GB2443625A - Lactic acid polymer - Google Patents
Lactic acid polymer Download PDFInfo
- Publication number
- GB2443625A GB2443625A GB0622263A GB0622263A GB2443625A GB 2443625 A GB2443625 A GB 2443625A GB 0622263 A GB0622263 A GB 0622263A GB 0622263 A GB0622263 A GB 0622263A GB 2443625 A GB2443625 A GB 2443625A
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- United Kingdom
- Prior art keywords
- polymer
- acid
- weight
- lactic acid
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- 229920000642 polymer Polymers 0.000 title claims abstract description 66
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 title claims abstract description 65
- 239000004310 lactic acid Substances 0.000 title claims abstract description 29
- 235000014655 lactic acid Nutrition 0.000 title claims abstract description 29
- 239000002253 acid Substances 0.000 claims abstract description 39
- KLDXJTOLSGUMSJ-JGWLITMVSA-N Isosorbide Chemical compound O[C@@H]1CO[C@@H]2[C@@H](O)CO[C@@H]21 KLDXJTOLSGUMSJ-JGWLITMVSA-N 0.000 claims abstract description 17
- 229960002479 isosorbide Drugs 0.000 claims abstract description 15
- JJTUDXZGHPGLLC-UHFFFAOYSA-N lactide Chemical compound CC1OC(=O)C(C)OC1=O JJTUDXZGHPGLLC-UHFFFAOYSA-N 0.000 claims abstract description 8
- 150000008064 anhydrides Chemical class 0.000 claims description 13
- 150000001875 compounds Chemical class 0.000 claims description 7
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 6
- 229920000747 poly(lactic acid) Polymers 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 5
- 229920000728 polyester Polymers 0.000 claims description 4
- 229920001577 copolymer Polymers 0.000 claims description 3
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims description 3
- 239000011976 maleic acid Substances 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 3
- 230000009477 glass transition Effects 0.000 abstract description 8
- 238000010438 heat treatment Methods 0.000 description 9
- 238000006243 chemical reaction Methods 0.000 description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- 238000000113 differential scanning calorimetry Methods 0.000 description 6
- 239000003054 catalyst Substances 0.000 description 5
- 239000000178 monomer Substances 0.000 description 5
- 150000007513 acids Chemical class 0.000 description 4
- JVTAAEKCZFNVCJ-REOHCLBHSA-N L-lactic acid Chemical compound C[C@H](O)C(O)=O JVTAAEKCZFNVCJ-REOHCLBHSA-N 0.000 description 3
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
- USIUVYZYUHIAEV-UHFFFAOYSA-N diphenyl ether Chemical compound C=1C=CC=CC=1OC1=CC=CC=C1 USIUVYZYUHIAEV-UHFFFAOYSA-N 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- -1 polyethylene terephthalate Polymers 0.000 description 3
- WXUAQHNMJWJLTG-UHFFFAOYSA-N 2-methylbutanedioic acid Chemical compound OC(=O)C(C)CC(O)=O WXUAQHNMJWJLTG-UHFFFAOYSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 description 2
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 2
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 description 2
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 2
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 229910052787 antimony Inorganic materials 0.000 description 2
- WATWJIUSRGPENY-UHFFFAOYSA-N antimony atom Chemical compound [Sb] WATWJIUSRGPENY-UHFFFAOYSA-N 0.000 description 2
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 239000010941 cobalt Substances 0.000 description 2
- 229910017052 cobalt Inorganic materials 0.000 description 2
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 description 2
- 238000000354 decomposition reaction Methods 0.000 description 2
- 238000006731 degradation reaction Methods 0.000 description 2
- SNRUBQQJIBEYMU-UHFFFAOYSA-N dodecane Chemical compound CCCCCCCCCCCC SNRUBQQJIBEYMU-UHFFFAOYSA-N 0.000 description 2
- 229910052732 germanium Inorganic materials 0.000 description 2
- GNPVGFCGXDBREM-UHFFFAOYSA-N germanium atom Chemical compound [Ge] GNPVGFCGXDBREM-UHFFFAOYSA-N 0.000 description 2
- 238000010348 incorporation Methods 0.000 description 2
- 239000011572 manganese Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- 238000004806 packaging method and process Methods 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 239000004626 polylactic acid Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 230000010512 thermal transition Effects 0.000 description 2
- 229910052718 tin Inorganic materials 0.000 description 2
- 239000010936 titanium Substances 0.000 description 2
- 229910052719 titanium Inorganic materials 0.000 description 2
- GGAUUQHSCNMCAU-ZXZARUISSA-N (2s,3r)-butane-1,2,3,4-tetracarboxylic acid Chemical compound OC(=O)C[C@H](C(O)=O)[C@H](C(O)=O)CC(O)=O GGAUUQHSCNMCAU-ZXZARUISSA-N 0.000 description 1
