GB2389357A - Dispenser for thixotropic viscous liquid or gel - Google Patents
Dispenser for thixotropic viscous liquid or gel Download PDFInfo
- Publication number
- GB2389357A GB2389357A GB0213187A GB0213187A GB2389357A GB 2389357 A GB2389357 A GB 2389357A GB 0213187 A GB0213187 A GB 0213187A GB 0213187 A GB0213187 A GB 0213187A GB 2389357 A GB2389357 A GB 2389357A
- Authority
- GB
- United Kingdom
- Prior art keywords
- weight
- parts
- dispenser according
- product
- gel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0065—Forms with gastric retention, e.g. floating on gastric juice, adhering to gastric mucosa, expanding to prevent passage through the pylorus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/734—Alginic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/42—Phosphorus; Compounds thereof
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D47/00—Closures with filling and discharging, or with discharging, devices
- B65D47/04—Closures with discharging devices other than pumps
- B65D47/06—Closures with discharging devices other than pumps with pouring spouts or tubes; with discharge nozzles or passages
- B65D47/08—Closures with discharging devices other than pumps with pouring spouts or tubes; with discharge nozzles or passages having articulated or hinged closures
- B65D47/0804—Closures with discharging devices other than pumps with pouring spouts or tubes; with discharge nozzles or passages having articulated or hinged closures integrally formed with the base element provided with the spout or discharge passage
- B65D47/0833—Hinges without elastic bias
- B65D47/0838—Hinges without elastic bias located at an edge of the base element
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D47/00—Closures with filling and discharging, or with discharging, devices
- B65D47/04—Closures with discharging devices other than pumps
- B65D47/06—Closures with discharging devices other than pumps with pouring spouts or tubes; with discharge nozzles or passages
- B65D47/18—Closures with discharging devices other than pumps with pouring spouts or tubes; with discharge nozzles or passages for discharging drops; Droppers
- B65D47/185—Closures with discharging devices other than pumps with pouring spouts or tubes; with discharge nozzles or passages for discharging drops; Droppers with sprinkling devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Inorganic Chemistry (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Molecular Biology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A dispenser comprises a compressible volume 1 containing a shear thinning and thixotropic viscous liquid or gel to be dispensed, the compressible volume 1 having an outlet 5, a plurality of openings are provided in the outlet 5, such that upon compression of the compressible volume 1, the liquid or gel is forced out through the plurality of openings. The viscous liquid or gel may be a gastrointestinal pharmaceutical product, the product may be a reflux suppressant, which may contain a liquid alginate. The product may be a pharmaceutical composition for the treatment of disorders of the oesophagus, for the treatment of reflux oesophagitis, gastritis, or dyspepsia. The compressible volume 1 may be provided by a squeezable bottle. A screw cap 2 may be provided which may fit over the complementary screw thread 3 on a neck of the bottle 1, the screw cap 2 may be provided with a flip up lid 4. The outlet with a plurality of openings may be provided by a metal mesh pad 5 which may be retained across the top of the bottle 1 and may be sandwiched between a shoulder on the lid 2 and the top of the bottle 1, or the mesh 5 may be an integral part of the cap 2.
Description
1- 2389357
A DISPENSER
The present invention relates to dispenser, and more particularly, to a dispenser for a homogenous viscous 5 liquid or a gel.
The present invention has particular relevance to the storage and dispensing of medical or pharmaceutical products, particularly gastrointestinal pharmaceutical I) products, although other applications such as the dispensing of toiletries such as shampoo, cosmetics such as skin moisturizer, food and the like are also envisaged. 15 Liquids/semisolids/gels that shear thin (l.e. have plastic, pseudo-plastic or thlxotropic rheology) often gel up or set on storage to various extents on standing.
This is beneficial, for example to prevent sedimentation and provide advantageous flow properties, such as the 2() ability to allow even spreading/coating under shear followed by gelling up to prevent the material running off of the surface that it has been applied to.
Stirring is commonly used to shear down the gelled 2- product to change it to a viscous liquid state.
Alternatively, in some applications, particularly those in the domestic environment shearing occurs by shaking the material before dispensing or squirting it through a small diameter orifice. These approaches have certain 30 disadvantages. Shaking requires a significant effort, and squirting the product through a narrow orifice can be difficult if the product has gelled up significantly.
