GB2498363A - A dosage measuring and administration device based on two parameters - Google Patents

A dosage measuring and administration device based on two parameters Download PDF

Info

Publication number
GB2498363A
GB2498363A GB201200416A GB201200416A GB2498363A GB 2498363 A GB2498363 A GB 2498363A GB 201200416 A GB201200416 A GB 201200416A GB 201200416 A GB201200416 A GB 201200416A GB 2498363 A GB2498363 A GB 2498363A
Authority
GB
United Kingdom
Prior art keywords
scale
text
substance
treatment
dose
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB201200416A
Other versions
GB201200416D0 (en
Inventor
Michael Anthony Swaddle
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to GB201200416A priority Critical patent/GB2498363A/en
Publication of GB201200416D0 publication Critical patent/GB201200416D0/en
Publication of GB2498363A publication Critical patent/GB2498363A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
    • A61J7/0015—Devices specially adapted for taking medicines
    • A61J7/0053—Syringes, pipettes or oral dispensers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31525—Dosing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
    • A61M5/31551—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe including axial movement of dose setting member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/31556—Accuracy improving means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3125—Details specific display means, e.g. to indicate dose setting
    • A61M2005/3126—Specific display means related to dosing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms

Abstract

A dose measuring and/or administration device, which utilises a personal physiological biometric scale 2 e.g. age or weight, to measure and make available for administration, consumption or use a substance for the treatment, maintenance or prophylaxis of a person or animal, referenced to a datum point or mark which is varied by a secondary biometric scale 3 e.g. height, temperature, or use of the substance. The syringe type device has a first scale 2 on the plunger 1 and a second scale 3 on a rotating collar 4, which may be clear or have the second gradation provided on its edge. The dose measurement according to the first scale, for example based on the age of the patient, is modified by the second scale, for example based on the weight of the patient.

