GB2355461A - TNFR-like protein with death domain - Google Patents
TNFR-like protein with death domainInfo
- Publication number
- GB2355461A GB2355461A GB0028324A GB0028324A GB2355461A GB 2355461 A GB2355461 A GB 2355461A GB 0028324 A GB0028324 A GB 0028324A GB 0028324 A GB0028324 A GB 0028324A GB 2355461 A GB2355461 A GB 2355461A
- Authority
- GB
- United Kingdom
- Prior art keywords
- deth
- protein
- tnfr
- present
- death domain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
The present invention provides a novel 45 kilodalton protein, <U>D</U>eath Domain <U>E</U>xpressing <U>T</U>umor Necrosis Factor Receptor Family <U>H</U>omologue, referred to as DETH. DETH has a role in apoptosis and appears to be a member of the TNFR1/FAS/NGFR family of receptors. The present invention also provides nucleic acid sequences encoding DETH, fragments thereof or variants thereof and methods of using DETH or fragment thereof to identify compounds that inhibit or induce apoptosis.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9812607.1A GB9812607D0 (en) | 1998-06-12 | 1998-06-12 | Protein |
PCT/GB1999/001793 WO1999066039A1 (en) | 1998-06-12 | 1999-06-08 | Tnfr-like protein with death domain |
Publications (2)
Publication Number | Publication Date |
---|---|
GB0028324D0 GB0028324D0 (en) | 2001-01-03 |
GB2355461A true GB2355461A (en) | 2001-04-25 |
Family
ID=10833585
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GBGB9812607.1A Ceased GB9812607D0 (en) | 1998-06-12 | 1998-06-12 | Protein |
GB0028324A Withdrawn GB2355461A (en) | 1998-06-12 | 1999-06-08 | TNFR-like protein with death domain |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GBGB9812607.1A Ceased GB9812607D0 (en) | 1998-06-12 | 1998-06-12 | Protein |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP1084244A1 (en) |
AU (1) | AU4277899A (en) |
GB (2) | GB9812607D0 (en) |
WO (1) | WO1999066039A1 (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6358508B1 (en) | 1997-06-11 | 2002-03-19 | Human Genome Sciences, Inc. | Antibodies to human tumor necrosis factor receptor TR9 |
CN1329086A (en) * | 2000-06-21 | 2002-01-02 | 上海博德基因开发有限公司 | A novel polypeptide-human TNFR/NGFR protein 15 contaiing cytochrome C structural domain and polynucleotide for coding this polypeptide |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0869179A1 (en) * | 1997-04-02 | 1998-10-07 | Smithkline Beecham Corporation | Tumor necrosis related receptor, TR7 |
WO1998056892A1 (en) * | 1997-06-11 | 1998-12-17 | Human Genome Sciences, Inc. | Human tumor necrosis factor receptor tr9 |
WO1999011790A1 (en) * | 1997-09-04 | 1999-03-11 | Zymogenetics, Inc. | Tumor necrosis factor receptor ztnfr-6 |
WO1999015663A1 (en) * | 1997-09-26 | 1999-04-01 | Millennium Pharmaceuticals, Inc. | Novel molecules of the tnf receptor superfamily and uses therefor |
WO1999031128A2 (en) * | 1997-12-16 | 1999-06-24 | Incyte Pharmaceuticals, Inc. | Human tumor necrosis factor-r2-like proteins |
-
1998
- 1998-06-12 GB GBGB9812607.1A patent/GB9812607D0/en not_active Ceased
-
1999
- 1999-06-08 AU AU42778/99A patent/AU4277899A/en not_active Abandoned
- 1999-06-08 WO PCT/GB1999/001793 patent/WO1999066039A1/en not_active Application Discontinuation
- 1999-06-08 GB GB0028324A patent/GB2355461A/en not_active Withdrawn
- 1999-06-08 EP EP99939794A patent/EP1084244A1/en not_active Withdrawn
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0869179A1 (en) * | 1997-04-02 | 1998-10-07 | Smithkline Beecham Corporation | Tumor necrosis related receptor, TR7 |
WO1998056892A1 (en) * | 1997-06-11 | 1998-12-17 | Human Genome Sciences, Inc. | Human tumor necrosis factor receptor tr9 |
WO1999011790A1 (en) * | 1997-09-04 | 1999-03-11 | Zymogenetics, Inc. | Tumor necrosis factor receptor ztnfr-6 |
WO1999015663A1 (en) * | 1997-09-26 | 1999-04-01 | Millennium Pharmaceuticals, Inc. | Novel molecules of the tnf receptor superfamily and uses therefor |
WO1999031128A2 (en) * | 1997-12-16 | 1999-06-24 | Incyte Pharmaceuticals, Inc. | Human tumor necrosis factor-r2-like proteins |
Non-Patent Citations (5)
Title |
---|
Febs Letters Vol. 431 1998. Pan G et.al. pages 351-356 * |
Nature Vol. 384 1996. Kitson J et.al. pages 372-375 * |
Science Vol. 274 1996. Chinnaiyan A M et.al. pages 990-992 * |
Science Vol. 276 1997. Pan G et.al. pages 111-113 * |
Science Vol. 277 1997. Pan G et.al. pages 815-818 * |
Also Published As
Publication number | Publication date |
---|---|
GB9812607D0 (en) | 1998-08-12 |
AU4277899A (en) | 2000-01-05 |
WO1999066039A1 (en) | 1999-12-23 |
GB0028324D0 (en) | 2001-01-03 |
EP1084244A1 (en) | 2001-03-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
WAP | Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1) |