These problems are of particular concern to the elderly or infirm who are the main users of gastrointestinal 35 products. Also, in the case of shaking, the extent of shear is quite low and consequently the consistency of
- 2 the product may not be completely changed with the effect that the product, when dispensed, is not smooth but contains gelled areas within the liquid areas thereby giving a lumpy appearance.
i According to the present invention there is provided a dispenser comprising a compressible volume containing a shear thinning and thixotropic viscous liquid or gel to be dispensed, the compressible volume having an outlet, a 10 plurality of openings being provided in the outlet, such that upon compression of the compressible volume, the liquid or gel is forced from the same body of VISCOUS liquid or gel out of the compressible volume through the plurality of openings.
As the dispenser relies on shearing the product in a number of openings, there is no need for a user to shake the dispenser prior to dispensing. However, the extrusion of the product through the openings results in 20 a dispensed product of uniform consistency. Also, the plurality of openings ensure a low resistance to flow, such that even an elderly or infirm user should have no ..........
Hindu ulrlculc In alspenslug one product.
25 The material being dispensed may be any viscous liquid or gel, particularly those which would benefit from being sheared as they are dispensed. The invention is particularly designed for gastrointestinal pharmaceutical products, such as a reflux suppressant, 30 and particularly one containing a liquid alginate.
Thus, the material being dispensed is preferably a pharmaceutical composition for the treatment of disorders of the oesophagus, the composition comprising: 35 (a) 0.1 to 11.0 parts by weight, preferably 2. 5 to 8 parts by weight alginatei
3 - (b) 0.01 to 3.0 parts by weight, preferably o.1 to 1.5 parts by weight of gum selected from xanthan gum, carageenan gum and mixtures thereof; and -I (c) o.O1 to 3.0 parts by weight, preferably 0.1 to 1.5 parts by weight of gum selected from a galactomannan, a glucomannan and mixtures thereof. JO Alternatively, the material being dispensed is a composition for the treatment of reflux oesophagitis, gastritis, dyspepsia and/or disorders of the oesophagus associated with reflux, the composition comprising: Monopotassium phosphate l.OOg Dipotasslum phosphate 4.00g Sodium bicarbonate 168g Methyl paraben 4.00g Propyl paraken 0.60g 20 Sodium saccharin l.OOg Xanthan gum 9.80g Calcium carbonate 8.00g Locust bean gum 4.og Sodium alginate LFR5/60 50.00g 75 Flavour 0.70g Deionised water to lOOOml Alternatively, the material being dispensed is a composition compclsing (a) 0.1 to 11.0 parts by weight, preferably 2.5 to 8 parts by weight alginate; fib) 0.01 to 3.0 parts by weight, preferably 0.1 to 1.5 parts by weight of gum selected from 35 xanthan gum, carageenan gum and mixtures thereof; and
4 - (c) 0.01 to 3.0 parts by weight, preferably 0.1 co 1.5 parts by weight of gum selected from a galactomannan, a glucomannan and mixtures thereof for use in a method of treatment and/or prevention of reflux oesophagitis, gastritis, dyspepsia and disorders of the oesophagus associated with reflux, which method comprises administering a pharmaceutically 10 effective amount of the composition to a patient in need thereof. Alternatively, the material being dispensed is an aqueous bioadhesive pourable liquid composition for lS coating a biological surface in the treatment and/or prevention of reflux oesophagitis, gastritis, dyspepsia and disorders of the oesophagus associated with reflex, the composition comprising: (a) 0.1 to 11% weight, preferably 2.5 to 8% weight 90 alginate salt; (b) 0.01 to 3.0% weight, preferably 0.1 to 1.5% weight xanthan gum; and (cj d.O' to.u weight, preferably U.1 to 1.
weight galactomannan or glucomannan Alternatively, the invention may be applicable to the dispensing of toiletries such as shampoo, cosmetics such as skin moisturizer, food and the like.
0 The compressible volume may be provided by a dispenser, the walls of which are compressible, for example a squeezable bottle, tube or sachet.
Alternatively, the dispenser may be a rigid container with a movable piston providing the compressible volume.
= 5 The average diameter of each opening is dependent upon the rheology of the product, but will typically be between 0.5 and 5 mm, preferably 2 to 4 mm, and more preferably 3 to 4 mm. Such values are applicable to a 5 weak gel in a pharmaceutical suspension or foodstuff.
The depth of each opening is preferably 0.2 to 0.5mm. It is believed that shallow openings will minimize the material adhering within the openings.
10 However, deeper openings provide greater shear, and under certain circumstances, may be up to 10 mm deep.
The plurality of openings are preferably provided by a perforate pad positioned across the outlet. The pad is 15 preferably a mesh e.g. of metal, or preferably plastic.
