GB2445617A - Process for producing preparing sulfonyl ethers from sulfonic acids - Google Patents
Process for producing preparing sulfonyl ethers from sulfonic acids Download PDFInfo
- Publication number
- GB2445617A GB2445617A GB0700515A GB0700515A GB2445617A GB 2445617 A GB2445617 A GB 2445617A GB 0700515 A GB0700515 A GB 0700515A GB 0700515 A GB0700515 A GB 0700515A GB 2445617 A GB2445617 A GB 2445617A
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- Prior art keywords
- substituted
- unsubstituted
- ether
- sulfonyl
- sulfonyl ether
- Prior art date
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- AKEJUJNQAAGONA-UHFFFAOYSA-N sulfur trioxide Chemical class O=S(=O)=O AKEJUJNQAAGONA-UHFFFAOYSA-N 0.000 title claims abstract description 42
- 238000000034 method Methods 0.000 title claims abstract description 20
- 150000003460 sulfonic acids Chemical class 0.000 title 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims abstract description 15
- 239000000047 product Substances 0.000 claims abstract description 15
- UHZZMRAGKVHANO-UHFFFAOYSA-M chlormequat chloride Chemical compound [Cl-].C[N+](C)(C)CCCl UHZZMRAGKVHANO-UHFFFAOYSA-M 0.000 claims abstract description 14
- 238000005292 vacuum distillation Methods 0.000 claims abstract description 14
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims abstract description 13
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims abstract description 10
- 125000005842 heteroatom Chemical group 0.000 claims abstract description 9
- DIORMHZUUKOISG-UHFFFAOYSA-N sulfoformic acid Chemical compound OC(=O)S(O)(=O)=O DIORMHZUUKOISG-UHFFFAOYSA-N 0.000 claims abstract description 9
- 239000007795 chemical reaction product Substances 0.000 claims abstract description 8
- BGJSXRVXTHVRSN-UHFFFAOYSA-N 1,3,5-trioxane Chemical compound C1OCOCO1 BGJSXRVXTHVRSN-UHFFFAOYSA-N 0.000 claims abstract description 6
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 claims abstract description 5
- 150000008064 anhydrides Chemical class 0.000 claims abstract description 5
- 229940098779 methanesulfonic acid Drugs 0.000 claims abstract description 5
- BEXNDOLMPZMPPY-UHFFFAOYSA-N methylsulfonyl(methylsulfonylmethoxy)methane Chemical group CS(=O)(=O)COCS(C)(=O)=O BEXNDOLMPZMPPY-UHFFFAOYSA-N 0.000 claims abstract description 4
- 125000001033 ether group Chemical group 0.000 claims abstract description 3
- ZYKVCFGIFGTEPR-UHFFFAOYSA-M 2-oxopropane-1-sulfonate Chemical group CC(=O)CS([O-])(=O)=O ZYKVCFGIFGTEPR-UHFFFAOYSA-M 0.000 claims abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 14
- 125000000217 alkyl group Chemical group 0.000 claims description 10
- 125000003545 alkoxy group Chemical group 0.000 claims description 9
- 229910052757 nitrogen Inorganic materials 0.000 claims description 7
- 239000002904 solvent Substances 0.000 claims description 6
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 5
- 239000005864 Sulphur Substances 0.000 claims description 5
- 125000001769 aryl amino group Chemical group 0.000 claims description 5
- 125000004104 aryloxy group Chemical group 0.000 claims description 5
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 5
- 125000001188 haloalkyl group Chemical group 0.000 claims description 5
- 125000001072 heteroaryl group Chemical group 0.000 claims description 5
- 125000005241 heteroarylamino group Chemical group 0.000 claims description 5
- 239000001257 hydrogen Substances 0.000 claims description 5
- 229910052739 hydrogen Inorganic materials 0.000 claims description 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 5
- 239000001301 oxygen Chemical group 0.000 claims description 5
- 229910052760 oxygen Chemical group 0.000 claims description 5
- 125000003282 alkyl amino group Chemical group 0.000 claims description 4
- 239000012296 anti-solvent Substances 0.000 claims description 4
- 125000006310 cycloalkyl amino group Chemical group 0.000 claims description 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 4
- 150000001924 cycloalkanes Chemical class 0.000 abstract 1
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 description 13
- 238000003786 synthesis reaction Methods 0.000 description 12
- 230000015572 biosynthetic process Effects 0.000 description 10
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 8
- 239000000203 mixture Substances 0.000 description 5
