GB2350061A - Obturators and tube assemblies - Google Patents
Obturators and tube assemblies Download PDFInfo
- Publication number
- GB2350061A GB2350061A GB0006918A GB0006918A GB2350061A GB 2350061 A GB2350061 A GB 2350061A GB 0006918 A GB0006918 A GB 0006918A GB 0006918 A GB0006918 A GB 0006918A GB 2350061 A GB2350061 A GB 2350061A
- Authority
- GB
- United Kingdom
- Prior art keywords
- obturator
- tube
- along
- machine end
- length
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/04—Tracheal tubes
- A61M16/0465—Tracheostomy tubes; Devices for performing a tracheostomy; Accessories therefor, e.g. masks, filters
- A61M16/0472—Devices for performing a tracheostomy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/04—Tracheal tubes
- A61M16/0402—Special features for tracheal tubes not otherwise provided for
- A61M16/0429—Special features for tracheal tubes not otherwise provided for with non-integrated distal obturators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/04—Tracheal tubes
- A61M16/0434—Cuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/04—Tracheal tubes
- A61M16/0488—Mouthpieces; Means for guiding, securing or introducing the tubes
Abstract
An obturator 2 for a tracheostomy tube (1) has a strap 25 extending along its length between a nose 21 at its patient end 20 and a machine end 32 with clips 34 that fasten to a coupling 13 on the tube. The strap 25 has one web 26 extending along its entire length and a second web 27 extending orthogonally on one side of the first web to form a T shape section along the major part 28 of the strap towards its patient end. This makes the patient end 20 of the strap 25 relatively rigid whilst its machine end 32 is relatively flexible to enable the machine end to be twisted to release the engagement of the clips 34 and to enable the obturator 2 to be pulled out of the tube (1).
Description
2350061 OBTURATORS AND TUBE ASSEMBLIES This invention relates to
obturators and to tube assemblies.
The invention is more particularly concerned with obturators for use in tracheostomy tubes.
Tracheostomy tubes are often inserted with the aid of an obturator having a pointed end projecting from the patient end of the tracheostomy tube. The tip of the obturator helps separate tissue, enabling smooth entry of the tube. The obturator also helps stiffen the tube and prevents ingress of tissue into the tube, which could cause blockage. Examples of tracheostomy obturators are described in US4246897, US5222487, GB2224213, GB2316321 and GB2341102. Any displacement of the obturator from its correct position may make insertion of the tube more difficult and, by reducing the smoothness of the patient end of the assembly, may cause trauma to tissue around the stoma. After insertion, the obturator is pulled out of the machine end of the tube. GB 2316321 describes an obturator with a machine end that clips onto the coupling of the tracheostomy tube, the clip being released by twisting it relative to the tube. In this arrangement, the main body of the obturator is a strap of rectangular section so it is relatively flexible to enable twisting. This obturator works well with tracheostomy tubes that are relatively stiff but it does not provide optimal rigidity with more flexible tubes. Although the obturator could be made stiffer to give the desired rigidity for insertion of the tube, this makes it difficult to twist its clip to release engagement with the coupling of the tracheostomy tube.
2 It is an object of the present invention to provide an alternative obturator and tube assembly.
According to one aspect of the present invention there is provided an obturator for a curved medical tube, the obturator having a patient end shaped with a tapered nose arranged to protrude from the patient end of the tube and a machine end adapted to fasten with the machine end of the tube, the machine end of the obturator being releasable from engagement with the machine end of the tube by twisting relative to the tube, the obturator being substantially rigid along a major part of its length extending from the patient end, and the obturator having a portion of its length adjacent its machine end that is relatively flexible to permit twisting.
