GB2453819A - Modulators of hypoxia inducible factor-1 and related uses - Google Patents

Modulators of hypoxia inducible factor-1 and related uses Download PDF

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Publication number
GB2453819A
GB2453819A GB0812342A GB0812342A GB2453819A GB 2453819 A GB2453819 A GB 2453819A GB 0812342 A GB0812342 A GB 0812342A GB 0812342 A GB0812342 A GB 0812342A GB 2453819 A GB2453819 A GB 2453819A
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GB
United Kingdom
Prior art keywords
modulators
inducible factor
hypoxia inducible
related uses
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB0812342A
Other versions
GB0812342D0 (en
Inventor
Mehran Khodadoust
Hans-Jurgen Hess
Sajjat Husson
Reimar C Bruening
Gregory E Gardiner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BTG International Ltd
Original Assignee
BTG International Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BTG International Ltd filed Critical BTG International Ltd
Publication of GB0812342D0 publication Critical patent/GB0812342D0/en
Publication of GB2453819A publication Critical patent/GB2453819A/en
Withdrawn legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J19/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 by a lactone ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A61K31/585—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J19/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 by a lactone ring
    • C07J19/005—Glycosides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C07J41/0011—Unsubstituted amino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C07J41/0016—Oximes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C07J41/0027—Azides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0038—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 with an androstane skeleton, including 18- or 19-substituted derivatives, 18-nor derivatives and also derivatives where position 17-beta is substituted by a carbon atom not directly bonded to a further carbon atom and not being part of an amide group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0088—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing unsubstituted amino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed

Abstract

The invention features compounds of formulas I or II: and pharmaceutically acceptable salts and prodrugs thereof, as well methods for modulating the effects of local and systemic hypoxic events using the compounds.
GB0812342A 2006-01-09 2007-01-09 Modulators of hypoxia inducible factor-1 and related uses Withdrawn GB2453819A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US75781406P 2006-01-09 2006-01-09
PCT/US2007/000340 WO2007081835A2 (en) 2006-01-09 2007-01-09 Modulators of hypoxia inducible factor-1 and related uses

Publications (2)

Publication Number Publication Date
GB0812342D0 GB0812342D0 (en) 2008-08-13
GB2453819A true GB2453819A (en) 2009-04-22

Family

ID=38256942

Family Applications (1)

Application Number Title Priority Date Filing Date
GB0812342A Withdrawn GB2453819A (en) 2006-01-09 2007-01-09 Modulators of hypoxia inducible factor-1 and related uses

Country Status (10)

Country Link
US (1) US20090023666A1 (en)
EP (1) EP1971618A2 (en)
JP (1) JP2009522383A (en)
CN (1) CN101400690A (en)
AU (1) AU2007205092A1 (en)
BR (1) BRPI0706377A2 (en)
CA (1) CA2635370A1 (en)
GB (1) GB2453819A (en)
MX (1) MX2008008608A (en)
WO (1) WO2007081835A2 (en)