- ZAFNJMIOTHYJRJ-UHFFFAOYSA-N Diisopropyl ether Chemical compound CC(C)OC(C)C ZAFNJMIOTHYJRJ-UHFFFAOYSA-N 0.000 description 4
- XTHFKEDIFFGKHM-UHFFFAOYSA-N Dimethoxyethane Chemical compound COCCOC XTHFKEDIFFGKHM-UHFFFAOYSA-N 0.000 description 4
- KOJRFUPYYSJFCF-UHFFFAOYSA-N acetyloxymethanesulfonic acid Chemical compound CC(=O)OCS(O)(=O)=O KOJRFUPYYSJFCF-UHFFFAOYSA-N 0.000 description 4
- 239000013078 crystal Substances 0.000 description 4
- 239000002002 slurry Substances 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 238000002425 crystallisation Methods 0.000 description 3
- 150000002170 ethers Chemical class 0.000 description 3
- 239000012535 impurity Substances 0.000 description 3
- 230000037361 pathway Effects 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 2
- 108010010803 Gelatin Proteins 0.000 description 2
- 230000002411 adverse Effects 0.000 description 2
- 230000008025 crystallization Effects 0.000 description 2
- 108010037444 diisopropylglutathione ester Proteins 0.000 description 2
- 229920000159 gelatin Polymers 0.000 description 2
- 239000008273 gelatin Substances 0.000 description 2
- 235000019322 gelatine Nutrition 0.000 description 2
- 235000011852 gelatine desserts Nutrition 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000004848 polyfunctional curative Substances 0.000 description 2
- 230000037452 priming Effects 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 description 2
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 2
- UYVWNPAMKCDKRB-UHFFFAOYSA-N 1,2,4,5-tetraoxane Chemical compound C1OOCOO1 UYVWNPAMKCDKRB-UHFFFAOYSA-N 0.000 description 1
- LCGLNKUTAGEVQW-UHFFFAOYSA-N Dimethyl ether Chemical class COC LCGLNKUTAGEVQW-UHFFFAOYSA-N 0.000 description 1
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 1
- BPGDAMSIGCZZLK-UHFFFAOYSA-N acetyloxymethyl acetate Chemical compound CC(=O)OCOC(C)=O BPGDAMSIGCZZLK-UHFFFAOYSA-N 0.000 description 1
- 239000000729 antidote Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000012043 crude product Substances 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 235000019256 formaldehyde Nutrition 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- SMQSMQUBQPWGAO-UHFFFAOYSA-N methylsulfonyl acetate Chemical compound CC(=O)OS(C)(=O)=O SMQSMQUBQPWGAO-UHFFFAOYSA-N 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- UOULCEYHQNCFFH-UHFFFAOYSA-M sodium;hydroxymethanesulfonate Chemical compound [Na+].OCS([O-])(=O)=O UOULCEYHQNCFFH-UHFFFAOYSA-M 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- -1 sulfonic acids Sulfonyl ethers Chemical class 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
- C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C309/07—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing oxygen atoms bound to the carbon skeleton
- C07C309/09—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing oxygen atoms bound to the carbon skeleton containing etherified hydroxy groups bound to the carbon skeleton
- C07C309/10—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing oxygen atoms bound to the carbon skeleton containing etherified hydroxy groups bound to the carbon skeleton with the oxygen atom of at least one of the etherified hydroxy groups further bound to an acyclic carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/12—Preparation of carboxylic acid esters from asymmetrical anhydrides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
A method of preparing a sulfonyl ether comprising the steps of: <SL> <LI>i) reacting a sulfonic acid with an anhydride, under continuous vacuum distillation conditions, to form a carboxysulfonate; <LI>ii) reacting the carboxysulfonate with an optionally substituted cycloalkane ring containing at least 3 heteroatoms to form a sulfonyl ether pre-mix comprising a sulfonyl ether and at least two additional reaction products each containing at least one ether linkage; <LI>iii) subjecting the pre-mix to continuous vacuum distillation conditions to remove at least some of the additional reaction products from the sulfonyl ether pre-mix to provide a crude sulfonyl ether product; and <LI>iv) purifying the crude sulfonyl ether product. </SL> The preferred sulfonic acid is a methanesulfonic acid and the preferred sulfonyl ether is bis(methanesulfonylmethyl)ether (BSME). The preferred carboxysulfonate is acetyl methane sulfonate (AMS). The preferred cycloalkane comprising three hetero atoms is trioxane.
