GB2413329A - Pantolactone hydrolase - Google Patents

Pantolactone hydrolase Download PDF

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Publication number
GB2413329A
GB2413329A GB0516602A GB0516602A GB2413329A GB 2413329 A GB2413329 A GB 2413329A GB 0516602 A GB0516602 A GB 0516602A GB 0516602 A GB0516602 A GB 0516602A GB 2413329 A GB2413329 A GB 2413329A
Authority
GB
United Kingdom
Prior art keywords
pantolactone
nucleotides sequences
pantolactone hydrolase
hydrolase
hydrolases
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB0516602A
Other versions
GB0516602D0 (en
GB2413329B (en
Inventor
Iqbal Gill
Dahai Guo
Martin Lehmann
Dermot P Moynagh
Rao Hanumantha Valivety
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DSM IP Assets BV
Original Assignee
DSM IP Assets BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DSM IP Assets BV filed Critical DSM IP Assets BV
Publication of GB0516602D0 publication Critical patent/GB0516602D0/en
Publication of GB2413329A publication Critical patent/GB2413329A/en
Application granted granted Critical
Publication of GB2413329B publication Critical patent/GB2413329B/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

The present invention relates to nucleotides sequences of a gene coding for a pantolactone hydrolase, as well as vectors and host cells containing such nucleotides sequences and pantolactone hydrolases encoded by such nucleotides sequences. Processes for making and using pantolactone hydrolases are also provided.

Description

GB 2413329 A continuation (72) Inventor(s): Iqbal Gill Dahai Guo Martin
Lehmann Dermot P Moynagh Rao Hanumantha Valivety (74) Agent and/or Address for Service: Forrester Ketley & Co Forrester House, 52 Bounds Green Road, LONDON, N11 2EY, United Kingdom
GB0516602A 2003-03-28 2004-03-19 Novel Enzymes Expired - Fee Related GB2413329B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45922003P 2003-03-28 2003-03-28
PCT/EP2004/002902 WO2004085651A2 (en) 2003-03-28 2004-03-19 Pantolactone hydrolase

Publications (3)

Publication Number Publication Date
GB0516602D0 GB0516602D0 (en) 2005-09-21
GB2413329A true GB2413329A (en) 2005-10-26
GB2413329B GB2413329B (en) 2007-09-19

Family

ID=33098294

Family Applications (1)

Application Number Title Priority Date Filing Date
GB0516602A Expired - Fee Related GB2413329B (en) 2003-03-28 2004-03-19 Novel Enzymes

Country Status (5)

Country Link
JP (1) JP4571936B2 (en)
KR (1) KR101156882B1 (en)
CN (1) CN1768141B (en)
GB (1) GB2413329B (en)
WO (1) WO2004085651A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105669837B (en) * 2015-06-03 2020-01-17 苏州大学 Vascular endothelial cadherin epitope, antibody and application thereof
CN110358687B (en) * 2018-12-19 2020-12-04 安徽瑞达健康产业有限公司 Gibberellin for producing D-pantolactone hydrolase and application and fermentation method thereof
EP3748009A1 (en) * 2019-06-07 2020-12-09 DSM IP Assets B.V. Synthesis of (r)-pantolactone acetate

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993011261A1 (en) * 1991-11-25 1993-06-10 Keygene N.V. A novel pcr method with a single primer for nucleic acid analysis
US5411875A (en) * 1991-11-01 1995-05-02 University Of Iowa Research Foundation Method for retrieval of unknown flanking DNA sequence
EP0794251A1 (en) * 1995-09-13 1997-09-10 Fuji Yakuhin Kogyo Kabushiki Kaisha D-pantolactone hydrolase and gene encoding the same
WO2001032890A1 (en) * 1999-10-29 2001-05-10 Basf Aktiengesellschaft L-pantolactone-hydrolase and a method for producing d-pantolactone
US6514706B1 (en) * 1998-10-26 2003-02-04 Christoph Von Kalle Linear amplification mediated PCR (LAM PCR)

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5411875A (en) * 1991-11-01 1995-05-02 University Of Iowa Research Foundation Method for retrieval of unknown flanking DNA sequence
WO1993011261A1 (en) * 1991-11-25 1993-06-10 Keygene N.V. A novel pcr method with a single primer for nucleic acid analysis
EP0794251A1 (en) * 1995-09-13 1997-09-10 Fuji Yakuhin Kogyo Kabushiki Kaisha D-pantolactone hydrolase and gene encoding the same
US6514706B1 (en) * 1998-10-26 2003-02-04 Christoph Von Kalle Linear amplification mediated PCR (LAM PCR)
WO2001032890A1 (en) * 1999-10-29 2001-05-10 Basf Aktiengesellschaft L-pantolactone-hydrolase and a method for producing d-pantolactone

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
EMBL database 1 June 2002 Acc. No. Q8TGG4 *
EMBL database 15 July 1998 Acc. No. 034940 *
EMBL database 16 Oct. 2001 Acc. No. Q9TTJ5 *
Genomics 1995, 25(3), pp.674-681 - Liu et al. *

Also Published As

Publication number Publication date
GB0516602D0 (en) 2005-09-21
WO2004085651A3 (en) 2005-01-20
JP2006521103A (en) 2006-09-21
KR20050119151A (en) 2005-12-20
KR101156882B1 (en) 2012-07-05
JP4571936B2 (en) 2010-10-27
CN1768141A (en) 2006-05-03
WO2004085651A2 (en) 2004-10-07
GB2413329B (en) 2007-09-19
CN1768141B (en) 2012-10-10

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 20210319