The major part of the obturator preferably has two orthogonal webs. The obturator may comprise a first web extending along the length of the obturator from the patient end nose to the machine end and a second orthogonal web extending along only the more rigid part of the obturator. One web may be arranged to extend along substantially in contact with the outside curve of the tube. The obturator is preferably of T shape in section along its major part. The nose of the obturator may have a bore extending through it along its length. The obturator may be a singlepiece moulding of a plastics material. The machine end preferably has two resilient arms extending forwardly on opposite sides and adapted to engage the tube. The machine end of the obturator may have a vent hole therein. The obturator is preferably curved along most of its length with a curvature substantially the same as that of the tube.
3 According to another aspect of the present invention there is provided a tracheostomy tube assembly comprising a tracheostomy tube and an obturator according to the above one aspect of the invention.
The tracheostomy tube is preferably curved with a constant radius along its length.
A tracheostomy tube assembly including an obturator according to the present invention, will now be described, by way of example, with reference to the accompanying drawings, in which:
Figure 1 is a side elevation view of the assembly; Figure 2 is a side elevation of the obturator; Figure 3 is an elevation view of the obturator along the line III in Figure 2; Figure 4 is an elevation view of the obturator along the line IV in Figure 2; and Figure 5 is a crosssectional view of the obturator along the line V-V of Figure 2; and Figure 6 is a cross-sectional view of the obturator along the line VINI of Figure 2.
4 The assembly comprises a tracheostomy tube 1 and an obturator 2.
The tube 1 has a conventional shaft 10 of circular section, which is moulded with a curved shape and a constant radius of curvature along its length_ The patient end 11 of the shaft 10 is cut square and tapered to be atraumatic. At its machine end, the shaft 10 is moulded integrally with a flange 12 by which the tube can be secured to the patient's neck. The machine end of the shaft 10 is also bonded to a coupling 13 having a female tapered bore 14 shaped to receive a male tapered coupling (not shown) connected to a patient ventilation or anaesthetic circuit. Alternatively, where the patient is breathing spontaneously, the coupling 13 is left open. Externally, the coupling 13 is of cylindrical shape apart from surface formations provided by two, short undercut lips 15 located diametrically opposite one another at the patient end of the coupling. The shaft 10 has an inflatable cuff 16 towards its patient end, for sealing with the inside of the trachea. Alternative tubes need not include such a cuff.
The obturator 2 is a single-piece, integral moulding of a stiff plastics material such as high density polyethylene. At its patient end 20, the obturator 2 has a bullet-shape nose 21, which is a close fit within the patient end 11 of the tube 1. The nose 21 has a tapered tip 22, which, in use, projects from the tube 1 so as to form a pointed continuation of the patient end of the shaft 10. A small diameter bore 23 extends along the nose 21 from its tip 22 to an opening 24 at its rear end.
Extending regwardly from the nose 21 the obturator has a curved strap 25 moulded to the curvature of the tube 1. Typically, the strap 25 is about 80= long. The strap 25 comprises a web 26 of substantially rectangular section arranged to extend diametrically of the tube shaft 10 as a close sliding fit along its entire length. The strap 25 also has an additional web 27 extending along the major part of the length of the strap, typically along about 60mm, from the patient end. This additional web 27 extends radially and orthogonally of the first web 26 projecting from one side only towards the outside of its curve so that it substantially contacts the inner wall of the shaft 10 of the tube I on the outside of its curvature. The major part 28 of the strap 25 from its patient end therefore has a substantially T-shape in section, as shown in Figure 5, with just a shallow rib 29 along the side opposite the additional web 27 and is substantially rigid. The machine end 30 of the strap 25 has a substantially rectangular shape in section, as shown in Figure 6 apart from the rib 29 and a similar shallow rib 31 being a continuation of the additional web 27 and is, therefore, more flexible than the major part 28.