- RYSXWUYLAWPLES-MTOQALJVSA-N (Z)-4-hydroxypent-3-en-2-one titanium Chemical compound [Ti].C\C(O)=C\C(C)=O.C\C(O)=C\C(C)=O.C\C(O)=C\C(C)=O.C\C(O)=C\C(C)=O RYSXWUYLAWPLES-MTOQALJVSA-N 0.000 description 1
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 1
- RTBFRGCFXZNCOE-UHFFFAOYSA-N 1-methylsulfonylpiperidin-4-one Chemical compound CS(=O)(=O)N1CCC(=O)CC1 RTBFRGCFXZNCOE-UHFFFAOYSA-N 0.000 description 1
- FALRKNHUBBKYCC-UHFFFAOYSA-N 2-(chloromethyl)pyridine-3-carbonitrile Chemical compound ClCC1=NC=CC=C1C#N FALRKNHUBBKYCC-UHFFFAOYSA-N 0.000 description 1
- RLHGFJMGWQXPBW-UHFFFAOYSA-N 2-hydroxy-3-(1h-imidazol-5-ylmethyl)benzamide Chemical compound NC(=O)C1=CC=CC(CC=2NC=NC=2)=C1O RLHGFJMGWQXPBW-UHFFFAOYSA-N 0.000 description 1
- NYHNVHGFPZAZGA-UHFFFAOYSA-N 2-hydroxyhexanoic acid Chemical compound CCCCC(O)C(O)=O NYHNVHGFPZAZGA-UHFFFAOYSA-N 0.000 description 1
- SJZRECIVHVDYJC-UHFFFAOYSA-N 4-hydroxybutyric acid Chemical compound OCCCC(O)=O SJZRECIVHVDYJC-UHFFFAOYSA-N 0.000 description 1
- MVEOHWRUBFWKJY-UHFFFAOYSA-N 7-hydroxynaphthalene-2-sulfonic acid Chemical compound C1=CC(S(O)(=O)=O)=CC2=CC(O)=CC=C21 MVEOHWRUBFWKJY-UHFFFAOYSA-N 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 239000004150 EU approved colour Substances 0.000 description 1
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 1
- 240000005523 Peganum harmala Species 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 239000001361 adipic acid Substances 0.000 description 1
- 235000011037 adipic acid Nutrition 0.000 description 1
- 239000004411 aluminium Substances 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- JFCQEDHGNNZCLN-UHFFFAOYSA-N anhydrous glutaric acid Natural products OC(=O)CCCC(O)=O JFCQEDHGNNZCLN-UHFFFAOYSA-N 0.000 description 1
- FPCJKVGGYOAWIZ-UHFFFAOYSA-N butan-1-ol;titanium Chemical compound [Ti].CCCCO.CCCCO.CCCCO.CCCCO FPCJKVGGYOAWIZ-UHFFFAOYSA-N 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 125000002843 carboxylic acid group Chemical group 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 229920006158 high molecular weight polymer Polymers 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 150000001261 hydroxy acids Chemical class 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 229910052738 indium Inorganic materials 0.000 description 1
- APFVFJFRJDLVQX-UHFFFAOYSA-N indium atom Chemical compound [In] APFVFJFRJDLVQX-UHFFFAOYSA-N 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000003999 initiator Substances 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 239000011133 lead Substances 0.000 description 1
- 229910052744 lithium Inorganic materials 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 description 1
- ABMFBCRYHDZLRD-UHFFFAOYSA-N naphthalene-1,4-dicarboxylic acid Chemical compound C1=CC=C2C(C(=O)O)=CC=C(C(O)=O)C2=C1 ABMFBCRYHDZLRD-UHFFFAOYSA-N 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 229940006093 opthalmologic coloring agent diagnostic Drugs 0.000 description 1
- 150000002902 organometallic compounds Chemical class 0.000 description 1
- 235000006408 oxalic acid Nutrition 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 238000006068 polycondensation reaction Methods 0.000 description 1
- 229920000139 polyethylene terephthalate Polymers 0.000 description 1
- 239000005020 polyethylene terephthalate Substances 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 238000007151 ring opening polymerisation reaction Methods 0.000 description 1
- 238000000646 scanning calorimetry Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 229940014800 succinic anhydride Drugs 0.000 description 1
- 239000001117 sulphuric acid Substances 0.000 description 1
- 235000011149 sulphuric acid Nutrition 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/66—Polyesters containing oxygen in the form of ether groups
- C08G63/664—Polyesters containing oxygen in the form of ether groups derived from hydroxy carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
- C08G63/06—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
- C08G63/08—Lactones or lactides
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
- C08G63/12—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from polycarboxylic acids and polyhydroxy compounds
- C08G63/16—Dicarboxylic acids and dihydroxy compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Polyesters Or Polycarbonates (AREA)
Abstract
A polymer is comprises derived from (i) lactic acid or lactide, (ii) isosorbide, and (iii) a polycarboxylic acid, wherein the lactic acid/lactide component (i) forms mopre than 50% by weight of the polymer. The polymer results in a polymer having a higher glass transition temperature.
