910 preclinical development Methods 0.000 description 1
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- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000000451 tissue damage Effects 0.000 description 1
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- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
- A61M5/31513—Piston constructions to improve sealing or sliding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
- A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/3129—Syringe barrels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
- A61L2/20—Gaseous substances, e.g. vapours
- A61L2/206—Ethylene oxide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
- A61L2/20—Gaseous substances, e.g. vapours
- A61L2/208—Hydrogen peroxide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
- A61L2202/20—Targets to be treated
- A61L2202/24—Medical instruments, e.g. endoscopes, catheters, sharps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M2005/3103—Leak prevention means for distal end of syringes, i.e. syringe end for mounting a needle
- A61M2005/3104—Caps for syringes without needle
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/3129—Syringe barrels
- A61M5/3137—Specially designed finger grip means, e.g. for easy manipulation of the syringe rod
- A61M2005/3139—Finger grips not integrally formed with the syringe barrel, e.g. using adapter with finger grips
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31501—Means for blocking or restricting the movement of the rod or piston
- A61M2005/31508—Means for blocking or restricting the movement of the rod or piston provided on the piston-rod
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31501—Means for blocking or restricting the movement of the rod or piston
- A61M5/31505—Integral with the syringe barrel, i.e. connected to the barrel so as to make up a single complete piece or unit
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Vascular Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Anesthesiology (AREA)
- Ophthalmology & Optometry (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Description
Claims (37)
Applications Claiming Priority (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP12174860 | 2012-07-03 | ||
EP12189649 | 2012-10-23 | ||
DE202012011016U DE202012011016U1 (en) | 2012-07-03 | 2012-11-16 | Aflibercept syringe |
AU2012101677A AU2012101677B4 (en) | 2012-07-03 | 2012-11-16 | Device |
AU2012101678A AU2012101678B4 (en) | 2012-07-03 | 2012-11-16 | Use of device |
DE202012011259U DE202012011259U1 (en) | 2012-07-03 | 2012-11-23 | Bevacizumab syringe |
DE202012011260U DE202012011260U1 (en) | 2012-07-03 | 2012-11-23 | Ranibizumab Injection |
EP12195360 | 2012-12-03 | ||
DE201320000688 DE202013000688U1 (en) | 2012-07-03 | 2013-01-23 | Glass syringe |
AU2013100070A AU2013100070B4 (en) | 2012-07-03 | 2013-01-23 | Use of device |
AU2013100071A AU2013100071C4 (en) | 2012-07-03 | 2013-01-23 | Device |
Publications (3)
Publication Number | Publication Date |
---|---|
GB201301368D0 GB201301368D0 (en) | 2013-03-13 |
GB2500092A true GB2500092A (en) | 2013-09-11 |
GB2500092B GB2500092B (en) | 2014-02-12 |
Family
ID=47790686
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB1301368.5A Active GB2500092B (en) | 2012-07-03 | 2013-01-25 | Syringe |
Country Status (2)
Country | Link |
---|---|
AU (5) | AU2013100071C4 (en) |
GB (1) | GB2500092B (en) |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2014087678A (en) * | 2012-07-03 | 2014-05-15 | Novartis Ag | Syringe |
WO2015173260A1 (en) * | 2014-05-12 | 2015-11-19 | Formycon Ag | Pre-filled plastic syringe containing a vegf antagonist |
WO2017087798A1 (en) * | 2015-11-18 | 2017-05-26 | Formycon Ag | Pre-filled pharmaceutical package comprising a liquid formulation of a vegf-antagonist |
WO2017209998A1 (en) | 2016-06-01 | 2017-12-07 | Centurion Medical Products Corporation | Methods for manufacturing non-glass prefilled containers |
WO2018217995A1 (en) * | 2017-05-24 | 2018-11-29 | Formycon Ag | Sterilizable pre-filled pharmaceutical packages comprising a liquid formulation of a vegf-antagonist |
WO2022117556A1 (en) * | 2020-12-01 | 2022-06-09 | Boehringer Ingelheim International Gmbh | Administration device for in particular intravitreal administration of a fluid |
US11654046B2 (en) | 2015-11-18 | 2023-05-23 | Sio2 Medical Products, Inc. | Pharmaceutical package for ophthalmic formulations |
US11786664B2 (en) | 2012-05-07 | 2023-10-17 | Medline Industries, Lp | Prefilled container systems |
WO2024049793A1 (en) * | 2022-08-30 | 2024-03-07 | Amgen Inc. | System and method of limiting subvisible particles in a syringe |
Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006047325A1 (en) * | 2004-10-21 | 2006-05-04 | Genentech, Inc. | Method for treating intraocular neovascular diseases |
US20060172944A1 (en) * | 2005-02-02 | 2006-08-03 | Wiegand Stanley J | Method of treating eye injury with local administration of a VEGF inhibitor |
WO2006128564A1 (en) * | 2005-05-31 | 2006-12-07 | Baxter International Inc. | Polypropylene hollow barrel with sliding coated rubber piston |
WO2007035621A1 (en) * | 2005-09-16 | 2007-03-29 | (Osi) Eyetech, Inc. | Ophthalmic syringe |
WO2007084765A2 (en) * | 2006-01-19 | 2007-07-26 | Potentia Pharmaceuticals, Inc. | Injectable combination therapy for eye disorders |
WO2007149334A2 (en) * | 2006-06-16 | 2007-12-27 | Regeneron Pharmaceuticals, Inc. | Vegf antagonist formulations suitable for intravitreal administration |
CN201578690U (en) * | 2010-01-21 | 2010-09-15 | 王建友 | Syringe |
US20120078224A1 (en) * | 2010-03-31 | 2012-03-29 | Ocuject, Llc | Device and method for intraocular drug delivery |
US20130012918A1 (en) * | 2011-07-07 | 2013-01-10 | Gary Foster | Steady grip ophthalmic surgical syringe and method |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6243938B1 (en) * | 1998-03-17 | 2001-06-12 | Becton, Dickinson And Company | Low silicone plastic prefillable syringe |
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Also Published As
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AU2013100147B4 (en) | 2013-04-18 |
AU2013100145A4 (en) | 2013-03-28 |
AU2013100071C4 (en) | 2013-05-02 |
GB2500092B (en) | 2014-02-12 |
AU2013100071A4 (en) | 2013-03-07 |
AU2013100071B4 (en) | 2013-03-28 |
AU2013100146A4 (en) | 2013-03-28 |
AU2013100146B4 (en) | 2013-04-18 |
GB201301368D0 (en) | 2013-03-13 |
AU2013100145B4 (en) | 2013-05-02 |
AU2013100070B4 (en) | 2013-04-04 |
AU2013100070A4 (en) | 2013-03-07 |
AU2013100147A4 (en) | 2013-03-28 |
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