GB2395718B - Crystal structure of cytochrome P450 3A4 and its use - Google Patents

Crystal structure of cytochrome P450 3A4 and its use

Info

Publication number
GB2395718B
GB2395718B GB0324870A GB0324870A GB2395718B GB 2395718 B GB2395718 B GB 2395718B GB 0324870 A GB0324870 A GB 0324870A GB 0324870 A GB0324870 A GB 0324870A GB 2395718 B GB2395718 B GB 2395718B
Authority
GB
United Kingdom
Prior art keywords
cytochrome
crystal structure
crystal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
GB0324870A
Other versions
GB0324870D0 (en
GB2395718A (en
Inventor
Ian James Tickle
Clemens Vonrhein
Pamela Ann Williams
Harren Jhoti
Stewart Brian Kirton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Astex Technology Ltd
Original Assignee
Astex Technology Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astex Technology Ltd filed Critical Astex Technology Ltd
Priority to GB0427006A priority Critical patent/GB2408509B/en
Publication of GB0324870D0 publication Critical patent/GB0324870D0/en
Publication of GB2395718A publication Critical patent/GB2395718A/en
Application granted granted Critical
Publication of GB2395718B publication Critical patent/GB2395718B/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C12N9/0077—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with a reduced iron-sulfur protein as one donor (1.14.15)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • C07K14/80—Cytochromes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
GB0324870A 2002-10-25 2003-10-24 Crystal structure of cytochrome P450 3A4 and its use Expired - Fee Related GB2395718B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB0427006A GB2408509B (en) 2002-10-25 2003-10-24 Crystal structure of cytochrome p450 3a4 and its use

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24106302P 2002-10-25 2002-10-25
US47944803P 2003-06-19 2003-06-19

Publications (3)

Publication Number Publication Date
GB0324870D0 GB0324870D0 (en) 2003-11-26
GB2395718A GB2395718A (en) 2004-06-02
GB2395718B true GB2395718B (en) 2005-01-19

Family

ID=29714861

Family Applications (1)

Application Number Title Priority Date Filing Date
GB0324870A Expired - Fee Related GB2395718B (en) 2002-10-25 2003-10-24 Crystal structure of cytochrome P450 3A4 and its use

Country Status (1)

Country Link
GB (1) GB2395718B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114136926B (en) * 2021-11-25 2023-12-22 中国科学院光电技术研究所 Cavity loss modeling-based optical cavity ring-down high-reflectivity measurement method

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6432639B1 (en) * 1997-09-10 2002-08-13 Dna Sciences Laboratories, Inc. Isolated CYP3A4 nucleic acid molecules and detection methods
WO2003102192A1 (en) * 2002-05-30 2003-12-11 Astex Technology Limited Methods of purification of cytochrome p450 proteins and of their crystallizing

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6432639B1 (en) * 1997-09-10 2002-08-13 Dna Sciences Laboratories, Inc. Isolated CYP3A4 nucleic acid molecules and detection methods
WO2003102192A1 (en) * 2002-05-30 2003-12-11 Astex Technology Limited Methods of purification of cytochrome p450 proteins and of their crystallizing

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
J Comp-Aided Mol Design; Vol 11, pp 265-272 (1997). "Molecular modeling of cytochrome P450 3A4" *
J Pharmacol Exper Therap; Vol 291, pp 424-433 (1999). Ekins et al. "Three-dimensional-quantitative structure..." *
Xenobiotica; Vol 26, pp 1067-1086 (1996). Lewis et al. "Molecular modelling of CYP3A4..." *

Also Published As

Publication number Publication date
GB0324870D0 (en) 2003-11-26
GB2395718A (en) 2004-06-02

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 20121024