GB2414547A - Topography and recognition imaging atomic force microscope and method of operation - Google Patents

Topography and recognition imaging atomic force microscope and method of operation Download PDF

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Publication number
GB2414547A
GB2414547A GB0509288A GB0509288A GB2414547A GB 2414547 A GB2414547 A GB 2414547A GB 0509288 A GB0509288 A GB 0509288A GB 0509288 A GB0509288 A GB 0509288A GB 2414547 A GB2414547 A GB 2414547A
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GB
United Kingdom
Prior art keywords
probe
force microscope
topography
atomic force
recognition imaging
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB0509288A
Other versions
GB2414547B (en
GB0509288D0 (en
Inventor
Peter Hinterdorfer
Jeremy Nelson
Stuart M Lindsay
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Molecular Imaging Corp
Original Assignee
Molecular Imaging Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Molecular Imaging Corp filed Critical Molecular Imaging Corp
Priority to GB0618432A priority Critical patent/GB2428292B/en
Publication of GB0509288D0 publication Critical patent/GB0509288D0/en
Publication of GB2414547A publication Critical patent/GB2414547A/en
Application granted granted Critical
Publication of GB2414547B publication Critical patent/GB2414547B/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01Q—SCANNING-PROBE TECHNIQUES OR APPARATUS; APPLICATIONS OF SCANNING-PROBE TECHNIQUES, e.g. SCANNING PROBE MICROSCOPY [SPM]
    • G01Q60/00—Particular types of SPM [Scanning Probe Microscopy] or microscopes; Essential components thereof
    • G01Q60/24—AFM [Atomic Force Microscopy] or apparatus therefor, e.g. AFM probes
    • G01Q60/38—Probes, their manufacture, or their related instrumentation, e.g. holders
    • G01Q60/42—Functionalisation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01Q—SCANNING-PROBE TECHNIQUES OR APPARATUS; APPLICATIONS OF SCANNING-PROBE TECHNIQUES, e.g. SCANNING PROBE MICROSCOPY [SPM]
    • G01Q10/00—Scanning or positioning arrangements, i.e. arrangements for actively controlling the movement or position of the probe
    • G01Q10/04—Fine scanning or positioning
    • G01Q10/06—Circuits or algorithms therefor
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/84—Manufacture, treatment, or detection of nanostructure
    • Y10S977/849—Manufacture, treatment, or detection of nanostructure with scanning probe
    • Y10S977/852—Manufacture, treatment, or detection of nanostructure with scanning probe for detection of specific nanostructure sample or nanostructure-related property

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Length Measuring Devices With Unspecified Measuring Means (AREA)
  • Microscoopes, Condenser (AREA)
  • Manufacturing Optical Record Carriers (AREA)

Abstract

A recognition force microscope for detecting interactions between a probe and a sensed agent on a scanned surface and methods for its operation are provided. The microscope includes a scanning probe having a tip that is sensitive to a property of the scanned surface, and the probe is adapted to oscillate with a low mechanical Q factor. Operation of the microscope includes recording the displacement of the probe tip as a function of time and simultaneously recording both topographic images and the spatial location of interactions between said probe and one or more sensed agents on the surface.

Description

GB 2414547 A continuation (74) Agent and/or Address for Service: (56) cont
David Keltie Associates APPLIED PHYSICS LETTERS AIP USA, vol. 69, no. 26, Fleet Place House, 2 Fleet Place, LONDON, 23 December 1996 (1996-12-231, pages 4111- 4113, EC4M 7ET, United Kingdom XP002325029 ISSN: 0003-6951 SULCHEK T ET AL: "High-speed tapping mode imaging with active Q control for atomic force microscopy" APPLIED PHYSICS LETTERS, AMERICAN INSTITUTE OF PHYSICS. NEW YORK,US, vol. 76, no. 11, 13 March 2000 (2000-03-131, pages 1473-1475, XP012024840 ISSN: 0003- 6951
SHUBEITA G T ET AL: "Scanning near-field optical
microscopy based on the heterodyne phase-controlled oscillator method" JOURNAL OF APPLIED PHYSICS, AMERICAN INSTITUTE OF PHYSICS. NEW YORK, US, vol. 88, no. 5, 1 September 2000 (2000-09-011, pages 2921-2927, XP01205
(58) Field of Search by ISA:
INT CL7 G12B Other: EPO-INTERNAL, WPUI, PAJ, INSPEC, COMPENDEX, BIOSIS
GB0509288A 2002-11-01 2003-10-31 Topography and recognition imaging atomic force microscope and method of operation Expired - Fee Related GB2414547B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB0618432A GB2428292B (en) 2002-11-01 2003-10-31 Screening reagents