Description
I
LACTIC ACID POLYMERS
The present invention relates to improved polylactic acid polymers.
In recent years, as environmental issues have become increasingly important, the need for polymers which are biodegradable but stable during normal conditions of use has increased, especially for the packaging of food and drinks. Polymers based on lactic acid can be biodegradable and may be of food grade, and so, potentially, could be of interest for such purposes.
Lactic acid can form polymers by polymerisation using a mono, di-, tn-, tetra-, or polyfunctional initiator, for example compounds with hydroxy and/or acid groups.
However, such polymers tend to have a low glass transition temperature and, consequently, are of restricted value for the preparation of rigid or semi-rigid containers, such as bottles. High molecular weight polymers formed by the ring opening polymerisation of lactide have a high molecular weight, but, despite that, the glass transition temperature is lower than that of plastics commonly used in rigid packages, e.g. polyethylene terephthalate and polystyrene. Furthermore, lactide is made by the polycondensation of lactic acid and subsequent decomposition of the resulting low molecular weight polylactic acid. These steps add complexity and expense to the preparation process and it would, therefore, be desirable if suitable polymers could be produced directly by the polymerisation of lactic acid.
Isosorbide has been incorporated into polymers of various types in order to achieve a variety of benefits. For example, W02004044032A1 discloses that isosorbide can be used to raise the glass transition temperature of polyesters. Other patents disclosing the use of isosorbide for various purposes include DE 2938464, US 6656577, US 7049390, US68 18730, US 6063495, US 6063465, and US 5959066.
We have now discovered that the incorporation into a lactic acid polymer of units derived from isosorbide and units derived from a polycarboxylic acid can give a polymer having the desired higher glass transition temperature. Although isosorbide is known to elevate the glass transition temperature in certain other polymers, we have surprisingly found that isosorbide alone is ineffective in lactic acid polymers and the presence of a polycarboxylic acid is necessary if the desired results are to be achieved.
Similar advantages may be expected by the incorporation of these units into polylactide polymers. Moreover, by appropriate selection of the relative amounts of the components of the polymer, it is possible to ensure that the polymer has a relatively high degradation temperature, an important consideration for materials used by the public.
Thus, the present invention consists in a polymer comprising units derived from: lactic acid; isosorbide; and a polycarboxylic acid, the lactic acid units comprising at least 50 weight % of the polymer.
The invention further consists in a process for preparing a lactic acid polymer, which comprises polymerising lactic acid, isosorbide and a polycarboxylic acid or anhydride thereof, the lactic acid comprising at least 50 weight % of the polymer components.
The invention further consists in a process for preparing a lactic acid polymer, which comprises polymerising lactjde, isosorbide and a polycarboxyljc acid or anhydride thereof, the lactide being present in sufficient amount to provide at least 50 weight % of lactic acid units in the lactic acid polymer.