Description
Synthesis This invention relates to a process for synthesising sulfonyl
ethers More particularly, this invention relates to a process of synthesizing sulfonyl ethers from sulfonic acids Sulfonyl ethers have numerous applications and are employed in the synthesis of compounds for use in a wide range of technical fields. For example, as confirmed in Japanese Patent Nos. 03-178958, 03-178959, 03-123768 and 03- 123769, sulfonyl ethers may be used in the synthesis of methyl ether derivatives which are useful in the field of photography as gelatin membrane hardeners, development accelerators and chemical sens:t:zcrs Thc use of sulfony! ethers as photographic gelatin hardeners is also disclosed in US 4100200 Additionally, as disclosed in UK Patent Application No 0616865.2, sulfonyl ethers may be used in the synthesis of HI 6, a bis-pyridinium oxime antidote to certain organophosphate nerve agents As a result of the utility of suffonyl ethers in the synthesis of a wide range of compounds, numerous synthetic pathways for sulfonyl ethers have been proposed For example, in US Patent No 4100200 and in Burness, Wright and Perkins, J. Org Che,n 1977, 42, 2910, a synthesis of bts(methylsulfonoxymethyl) ether is disclosed in which acetyl methylsulfonate is reacted with trioxane to form bis(methylsulfonoxymethyi) ether which was then purified.
Further examples of syntheses of sulfonyl ethers are provided in Japanese Patent Nos. 03-178958, 03-178959, 03-123768 and 03-123769 In each of those patents, pathways for producing sulfonyl ethers from acetoxymethanesulfonate are disclosed.
While the synthetic pathways disclosed in the above-mentioned documents result in sulfonyl ethers of acceptable purity for use in the field of photography, in other fields, the purity requirement will be higher. It would therefore be desirable to provide a synthesis of high purity sulfonyl ethers Thus, according to a first aspect of the present invention, there is provided a method of preparing a sulfonyl ether comprising the steps of i) reacting a sulfonic acid with an anhydride, under continuous vacuum distillation conditions, to form a carboxysulfonate, ii) reacting the carboxysulfonate with an optionally substituted cycloalkane ring containing at least 3 heteroatoms to form a sulfonyl ether pre-mix comprising a sulfonyl ether and at least two additional reaction products each containing at least one ether linkage; iii) subjecting the pre-mix to continuous vacuum distillation conditions to remove at least some of the additional reaction products from the sulfonyl ether pre-mix to provide a crude sulfonyl ether product; and iv) purifying the crude sulfonyl ether product.
Using this process, sulfonyl ether products having a purity of greater than 97% have been obtained It will be understood by those skilled in the art that such high purity products may be used in the synthesis of a wider range of compounds than the sulfonyl ethers prepared according to the prior art methods discussed above In preferred embodiments, the sulfonic acid has the formula.