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US42322202P 2002-11-01 2002-11-01
US10/697,841 US6952952B2 (en) 2002-11-01 2003-10-30 Topography and recognition imaging atomic force microscope and method of operation
PCT/US2003/034767 WO2004042741A2 (en) 2002-11-01 2003-10-31 Topography and recognition imaging atomic force microscope and method of operation

Publications (3)

Publication Number Publication Date
GB0509288D0 GB0509288D0 (en) 2005-06-15
GB2414547A true GB2414547A (en) 2005-11-30
GB2414547B GB2414547B (en) 2006-12-13

Family

ID=32314480

Family Applications (1)

Application Number Title Priority Date Filing Date
GB0509288A Expired - Fee Related GB2414547B (en) 2002-11-01 2003-10-31 Topography and recognition imaging atomic force microscope and method of operation

Country Status (5)

Country Link
US (2) US6952952B2 (en)
AU (1) AU2003286828A1 (en)
DE (1) DE10393612B4 (en)
GB (1) GB2414547B (en)
WO (1) WO2004042741A2 (en)

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* Cited by examiner, † Cited by third party
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US6952952B2 (en) * 2002-11-01 2005-10-11 Molecular Imaging Corporation Topography and recognition imaging atomic force microscope and method of operation
JP2004264039A (en) * 2003-01-30 2004-09-24 Hitachi Ltd Scanning probe microscope, and compact disk/cross-sectional profile measuring method as well as semiconductor device manufacturing method
CN100458431C (en) * 2004-12-30 2009-02-04 中国科学院电工研究所 Method and devices of biochemical detection by using micro semi girder
JP4616759B2 (en) * 2005-03-14 2011-01-19 日本電子株式会社 Atomic force microscope and method of forming energy dissipation image using atomic force microscope
US7420106B2 (en) * 2005-03-18 2008-09-02 The University Of Utah Research Foundation Scanning probe characterization of surfaces
ES2264647B1 (en) * 2005-06-24 2007-12-01 Consejo Superior Investigaciones Cientificas METHOD OF USE OF A MICROSCOPE OF ATOMIC FORCES AND MICROSCOPE.
US7357018B2 (en) * 2006-02-10 2008-04-15 Agilent Technologies, Inc. Method for performing a measurement inside a specimen using an insertable nanoscale FET probe
US20070186629A1 (en) * 2006-02-10 2007-08-16 Ying-Lan Chang Functionalizable nanowire-based AFM probe
US20080061231A1 (en) * 2006-04-28 2008-03-13 Chamberlin Danielle R Nanowire scanning probe microscopy probe for molecular recognition imaging
US7745206B2 (en) * 2007-01-29 2010-06-29 Arizona State University AFM for simultaneous recognition of multiple factors
US8892371B2 (en) * 2007-04-20 2014-11-18 Invensys Systems, Inc. Wet gas measurement
WO2009093241A2 (en) * 2008-01-23 2009-07-30 N-Trig Ltd. Graphical object manipulation with a touch sensitive screen
US7753849B2 (en) * 2008-05-09 2010-07-13 Alcatel-Lucent Usa Inc. Doppler radar cardiopulmonary sensor and signal processing system and method for use therewith
SG171994A1 (en) 2008-12-11 2011-07-28 Infinitesima Ltd Dynamic probe detection system
US20100175155A1 (en) * 2009-01-06 2010-07-08 President And Fellows Of Harvard College Measurement and Mapping of Molecular Stretching and Rupture Forces
US8424370B2 (en) * 2009-01-16 2013-04-23 Matrix Sensors, Inc. Liquid analysis using capacitative micromachined ultrasound transducers
US8082593B2 (en) * 2009-02-25 2011-12-20 The Board Of Trustees Of The Leland Stanford Junior University Atomic force microscopy devices, arrangements and systems
US8726410B2 (en) * 2010-07-30 2014-05-13 The United States Of America As Represented By The Secretary Of The Air Force Atomic force microscopy system and method for nanoscale measurement
US20120127120A1 (en) * 2010-11-22 2012-05-24 Himax Technologies Limited Touch device and touch position locating method thereof
US8752211B2 (en) * 2012-08-03 2014-06-10 Ut-Battelle, Llc Real space mapping of oxygen vacancy diffusion and electrochemical transformations by hysteretic current reversal curve measurements
DE102016110407A1 (en) * 2016-06-06 2017-12-07 Carl Zeiss Microscopy Gmbh Digital microscope with a lens and an image sensor
CN113030602B (en) * 2021-03-02 2022-10-21 北京纳米能源与系统研究所 Method, device, equipment and medium for measuring electrical property of sample material

