GB2453341B - Methods of identifying modulators of an EHD family polypeptide - Google Patents

Methods of identifying modulators of an EHD family polypeptide

Info

Publication number
GB2453341B
GB2453341B GB0719252A GB0719252A GB2453341B GB 2453341 B GB2453341 B GB 2453341B GB 0719252 A GB0719252 A GB 0719252A GB 0719252 A GB0719252 A GB 0719252A GB 2453341 B GB2453341 B GB 2453341B
Authority
GB
United Kingdom
Prior art keywords
ehd
methods
family polypeptide
identifying modulators
modulators
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
GB0719252A
Other versions
GB0719252D0 (en
GB2453341A (en
Inventor
Harvey T Mcmahon
Gary J Doherty
Richard Lundmark
Oli Daumke
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medical Research Council
Original Assignee
Medical Research Council
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medical Research Council filed Critical Medical Research Council
Priority to GB0719252A priority Critical patent/GB2453341B/en
Publication of GB0719252D0 publication Critical patent/GB0719252D0/en
Priority to PCT/GB2008/003355 priority patent/WO2009044156A2/en
Priority to EP08806500A priority patent/EP2205756A2/en
Publication of GB2453341A publication Critical patent/GB2453341A/en
Application granted granted Critical
Publication of GB2453341B publication Critical patent/GB2453341B/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/42—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving phosphatase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/916—Hydrolases (3) acting on ester bonds (3.1), e.g. phosphatases (3.1.3), phospholipases C or phospholipases D (3.1.4)
GB0719252A 2007-10-03 2007-10-03 Methods of identifying modulators of an EHD family polypeptide Expired - Fee Related GB2453341B (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
GB0719252A GB2453341B (en) 2007-10-03 2007-10-03 Methods of identifying modulators of an EHD family polypeptide
PCT/GB2008/003355 WO2009044156A2 (en) 2007-10-03 2008-10-01 Methods of identifying modulators of an ehd polypeptide
EP08806500A EP2205756A2 (en) 2007-10-03 2008-10-01 Methods of identifying modulators of an ehd polypeptide

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB0719252A GB2453341B (en) 2007-10-03 2007-10-03 Methods of identifying modulators of an EHD family polypeptide

Publications (3)

Publication Number Publication Date
GB0719252D0 GB0719252D0 (en) 2007-11-14
GB2453341A GB2453341A (en) 2009-04-08
GB2453341B true GB2453341B (en) 2010-08-25

Family

ID=38739010

Family Applications (1)

Application Number Title Priority Date Filing Date
GB0719252A Expired - Fee Related GB2453341B (en) 2007-10-03 2007-10-03 Methods of identifying modulators of an EHD family polypeptide

Country Status (3)

Country Link
EP (1) EP2205756A2 (en)
GB (1) GB2453341B (en)
WO (1) WO2009044156A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102787122B (en) * 2012-06-21 2013-06-19 南京农业大学 Gene OsEHD4 for controlling paddy rice heading stage and mutant and application thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020115069A1 (en) * 1997-02-21 2002-08-22 Mia Horowitz Eh domain containing genes and proteins

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002367786A1 (en) * 2001-11-14 2003-11-10 Digital Gene Technologies, Inc. Regulation of gene expression by neuromodulators and discovery of a novel ngf-induced protein termed pincher
WO2007079581A1 (en) * 2006-01-09 2007-07-19 University Of Manitoba Prohibitin attenuates insulin-stimulated glucose and fatty acid oxidation in adipose tissue by inhibition of pyruvate carobxylase

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020115069A1 (en) * 1997-02-21 2002-08-22 Mia Horowitz Eh domain containing genes and proteins

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
J. Biol. Chem., Vol.280, 2005, Lee, D.-W. et al., "ATP binding regulates...", pp.17213-17220 *
Nature, Vol.449, 2007, Daumke, O. et al., "Architectural and mechanistic insights...", pp.923-929 *

Also Published As

Publication number Publication date
GB0719252D0 (en) 2007-11-14
GB2453341A (en) 2009-04-08
WO2009044156A3 (en) 2009-07-23
EP2205756A2 (en) 2010-07-14
WO2009044156A2 (en) 2009-04-09

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 20111003