R1-S-OH wherein R1 is selected from the group consisting of hydrogen, substituted and unsubstituted branched and straight-chain alkyl, alkoxy, haloalkyl, alkoxylated alkyl, alkoxylated alkoxy, alkylamino, substituted and unsubstituted cycloalkyl, substituted and unsubstituted cycloalkylamino, substituted and unsubstituted carbocyclic aryl, substituted and unsubstituted carbocylic aryloxy, substituted and unsubstitufed heteroaryl, substituted and unsubstituted carbocylic arylamino and substituted and unsubstituted heteroarylamino, wherein the or each heteroatom is independently selected from sulphur, nitrogen and oxygen In a most preferred embodiment, R1 is alkyl, more preferably methyl In a preferred embodiment the anhydride has the formula R2OR2 wherein R2 are the same or different and are selected from the group consisting of hydrogen, substituted and unsubstituted branched and straight-chain alkyl, alkoxy, haloalkyl, alkoxylated alkyl, alkoxylated alkoxy, alkylamino, substituted and unsubstituted cycloalkyl, substituted and unsubstituted cycloalkylamino, substituted and unsubstituted carbocyclic aryl, substituted and unsubstituted carbocylic aryloxy, substituted and unsubstituted heteroaryl, substituted and unsubstituted carbocylic arylamino and substituted and unsubstituted heteroarylamino, wherein the or each heteroatom is independently selected from sulphur, nitrogen and oxygen In the most preferred embodiment, R2 is alky, more preferably methyl.
Preferably, the carboxysulfonate has the formula:
R H0 2
wherein R1 and R2 are as identified above The optionally substituted cycloalkane ring may take any form provided that it does not adversely affect the purity of the final sulfonyl ether The cycloalkane ring is preferably 4 to 10 membered. The cycloalkane ring may be substituted with any substituent selected from the group consisting of hydrogen, substituted and unsubstituted branched and straight-chain alkyl, alkoxy, haloalkyl, dikaxylated aikyl, alkoxyted aikoxy, alkyiduhirlo, substituted dnd unsubstituted cycloalkyl, substituted and unsubstituted cycloalkylamino, substituted and unsubstituted carbocyclic aryl, substituted and unsubstituted carbocylic aryloxy, substituted and unsubstituted heteroaryl, substituted and unsubstituted carbocylic arylamino and substituted and unsubstituted heteroarylamino, wherein the or each heteroatom is independently selected from sulphur, nitrogen and oxygen However, it is especially preferred that the cycloalkane ring is unsubstituted. For example, the cycloalkane ring may be trioxane or tetraoxane In a most preferred embodiment, the cycloalkane ring is trioxane In a preferred embodiment, the sulfonyl ether has the formula: 1? ii R1 S R1 0 0 wherein R1 is as identified above Most preferably, the sulfonyl ether is bis(methanesulfonylmethyl)ether The pre-mix includes at least two reaction products besides the sulfonyl ether, which each contain at least one ether linkage The most likely additional reaction products which will be included in the pre-mix will have the formula: OO R2 R O R
S
wherein R2 is as identified above.
These additional products are removed using continuous vacuum distillation conditions and may be discarded or utilized in other syntheses.
The continuous vacuum distillation conditions used in steps i) and I or iii) may be provided using any apparatus known in the art which does not adversely affect the purity of the final sulfonyl ether product However, in preferred embodiments, the continuous vacuum distillation conditions are provided using wiped film evaporator apparatus.
The crude sulfonyl ether product may be purified in any way. Preferably, a solvent / anti-solvent combination is employed For example, the solvent / anti-solvent combination may be applied to the crude product to separate the sulfonyl ether product from impurities The sulfonyl ether product could then be subjected to low temperature conditions to yield sulfonyl ether crystals which could then be filtered off, leaving the solvent and any other impurities. Additionally, the sulfonyl ether crystals could be washed to remove any adhered solvent / impurity In a particularly preferred embodiment, the crude sulfonyl ether product is charged to 1,2-dimethoxyethane (1 lwt) at ambient temperature To this a solvent I anti-solvent combination, for example a mixture of diisopropyl ether (i.Owt) & tetrahydrofuran (0 O6wt), may be charged whiie maintaining the temperature at 10 to 15 C Seed crystals may be added and crystallization occurs in this temperature range The resulting slurry is cooled to 0-5 C and stirred, preferably for at least an hour It is then filtered and rinsed with, for example, DIPE/THF mixture (2x1.Owt). The slurry is then filtered again, in a pressure (PALL) filter and is not exposed to air/moisture The resulting cake is dried under a nitrogen stream.
