GB2469754B - Composition for use in the sublingual delivery of medicaments to humans - Google Patents

Composition for use in the sublingual delivery of medicaments to humans

Info

Publication number
GB2469754B
GB2469754B GB1006818.7A GB201006818A GB2469754B GB 2469754 B GB2469754 B GB 2469754B GB 201006818 A GB201006818 A GB 201006818A GB 2469754 B GB2469754 B GB 2469754B
Authority
GB
United Kingdom
Prior art keywords
medicaments
humans
composition
sublingual delivery
sublingual
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
GB1006818.7A
Other versions
GB201006818D0 (en
GB2469754A (en
Inventor
Calvin John Ross
Clive Booles
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LondonPharma Ltd
Original Assignee
LondonPharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/GB2009/050416 external-priority patent/WO2010122276A1/en
Application filed by LondonPharma Ltd filed Critical LondonPharma Ltd
Publication of GB201006818D0 publication Critical patent/GB201006818D0/en
Publication of GB2469754A publication Critical patent/GB2469754A/en
Application granted granted Critical
Publication of GB2469754B publication Critical patent/GB2469754B/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/465—Nicotine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
GB1006818.7A 2009-04-23 2010-04-23 Composition for use in the sublingual delivery of medicaments to humans Expired - Fee Related GB2469754B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0906977A GB2469792A (en) 2009-04-23 2009-04-23 Oil-based pharmaceutical formulation for sublingual delivery
PCT/GB2009/050416 WO2010122276A1 (en) 2009-04-23 2009-04-23 Drug delivery

Publications (3)

Publication Number Publication Date
GB201006818D0 GB201006818D0 (en) 2010-06-09
GB2469754A GB2469754A (en) 2010-10-27
GB2469754B true GB2469754B (en) 2012-07-18

Family

ID=40774840

Family Applications (2)

Application Number Title Priority Date Filing Date
GB0906977A Withdrawn GB2469792A (en) 2009-04-23 2009-04-23 Oil-based pharmaceutical formulation for sublingual delivery
GB1006818.7A Expired - Fee Related GB2469754B (en) 2009-04-23 2010-04-23 Composition for use in the sublingual delivery of medicaments to humans

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GB0906977A Withdrawn GB2469792A (en) 2009-04-23 2009-04-23 Oil-based pharmaceutical formulation for sublingual delivery

Country Status (1)

Country Link
GB (2) GB2469792A (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2481728B (en) * 2010-06-30 2012-05-23 Londonpharma Ltd Formulations and delivery devices for the sublingual administration of opioids
GB201414919D0 (en) * 2014-08-21 2014-10-08 Corbitt Terence Simon Formulations for transmucosal delivery
WO2018169497A1 (en) * 2017-03-17 2018-09-20 İlko Ilaç Sanayi Ve Ticaret Anonim Şirketi Spray formulation comprising cholecalciferol (vitamin d3) with improved stability
US20220312826A1 (en) * 2021-04-06 2022-10-06 Altria Client Services Llc Liquid mixtures of triglyceride and liquid nicotine

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993021909A1 (en) * 1992-04-27 1993-11-11 Vyrex Corporation Improved delivery formulation for lipophilic drugs
WO1998025599A1 (en) * 1996-12-12 1998-06-18 Pharmacia & Upjohn Company An oil composition of dihydropolyprenols
US20020099067A1 (en) * 1993-07-08 2002-07-25 Ulrich Posanski Pharmaceutical compositions for sparingly soluble therapeutic agents
GB2380129A (en) * 2001-02-14 2003-04-02 Gw Pharma Ltd Self-emulsifying pharmaceutical compositions
US20050025716A1 (en) * 1997-10-01 2005-02-03 Novadel Pharma, Inc. Buccal, polar and non-polar spray or capsule containing drugs for treating disorders of the gastrointestinal tract or urinary tract
WO2005123090A1 (en) * 2004-06-17 2005-12-29 Galderma S.A. Composition in spray form comprising a combination of a corticoid and a vitamin d derivative in an oily phase
WO2007036802A2 (en) * 2005-07-07 2007-04-05 Teva Pharmaceutical Industries Limited Sublingual dosage form comrising vitamin d analogue, in particular calcitriol
WO2007087431A2 (en) * 2006-01-25 2007-08-02 Insys Therapeutics Inc. Sublingual fentanyl spray
GB2437488A (en) * 2006-04-25 2007-10-31 Optinose As Pharmaceutical oily formulation for nasal or buccal administration
US20070287755A1 (en) * 2006-06-12 2007-12-13 Rosario Ammirante Orally administered compound for preventing neonatal hemorrhages, in a tardy form, caused by a K-vitamin dificiency