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JPH05281276A (en) * 1991-07-31 1993-10-29 Toshiba Corp Device for detecting electrostatic power in liquid
US5519212A (en) 1992-08-07 1996-05-21 Digital Instruments, Incorporated Tapping atomic force microscope with phase or frequency detection
US5383354A (en) * 1993-12-27 1995-01-24 Motorola, Inc. Process for measuring surface topography using atomic force microscopy
US5513518A (en) 1994-05-19 1996-05-07 Molecular Imaging Corporation Magnetic modulation of force sensor for AC detection in an atomic force microscope
US5515719A (en) 1994-05-19 1996-05-14 Molecular Imaging Corporation Controlled force microscope for operation in liquids
US6008489A (en) * 1997-12-03 1999-12-28 Digital Instruments Method for improving the operation of oscillating mode atomic force microscopes
US6121611A (en) * 1998-05-20 2000-09-19 Molecular Imaging Corporation Force sensing probe for scanning probe microscopy
US6952952B2 (en) * 2002-11-01 2005-10-11 Molecular Imaging Corporation Topography and recognition imaging atomic force microscope and method of operation

Non-Patent Citations (6)

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Title
Database accession no. PREV199698791826 cited in the application -& PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 93, no. 8,1996, pages 3477-3481, XP002325028 ISSN: 0027-8424 *
DATABASE BIOSIS «Online© BIOSCIENCES INFORMATION SERVICE,PHILADELPHIA, PA, US; 1996, HINTERDORFER PETER ET AL: "Detection and localization of individual antibody-antigen recognition events by atomic force microscopy" XP002325030 *
KIENBERGER F ET AL: "Static and dynamical properties of single poly(ethylene glycol) molecules investigated byforce spectroscopy" SINGLE MOLECULES WILEY-VCH GERMANY, vol. 1, no. 2, 2000, pages 123-128, XP008045771 *
SHUBEITA G T ET AL: "Scanning near-field optical microscopy based on the heterodyne phase-controlled oscillator method" JOURNAL OF APPLIED PHYSICS, AMERICAN INSTITUTE OF PHYSICS. NEW YORK, US, vol. 88, no. 5, 1 September 2000 (2000-09-01), pages 2921-2927, XP01205 *
SULCHEK T ET AL: "High-speed tapping mode imaging with active Q control for atomic force microscopy" APPLIED PHYSICS LETTERS, AMERICAN INSTITUTE OF PHYSICS. NEW YORK,US, vol. 76, no. 11, 13 March 2000 (2000-03-13), pages 1473-1475, XP012024840 ISSN: 0003-6951 *
WENHAI HAN ET AL: "A magnetically driven oscillating probe microscope for operation in liquids" APPLIED PHYSICS LETTERS AIP USA, vol. 69, no. 26, 23 December 1996 (1996-12-23), pages 4111-4113, XP002325029 ISSN: 0003-6951 *

Also Published As

Publication number Publication date
US7152462B2 (en) 2006-12-26
US20060016251A1 (en) 2006-01-26
GB2414547B (en) 2006-12-13
US6952952B2 (en) 2005-10-11
AU2003286828A1 (en) 2004-06-07
US20040129064A1 (en) 2004-07-08
WO2004042741A2 (en) 2004-05-21
GB0509288D0 (en) 2005-06-15
DE10393612T5 (en) 2005-10-27
WO2004042741A3 (en) 2005-06-16
DE10393612B4 (en) 2016-08-18

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732E Amendments to the register in respect of changes of name or changes affecting rights (sect. 32/1977)

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PCNP Patent ceased through non-payment of renewal fee

Effective date: 20141031