At its machine end 32, the obturator 2 has an enlarged, cruciform section formed by a vertical plate 132 and a horizontal plate 232. The machine end 32 has a tapered exterior, which is a close friction fit within the coupling 13 of the tube 1. A flange 33 extends radially at the machine end of the cruciform section 32 and provides a grip by which the obturator 2 can be inserted and removed from the tube 1. Two resilient arms 34 extend forwardly from the flange 33 on opposite sides of the obturator 2. The arms 34 are terminated at their patient end by surface fon-nations in the form of inwardly-directed catches 3 5 formed by an inclined ramp 36 and a ledge 37. The dimensions of the arms 34 are such that, when the flange 33 abuts the machine end of the coupling 13, the arms extend along opposite sides of the coupling with the catches 3 5 engaging under the lips 15, thereby preventing the obturator 2 6 being removed from the tube. Two vent holes 3 8 are formed through the flange 3 3 in alignment with the comers between the cruciform section 32.
In use, the obturator 2 is pushed fully into the tube I so that the nose 21 projects from the patient end I I of the tube and so that the catches 3 5 engage the lips 15 on the coupling 13, thereby fastening the machine end of the obturator with the machine end of the tube. The assembly is inserted into the patient in the usual way, the obturator 2 providing a tapered lead for the tube into the tracheostomy. The T-shape section along most of the length of the obturator 2 makes it relatively stiff so as to significantly increase the stiffness of the tracheostomy tube I and facilitate introduction. Rearward movement of the obturator 2 relative to the tube I is prevented by engagement of the catches 35 with the lips 15. Rearward movement of the nose 21 of the obturator 2 within the tube I is also resisted by contact of the additional web 27 with the wall of the tube. The patient can breath through the assembly during insertion because of the bore 23 through the nose 2 1, the passage between the strap 25 and the inside of the tube, and the holes 38 in the flange 33. If desired, a guidewire (not shown) could be threaded through the bore 23 prior to insertion and the assembly slid into position along the guidewire. In order to prevent the rear end of the guidewire catching on the vertical plate 132 when the guidewire is inserted from the patient end of the obturator, the leading edge 133 of the vertical plate is tapered. When the assembly has been inserted to the correct location, the obturator 2 is removed by gripping the flange 33 and twisting it through about 20' so that the catches 35 come out of engagement with the lips 15 and can be pulled rear-wardly along the outside of the coupling 13. The flange 33 can be twisted easily despite the stiffness of the patient end of the obturator 2 because the machine end 30 of the obturator
7 is flexible to allow twisting. After removal of the obturator 2, the coupling 13 can be connected to a ventilation circuit or left open, in the usual way.
It will be appreciated that there are alternative twist-releasable arrangements that could be used to fasten the obturator with the tube. The invention could be used with tubes, other than tracheal tubes, where it is necessary to prevent displacement of an obturator relative to a tube.
1 8
Claims (15)
- An obturator for a curved medical tube, the obturator having a patient end shaped with a tapered nose arranged to protrude from the patient end of the tube and a machine end adapted to fasten with the machine end of the tube, the machine end of the obturator being releasable from engagement with the machine end of the tube by twisting relative to the tube, wherein the obturator is substantially rigid along a major part of its length extending from the patient end, and wherein the obturator has a portion of its length adjacent its machine end that is relatively flexible to permit twisting.
- 2. An obturator according to Claim 1, wherein the said major part of the obturator has two orthogonal webs.
- 3. An obturator according to Claim 2, wherein the obturator comprises a first web extending along the length of the obturator from the patient end nose to the machine end and a second orthogonal web extending along only the more rigid part of the obturator.
- 4. An obturator according to Claim 2 or 3, wherein one web is arranged to extend along substantially in contact with the outside curve of the tube.9
- 5. An obturator according to any one of the preceding claims, wherein the obturator is of T shape in section along its said major part.
- 6. An obturator according to any one of the preceding claims, wherein the nose of the obturator has a bore extending through it along its length.
- 7. An obturator according to any one of the preceding claims, wherein the obturator is a single-piece moulding of a plastics material-
- 8. An obturator according to any one of the preceding claims, wherein the machine end has two resilient arms extending forwardly on opposite sides and adapted to engage the tube.
- 9. An obturator according to any one of the preceding claims, wherein the machine end of the obturator has a vent hole therein.