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Publication number Priority date Publication date Assignee Title
GB0713463D0 (en) * 2007-07-11 2007-08-22 Btg Int Ltd Modulators of hypoxia inducible factor-1 and related uses
JP2011530535A (en) 2008-08-07 2011-12-22 セントローズ， エルエルシー Glycoside compound and pharmaceutical composition thereof
WO2010024930A2 (en) * 2008-08-28 2010-03-04 President And Fellows Of Harvard College Cortistatin analogues and syntheses therof
WO2010102673A1 (en) * 2009-03-13 2010-09-16 Unibioscreen S.A. Hellebrin and hellebrigenin derivatives
JP2012524778A (en) * 2009-04-22 2012-10-18 プレジデント アンド フェロウズ オブ ハーバード カレッジ Angiogenesis inhibitor
CN103980338B (en) 2010-01-15 2017-04-26 苏州润新生物科技有限公司 Bufalin derivatives, pharmaceutical compositions and methods thereof
WO2012027957A1 (en) 2010-08-28 2012-03-08 Suzhou Neupharma Co., Ltd. Bufalin derivatives, pharmaceutical compositions and use thereof
EP3453714B1 (en) 2011-02-02 2020-11-04 Suzhou Neupharma Co., Ltd Cardenolide and bufadienolide 3-carbonate and 3-carbamate derivatives for the treatment of cancer and compositions thereof
NO2686520T3 (en) 2011-06-06 2018-03-17
KR101380466B1 (en) * 2011-09-27 2014-04-02 한국생명공학연구원 Novel compounds as HIF-1α inhibitors and manufacturing process thereof
CN109354598A (en) * 2012-04-29 2019-02-19 润新生物公司 Chemical entity, pharmaceutical composition and cancer treatment method
CN103570792B (en) * 2012-08-10 2016-09-14 中国科学院上海药物研究所 Toadpoison Medicine derivant, its preparation method, pharmaceutical composition and purposes
PT3007695T (en) 2013-06-13 2024-03-07 Akebia Therapeutics Inc Compositions and methods for treating anemia
PE20160945A1 (en) 2013-11-15 2016-09-26 Akebia Therapeutics Inc SOLID FORMS OF {[5- (3-CHLOROPHENYL) -3-HYDROXYPYRIDIN-2-CARBONYL] AMINO} ACID, COMPOSITIONS, AND USES OF THEM
EA201891279A1 (en) 2013-12-24 2019-01-31 Президент Энд Феллоус Оф Гарвард Колледж ANALOGUES OF CORTISTATIN, THEIR SYNTHESIS AND APPLICATIONS
CA2974691A1 (en) 2015-01-23 2016-07-28 Akebia Therapeutics, Inc. Solid forms of 2-(5-(3-fluorophenyl)-3-hydroxypicolinamido)acetic acid, compositions, and uses thereof
IL292262B2 (en) 2015-04-01 2024-02-01 Akebia Therapeutics Inc Oral dosage formulation of {[ 5-(3-(chlorophenyl)- 3-hydroxypyridine-2-carbonyl] amino} acetic acid
EP3294298A4 (en) 2015-05-08 2018-10-17 President and Fellows of Harvard College Cortistatin analogues, syntheses, and uses thereof
EP3316889A4 (en) 2015-07-01 2018-11-14 President and Fellows of Harvard College Cortistatin analogues and syntheses and uses thereof
AU2019265629A1 (en) 2018-05-09 2021-01-07 Akebia Therapeutics, Inc. Process for preparing 2-((5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl)amino)acetic acid
US11524939B2 (en) 2019-11-13 2022-12-13 Akebia Therapeutics, Inc. Solid forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino} acetic acid

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1346350A (en) * 1970-07-24 1974-02-06 Hoffmann La Roche Cardenolides and bufadienolides and a process for the manu facture thereof
US3914213A (en) * 1972-11-04 1975-10-21 Hoechst Ag Cardenolido-3-{8 4{40 -amino-2{40 , 3{40 , 4{40 -tridesoxy-glycosides{9 {0 and process for their manufacture
DD142889A1 (en) * 1979-04-05 1980-07-16 Konrad Schwabe PROCESS FOR PREPARING ALPHA-L-ARABINOFURANOSIDES HERZWIRKSAMER CARDENOLIDSTEROIDE
WO2002014343A1 (en) * 2000-08-17 2002-02-21 Terness, Peter Bufadienolide derivatives and use as immunosuppressive, antiinflammatory and analgesic agents
WO2005060951A2 (en) * 2003-12-19 2005-07-07 Bionaut Pharmaceuticals, Inc. Anti-neoplastic agents, combination therapies and related methods
WO2006002381A1 (en) * 2004-06-24 2006-01-05 Wisconsin Alumni Research Foundation Neoglycorandomization and digitoxin analogs

