GB2451608A - An isolated IL-12 molecule or chimeric molecules therof - Google Patents
An isolated IL-12 molecule or chimeric molecules therof Download PDFInfo
- Publication number
- GB2451608A GB2451608A GB0821715A GB0821715A GB2451608A GB 2451608 A GB2451608 A GB 2451608A GB 0821715 A GB0821715 A GB 0821715A GB 0821715 A GB0821715 A GB 0821715A GB 2451608 A GB2451608 A GB 2451608A
- Authority
- GB
- United Kingdom
- Prior art keywords
- isolated
- molecule
- therof
- present
- chimeric molecules
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 108010065805 Interleukin-12 Proteins 0.000 title abstract description 8
- 102000013462 Interleukin-12 Human genes 0.000 title abstract description 8
- 108090000623 proteins and genes Proteins 0.000 abstract description 2
- 235000016709 nutrition Nutrition 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 1
- 230000035764 nutrition Effects 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 230000000069 prophylactic effect Effects 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 229940117681 interleukin-12 Drugs 0.000 description 2
- 241000283690 Bos taurus Species 0.000 description 1
- 241000030939 Bubalus bubalis Species 0.000 description 1
- 108010017515 Interleukin-12 Receptors Proteins 0.000 description 1
- 102000004560 Interleukin-12 Receptors Human genes 0.000 description 1
- 108010002350 Interleukin-2 Proteins 0.000 description 1
- 230000004988 N-glycosylation Effects 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 210000003719 b-lymphocyte Anatomy 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229940022399 cancer vaccine Drugs 0.000 description 1
- 238000009566 cancer vaccine Methods 0.000 description 1
- 230000009260 cross reactivity Effects 0.000 description 1
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 230000001434 glomerular Effects 0.000 description 1
- 230000013595 glycosylation Effects 0.000 description 1
- 238000006206 glycosylation reaction Methods 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- 230000001323 posttranslational effect Effects 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5434—IL-12
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
The present invention relates generally to the fields of proteins, diagnostics, therapeutics and nutrition. More particularly, the present invention provides an isolated IL-12 molecule wherein the IL-12 or chimeric molecule thereof has a profile of measurable physiochemical parameters, wherein the profile is indicative of, associated with or forms the basis of one or more pharmacological traits. The present invention further contemplates the use of the isolated IL-12 or chimeric molecule thereof in a range of diagnostic, prophylactic, therapeutic, nutritional and/or research applications.
Description
GB 2451608 A continuation (56) cont THE JOURNAL OF IMMUNOLOGY, Vol. 164, 2000, Carra et al, Biosynthesis and posttranslational regulation of human IL-12' pages 4752 -4761 IMMUNOLOGICAL RESEARCH, Vol. 29, 2004, Cimino et al, Cancer vaccine development' pages 231 -240 THE JOURNAL OF GENE MEDICINE, Vol. 6, 2004, Ji et al, Synergistic anti-tumor effect of glycosylphosphatidylinositol-anchored IL-2 and IL-12', pages 777 -785 HAEMATOLOGICA, Vol. 87, 2002, Airoldi et al, The interleukin-12 and interleukin-12 receptor system in normal and transformed human b-lymphocytes' pages 434 -442 NATURE BIOTECHNOLOGY, Vol. 20, 2002, Ha et al, Engineering N-glycosylation mutations in IL-i 2 enhances sustained cytotoxic T lymphocyte responses for DNA immunisation', pages 381 -386 NEPHROLOGY DIALYSIS TRANSPLANTATION, Vol. 17, 2002, Kobayashi et al, lnterleukin-12 alters the physiocemical characteristics of serum and glomerular IgA and modifies glycosylation in a ddY mouse strain having high IgA levels', pages 2108-MOLECULAR IMMUNOLOGY, Vol. 43, 2006, Premraj et al, Buffalo (Bubalus bubalis) interleukin-12: Analysis of expression profiles and functional cross-reactivity with bovine system', pages 822 -829