- 10. An obturator according to any one of the preceding claims, wherein the obturator is curved along most of its length with a curvature substantially the same as that of the tube.
- 11. An obturator substantially as hereinbefore described with reference to the accompanying drawings.
- 12. A tracheostomy tube assembly comprising a tracheostomy tube and an obturator according to any one of the preceding claims.
- 13. An assembly according to Claim 12, wherein the tracheostomy tube is curved with a constant radius along its length.
- 14. A tracheostomy tube assembly substantially as hereinbefore described with reference to the accompanying drawings.
- 15. Any novel and inventive feature or combination of features as hereinbefore described.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9908136.6A GB9908136D0 (en) | 1999-04-12 | 1999-04-12 | Obturators and tube assemblies |
Publications (3)
Publication Number | Publication Date |
---|---|
GB0006918D0 GB0006918D0 (en) | 2000-05-10 |
GB2350061A true GB2350061A (en) | 2000-11-22 |
GB2350061B GB2350061B (en) | 2003-06-04 |
Family
ID=10851235
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GBGB9908136.6A Ceased GB9908136D0 (en) | 1999-04-12 | 1999-04-12 | Obturators and tube assemblies |
GB0006918A Expired - Fee Related GB2350061B (en) | 1999-04-12 | 2000-03-23 | Obturators and tube assemblies |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GBGB9908136.6A Ceased GB9908136D0 (en) | 1999-04-12 | 1999-04-12 | Obturators and tube assemblies |
Country Status (11)
Country | Link |
---|---|
US (1) | US6481436B1 (en) |
EP (1) | EP1044701B1 (en) |
JP (1) | JP4495300B2 (en) |
AT (1) | ATE295196T1 (en) |
AU (1) | AU765068B2 (en) |
CA (1) | CA2305055C (en) |
DE (1) | DE60020002T2 (en) |
ES (1) | ES2238252T3 (en) |
GB (2) | GB9908136D0 (en) |
NZ (1) | NZ503623A (en) |
ZA (1) | ZA200001797B (en) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030131853A1 (en) * | 2002-01-17 | 2003-07-17 | Wall William H. | Oro-pharyngeal airway and gas-assisted injection molding method therefor |
US7036501B2 (en) * | 2002-01-17 | 2006-05-02 | Wall W Henry | Oro-pharyngeal airway with breath monitor |
US20040154623A1 (en) * | 2003-02-03 | 2004-08-12 | Cook Critical Care | Tracheostomy tube and loading dilator |
JP3955551B2 (en) * | 2003-06-10 | 2007-08-08 | 規方 田熊 | Airway |
WO2006087032A1 (en) * | 2005-02-15 | 2006-08-24 | Patents Exploitation Company Bv | Dilatative percutaneous tracheotomy device |
US8434487B2 (en) | 2006-06-22 | 2013-05-07 | Covidien Lp | Endotracheal cuff and technique for using the same |
US8196584B2 (en) | 2006-06-22 | 2012-06-12 | Nellcor Puritan Bennett Llc | Endotracheal cuff and technique for using the same |
CA2664238C (en) | 2006-09-22 | 2016-02-23 | Romano Guerra | Tracheostomy apparatus and device |
US7950393B2 (en) | 2006-09-29 | 2011-05-31 | Nellcor Puritan Bennett Llc | Endotracheal cuff and technique for using the same |
US8307830B2 (en) | 2006-09-29 | 2012-11-13 | Nellcor Puritan Bennett Llc | Endotracheal cuff and technique for using the same |
DE102009013205A1 (en) | 2009-03-17 | 2010-09-23 | Dolphys Technologies B.V. | Jet ventilation catheter, in particular for the ventilation of a patient |