The polymerisation reactions of the present invention may be carried out under any conditions known in the art for the polymerisation of such monomers, but is preferably carried out in the presence of a catalyst, and preferably with heating. Any catalyst known for use in such polymerisatjon reactions may equally be used here, and examples of suitable catalysts include such esteriflcation catalysts as: acids, such as p-toluenesulplionjc acid or sulphuric acid; metallic or organometallic compounds containing elements of groups I-VillA and/or groups IB-VIIB in the Periodic Table of Elements, including compounds of lithium, calcium, magnesium, manganese, zinc, lead, titanium, germanium, antimony, cobalt, or tin, especially compounds of titanium, germanium, antimony, cobalt, or tin, for example titanium (IV) butoxide or titanium acetylacetonate.
The polymerisatjon reaction may take place at ambient temperature, depending on the catalyst and monomers used, but is preferably carried out with heating, e.g. to a temperature of from 100 C to 250 C, more preferably 140 C to 210 C, and most preferably from 150 C to 190 C.
The reaction is carried out under conditions such as to remove the water formed in the course of the reaction, i.e. at temperature of at least 100 C and preferably under sub-atmospheric pressure, more preferably under vacuum.
The reaction is preferably carried out in the absence of any solvent other than the reagents, but, if desired, an organic solvent may be present. If used, examples of such organic solvents include: ethers, such as diphenyl ether, and dioxane; and hydrocarbons, such as toluene, xylene, and dodecane The reaction is preferably carried out under essentially anhydrous conditions.
The lactic acid is the major component of the reaction mixture, and is present in sufficient amount to make up at least 50 weight % of the polymer, preferably at least 60%, more preferably from 65 to 90% and most preferably from 65 to 75%. The lactic acid may be L, D or DL.
The isosorbide is present in a minor proportion in the final polymer, for example no more than 20 weight %, and we prefer to use sufficient to provide from 2 to 20 weight % of units in the final polymer, more preferably from 2 to 15% and most preferably from 5 to 11%.
The polycarboxylic acid or anhydride thereof is a compound having at least two, and preferably from two to six, carboxylic acid groups, or is an anhydride of such a compound. It should be capable of reacting with the isosorbide, and examples of suitable such acids include: acid, 1,2,3,4-butanetetracarboxylic acid, maleic acid, succinic acid, methylsuccinic acid, glutaric acid, adipic acid, oxalic acid, malonic acid, terephthaljc acid, isophthaljc acid, 2,6- naphthalenecijca.rboxyljc acid, 27-naphthalenedicarboxy1ic acid, 1,4-naphthalenedicarboxylic acid, 3,4'-diphenyl ether dicarboxylic acid, 4,4'-diphenyl ether dicarboxyljc acid, triinellitic acid, pyromelljtjc acid,. Anhydrides of these acids may also be used. The preferred polycarboxylic acids are 1,2,3,4,5,6, cyclohexanehexacarboxyljc acid, l234-butanetetracarboxyIjc acid, maleic acid, succinic acid, of which acid and 1,2,3,4-butanetetracarboxyije acid are most preferred. The carboxylic acid compound is also preferably present in a minor proportion in the final polymer, for example no more than weight %, and we prefer to use sufficient to provide from 3 to 20 weight % of units in the final polymer, more preferably from 4 to 18% and most preferably from 5 to 11%.
In addition to the lactic acid or lactide, isosorbjde and polycarboxyjic acid or anhydride, other monomers may be included in the polyinerjsatjon reaction and so in the final polymer, if desired. Examples of such monomers include: other hydroxy acids, such as glycolic acid, hydroxybutyric acid, or hydroxycaproic acid. If used, such additional monomers are preferably present in minor amounts.
For practical use, the copolyiners of the present invention are preferably formulated with conventional additives commonly used in the plastics industry, such as plasticisers, fillers, colouring agents, etc. also, if desired, the copolymers may be formulated as compositions in admixture with at least one polyester (different from the copolymer of the present invention) such as a polylactide.
The resulting polymers or compositions may be formed into films or shaped articles, such as containers, for example bottles or boxes, by known means, and are especially suitable for packaging of substances for human or animal consumption, for example food, electronic equipment or medicines.
The invention is further illustrated by the following non-limiting Examples.
EXAMPLES 1-12
1:a) Dryin2 of Lactic Acid The lactic acid was dried using a rotary evaporator attached to a water cooler. A known amount of lactic acid was placed into a bottle beaker, which was heated in an oil
S
bath under atmospheric pressure. The bottle was placed in the oil bath at ambient temperame and the temperature was raised to 180 C within approximately 30 minutes and kept at this temperature for 4 hours from placing the bottle in the oil bath. After this, the bottle was capped and allowed to cool to ambient temperature. The lactic acid was dried separately for all the polymerjsatious, and a sample was taken from four batches for the determination of the acid number by titration.
fkU'oiymerjsatjon Procedure The polymerisatjons were conducted in vacuum using a rotary evaporator attached to a water cooler. The polymerisatjon temperature was 150 C, and it was reached within about 30 minutes after starting the heating from approximately 22 C.
