GB2336327A - Method and apparatus for chemical synthesis - Google Patents

Method and apparatus for chemical synthesis

Info

Publication number
GB2336327A
GB2336327A GB9913683A GB9913683A GB2336327A GB 2336327 A GB2336327 A GB 2336327A GB 9913683 A GB9913683 A GB 9913683A GB 9913683 A GB9913683 A GB 9913683A GB 2336327 A GB2336327 A GB 2336327A
Authority
GB
United Kingdom
Prior art keywords
chemical synthesis
reaction chamber
fluid pathway
main fluid
inputs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB9913683A
Other versions
GB2336327A8 (en
GB2336327B (en
GB9913683D0 (en
Inventor
Derek Adeyemi Palmer
Martin Thomas French
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kalibrant Ltd
Original Assignee
Kalibrant Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9726482.4A external-priority patent/GB9726482D0/en
Application filed by Kalibrant Ltd filed Critical Kalibrant Ltd
Priority to GB9913683A priority Critical patent/GB2336327B/en
Publication of GB9913683D0 publication Critical patent/GB9913683D0/en
Publication of GB2336327A publication Critical patent/GB2336327A/en
Publication of GB2336327A8 publication Critical patent/GB2336327A8/en
Application granted granted Critical
Publication of GB2336327B publication Critical patent/GB2336327B/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00281—Individual reactor vessels
    • B01J2219/00286—Reactor vessels with top and bottom openings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00423—Means for dispensing and evacuation of reagents using filtration, e.g. through porous frits
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00452—Means for the recovery of reactants or products
    • B01J2219/00454—Means for the recovery of reactants or products by chemical cleavage from the solid support
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00479—Means for mixing reactants or products in the reaction vessels
    • B01J2219/00481—Means for mixing reactants or products in the reaction vessels by the use of moving stirrers within the reaction vessels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00495—Means for heating or cooling the reaction vessels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/005—Beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00585—Parallel processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/0059—Sequential processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00698—Measurement and control of process parameters
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/14—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)

Abstract

The present invention provides a chemical synthesis apparatus comprising a plurality of reagent inputs (2) and a solid support input (1). Each input (1, 2) is connectable to a main fluid pathway via a respective switchable valve (3). The apparatus further includes a reaction chamber (4) fluidly connectable to the main fluid pathway by a respective switchable valve (3) downstream of the inputs (1, 2). The reaction chamber (4) further includes an outlet downstream of a barrier (5) arranged to prevent passage of said solid supports but allows passage of unbound molecules.
GB9913683A 1997-12-15 1998-12-15 Method and apparatus for chemical synthesis Expired - Fee Related GB2336327B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB9913683A GB2336327B (en) 1997-12-15 1998-12-15 Method and apparatus for chemical synthesis

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9726482.4A GB9726482D0 (en) 1997-12-15 1997-12-15 Method and apparatus for chemical synthesis
GB9913683A GB2336327B (en) 1997-12-15 1998-12-15 Method and apparatus for chemical synthesis
PCT/GB1998/003761 WO1999030817A1 (en) 1997-12-15 1998-12-15 Method and apparatus for chemical synthesis

Publications (4)

Publication Number Publication Date
GB9913683D0 GB9913683D0 (en) 1999-08-11
GB2336327A true GB2336327A (en) 1999-10-20
GB2336327A8 GB2336327A8 (en) 1999-11-03
GB2336327B GB2336327B (en) 2000-03-08

Family

ID=26312774

Family Applications (1)

Application Number Title Priority Date Filing Date
GB9913683A Expired - Fee Related GB2336327B (en) 1997-12-15 1998-12-15 Method and apparatus for chemical synthesis

Country Status (1)

Country Link
GB (1) GB2336327B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2347141A (en) * 1998-09-26 2000-08-30 Brendan James Hamill Combinatorial synthesiser

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1985001224A1 (en) * 1983-09-22 1985-03-28 Saneii Hossain H Solid phase peptide synthesizer
FR2630928A1 (en) * 1988-05-03 1989-11-10 Rhone Poulenc Chimie APPARATUS FOR SUPPORTING AND HEATING REACTION, TREATMENT OR ANALYSIS CONTAINERS OF VARIOUS PRODUCTS
WO1991017823A1 (en) * 1990-05-15 1991-11-28 Protos Corporation Method and apparatus for biopolymer synthesis
WO1995012608A1 (en) * 1993-11-02 1995-05-11 Affymax Technologies N.V. Synthesizing and screening molecular diversity
WO1997006884A1 (en) * 1995-08-17 1997-02-27 Pharmacia Biotech Ab Machine for synthesizing oligonucleotides
WO1997007126A1 (en) * 1995-08-17 1997-02-27 Hybridon, Inc. Apparatus and process for multi-stage solid-phase synthesis of long-chained organic molecules
EP0794001A2 (en) * 1988-12-21 1997-09-10 The Perkin-Elmer Corporation Automated system for polynucleotide synthesis and purification

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1985001224A1 (en) * 1983-09-22 1985-03-28 Saneii Hossain H Solid phase peptide synthesizer
FR2630928A1 (en) * 1988-05-03 1989-11-10 Rhone Poulenc Chimie APPARATUS FOR SUPPORTING AND HEATING REACTION, TREATMENT OR ANALYSIS CONTAINERS OF VARIOUS PRODUCTS
EP0794001A2 (en) * 1988-12-21 1997-09-10 The Perkin-Elmer Corporation Automated system for polynucleotide synthesis and purification
WO1991017823A1 (en) * 1990-05-15 1991-11-28 Protos Corporation Method and apparatus for biopolymer synthesis
WO1995012608A1 (en) * 1993-11-02 1995-05-11 Affymax Technologies N.V. Synthesizing and screening molecular diversity
WO1997006884A1 (en) * 1995-08-17 1997-02-27 Pharmacia Biotech Ab Machine for synthesizing oligonucleotides
WO1997007126A1 (en) * 1995-08-17 1997-02-27 Hybridon, Inc. Apparatus and process for multi-stage solid-phase synthesis of long-chained organic molecules

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2347141A (en) * 1998-09-26 2000-08-30 Brendan James Hamill Combinatorial synthesiser
GB2347141B (en) * 1998-09-26 2002-01-16 Brendan James Hamill Combinatorial synthesiser

Also Published As

Publication number Publication date
GB2336327A8 (en) 1999-11-03
GB2336327B (en) 2000-03-08
GB9913683D0 (en) 1999-08-11

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 20021215