AU2008240298A1 (en) * | 2007-04-11 | 2008-10-23 | John J. Davis | Atraumatic introducer for nasal endotracheal tubes and its method of use |
US20090064999A1 (en) * | 2007-09-12 | 2009-03-12 | E. Benson Hood Laboratories | Tracheostomy tube with inner cannula and obturator for regular and extra-long stomas |
US8607795B2 (en) | 2007-09-20 | 2013-12-17 | Kimberly-Clark Worldwide, Inc. | Balloon cuff tracheostomy tube |
US8313687B2 (en) | 2007-09-20 | 2012-11-20 | Kimberly-Clark Worldwide, Inc. | Method of making an improved balloon cuff tracheostomy tube |
US8750978B2 (en) | 2007-12-31 | 2014-06-10 | Covidien Lp | System and sensor for early detection of shock or perfusion failure and technique for using the same |
US8590534B2 (en) | 2009-06-22 | 2013-11-26 | Covidien Lp | Cuff for use with medical tubing and method and apparatus for making the same |
US8887717B2 (en) * | 2009-10-15 | 2014-11-18 | Airway Cam Technologies, Inc. | Introducer for surgical airway catheters |
EP2488115A1 (en) * | 2009-10-15 | 2012-08-22 | Airway Cam Technologies, Inc. | Introducer for surgical airway catheters |
US9010326B2 (en) * | 2012-08-02 | 2015-04-21 | Covidien Lp | Compressible connector for an inner cannula |
US9393374B2 (en) | 2013-03-25 | 2016-07-19 | Richard M. Levitan | Introducer for surgical airway catheters |
WO2014162392A1 (en) * | 2013-04-01 | 2014-10-09 | テルモ株式会社 | Guide wire |
US9539402B2 (en) * | 2013-06-10 | 2017-01-10 | Guidance Airway Solutions, Llc | Combined laryngo-tracheal anesthetic and stylet device |
DE202013009822U1 (en) * | 2013-11-27 | 2014-02-11 | Primed Halberstadt Medizintechnik Gmbh | Device in the form of an atraumatic insertion aid for inserting a tracheostomy tube into a tracheostoma |
GB201511113D0 (en) | 2015-06-24 | 2015-08-05 | Smiths Medical Int Ltd | Tube introducers, assemblies and methods |
DE102015122810A1 (en) | 2015-12-23 | 2017-06-29 | Tracoe Medical Gmbh | insertion |
DE102018133449A1 (en) | 2018-12-21 | 2020-06-25 | Tracoe Medical Gmbh | Insertion aid for tracheostomy tubes |
GB202104206D0 (en) | 2021-03-25 | 2021-05-12 | Smiths Medical International Ltd | Obturators and tube assemblies |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5067496A (en) * | 1988-04-07 | 1991-11-26 | Shiley Incorporated | Tracheostomy tube |
US5546937A (en) * | 1993-12-13 | 1996-08-20 | Stuart; J. Michael | Obturator and tracheostomy tube containing the obturator |
GB2316321A (en) * | 1996-08-21 | 1998-02-25 | Smiths Industries Ltd | Tracheostomy Assembly Including Obturator with Connecting Means. |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
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US2541402A (en) * | 1948-01-13 | 1951-02-13 | Curtis W Caine | Endobronchial intubating stylet |
US4246897A (en) | 1979-02-15 | 1981-01-27 | Rudolph Muto | Tracheotomy obturator and tube flange |
GB2213384B (en) * | 1988-01-09 | 1991-12-18 | Smiths Industries Plc | Tracheal tube fittings and assemblies |
CA1313101C (en) * | 1988-09-30 | 1993-01-26 | Denis Labombard | Hinged tracheostomy tube obturator |
US5042475A (en) * | 1988-09-30 | 1991-08-27 | Portex, Inc. | Hinged tracheostomy tube obturator |