The pressure setting of the vacuum pump was lowered slowly from about 800 mbar to I mbar over 4 hours after the temperature had reached 150 C. After the pressure setting had been lowered to I mbar, the polymerjsajo was continued at 150 C for a minimum of 54 hours. The vacuum pump was stopped and the beaker removed to allow samples to be taken after specific time intervals, after which the pressure was lowered to vacuum immediately.
fç) Differential Scanning Calorimetry fflS The Differential Scanning Calorimetry (DSC) instrument used to measure the thermal transitions was a Perkin Elmer (Bucks, United Kingdom) DSC 7. The DSC equipment was calibrated with indium and an empty pan was used as a reference. The samples were weighed into an aluminium pan and hermetically sealed. The samples were first heated from -30 C to 200 C, and then cooled back to -30 C, after which a second heating scan similar to the first one was performed. Both the heating and the cooling rates were I 0 C/mm. The GPC results are presented for the conventional calibration technique, which uses the refractive index detector and the results are not dependent on knowledge of the absolute concentration of the sample.
The results are shown in the following Table 1.
Table I
Ex. No. LLA BTCA ISB SA Time Tg ( C) Mn Mw Mz (%) (%) (%) (%) (ii) 85.6 8.8 5.5 -5.5 13.47 807 1006 1284 24 44.31 1958 4360 7528 50.84 2204 5491 9814 48 55.49 2931 9924 53800 54 56.31 3636 14980 64600 2 88.3 8.8 2.8 -9 29.75 1248 13520 15260O 24 47.04 1624 13160 425600 54 59.78 3 80.1 8.8 11.0 -7 20.43 925 21560 2867OcY 24 46.57 1481 3479 6081 54 59.18 4 90.0 4.4 5.5 -5.5 7.95 639 785 982 24 39.14 1446 3748 7499 32.5 44.59 2429 6706 19990 48 46.63 2782 9003 19370 54 47.08 3549 17260 186100 76.8 17.6 5.5 -8 38.38 697 1121 174O 24 50.03 933 1980 3524 54 61.88 6 71.6 17.4 10.9 -8.75 37.09 1358 2112 324 24 55.7 2256 4379 7564 34 59.83 1903 405g 7114 48.5 62.48 1912 5085 9960 54 63.67 1042 3623 9452 7 85.0 -15.0 -12 6.76 709 958 1287 (Comp) 24 15.02 761 1218 1783 36 15.39 789 1344 2040 48 13.34 685 1138 1736 9.23 564 895 1300 _____________ 72 9.66 525 822 1198 8 81.8 -10.0 8.1 7 4.50 652 990 1442 24 31.36 1514 2677 4139 31 37. 45 1878 3373 5195 48 44.79 2682 5194 7676 _____ 54 46.49 2670 5664 8921 963. 8 -20.0 16.1 11 12.99 721 1252 252 24 30.13 1199 2068 3107 30.5 36.02 1362 2377 3538 48 42.68 1916 3569 5448 54 42.55 1997 3759 5747 72.8 -15.0 12. 12 5.5 6.49 541 1169 2932 24 31.66 1236 2471 4118 29.5 37.28 1395 2820 4522 2479 4754 7304 48 44.32 2091 4516 7196 54 47.08 2660 4936 7249 11 100 ---10 14.30 863 1333 2001 (Comp) 24 32.72 1806 3508 5663 2115 4176 6645 37.57 2447 4510 6964 48 41.89 3007 7001 12250 54 39.68 3800 7986 13680 12 91.1 8.8 --9 27.23 1755 91370 1079000 (Coinp) 24 46.51 1410 4159 17520 33.75 50.21 4539 24390 35200 48 50.91 1808 7074 73230 54 50.66 1682 3649 5809 In the Table, the following abbreviations are used: LLA L-lactjc acid BTCA = butanetetracarboxylic acid JSB isosorbjde SA = succinic anhydride Tg = glass transition temperature h =hours Mn = number average molecular weight Mw = weight average molecular weight Mz = z average molecular weight Comp = comparative, i.e. not an example of the invention.