Description

The invention is a biometric based dosage measuring and administration device.
It relates to the measurement and administration, usually orally, of substances for the treatment, maintenance and prophylaxis of persons or animals calculated from their personal physiological biometrics observed at the time of dosage.
Background
When medication is used in treatment or prophylaxis of disease the dose has to be administered in fixed amounts which vary according to the personal physiological characteristics of the patient, biometrics. With liquid medication for oral use this dose is currently expressed in millilitres, ml, or in portions or multiples of a standard SmI spoon.
Additional information either on the label or accompanying leaflet will specify the correct amount to be administered for given age ranges or weights of patients as well as the frequency of administration.
For ease of use and to limit patient or carer confusion dosages are split into age or weight ranges. These ranges lead to abrupt changes in the dosage when the patient moves from one range to another.
Example. The dosages currently recommended in the United Kingdom for Paracetamol Infant Suspension l2Omg/5m1 are; * 2-3 months 2.5m1 usually once, but a second dose permitted 4-6 hours later * 3-6 months 2.5m1 -up to 4 times a day * 5-24 months SmI -up to 4 times a day * 2-4 years 7.5m1 -up to 4 times a day * 4-6 years lOmI up to 4 times a day From this table it is clear that a child of 5 months and 3 weeks will be given 2.Sml per dose but this will double to SmI per dose two weeks later. A small for age child may easily receive a greater than optimal dose and similarly a tall, well muscled, heavier child may receive a dosage that is inadequate.
This becomes even more important when considering the administration of antibiotics where drug blood levels are crucial to the success of treatment and the relevant biometrics would be the patient's weight. For dose sensitive antibiotics used in the treatment of acute life threatening illness Body Mass Index, blood volume or other biometrics would be used.
The Invention To overcome this the proposed invention proposes a dose measuring device which is calibrated directly with a physiological biometric scale. At each administration of substance the appropriate volume is measured into the device by direct correlation to the biometric scale measured against a datum mark which is modified by an independent scale that is either another biometric or a specific use of the substance.
In the above example for paracetamol the amount measured would be a volume correlated to the age of the patient on the primary graduated scale. The secondary scale would move the datum of the primary scale in correlation to another patient biometric or substance use. Body temperature could be used to increase the datum point increasing the dose in relation to the body temperature recorded immediately prior to dose administration.
Using this invention more accurate dosing will be achieved and there will be a reduction in errors in transposing information from an external reference and converting the reading to a volumetric measurement the appropriate biometric for the treatment being used directly to determine the dose at the point and time of administration. In the above example the suitable scales would be the weight of the child modified by the secondary scale body temperature datum shifter.
A more important use will be in the administration of antibiotic liquids for children. For antibiotic solutions to give optimal results in eliminating infection it is important that adequate blood concentrations are achieved. Regular dosing at even intervals is important but the crucial factor is that an adequate quantity of the antibiotic is given to achieve clinically significant results at each dose. This is best done by correlating the amount of drug administered with the blood volume of the patient.
Blood volume is in direct relationship to weight and height. Increased incidence of patient obesity has made age related dosing inadequate and ineffective.
Using the invention both weight and height can be used to determine the volume of any given antibiotic mixture and therefore the optimal dose can be given in any situation without the need for complex calculation of blood volume.
Antibiotic dosage is sometime different depending on the nature of the condition or the vascularisation of the area to be treated. E.g. the optimal dosage of Flucloxicillin is lower for treatment of infections of the lung, with a rich blood supply, than it is for an infection of the outer cornified (Stratum Corneum) layer of the skin which is poorly vasculated. The secondary datum shifter could be arranged so that it is stepped and the scale altered to represent the condition being treated or a single tertiary device could be added which moves the datum shifter a fixed amount appropriate for the condition permitting the secondary biometric scale shifter to continue to be used from an elevated reference point.
Description
The invention will now be described solely by way of example with reference to Figure 1.
It is similar to a dosage syringe with a plunger (1) that fits with a body (7) with no needle attaching device but a simple entry orifice (9). The biometric scale (2) is marked on the plunger which is a close fit with the bore of the syringe (7). The datum shifter (5) is a device, which enables the secondary scale (3), to be presented to the primary scale, in the example a collar (4), with either a) an edge that is the datum line for the secondary biometric scale orb) a clear collar with markings to represent the datum line. The secondary scale may be presented on the datum shift device (5) or elsewhere on the body (7) and read with an indexing device on the datum shifter (5). The tertiary datum shifter (6) would be a simple collar or similar device that raises the primary datum shifter(s).
As each device will be specific to one strength and preparation of substance the complex calculations required to calculate the optimal dosage for a substance can be reduced to a scale, which may be non linear and complex, yet easily read from the device.
Other than the use in clinically appropriate medicine dosage measurement the device could be used extensively in animal medicine where breed and weight are the principle biometrics. In external applications where age and area to be treated are the biometrics.
E.g. Child! hand, adult/arm etc. In farming, milk yield/breed or weight to determine feed volume.
References 1. Adjustment of dosing of antimicrobial agents for bodyweight in adults, Els Mehuys,Egide Kayitare.
chris Vervaet, Jean-Paul Remon, The Lancet Vol. 375 No. 9719, March 202010 2. Best drug treatment for multidrug-resistant and extensively drug-resistant tuberculosis, Dr José A caminero MD, Giovanni Sotgiu PhD) Alimuddin Zumla FRcP, Giovanni Battista Migliori MD. The Luncet Infectious Diseases, Vol. lONo. 9 pp 621-629. Sep 2010 3. Protecting our futures -preventing antibiotic resistance Niall Hunt Chemist and Druggist 18 November 4. Antibiotic Tissue Concentrations and Obesity From the Division of Pharmacy Practice) college of Pharmacy) university of New Mexico, Albuquerque) New Mexico (Dr. Pai); and the Department of Pharmacy Practice) college of Pharmacy, Oregon State University, Portland, Oregon (Dr. Dearden).
S. Rising obesity prompts higher antibiotic doses call Emma Wilkinson, Health reporter, BBC News 15 January 2010 6. Antimicrobial Dosing in Obese Patients Rebecca Wurtz, Gail Itokazu, and Keith Rodvold From the Department of Medicine, Evanston Hospital, Evanston; and the Department of Medicine, Northwestern university Medical School, Cook County Hospital, and University of Illinois at Chicago College of Pharmacy, Chicago, Illinois. clinical Infectious Diseases 1997;25:112-8 7. Optimal antibiotic dosing for obese patients a challenge for clinicians Elizabeth Dodds Ashley, INFECTIOUS DISEASE NEwsJune 2007 http://www.infectiousdiseasenews.com/view.aspx?rid=33615
Prior Art is detailed separately
END 11/01/2012

Claims (1)

  1. <claim-text>A physiological biometric based dosage measuring and administration device. Claim1. A dose measuring device which references a personal physiological biometric e.g. age, weight, to measure and make available for administration, consumption or use a substance for the treatment, maintenance or prophylaxis of a person or animal cross referenced to a datum point or mark which is varied by a secondary biometric e.g. height, temperature, or use of the substance.</claim-text> <claim-text>2. A measuring device according to claimi, which has incorporated a delivery mechanism for direct administration of the substance.</claim-text> <claim-text>3. A dose measuring device according to claim 1, which has a datum modifier for the secondary biometric that is applied modify the dose measured according to the use of the substance, the nature of the treatment, the condition being treated, the location of the treatment or the nature of the person or animal.</claim-text> <claim-text>4. A dose measuring device according to claim 2, which has a datum modifier for the secondary biometric that is applied modify the dose measured according to the use of the substance, the nature of the treatment, the condition being treated, the location of the treatment or the nature of the person or animal.</claim-text>
GB201200416A 2012-01-11 2012-01-11 A dosage measuring and administration device based on two parameters Withdrawn GB2498363A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB201200416A GB2498363A (en) 2012-01-11 2012-01-11 A dosage measuring and administration device based on two parameters