In Theological terms, the storage modulus G is used to describe the elastic solid, or gel like nature of a viscoelastic liquid, whereas the loss modulus G is used 20 to describe the viscous liquid, or flowable like nature.
Furthermore, pharmaceutical products such as liquid alglnate anti-reflux products are often in the form of a suspension and for such products to remain In suspension it is known that the storage modulus G' should dominate IS over the loss modulus G" of the liquid. However, a liquid oral product will become more unpalatable or undrinkable if its storage modulus dominates over its loss modulus to such an extent that it ceases to become a Plowable liquid.
3() It is known that liquid alginate anti-reflux products, for example, are susceptible to thermal gelling wher1 cooled from their normal storage temperature, such that certain products will gel when cooled from 20 c to 3s 4 C and others may gel when stored for an extended period at 30 C or 25 C. Such gelling can lead to unpalatability
but can often be reversed by the introduction of shear to
the system.
For example: A liquid alginate anti reflex product 5 containing 5% sodium alginate was found to have gelled on storage after one year in glass bottles at 25 C. The product was not drinkable and could not be poured in the unshaken state, but could be shaken down into a drinkable liquid which was easily poured from the bottle. The lo reduction of the two moduli, G and G with shaking the bottle 10, 20 and 30 times is shown in the following table, in which the product, shaken and unshaken, was analyzed on a Bohlin CV0-120 rheometer with a cone and plate 4 40 mm diameter geometry at 25 C in oscillation 15 mode. The values obtained (at 1. 027HZ) were using a stress from the middle of the linear visco-elastic region of the amplitude sweep.
G' (Pa.) G (Pa.) Unshaken product 46.6 17.5 Shaken 10 times 36.6 16.8 Shaken 20 times 32.7 16.0 Shaken 30 times 32.3 16.0 20 Rheological analysis of the same product taken from another bottle (unshaken) and forced to extrude through a 4 mm diameter orifice at a rate of 10 ml/second gave the following results: . G (Pa.) G (Pa.) _ Unshaken product 48.2 19.1 Extruded product 32.8 15.1 This illustrates the principle that extruding the contents of a bottle through a 4 mm diameter orifice is
- 7 - capable of giving similar benefits to the process of shaking in a bottle 20 or 30 times.
Examples of dispensers constructed in accordance with the present invention will now be described with reference to the accompanying drawings, in which: Fig. 1 is a cross section through a bottle in accordance with a first example; and 1() Fig. 2 Is a similar view of the second example.
As shown in Fig. l, the dispenser is a freestanding bottle which has thin plastic walls 1 which are IN deformable to force the material from the bottle. The screw cap 2 fits over the complementary screw thread 3 on the neck of the bottle. The screw cap has a flip up lid 4 (shown partially open in Fig. 1) to close the top of the bottle. A metal mesh pad 5 is retained across the 20 top of the bottle and is sandwiched between a shoulder on the lid 2 and the top of the bottle. Alternatively, the mesh may be an integral part of the cap.
The mesh is preferably provided with a plurality of 25 orifices having an average diameter of 3 to 4 mm. The pad is preferably 0.2 to 0.5 mm thick.
An alternative construction is shown in Fig. 2. This is similar to the construction of Fig. 1. The only lo differences are that the metal mesh pad 6 is induction sealed across the top of the cap 2 and the cap 7 is a screw cap without a flip up lid. The cap being unscrewed to open the bottle.
35 The bottle of Figs. 1 and 2 is particularly useful for storing and then dispensing oral liquid formulations
- 8 for alleviating gastrolutestinal problems. This formulation is a viscous material which becomes more gel like on storage. The increased gelling viscosity of the material which may occur after storage renders the 5 formulation unpalatable and difficult to swallow.
It has been found that by extruding the formulation through the mesh pad, shear force is applied to the formulation reducing the viscosity of the material on 1() extrusion arid resulting in a more palatable formulation being received by the consumer.
Claims (12)
1. A dispenser comprising a compressible volume containing a shear thinning and thixotropic viscous liquid or gel to be dispensed, the compressible volume having an outlet, a plurality of openings being provided in the outlet, such that upon compression of the compressible volume, the liquid or gel is forced from the same body of viscous liquid or gel out of the I() compressible volume through the plurality of openings.