FXAMPLES 13-24 f) Drvjn of Lactic Acid 88% L-lactic acid (ex Purac) was dried using a rotary evaporator and a water cooler. A known amount of lactic acid was placed into a bottle beaker, which was heated in an oil bath under atmospheric pressure. The oil bath was preheated to the drying temperatje, which was 155C. The progress of the drying was followed by collecting and condensing the water distilled from the beaker at short time intervals.
When the weight of the condensed water was approximately 12% of the initial weight of the 88% lactic acid, the drying was stopped and the bottle capped, weighed, and allowed to cool to ambient temperature.
(bi Polyinerisatjon Procedure The polymerisatjons were conducted on an oil bath under vacuum using a rotary evaporator and a water cooler. The polymerisatjon temperature was 180 C, and the oil bath was preheated to this temperature. The system was filled with nitrogen prior to the beginning of the polymerisation and before taking the samples. The pressure setting of the vacuum pump was lowered to I mbar stepwise at the beginning of the polymerisation over a period of 4 hours. The actual pressure was approximately 27 mbar after 4 hours, when the pressure setting had just been lowered to I bar, but reduced to 3 mbar before taking the first sample after 6 hours. The pressure was 3 mbar also before taking the second sample after 22 hours, but slightly higher, between 6 and mbar, before taking the last 3 samples after 30, 46, and 54 hours.
After the pressure setting had been lowered to I mbar, the polymerisatjop were Continued at 180 C for 50 hours. The vacuum pump was stopped and the beaker removed for taking samples after specific time intervals, after which the pressure was lowered to vacuum immediately. The polymerisation times of the samples were counted from the start of the polymerjsatjon at atmospheric pressure.
fftDifferentiaj Scannj2 Calorjmetjy Wç The Differential Scanning Calorimetiy (DSC) instrument used to measure the thermal transitions was as described in Examples 1-12.
(i ThermoEravjmetrjc Analysis (TG The TGA equipment used was Seiko Instruments TG1DTA 6200 module with an Exstar 6000 base unit. The samples were analysed using Program I (heat from 20 C to 500 C at l0 C/minute) or using isothermal analysis, i.e. Program II (heat from 20 C to 300 C at SO C/minute, and then hold at 300 C for 1 hour).
The results and polymer compositions are shown in Table 2.
Table 2
Ex. No. LLA (%) BTCA ISB SA (%) Polyni. IDT ( C) Dcgr. Td5 ( C) TdlO ( C) Td20 ( C) Td50 ( C) Residue at (%) (%) Time (h) Onset ( C) 500 C (TG%) 13 85.6 8.8 5.5 -24 205 263 231 257 276 311 2.6 301 4 1 16 90.0 4.4 5.5 -54 205 256 232 251 268 293 2.4 24 204 263 231 260 282 323 4.5 34 204 268 247 265 286 326 4.7 48.5 206 267 244 264 285 326 4.3 54 219 268 246 267 289 327 4.9 -48 168 230 180 211 233 260 1.5 22 72.8 -15.0 12.12 54 2. 4 -54 211 257 228 251 268 296 0.5 (Comp) -24 217 283 250 270 287 311 0.9 54232 289 257 276 293 313 0.4 IDT Initial Decomposition Temperature Td5 The temperature, at which the sample has lost 5% of its initial weight Td 10= The temperature, at which the sample has lost 10% of its initial weight Td20 The temperature, at which the sample has lost 20% of its initial weight Td50 = The temperature, at which the sample has lost 50% of its initial weight Residue at 500C = The weight-% of sample left at 500C compared to its initial weight From these results, it can be seen that the polymers of the present invention have high glass transition temperatures and are resistant to thermal degradation.
EXAMPLE 25
The procedure described in Examples 13-24 was repeated, using 71.6 w-% LLA, 17.4 w-% BTCA and 10.9 w-%, but carrying out the polymerisation for longer periods.
The results are shown in Table 3.
1 ITg from the First Tg from then Polymer isat ion I I Heating Cycle Second Heating I I Timei(h) 1 I (C) Cycle (C) 6 42.2 48.6 22 J 59.7 63.3 67.9 73.6 46 70.2 78.8 LI 54 74.2 79.8
EXAMPLE 26
70.8 weight % L-Iactic acid (dried as described in Examples 13-24), 18.2 weight % l2)3,4,5,6..cyc1ohexanehexac&bo F acid (I-{CA), and 10.9 weight % isosorbide (HF-004-046) were polymerised as described in Examples 13-24. The total weight of the batch was 20g.