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DE2013032C3 (en) * 1970-03-19 1978-12-07 Hoechst Ag, 6000 Frankfurt 3-Amino-cardenolide, process for their preparation and their use in combating cardiovascular diseases
US3901882A (en) * 1970-07-24 1975-08-26 Hoffmann La Roche 3-amino cardenolides and bufadienolides, derivatives and salts thereof
US20060009506A1 (en) * 2004-07-09 2006-01-12 Odyssey Thera, Inc. Drugs for the treatment of neoplastic disorders
WO2006029018A2 (en) * 2004-09-02 2006-03-16 Bionaut Pharmaceuticals, Inc. Combinatorial chemotherapy treatment using na+/k+-atpase inhibitors
WO2006028969A1 (en) * 2004-09-02 2006-03-16 Bionaut Pharmaceuticals, Inc. Pancreatic cancer treatment using na+/k+ atpase inhibitors
US20060135468A1 (en) * 2004-09-02 2006-06-22 Bionaut Pharmaceuticals, Inc. Treatment of refractory cancers using NA+/K+ ATPase inhibitors
US20080027010A1 (en) * 2004-09-02 2008-01-31 Bionaut Pharmaceuticals, Inc. Treatment of refractory cancers using Na+/K+-ATPase inhibitors
EP1812010A2 (en) * 2004-10-18 2007-08-01 BTG International Limited Use of na+/ k+-atpase inhibitors and antagonists thereof
US20110076278A1 (en) * 2005-08-02 2011-03-31 Mehran Khodadoust Modulators of Hypoxia Inducible Factor-1 and Related Uses for the Treatment of Ocular Disorders
GB0713463D0 (en) * 2007-07-11 2007-08-22 Btg Int Ltd Modulators of hypoxia inducible factor-1 and related uses

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1346350A (en) * 1970-07-24 1974-02-06 Hoffmann La Roche Cardenolides and bufadienolides and a process for the manu facture thereof
US3914213A (en) * 1972-11-04 1975-10-21 Hoechst Ag Cardenolido-3-{8 4{40 -amino-2{40 , 3{40 , 4{40 -tridesoxy-glycosides{9 {0 and process for their manufacture
DD142889A1 (en) * 1979-04-05 1980-07-16 Konrad Schwabe PROCESS FOR PREPARING ALPHA-L-ARABINOFURANOSIDES HERZWIRKSAMER CARDENOLIDSTEROIDE
WO2002014343A1 (en) * 2000-08-17 2002-02-21 Terness, Peter Bufadienolide derivatives and use as immunosuppressive, antiinflammatory and analgesic agents
WO2005060951A2 (en) * 2003-12-19 2005-07-07 Bionaut Pharmaceuticals, Inc. Anti-neoplastic agents, combination therapies and related methods
WO2006002381A1 (en) * 2004-06-24 2006-01-05 Wisconsin Alumni Research Foundation Neoglycorandomization and digitoxin analogs

Non-Patent Citations (9)

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Title
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Chem. Pharm. Bull., 1970, Vol.18(3), Saito et al., pp.629-631. *
Chem. Pharm. Bull., 1973, Vol.21(5), Shimada et al., pp.1031-1036. *
Chemistry of Natural Compounds, 2005, Vol.41(1), Makarevich et al., pp.52-55. *
Experientia, 1980, Vol.36(10), Monji et al., pp.1141-1143. *
Farmaco, Edizione Scientifica, 1981, Vol.36(11), Valcavi et al., pp.971-982. *
Helvetica Chimica Acta, 1955, Vol.38(6), Pataki et al., pp.1631-1649. *
Internal Immunopharmacology, 2001, Vol.1, Terness et al., pp.119-134. *
Pharmazie, 1995, Vol.50(10), Heber et al., pp.663-667. *

Also Published As

Publication number Publication date
JP2009522383A (en) 2009-06-11
WO2007081835A3 (en) 2008-08-14
EP1971618A2 (en) 2008-09-24
US20090023666A1 (en) 2009-01-22
CA2635370A1 (en) 2007-07-09
MX2008008608A (en) 2009-03-04
GB0812342D0 (en) 2008-08-13
CN101400690A (en) 2009-04-01
WO2007081835A2 (en) 2007-07-19
AU2007205092A1 (en) 2007-07-19
BRPI0706377A2 (en) 2011-03-22

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