2. A dispenser according to claim 1, wherein the viscous liquid or gel is a gastrointestinal pharmaceutical product.
1'
3. A dispenser according to claim 2, wherein the product is a reflux suppressant.
4. A dispenser according to claim 3, wherein the fin reflex suppressant contains a liquid alginate.
5. A dispenser according to claim 2, wherein the product is a pha--f=GuLic1 coiltion for The Treatment of disorders of the oesophagus, the composition 2> comprising: (a) 0.1 to 11.0 parts by weight, preferably 2. 5 to 8 parts by weight alginate; (b) 0.01 to 3.0 parts by weight, preferably 0.1 to 3() 1.5 parts by weight of gum selected from xanthan gum, carageenan gum and mixtures thereof; and (c) 0.01 to 3.0 parts by weight, preferably C.1 to 1.5 parts by weight of gum selected from a 35 galactomannan, a glucomannan and mixtures thereof.
1 0
6. A dispenser according to claim 2 wherein the product is a composition for the treatment of reflux oesophagltis, gastritis, dyspepsia and/or disorders of the oesophagus associated with reflux, the composition comprising: Monopotassium phosphate l.OOg Dipotassium phosphate 4.00g l0 Sodium bicarbonate 16.8g Methyl paraben 4 r Cog Propyl paraben 0.60g Sodium saccharin l.OOg Xanthan gum 9.80g 15 Calcium carbonate 8.00g Locust bean gum 420g Sodium alginate LFR5/60 50.00g Flavour 0.70g Deionised water to lOOOml
7. A dispenser according to claim 2, wherein the product is a composition comprising: (a) 0.1 to 11.0 parts by weight, preferably 2.5 to 25 parts by weight alginate; (b) 0.01 to 3.0 parts by weight, preferably 0.1 to 1.5 parts by weight of gum selected from xanthan gum, carageenan gum and mixtures thereof; and 3) (c) 0.01 to 3.0 parts by weight, preferably 0.1 to 1.5 parts by weight of gum selected from a galactomannan, a glucomannan and mixtures thereof 35 for use in a method of treatment and/or prevention of reflux oesophagitis, gastritis, dyspepsia and
disorders of the oesophagus associated with reflex, WhlC method comprises administering a pharmaceutically effective amount of the composition to a patient in need thereof.
8. A dispenser according to claim 2, wherein the product is an aqueous bioadhesive pourable liquid composition for coating a biological surface in the treatment and/or prevention of reflux oesophaglUls, 10 gastritis, dyspepsia and disorders of the oesophagus associated with reflex, the composition comprising: (a) 0.1 to 11% weight, preferably 2.5 to B% weigh: alginate salt; 15 (b) 0.01 to 3.0% weight, preferably o.1 to 1.t weight xanthan gum; and (c) 0.01 to 3.0% weight, preferably 0.1 to 1.5% weight galactomannan or glucomannan.
20
9. A dispenser according to any one of the preceding claims, wherein the compressible volume is provided by the walls of the dispenser being compressible. 25
10. A dispenser according to claim 9, wherein the dispenser is a squeezable bottle.
11. A dispenser according to any one of the preceding claims wherein the average diameter of each 3(, opening is between 0.5 and 5mm, preferably 2 to 4mm and more preferable 3 to 4mm.
12. A dispenser according to any one of the preceding claims, wherein the depth of each opening is up 3s to lOmm, and is preferably 0.2 to 0.5mm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0213187A GB2389357A (en) | 2002-06-08 | 2002-06-08 | Dispenser for thixotropic viscous liquid or gel |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0213187A GB2389357A (en) | 2002-06-08 | 2002-06-08 | Dispenser for thixotropic viscous liquid or gel |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| GB0213187D0 GB0213187D0 (en) | 2002-07-17 |
| GB2389357A true GB2389357A (en) | 2003-12-10 |
Family
ID=9938209
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB0213187A Withdrawn GB2389357A (en) | 2002-06-08 | 2002-06-08 | Dispenser for thixotropic viscous liquid or gel |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB2389357A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100320235A1 (en) * | 2007-10-10 | 2010-12-23 | Deltona Innovations Ag | Plastic closure |
| FR2954935A1 (en) * | 2010-01-06 | 2011-07-08 | Hema | METHOD AND DEVICE FOR PROCESSING CONTAINERS |
| ITVI20110267A1 (en) * | 2011-10-05 | 2013-04-06 | Giflor S R L | CONTAINER FOR PRODUCTS, IN PARTICULAR FOR FLUID PRODUCTS. |
