GB2364785A - Methods of magnetic resonance imaging (MRI) using contract agent solutions formed from the dissolution of hyperpolarised materials - Google Patents

Methods of magnetic resonance imaging (MRI) using contract agent solutions formed from the dissolution of hyperpolarised materials

Info

Publication number
GB2364785A
GB2364785A GB0126355A GB0126355A GB2364785A GB 2364785 A GB2364785 A GB 2364785A GB 0126355 A GB0126355 A GB 0126355A GB 0126355 A GB0126355 A GB 0126355A GB 2364785 A GB2364785 A GB 2364785A
Authority
GB
United Kingdom
Prior art keywords
sample
magnetic resonance
data
nuclear spin
dissolution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB0126355A
Other versions
GB0126355D0 (en
GB2364785B (en
Inventor
Oskar Axelsson
Haukur Johannesson
Jan Henrik Ardenkjaer-Larsen
Ib Laursen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GE Healthcare AS
Original Assignee
Nycomed Imaging AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9911682.4A external-priority patent/GB9911682D0/en
Priority claimed from GBGB9916567.2A external-priority patent/GB9916567D0/en
Application filed by Nycomed Imaging AS filed Critical Nycomed Imaging AS
Priority claimed from PCT/GB2000/001888 external-priority patent/WO2000072031A1/en
Publication of GB0126355D0 publication Critical patent/GB0126355D0/en
Publication of GB2364785A publication Critical patent/GB2364785A/en
Application granted granted Critical
Publication of GB2364785B publication Critical patent/GB2364785B/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Signal Processing (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • General Physics & Mathematics (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The present invention provides a method of magnetic resonance investigation of a sample, preferably of a human or non-human animal body, said method comprising: (i) nuclear spin polarising a solid MR imaging agent (i.e. a material containing in its molecular structure a non-zero nuclear spin nucleus) by (a) spin refrigeration, or by, (b) irradiating with circularly polarised light; (ii) administering the nuclear spin polarised MR imaging agent to said sample, preferably after dissolution in a physiologically tolerable solvent and also preferably after separation form some or all of the paramagnetic species or chromophores; (iii) exposing said sample to a radiation at a frequency selected to excite nuclear spin transitions in selected nuclei therein, e.g. the spin polarised nuclei of the MR imaging agent; (iv) detecting magnetic resonance signals form said sample; and (v) optionally generating an image, dynamic flow data, diffusion data, perfusion data, physiological data (e.g. pH, pO<SB>2</SB>, pCO<SB>2</SB>, temperature or ionic concentrations) or metabolic data from said detected signals.
GB0126355A 1999-05-19 2000-05-17 Methods of magnetic resonance imaging (MRI) using contract agent solutions formed from the dissolution of hyperpolarised materials Expired - Fee Related GB2364785B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9911682.4A GB9911682D0 (en) 1999-05-19 1999-05-19 Method
GBGB9916567.2A GB9916567D0 (en) 1999-07-14 1999-07-14 Method
PCT/GB2000/001888 WO2000072031A1 (en) 1999-05-19 2000-05-17 Methods of magnetic resonance imaging (mri) using contract agent solutions formed from the dissolution of hyperpolarised materials

Publications (3)

Publication Number Publication Date
GB0126355D0 GB0126355D0 (en) 2002-01-02
GB2364785A true GB2364785A (en) 2002-02-06
GB2364785B GB2364785B (en) 2004-06-23

Family

ID=26315568

Family Applications (1)

Application Number Title Priority Date Filing Date
GB0126355A Expired - Fee Related GB2364785B (en) 1999-05-19 2000-05-17 Methods of magnetic resonance imaging (MRI) using contract agent solutions formed from the dissolution of hyperpolarised materials

Country Status (2)

Country Link
AU (1) AU4598600A (en)
GB (1) GB2364785B (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998058272A1 (en) * 1997-06-19 1998-12-23 Nycomed Imaging As Overhauser magnetic resonance imaging (ormi) method comprising ex vivo polarization of a magnetic resonance (mr) imaging agent

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998058272A1 (en) * 1997-06-19 1998-12-23 Nycomed Imaging As Overhauser magnetic resonance imaging (ormi) method comprising ex vivo polarization of a magnetic resonance (mr) imaging agent

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Physical Review B (Condensed Matter), 1 June 1988, USA, vol 37, no 16, pp9208-9221 *

Also Published As

Publication number Publication date
GB0126355D0 (en) 2002-01-02
GB2364785B (en) 2004-06-23
AU4598600A (en) 2000-12-12

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 20050517