The invention will now be more particularly described with reference to the
following example
Example I
Synthesis of bis (met hanesulfonylmethyl) ether from the reaction of acetoxymethanesulfonate with tnoxane utilising continuous vacuum distillation Step 1 Synthesis of Acetoxymethanesulfonate (AMS) o o 0 0 0 0 S-C H + conbnuousd istiilation \O + OH t 0 0 removed by distiiIaton acetoxymethanesulfonate (AMS) To acetic anhydride (AA) (1751 g, 17 1 mols, 3 mol equiv) in a flask is added methanesulfonic acid (MSA) (550 g, 5 7 mols, 1 mol equiv) with stirring The resulting yeliow solution is suited for 20-30 miii The material is then pumped into an apparatus suitable for continuous vacuum distillation (wiped film evaporator 2 inch [5 cm] column diameter, flow rate, 9.9 mI/mm). After appropriate priming of the apparatus distillate (1546 g) and residue (713 g) are collected The residue is analysed by 1H nmr (wlw%) 93.6 AMS, 4 0 MSA, 1 4 AA, 0.6 AcOH Step 2 Reaction of crude AMS with tnoxane o o + . rMSOOOMS + AcO0Ac mixed ethersl o BSME pre-mix To crude AMS (710 g, 4.83 mol AMS) with good stirring was added solid trioxane (222 3 g, 2 47 mol, 0 5 mol equiv relative to AMS + AA) at such a rate to maintain a temperature of 60-65 C At the end of the addition the reaction rn,xture was stirred for approximately 2 h at 60 C Analysis of this material by 1H nmr revealed it to be a complex mixture of mixed sulfonyl and acetyl ethers, methylene diacetate and product bis(methanesulfonylmethyl)ether BSME Step 3 Continuous vacuum distillation of the BSME pre-mix from step 2 n---r---np + Ar(I OAr BSME pre-mix -.* crude BSME oil removed by distillation The crude BSME pre-mix liquid (932.6 g) is pumped into an apparatus suitable for continuous vacuum distillation (wiped film evaporator 2 inch [5 cm] column diameter, flow rate, 9 9 mI/mm) After appropriate priming of the apparatus distillate is collected (270 g) and residue (573 g) The residue is analysed by 1H nmr (w/w%) 62 6 BSME.
Step 4 Crystallization/purification of BSME MsOOOMs crystaIhsationfsoiation MsOOOMs crude BSME oil bis(methanesulfonyimethyl)ether BSME Crude BSME (345g, 626 %w/w) is charged to 1,2-dimethoxyethane (385g) at ambient temperature To this a mixture of diisopropyl ether (361g) and tetrahydrofuran (19g) are carefully charged whilst maintaining the temperature at 10-15 C Some BSME seed crystals are added and crystallisation occurs in this temp range The slurry is cooled to 0-5 C and stirred for another hour, filtered and rinsed with DIPE/THF mixture (2x340g) The slurry is filtered in a pressure (PALL) filter and is not exposed to air/moisture The pale brown cake (165g) is dried under nitrogen stream ready for the next step of the process nmr CDCI3 553 CH2O (4H), 3.13 OS(O)2CH3(6H)
Claims (1)