| EP2973369A4 (en) * | 2013-03-12 | 2016-08-17 | Panacea Biomatx Inc | Method and system for making customized formulations for individuals |
| US9482599B1 (en) * | 2014-06-20 | 2016-11-01 | Lyle Johnson | Water testing method and apparatus |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB575563A (en) * | 1944-03-27 | 1946-02-22 | Betts & Co Ltd | Improvements in collapsible tubes |
| GB2181105A (en) * | 1985-10-04 | 1987-04-15 | Unilever Plc | Squeeze-to-use container |
| JPH08310551A (en) * | 1995-05-17 | 1996-11-26 | Kao Corp | Squeeze container |
| US5957336A (en) * | 1998-02-12 | 1999-09-28 | Radassao; Dan | Inverted dispenser |
| WO2000026095A1 (en) * | 1998-11-02 | 2000-05-11 | Feret Michael | Dispensing container for more or less viscous liquid |
| JP2001020651A (en) * | 1999-07-12 | 2001-01-23 | Okabe Co Ltd | Drill bit |
-
2002
- 2002-06-08 GB GB0213187A patent/GB2389357A/en not_active Withdrawn
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB575563A (en) * | 1944-03-27 | 1946-02-22 | Betts & Co Ltd | Improvements in collapsible tubes |
| GB2181105A (en) * | 1985-10-04 | 1987-04-15 | Unilever Plc | Squeeze-to-use container |
| JPH08310551A (en) * | 1995-05-17 | 1996-11-26 | Kao Corp | Squeeze container |
| US5957336A (en) * | 1998-02-12 | 1999-09-28 | Radassao; Dan | Inverted dispenser |
| WO2000026095A1 (en) * | 1998-11-02 | 2000-05-11 | Feret Michael | Dispensing container for more or less viscous liquid |
| JP2001020651A (en) * | 1999-07-12 | 2001-01-23 | Okabe Co Ltd | Drill bit |
Cited By (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8376195B2 (en) * | 2007-10-10 | 2013-02-19 | Deltona Innovations Ag | Plastic closure for dispensing thixotropic fluids |
| US20100320235A1 (en) * | 2007-10-10 | 2010-12-23 | Deltona Innovations Ag | Plastic closure |
| CN102712452B (en) * | 2010-01-06 | 2014-10-01 | Hema公司 | Method and device for handling containers |
| US9586801B2 (en) | 2010-01-06 | 2017-03-07 | Hema | Method and device for processing containers |
| WO2011083106A1 (en) * | 2010-01-06 | 2011-07-14 | Hema | Method and device for processing containers |
| FR2954935A1 (en) * | 2010-01-06 | 2011-07-08 | Hema | METHOD AND DEVICE FOR PROCESSING CONTAINERS |
| CN102712452A (en) * | 2010-01-06 | 2012-10-03 | Hema公司 | Method and device for handling containers |
| ITVI20110267A1 (en) * | 2011-10-05 | 2013-04-06 | Giflor S R L | CONTAINER FOR PRODUCTS, IN PARTICULAR FOR FLUID PRODUCTS. |
| WO2013051038A1 (en) * | 2011-10-05 | 2013-04-11 | Giflor S.R.L. | Container for products, particularly for fluid products |
| CN103842262A (en) * | 2011-10-05 | 2014-06-04 | 吉弗洛尔有限责任公司 | Container for products, particularly for fluid products |
| US9067704B2 (en) | 2011-10-05 | 2015-06-30 | Giflor S.R.L. | Container for products, particularly for fluid products |
| US10776701B2 (en) | 2013-03-12 | 2020-09-15 | Panacea Biomatx, Inc. | Method and system for making customized formulations for individuals |
| US9704096B2 (en) | 2013-03-12 | 2017-07-11 | Panacea Biomatx, Inc. | Method and system for making customized formulations for individuals |
| EP3300015A1 (en) * | 2013-03-12 | 2018-03-28 | Panacea Biomatx Inc. | Method and system for making customized formulations for individuals |
| EP2973369A4 (en) * | 2013-03-12 | 2016-08-17 | Panacea Biomatx Inc | Method and system for making customized formulations for individuals |
| US10776702B2 (en) | 2013-03-12 | 2020-09-15 | Panacea Biomatx, Inc. | Method and system for making customized formulations having a thixotropic hydrocolloid for individuals |
| US10776703B2 (en) | 2013-03-12 | 2020-09-15 | Panacea Biomatx, Inc. | Apparatus and machine for making customized formulations having a thixotropic hydrocolloid for individuals |
| US11049020B2 (en) | 2013-03-12 | 2021-06-29 | Panacea Biomatx, Inc. | Apparatus and machine for making customized formulations based on user input |
| US9482599B1 (en) * | 2014-06-20 | 2016-11-01 | Lyle Johnson | Water testing method and apparatus |
Also Published As
| Publication number | Publication date |
|---|---|
| GB0213187D0 (en) | 2002-07-17 |
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