GB2418668A - Anti-inflammatory assay and compounds - Google Patents

Anti-inflammatory assay and compounds Download PDF

Info

Publication number
GB2418668A
GB2418668A GB0602172A GB0602172A GB2418668A GB 2418668 A GB2418668 A GB 2418668A GB 0602172 A GB0602172 A GB 0602172A GB 0602172 A GB0602172 A GB 0602172A GB 2418668 A GB2418668 A GB 2418668A
Authority
GB
United Kingdom
Prior art keywords
compounds
inflammatory assay
inflammatory agents
mnk
inflammatory
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB0602172A
Other versions
GB0602172D0 (en
GB2418668B (en
Inventor
Christopher Gregory Proud
Maria Buxade Fortuny
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Dundee
Original Assignee
University of Dundee
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Dundee filed Critical University of Dundee
Publication of GB0602172D0 publication Critical patent/GB0602172D0/en
Publication of GB2418668A publication Critical patent/GB2418668A/en
Application granted granted Critical
Publication of GB2418668B publication Critical patent/GB2418668B/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/52—Assays involving cytokines
    • G01N2333/525—Tumor necrosis factor [TNF]

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

A method of identifying new lead anti-inflammatory agents based on the use of MNK and its action on AREBP(s) and subsequent effect on TNFcc expression is provided. The invention also relates to novel anti-inflammatory agents which disrupt MNK activity.

Description

GB 2418668 A continuation (74) Agent and/or Address for Service: (58)
Field of Search by ISA: Marks & Clerk INT CL G01N 19 Royal Exchange Square, GLASGOW, Other: EPO-lnternal, BIOSIS, EMBASE, WPI Data G1 3AE, United Kingdom
GB0602172A 2003-07-03 2004-07-05 Anti-inflammatory assay and compounds Expired - Fee Related GB2418668B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0315587.6A GB0315587D0 (en) 2003-07-03 2003-07-03 Anti-inflammatory assay and compounds
PCT/GB2004/002934 WO2005003785A2 (en) 2003-07-03 2004-07-05 Anti-inflammatory assay and compounds

Publications (3)

Publication Number Publication Date
GB0602172D0 GB0602172D0 (en) 2006-03-15
GB2418668A true GB2418668A (en) 2006-04-05
GB2418668B GB2418668B (en) 2008-01-16

Family

ID=27741521

Family Applications (2)

Application Number Title Priority Date Filing Date
GBGB0315587.6A Ceased GB0315587D0 (en) 2003-07-03 2003-07-03 Anti-inflammatory assay and compounds
GB0602172A Expired - Fee Related GB2418668B (en) 2003-07-03 2004-07-05 Anti-inflammatory assay and compounds

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GBGB0315587.6A Ceased GB0315587D0 (en) 2003-07-03 2003-07-03 Anti-inflammatory assay and compounds

Country Status (2)

Country Link
GB (2) GB0315587D0 (en)
WO (1) WO2005003785A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2929742C (en) 2013-12-04 2022-09-20 Evotec International Gmbh Sulfoximine substituted quinazolines for pharmaceutical compositions
JP6479854B2 (en) 2014-05-07 2019-03-06 エヴォテック・インターナショナル・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＥｖｏｔｅｃ Ｉｎｔｅｒｎａｔｉｏｎａｌ ＧｍｂＨ Sulfoxyimine substituted quinazolines for pharmaceutical compositions

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
Biochemical Pharmacology (2000); Vol 60, pp 1237-1243, "Phosphorylation of the cap-binding...", Pyronnet *
Biochemistry (1994); Vol 33, pp 11382-11390, "Regulation of in vitro nucleic acid...", Idriss et al *
EMBO Journal (2002); Vol 21, pp 6505-6514, "Inhibition of SAPK2a/p38 prevents hnRNP...", Rousseau et al *
Journal of Biological Chemistry (2002), Vol 277, pp 3065-3068, "MK2 targets AU-rich elements and...", Neininger et al *
Molecular & Cellular Biology (2001), Vol 21, pp 5500-5511, "Negative regulation of protein...", Knauf et al *

Also Published As

Publication number Publication date
GB0315587D0 (en) 2003-08-13
GB0602172D0 (en) 2006-03-15
WO2005003785A3 (en) 2005-03-24
GB2418668B (en) 2008-01-16
WO2005003785A2 (en) 2005-01-13

Similar Documents

Publication Publication Date Title
MXPA04000062A (en) Homocysteinylated transthyretin.
GB2392978A (en) Identification and use of conserved noncoding sequences
AU2003275613A1 (en) Novel fructosyl peptide oxidase and utilization thereof
HUP0103160A2 (en) Pharmaceutical compositions for treating pulmonary diseases containing pde4 inhibitor
WO2006078287A3 (en) Pde4b inhibitors and uses therefor
WO2002058690A3 (en) Methods for the treatment of diseases using malonyl-coa decarbox ylase inhibitors
EP2163653A3 (en) Nucleic acid detection method having increased sensitivity
WO2002079486A3 (en) Milieux de detection specific de staphylococcus aureus
MY144770A (en) Polishing composition
MA27606A1 (en) Association for the treatment of ADHD
GB2391015A (en) Treatment of hydrocarbons containing sulfides
TW200700725A (en) Detection of nucleic acid associated with disease
WO2005051318A3 (en) Compounds, compositions and methods for treatment and prophylaxis of hepatitis c viral infections and associated diseases
GB2418668A (en) Anti-inflammatory assay and compounds
AU2003252380A1 (en) Method for protein determination, indicator for protein determination, and test piece for protein determination
AU6842900A (en) Congener independent detection of microcystin and nodularin congeners
NO20063058L (en) Process for the preparation of (3-oxo-2,3-dihydro-1H-isoindol-1-yl) acetylguanidine derivatives
DE602005020256D1 (en) LINSEED EXTRACT FOR THE TREATMENT OF XEROSTOMY
GB2422837A (en) Transcriptional regulators and methods thereof
WO2004042352A3 (en) Substrates of n-end rule ubiquitylation and methods for measuring the ubiquitylation of these substrates
WO2003087054A3 (en) Methods for identifying compounds that modulate enzymatic activity
AU2002349247A1 (en) Substrate for tafi (a)
DK1163248T3 (en) 1,5-anhydro-D-fructose substituted with a hydrophobic group for use as an antioxidant and / or emulsifier
WO2001085773A8 (en) Luxo-sigma54 interactions and methods of use
CA2473011A1 (en) Methods and compositions for regrowth of cryopreserved conifer embryos

Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 20110705