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB201200416A GB2498363A (en) 2012-01-11 2012-01-11 A dosage measuring and administration device based on two parameters

Publications (2)

Publication Number Publication Date
GB201200416D0 GB201200416D0 (en) 2012-02-22
GB2498363A true GB2498363A (en) 2013-07-17

Family

ID=45788767

Family Applications (1)

Application Number Title Priority Date Filing Date
GB201200416A Withdrawn GB2498363A (en) 2012-01-11 2012-01-11 A dosage measuring and administration device based on two parameters

Country Status (1)

Country Link
GB (1) GB2498363A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104224547A (en) * 2013-06-14 2014-12-24 李爱民 Medicine taking device for point application therapy

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4308450A (en) * 1978-12-22 1981-12-29 Baxter Travenol Laboratories, Inc. Two-piece slide calculator for determining metabolic requirements and parenteral feeding dosages
US20040024372A1 (en) * 1989-08-04 2004-02-05 Grogan Jack Raymond Dose by weight medicine dropper
WO2004077363A1 (en) * 2003-02-25 2004-09-10 Rosti A/S Method and apparatus for controlling a dispensing apparatus for dispensing medication
US20070225656A1 (en) * 2006-03-24 2007-09-27 Hoyle John D Jr Dosage Control Syringe
US20080306438A1 (en) * 2006-03-16 2008-12-11 Ferrara Kenneth D System for facilitating preparation of medication doses

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4308450A (en) * 1978-12-22 1981-12-29 Baxter Travenol Laboratories, Inc. Two-piece slide calculator for determining metabolic requirements and parenteral feeding dosages
US20040024372A1 (en) * 1989-08-04 2004-02-05 Grogan Jack Raymond Dose by weight medicine dropper
WO2004077363A1 (en) * 2003-02-25 2004-09-10 Rosti A/S Method and apparatus for controlling a dispensing apparatus for dispensing medication
US20080306438A1 (en) * 2006-03-16 2008-12-11 Ferrara Kenneth D System for facilitating preparation of medication doses
US20070225656A1 (en) * 2006-03-24 2007-09-27 Hoyle John D Jr Dosage Control Syringe

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104224547A (en) * 2013-06-14 2014-12-24 李爱民 Medicine taking device for point application therapy

Also Published As

Publication number Publication date
GB201200416D0 (en) 2012-02-22

Similar Documents

Publication Publication Date Title
Cuvillon et al. Comparison of subgluteal sciatic nerve block duration in type 2 diabetic and non-diabetic patients
RU2012133280A (en) SYSTEM FOR ADMINISTRATION OF MEDICINES TO A PATIENT BASED ON URINE INDICATORS AND METHOD
Burkhardt et al. Penetration of ertapenem into skeletal muscle and subcutaneous adipose tissue in healthy volunteers measured by in vivo microdialysis
Lubens et al. Anesthetic patch for painful procedures such as minor operations
US20200289761A1 (en) Syringe having at least one radially-outwardly extending panel
Leef Evidence-based review of oral sucrose administration to decrease the pain response in newborn infants.
GB2498363A (en) A dosage measuring and administration device based on two parameters
Crumby et al. Pharmacokinetic comparison of nomogram-based and individualized vancomycin regimens in neonates
Roth Historical review: comparison with other methods
Rodriguez et al. Adherence to antibiotic prophylaxis in children with vesicoureteral reflux
Chauhan et al. Study of Preterm Infants with Different Gestational Age: Modifying Amikacin Sulphate Dosage Regimen
van den Berg et al. 15 The relation between the serum trough concentration of paracetamol and pain reduction in preterm and term neonates: a retrospective observational study
Wright et al. 14 A comparison of age-banded and weight-based oral paracetamol dosing in hospitalised children
Sholpan et al. Analysis of antibiotic consumption at the National Center for Children’s Rehabilitation for 2016-2018
Lee et al. Stability of commonly used antibiotics solutions in the accufuser elastometric infusion device under recommenrted storage and used conditions
Khan et al. Abdominal pain with rigidity secondary to the anti-emetic drug metoclopramide
McKinlay et al. Use of 100 units/ml insulin in treatment of diabetic children.
Villalba et al. Ibuprofen gummies as a new pediatric dosage form
Griffiths et al. 57 Personal protective equipment (PPE) and lung function testing; the impact on patient experience feedback
Di Munno et al. Clinical equivalence between deflazacort oral drops and tablets in active rheumatoid arthritis
Mehmood et al. Household teaspoon and Oral liquid medication: the present scenario
Awuah et al. 59 A functional assay to measure the t cell response to SARS-COV-2 in primary immunodeficiency patients
Göböová et al. Is gentamicin administered to individual patients in optimal doses already at the beginning of therapy?
Malik et al. Prescription Pattern of Antibiotics in Paediatric Patients in a Rural Teaching Hospital of North India.
Philpott Children's pain: A difficult balance

Legal Events

Date Code Title Description
WAP Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1)