(58) Field of Search by ISA:
Other: ONLINE: STN-CA, MEDLINE, WPIDS, BIOSIS
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2006902854A AU2006902854A0 (en) | 2006-05-26 | A molecule and chimeric molecules thereof | |
| PCT/AU2007/000710 WO2007137328A1 (en) | 2006-05-26 | 2007-05-24 | An isolated il-12 molecule or chimeric molecules thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| GB0821715D0 GB0821715D0 (en) | 2008-12-31 |
| GB2451608A true GB2451608A (en) | 2009-02-04 |
| GB2451608A8 GB2451608A8 (en) | 2009-02-18 |
Family
ID=38777990
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB0821715A Withdrawn GB2451608A (en) | 2006-05-26 | 2008-11-27 | An isolated IL-12 molecule or chimeric molecules therof |
Country Status (3)
| Country | Link |
|---|---|
| AU (1) | AU2007266306A1 (en) |
| GB (1) | GB2451608A (en) |
| WO (1) | WO2007137328A1 (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103267864A (en) * | 2013-05-22 | 2013-08-28 | 苏州市马尔泰新材料有限公司 | Application of kit for diagnosing oropharyngeal cancer |
| CN104807998B (en) * | 2015-05-12 | 2017-01-11 | 先思达（南京）生物科技有限公司 | Diagnostic kit for early liver cancer and use method thereof |
| EP3478321A4 (en) | 2016-06-30 | 2020-04-22 | Oncorus, Inc. | Pseudotyped oncolytic viral delivery of therapeutic polypeptides |
| EP3731850A4 (en) | 2017-12-29 | 2021-12-01 | Oncorus, Inc. | Oncolytic viral delivery of therapeutic polypeptides |
| WO2022150379A1 (en) * | 2021-01-08 | 2022-07-14 | Regents Of The University Of Minnesota | Nk cell engager molecules and methods of use |
| CN116535491B (en) * | 2022-05-06 | 2024-03-22 | 珠海丽凡达生物技术有限公司 | Therapeutic nucleic acid molecules, mixtures, medicaments and their use in the treatment of solid tumors |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001068802A2 (en) * | 2000-03-15 | 2001-09-20 | Pohang University Of Science And Technology | Genes of il-12p40 subunit mutated for improving the activity of il-12 and use thereof for dna vaccine adjuvant |
| WO2002012500A2 (en) * | 2000-08-07 | 2002-02-14 | Centocor, Inc. | Anti-il-12 antibodies, compositions, methods and uses |
| WO2002097048A2 (en) * | 2001-05-30 | 2002-12-05 | Centocor, Inc. | ANTI-p40 IMMUNOGLOBULIN DERIVED PROTEINS, COMPOSITIONS, METHODS AND USES |
-
2007
- 2007-05-24 WO PCT/AU2007/000710 patent/WO2007137328A1/en active Application Filing
- 2007-05-24 AU AU2007266306A patent/AU2007266306A1/en not_active Abandoned
-
2008
- 2008-11-27 GB GB0821715A patent/GB2451608A/en not_active Withdrawn
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001068802A2 (en) * | 2000-03-15 | 2001-09-20 | Pohang University Of Science And Technology | Genes of il-12p40 subunit mutated for improving the activity of il-12 and use thereof for dna vaccine adjuvant |
| WO2002012500A2 (en) * | 2000-08-07 | 2002-02-14 | Centocor, Inc. | Anti-il-12 antibodies, compositions, methods and uses |
| WO2002097048A2 (en) * | 2001-05-30 | 2002-12-05 | Centocor, Inc. | ANTI-p40 IMMUNOGLOBULIN DERIVED PROTEINS, COMPOSITIONS, METHODS AND USES |
Non-Patent Citations (12)
Also Published As
| Publication number | Publication date |
|---|---|
| WO2007137328A1 (en) | 2007-12-06 |
| GB0821715D0 (en) | 2008-12-31 |
| AU2007266306A1 (en) | 2007-12-06 |
| GB2451608A8 (en) | 2009-02-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| WAP | Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1) |