When inserting the ingredients into the beaker, a thin layer of!-ICA fastened on the funnel and the actual amount in the batch can therefore be slightly smaller than the calculated values. The amount was, however, very small and its effect on the batch composition was assumed to be negligible.
The polymer was white coloured and looked cloudy at the beginning of the polymerjsatjon After 4 hours from the beginning of the polymerisatjo, the colour had darkened slightly. After approximately 5 hours, the polymer looked completely clear.
However, when taking a sample after 6 hours from the start of the polymerisation, it was noticed that the polymer Contained a small amount of white particles, and these particles were visible until the polymer become more viscOus and started to Contain trapped bubbles, which made it impossible to see the colour of the material well enough. All the samples taken were hard and felt brittle after they had cooled down.
Differenijai Scanning Calorimetry (DSC) The Tg values for the polymerisation of 70.8 weight % LLA, 18.2 weight % HCA, and 10.9 weight % JSB are shown in Table 4. As can be Seen from the table, the values obtained were higher than the ones obtained when using the same weight-% ISB with BTCA as the polyacid. The Tg values rose to a level close to 90C at the end of the polymerisatjon
Table 4
iYznerisa[igfro the FTg from the Second7 (hours) Heating Cycle ( C) Heating Cycle ( C) r 6 32.7 40.7 12 46.2 55.2 L 24 45.1 61.1 76.9 77.7 48 88.2 86.3 The Tg values obtained in the polymerisatjon of 70.8 weight % LLA, 18.2 weight % HCA, and 10.9 weight % ISB after a polymerisaijon time of about 30 hours were significantly higher than typical Tg values for PLA, and also higher than the ones obtained in the earlier polymerisatjo with ISB and BTCA.
Claims (18)
- CLAIMS: I. A polymer comprising units derived from: lactic acid;isosorbide; and a polycarboxylic acid, the lactic acid units comprising at least SO weight % of the polymer.
- 2. A polymer according to Claim 1, in which the lactic acid units comprise at least 60 weight % of the polymer.
- 3. A polymer according to Claim I, in which the lactic acid units comprise from 65 to weight % of the polymer.
- 4. A polymer according to Claim I, in which the lactic acid units comprise from 65 to weight % of the polymer.
- S. A polymer according to any one of the preceding Claims, in which the isosorbjde units comprise no more than 20 weight % of the polymer.
- 6. A polymer according to Claim 5, in which the isosorbide units comprise from 2 to 20 weight % of the polymer.
- 7. A polymer according to Claim 6, in which the isosorbjde units comprise from 2 to 15 weight % of the polymer.
- 8. A polymer according to Claim 6, in which the isosorbide units comprise from 5 to 11 weight % of the polymer.
- 9. A polymer according to any one of the preceding Claims, in which the polycarboxylic acid or anhydride thereof is a compound having at least two, and preferably from two to six, carboxyljc acid groups, or is an arthydiide of such a compound.
- 10. A polymer according to Claim 9, in which the polycarboxyljc acid or anhydride thereof is acid, l234-butanetetracarboxyJjc acid, maleic acid or succjnic acid, or an anhydride thereof.
- 11. A polymer according to any one of the preceding Claims, in which the polycarboxylic acid Oranhydrjde units comprise no more than 20 weight % of the polymer.
- 12. A polymer according to Claim 11, in which the polycarboxylic acid or anhydride units comprise from 3 to 20 weight % of units in the polymer.
- 13. A polymer according to Claim 12, in which the polycarboxylic acid or anhydride units comprise from 4 to 18 weight % of units in the polymer.
- 14. A polymer according to Claim 13, in which the polycarboxylic acid or anhydride units comprise from 5 to 11 weight % of units in the polymer.
- 15. A process for preparing a lactic acid polymer as claimed in any one of the preceding Claims, which comprises polymerising lactide, isosorbide and a polycarboxyjic acid or anhydride thereof, the lactide being present in sufficient amount to provide at least 50 weight % of lactic acid units in the lactic acid polymer.
- 16. A process according to Claim 15, in which the polymerjsaljon is carried out at a temperature of from 100 C to 250 C.
