GB2494595B - Phenylbutyryl curcumin derivatives and use thereof in manufacturing medicaments for preventing tumors - Google Patents

Phenylbutyryl curcumin derivatives and use thereof in manufacturing medicaments for preventing tumors

Info

Publication number
GB2494595B
GB2494595B GB1223251.8A GB201223251A GB2494595B GB 2494595 B GB2494595 B GB 2494595B GB 201223251 A GB201223251 A GB 201223251A GB 2494595 B GB2494595 B GB 2494595B
Authority
GB
United Kingdom
Prior art keywords
phenylbutyryl
curcumin derivatives
preventing tumors
manufacturing medicaments
medicaments
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
GB1223251.8A
Other versions
GB201223251D0 (en
GB2494595A (en
Inventor
Xu Jianhua
Liu Yang
Wu Lixian
Lin Yanfang
Wu Zhijuan
Guo Xiaodan
Wu Min
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujian Medical University
Original Assignee
Fujian Medical University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujian Medical University filed Critical Fujian Medical University
Publication of GB201223251D0 publication Critical patent/GB201223251D0/en
Publication of GB2494595A publication Critical patent/GB2494595A/en
Application granted granted Critical
Publication of GB2494595B publication Critical patent/GB2494595B/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/40—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/42—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
GB1223251.8A 2010-05-26 2011-05-09 Phenylbutyryl curcumin derivatives and use thereof in manufacturing medicaments for preventing tumors Expired - Fee Related GB2494595B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN2010101835096A CN101830819B (en) 2010-05-26 2010-05-26 Phenylbutyryl curcumin derivate and application thereof in anti-tumor drug preparation
PCT/CN2011/073844 WO2011147254A1 (en) 2010-05-26 2011-05-09 Phenylbutyryl curcumin derivatives and uses for preparing anti-tumor drugs thereof

Publications (3)

Publication Number Publication Date
GB201223251D0 GB201223251D0 (en) 2013-02-06
GB2494595A GB2494595A (en) 2013-03-13
GB2494595B true GB2494595B (en) 2018-03-21

Family

ID=42715062

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1223251.8A Expired - Fee Related GB2494595B (en) 2010-05-26 2011-05-09 Phenylbutyryl curcumin derivatives and use thereof in manufacturing medicaments for preventing tumors

Country Status (3)

Country Link
CN (1) CN101830819B (en)
GB (1) GB2494595B (en)
WO (1) WO2011147254A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101830819B (en) * 2010-05-26 2013-08-28 福建医科大学 Phenylbutyryl curcumin derivate and application thereof in anti-tumor drug preparation
CN102552224A (en) * 2011-12-16 2012-07-11 西安交通大学 Application of curcumin derivative C2 in anti-colon cancer medicaments

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004031122A1 (en) * 2002-10-01 2004-04-15 Dr. André Rieks - Labor Für Enzymtechnologie Gmbh Novel curcumin/tetrahydrocurcumin derivatives for using in cosmetics, pharmaceuticals and for nutrition
WO2008045534A2 (en) * 2006-10-12 2008-04-17 Research Foundation Of The City University Of New York Novel curcumin and tetrahydrocurcumin derivatives
CN101669931A (en) * 2008-09-08 2010-03-17 北京鼎国昌盛生物技术有限责任公司 Application of long effective curcumin derivative in preparing anti-tumor disease drug
CN101830819A (en) * 2010-05-26 2010-09-15 福建医科大学 Phenylbutyryl curcumin derivate and application thereof in anti-tumor drug preparation

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7355081B2 (en) * 2002-04-17 2008-04-08 The University Of North Carolina At Chapel Hill Curcumin analogues and uses thereof
CN101003470B (en) * 2007-01-22 2011-11-02 温州医学院生物与天然药物开发中心有限公司 Analog of mono carbonyl structure of curcumin, and usage
CN101255119B (en) * 2008-01-07 2014-05-21 沈阳药科大学 Novel tetrahydro curcumin derivatives and salt
CN101434524B (en) * 2008-06-05 2012-07-25 福建医科大学 4-(4-hydroxy-3-methoxybenzene methylene) curcumin, preparation thereof and use in preparing anti-cancer medicament
CN101524546B (en) * 2008-11-07 2012-06-06 浙江中医药大学 Conjugate conjugated from polyethylene glycol and curcumin derivative

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004031122A1 (en) * 2002-10-01 2004-04-15 Dr. André Rieks - Labor Für Enzymtechnologie Gmbh Novel curcumin/tetrahydrocurcumin derivatives for using in cosmetics, pharmaceuticals and for nutrition
WO2008045534A2 (en) * 2006-10-12 2008-04-17 Research Foundation Of The City University Of New York Novel curcumin and tetrahydrocurcumin derivatives
CN101669931A (en) * 2008-09-08 2010-03-17 北京鼎国昌盛生物技术有限责任公司 Application of long effective curcumin derivative in preparing anti-tumor disease drug
CN101830819A (en) * 2010-05-26 2010-09-15 福建医科大学 Phenylbutyryl curcumin derivate and application thereof in anti-tumor drug preparation

Also Published As

Publication number Publication date
WO2011147254A1 (en) 2011-12-01
CN101830819A (en) 2010-09-15
CN101830819B (en) 2013-08-28
GB201223251D0 (en) 2013-02-06
GB2494595A (en) 2013-03-13

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 20230509