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5955098A (en) * 1996-04-12 1999-09-21 Flemington Pharmaceutical Corp. Buccal non polar spray or capsule
SE9703458D0 (en) * 1997-09-25 1997-09-25 Pharmacia & Upjohn Ab Nicotine compositions and methods of formulation thereof
US20040136913A1 (en) * 1997-10-01 2004-07-15 Dugger Harry A. Buccal, polar and non-polar spray containing sumatriptan
IT1302682B1 (en) * 1998-10-16 2000-09-29 Formenti Farmaceutici Spa ORAL PHARMACEUTICAL COMPOSITIONS CONTAINING BUPRENORPHINE
US6617356B2 (en) * 2000-01-03 2003-09-09 Naturally Scientific Inc Gel system for oral and topical administration of water insoluble and/or water intolerant drugs and supplements
GB0720967D0 (en) * 2007-10-25 2007-12-05 Protophama Ltd Anti-material pharmaceutical composition

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993021909A1 (en) * 1992-04-27 1993-11-11 Vyrex Corporation Improved delivery formulation for lipophilic drugs
US20020099067A1 (en) * 1993-07-08 2002-07-25 Ulrich Posanski Pharmaceutical compositions for sparingly soluble therapeutic agents
WO1998025599A1 (en) * 1996-12-12 1998-06-18 Pharmacia & Upjohn Company An oil composition of dihydropolyprenols
US20050025716A1 (en) * 1997-10-01 2005-02-03 Novadel Pharma, Inc. Buccal, polar and non-polar spray or capsule containing drugs for treating disorders of the gastrointestinal tract or urinary tract
GB2380129A (en) * 2001-02-14 2003-04-02 Gw Pharma Ltd Self-emulsifying pharmaceutical compositions
WO2005123090A1 (en) * 2004-06-17 2005-12-29 Galderma S.A. Composition in spray form comprising a combination of a corticoid and a vitamin d derivative in an oily phase
WO2007036802A2 (en) * 2005-07-07 2007-04-05 Teva Pharmaceutical Industries Limited Sublingual dosage form comrising vitamin d analogue, in particular calcitriol
WO2007087431A2 (en) * 2006-01-25 2007-08-02 Insys Therapeutics Inc. Sublingual fentanyl spray
GB2437488A (en) * 2006-04-25 2007-10-31 Optinose As Pharmaceutical oily formulation for nasal or buccal administration
US20070287755A1 (en) * 2006-06-12 2007-12-13 Rosario Ammirante Orally administered compound for preventing neonatal hemorrhages, in a tardy form, caused by a K-vitamin dificiency

Also Published As

Publication number Publication date
GB2469792A (en) 2010-11-03
GB201006818D0 (en) 2010-06-09
GB0906977D0 (en) 2009-06-03
GB2469754A (en) 2010-10-27

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Legal Events

Date Code Title Description
COOA Change in applicant's name or ownership of the application

Owner name: LONDONPHARMA LIMITED

Free format text: FORMER OWNER: CALVIN JOHN ROSS

PCNP Patent ceased through non-payment of renewal fee

Effective date: 20210423

S28 Restoration of ceased patents (sect. 28/pat. act 1977)

Free format text: APPLICATION FILED

S28 Restoration of ceased patents (sect. 28/pat. act 1977)

Free format text: RESTORATION ALLOWED

Effective date: 20220511

PCNP Patent ceased through non-payment of renewal fee

Effective date: 20230423