1 A method of preparing a sulfonyl ether comprising the steps of.
i) reacting a sulfonic acid with an anhydride, under continuous vacuum distillation conditions, to form a carboxysulfonate; ii) reacting the carboxysulfonate with an optionally substituted cycloalkane ring containing at least 3 heteroatoms to form a sulfonyl ether pre-mix comprising a sulfonyl ether and at least two additional reaction products each containing at least one ether linkage, iii) subjecting the pre-mix to continuous vacuum distillation conditions to remove at least some of the additional reaction products from the fri n ii,i+ ke, r n rn rn iv fri nm, rl r, .-i-i rI I tu r I I Ifru ruu ii,+k ni r n rrurl i p nI n in I Ji iy I u.. LI IL I JI L.I I IA LIJ Li V Ii..1L (A i..tI LILIL. ..LII I LII iy I L. LI IL.I JI 4L1L.L, CU ILl v) purifying the crude sulfonyl ether product 2. The process of Claim 1 wherein the methanesulfonic acid has the formula R1-S-------OH wherein R1 is selected from the group consisting of hydrogen, substituted and unsubstituted branched and straight-chain alkyl, alkoxy, haloalkyl, alkoxylated alkyl, alkoxylated alkoxy, alkylamino, substituted and unsubstituted cycloalkyl, substituted and unsubstituted cycloalkylamino, substituted and unsubstituted carbocyclic aryl, substituted and unsubstituted carbocylic aryloxy, substituted and unsubstituted heteroaryl, substituted and unsubstituted carbocylic arylamino and I () substituted and unsubstituted heteroarylamino, wherein the or each heteroatom is independently selected from sulphur, nitrogen and oxygen.
3 The process of Claim 2 wherein R1 is methyl.
4 The process of any one of Claims 1 to 3, wherein the anhydride has the formula R2 R2 wherein R2 are the same or different and are selected from the group consisting of hydrogen, substituted and unsubstituted branched and straight-chain alkyl, alkoxy, haloalkyl, alkoxylated alkyl, alkoxylated alkoxy, alkylamino, substituted and unsubstituted cycloalkyl, substituted and unsubstituted cycloalkylamtno, substituted and unsubstituted carbocyclic aryl, substituted and unsubstituted carbocylic aryloxy, substituted and unsubstituted heteroaryl, substituted and unsubstituted carbocylic arylamino and substituted and unsubstituted heteroarylamino, wherein the or each heteroatom is independently selected from sulphur, nitrogen and oxygen The process of Claim 3 wherein R2 is methyl.
6 The process of any one of Claims 1 to 5, wheiein the carboxysuifonate has the formula. R2
7 The process of Claim 6 wherein the carboxysulfonate is acetyl methane sulfonate 8 The process of Claims 1 to 7 wherein the cycloalkane ring is trioxane 9. The process of any one of Claims 1 to 8, wherein the sulfonyl ether has the formula.
R1 o o S-R1 The process of any one of Claims 1 to 9 wherein the sulfonyl ether is bis(methanesulfonylmethyl)ether.
11 The process of any one of Claims 1 to 10 wherein the continuous vacuum distillation conditions used in steps i) and I or iii) are provided using wiped film evaporator apparatus.
12 The process of any one of Claims 1 to 11 wherein the crude sulfonyl ether product is purified in step iv) using a solvent / anti-solvent combination
Priority Applications (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0700515.0A GB2445617B (en) | 2007-01-11 | 2007-01-11 | Improved synthesis for the preparation of sulfonyl ethers |
| PCT/EP2008/050152 WO2008084048A1 (en) | 2007-01-11 | 2008-01-08 | Synthesis |
| EP08701318A EP2121587A1 (en) | 2007-01-11 | 2008-01-08 | Synthesis |
| US12/522,899 US20100094038A1 (en) | 2007-01-11 | 2008-01-08 | Synthesis |
| CNA2008800020582A CN101610994A (en) | 2007-01-11 | 2008-01-08 | Synthesize two (alkylsulfonyl) ethers from sulfonic acid via the corresponding carboxylic acid sulphonic acid anhydride |