GB8828012D0 (en) * | 1988-12-01 | 1989-01-05 | Shetty D | Tracheostomy tube assembly & use |
DE69227110T2 (en) * | 1991-06-21 | 1999-04-15 | Smiths Ind Med Syst Inc | COMBINATION OF AN OBTURATOR AND A TUBE CANNULA |
CA2064396C (en) * | 1992-03-30 | 1996-04-23 | Joseph Arnold Fisher | Endotracheal tube introducer |
US5279610A (en) * | 1992-11-06 | 1994-01-18 | Cook Incorporated | Oroesophageal, instrument introducer assembly and method of use |
US5791338A (en) * | 1994-01-26 | 1998-08-11 | William T. Merchant | Endotracheal intubation apparatus |
GB9604093D0 (en) * | 1996-02-27 | 1996-05-01 | Smiths Industries Plc | Tracheal assemblies |
GB9608483D0 (en) * | 1996-04-25 | 1996-07-03 | Smiths Industries Plc | Introducers and assemblies |
GB9617545D0 (en) * | 1996-08-21 | 1996-10-02 | Smiths Industries Ltd | Medical tube assemblies |
US5937860A (en) * | 1997-04-10 | 1999-08-17 | Cook; Daniel J. | Laryngeal mask |
GB9819330D0 (en) | 1998-09-05 | 1998-10-28 | Smiths Industries Plc | Introducers and tube assemblies |
-
1999
- 1999-04-12 GB GBGB9908136.6A patent/GB9908136D0/en not_active Ceased
-
2000
- 2000-03-23 DE DE60020002T patent/DE60020002T2/en not_active Expired - Lifetime
- 2000-03-23 AT AT00302375T patent/ATE295196T1/en not_active IP Right Cessation
- 2000-03-23 GB GB0006918A patent/GB2350061B/en not_active Expired - Fee Related
- 2000-03-23 EP EP00302375A patent/EP1044701B1/en not_active Expired - Lifetime
- 2000-03-23 ES ES00302375T patent/ES2238252T3/en not_active Expired - Lifetime
- 2000-03-27 NZ NZ503623A patent/NZ503623A/en unknown
- 2000-03-29 US US09/537,085 patent/US6481436B1/en not_active Expired - Lifetime
- 2000-04-04 AU AU25244/00A patent/AU765068B2/en not_active Ceased
- 2000-04-10 ZA ZA200001797A patent/ZA200001797B/en unknown
- 2000-04-11 CA CA002305055A patent/CA2305055C/en not_active Expired - Fee Related
- 2000-04-12 JP JP2000110449A patent/JP4495300B2/en not_active Expired - Fee Related
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5067496A (en) * | 1988-04-07 | 1991-11-26 | Shiley Incorporated | Tracheostomy tube |
US5546937A (en) * | 1993-12-13 | 1996-08-20 | Stuart; J. Michael | Obturator and tracheostomy tube containing the obturator |
GB2316321A (en) * | 1996-08-21 | 1998-02-25 | Smiths Industries Ltd | Tracheostomy Assembly Including Obturator with Connecting Means. |
Also Published As
Publication number | Publication date |
---|---|
DE60020002T2 (en) | 2005-10-20 |
ZA200001797B (en) | 2000-10-30 |
US6481436B1 (en) | 2002-11-19 |
AU2524400A (en) | 2000-10-19 |
EP1044701A3 (en) | 2001-07-11 |
ATE295196T1 (en) | 2005-05-15 |
CA2305055C (en) | 2007-10-02 |
GB0006918D0 (en) | 2000-05-10 |
JP4495300B2 (en) | 2010-06-30 |
EP1044701A2 (en) | 2000-10-18 |
DE60020002D1 (en) | 2005-06-16 |
EP1044701B1 (en) | 2005-05-11 |
NZ503623A (en) | 2000-11-24 |
JP2000308683A (en) | 2000-11-07 |
GB2350061B (en) | 2003-06-04 |
ES2238252T3 (en) | 2005-09-01 |
GB9908136D0 (en) | 1999-06-02 |
AU765068B2 (en) | 2003-09-11 |
CA2305055A1 (en) | 2000-10-12 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PCNP | Patent ceased through non-payment of renewal fee |
Effective date: 20180323 |