- 17. A composition comprising a copolymer according to any one of the preceding Claims in admixture with at least one polyester.
- 18. A composition according to Claim 17, in which said polyester is a polylactide.
Priority Applications (4)
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GB0622263A GB2443625A (en) | 2006-11-08 | 2006-11-08 | Lactic acid polymer |
TW096142015A TW200829646A (en) | 2006-11-08 | 2007-11-07 | Lactic acid polymers |
US11/936,170 US20080108759A1 (en) | 2006-11-08 | 2007-11-07 | Lactic Acid Polymers |
PCT/GB2007/004240 WO2008056136A1 (en) | 2006-11-08 | 2007-11-08 | Lactic acid polymers |
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CN103804663A (en) * | 2014-03-07 | 2014-05-21 | 中国科学院长春应用化学研究所 | Aliphatic series-polylactic acid segmented copolymer and preparation method thereof |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
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DE19939403A1 (en) * | 1999-08-19 | 2001-02-22 | Fzmb Forschungszentrum Fuer Me | Biodegradable composite paste, for medical applications e.g. as bone cement, contains bioresorbable liquid monomers, thickener, initiator-coated resorbable inorganic filler and activator-coated filler |
WO2003089492A1 (en) * | 2002-04-22 | 2003-10-30 | Novamont S.P.A. | Biodegradable thermoplastic polyesters |
WO2003089493A1 (en) * | 2002-04-22 | 2003-10-30 | Novamont S.P.A. | Biodegradable saturated/unsaturated thermoplastic polyesters |
US20060009610A1 (en) * | 2004-07-09 | 2006-01-12 | Hayes Richard A | Sulfonated copolyetherester compositions from hydroxyalkanoic acids and shaped articles produced therefrom |
US20060009609A1 (en) * | 2004-07-09 | 2006-01-12 | Hayes Richard A | Sulfonated aromatic copolyesters containing hydroxyalkanoic acid groups and shaped articles produced therefrom |
US20060009611A1 (en) * | 2004-07-09 | 2006-01-12 | Hayes Richard A | Copolyetherester compositions containing hydroxyalkanoic acids and shaped articles produced therefrom |
JP2006096845A (en) * | 2004-09-29 | 2006-04-13 | Toray Ind Inc | Polyester composition, and fiber and film consisting of the same |
-
2006
- 2006-11-08 GB GB0622263A patent/GB2443625A/en not_active Withdrawn
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- 2007-11-07 TW TW096142015A patent/TW200829646A/en unknown
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DE19939403A1 (en) * | 1999-08-19 | 2001-02-22 | Fzmb Forschungszentrum Fuer Me | Biodegradable composite paste, for medical applications e.g. as bone cement, contains bioresorbable liquid monomers, thickener, initiator-coated resorbable inorganic filler and activator-coated filler |
WO2003089492A1 (en) * | 2002-04-22 | 2003-10-30 | Novamont S.P.A. | Biodegradable thermoplastic polyesters |
WO2003089493A1 (en) * | 2002-04-22 | 2003-10-30 | Novamont S.P.A. | Biodegradable saturated/unsaturated thermoplastic polyesters |
US20060009610A1 (en) * | 2004-07-09 | 2006-01-12 | Hayes Richard A | Sulfonated copolyetherester compositions from hydroxyalkanoic acids and shaped articles produced therefrom |
US20060009609A1 (en) * | 2004-07-09 | 2006-01-12 | Hayes Richard A | Sulfonated aromatic copolyesters containing hydroxyalkanoic acid groups and shaped articles produced therefrom |
US20060009611A1 (en) * | 2004-07-09 | 2006-01-12 | Hayes Richard A | Copolyetherester compositions containing hydroxyalkanoic acids and shaped articles produced therefrom |
WO2006010061A1 (en) * | 2004-07-09 | 2006-01-26 | E.I. Dupont De Nemours And Company | Copolyetherester compositions containing hydroxyalkanoic acids and shaped articles produced therefrom |
JP2006096845A (en) * | 2004-09-29 | 2006-04-13 | Toray Ind Inc | Polyester composition, and fiber and film consisting of the same |
Cited By (1)
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CN103804663A (en) * | 2014-03-07 | 2014-05-21 | 中国科学院长春应用化学研究所 | Aliphatic series-polylactic acid segmented copolymer and preparation method thereof |
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