| CA002674873A CA2674873A1 (en) | 2007-01-11 | 2008-01-08 | Synthesis of a bis (sulfonyl) ether from sulfonic acid via the corresponding carboxysulfonate |
| AU2008204534A AU2008204534B2 (en) | 2007-01-11 | 2008-01-08 | Synthesis |
| JP2009545169A JP2010515703A (en) | 2007-01-11 | 2008-01-08 | Synthesis method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0700515.0A GB2445617B (en) | 2007-01-11 | 2007-01-11 | Improved synthesis for the preparation of sulfonyl ethers |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| GB0700515D0 GB0700515D0 (en) | 2007-02-21 |
| GB2445617A true GB2445617A (en) | 2008-07-16 |
| GB2445617B GB2445617B (en) | 2012-02-15 |
Family
ID=37809789
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB0700515.0A Expired - Fee Related GB2445617B (en) | 2007-01-11 | 2007-01-11 | Improved synthesis for the preparation of sulfonyl ethers |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20100094038A1 (en) |
| EP (1) | EP2121587A1 (en) |
| JP (1) | JP2010515703A (en) |
| CN (1) | CN101610994A (en) |
| AU (1) | AU2008204534B2 (en) |
| CA (1) | CA2674873A1 (en) |
| GB (1) | GB2445617B (en) |
| WO (1) | WO2008084048A1 (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4100200A (en) * | 1975-07-21 | 1978-07-11 | Eastman Kodak Company | Use of novel ethers as oxydimethylating agents |
| US5130438A (en) * | 1985-11-20 | 1992-07-14 | The United States Of America As Represented By The Secretary Of The Army | Bis-methylene ether pyridinium compound preparation |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4008271A (en) * | 1974-03-18 | 1977-02-15 | Ethyl Corporation | Process for preparing a mixed anhydride of a sulfonic acid and a carboxylic acid |
| JPH03123768A (en) | 1989-10-06 | 1991-05-27 | Konica Corp | Production of bisalkylsofonoxymethyl ethers or bisarylsulfonoxymethyl ethers |
| JPH03123769A (en) | 1989-10-06 | 1991-05-27 | Konica Corp | Production of bismethylsulfonoxymethyl ether |
| JPH03178958A (en) | 1989-12-07 | 1991-08-02 | Konica Corp | Production of bisalkylsulfonoxymethyl ethers or bisarylsulfonoxymethyl ethers |
| JPH03178959A (en) | 1989-12-07 | 1991-08-02 | Konica Corp | Production of bisalkylsulfonomethyl ethers or bisarylsulfonoxymethyl ethers |
-
2007
- 2007-01-11 GB GB0700515.0A patent/GB2445617B/en not_active Expired - Fee Related
-
2008
- 2008-01-08 AU AU2008204534A patent/AU2008204534B2/en not_active Ceased
- 2008-01-08 CA CA002674873A patent/CA2674873A1/en not_active Abandoned
- 2008-01-08 CN CNA2008800020582A patent/CN101610994A/en active Pending
- 2008-01-08 US US12/522,899 patent/US20100094038A1/en not_active Abandoned
- 2008-01-08 EP EP08701318A patent/EP2121587A1/en not_active Withdrawn
- 2008-01-08 JP JP2009545169A patent/JP2010515703A/en not_active Withdrawn
- 2008-01-08 WO PCT/EP2008/050152 patent/WO2008084048A1/en active Application Filing
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4100200A (en) * | 1975-07-21 | 1978-07-11 | Eastman Kodak Company | Use of novel ethers as oxydimethylating agents |
| US5130438A (en) * | 1985-11-20 | 1992-07-14 | The United States Of America As Represented By The Secretary Of The Army | Bis-methylene ether pyridinium compound preparation |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2121587A1 (en) | 2009-11-25 |
| WO2008084048A1 (en) | 2008-07-17 |
| AU2008204534A1 (en) | 2008-07-17 |
| CN101610994A (en) | 2009-12-23 |
| JP2010515703A (en) | 2010-05-13 |
| GB2445617B (en) | 2012-02-15 |
| AU2008204534B2 (en) | 2012-06-21 |
| US20100094038A1 (en) | 2010-04-15 |
| GB0700515D0 (en) | 2007-02-21 |
| CA2674873A1 (en) | 2008-07-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PCNP | Patent ceased through non-payment of renewal fee |
Effective date: 20130111 |