GB2335923A - Amino-butyrate derivatives of venoms - Google Patents

Amino-butyrate derivatives of venoms

Info

Publication number
GB2335923A
GB2335923A GB9915067A GB9915067A GB2335923A GB 2335923 A GB2335923 A GB 2335923A GB 9915067 A GB9915067 A GB 9915067A GB 9915067 A GB9915067 A GB 9915067A GB 2335923 A GB2335923 A GB 2335923A
Authority
GB
United Kingdom
Prior art keywords
amino
venom
venoms
synthetic peptides
butyrate derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB9915067A
Other versions
GB9915067D0 (en
GB2335923B (en
Inventor
Jean-Marc Sabatier
Modhammed El-Ayeb
Rietschoten Jurphaas Van
Herve Rochat
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Armel SA
Original Assignee
Armel SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Armel SA filed Critical Armel SA
Publication of GB9915067D0 publication Critical patent/GB9915067D0/en
Publication of GB2335923A publication Critical patent/GB2335923A/en
Application granted granted Critical
Publication of GB2335923B publication Critical patent/GB2335923B/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43513—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae
    • C07K14/43522—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae from scorpions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Insects & Arthropods (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Synthetic peptides have amino acid sequences homolologous or substantially homologous to those of naturally occurring peptide animal or plant venoms save that each cystine residue present in the venom has been replaced in the synthetic peptide by two alpha-amino-butyric acid residues. The synthetic peptides are non-toxic but retain the antigenic properties of the venom. They can therefore be used to raise vaccines against the venom, and also for treatment of persons already envenomated.
GB9915067A 1996-12-31 1997-12-30 Amino-butyrate derivatives of venoms Expired - Lifetime GB2335923B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9627115.0A GB9627115D0 (en) 1996-12-31 1996-12-31 Alpha-amino-butyrate derivatives of venoms
PCT/EP1997/007333 WO1998029445A1 (en) 1996-12-31 1997-12-30 α-AMINO-BUTYRATE DERIVATIVES OF VENOMS

Publications (3)

Publication Number Publication Date
GB9915067D0 GB9915067D0 (en) 1999-08-25
GB2335923A true GB2335923A (en) 1999-10-06
GB2335923B GB2335923B (en) 2001-03-14

Family

ID=10805140

Family Applications (2)

Application Number Title Priority Date Filing Date
GBGB9627115.0A Pending GB9627115D0 (en) 1996-12-31 1996-12-31 Alpha-amino-butyrate derivatives of venoms
GB9915067A Expired - Lifetime GB2335923B (en) 1996-12-31 1997-12-30 Amino-butyrate derivatives of venoms

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GBGB9627115.0A Pending GB9627115D0 (en) 1996-12-31 1996-12-31 Alpha-amino-butyrate derivatives of venoms

Country Status (3)

Country Link
AU (1) AU5861198A (en)
GB (2) GB9627115D0 (en)
WO (1) WO1998029445A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040039167A1 (en) * 2000-09-04 2004-02-26 Jean-Marc Sabatier Maurotoxin, pi1 and hstx1 derivatives

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
1991 9 (12) PGS 907-910 VACCINE. CHAVEZ-OLORTEGUI ET AL. *
1994 33 (17) PGS 5253-5261 BIOCHEMISTRY. XU ET AL. *
1996 35 (33) PGS 10641-10647 BIOCHEMISTRY. SABATIER ET AL. *
1997 15 (2) PGS 187-194 VACCINE. ZENOUKI ET AL. *

Also Published As

Publication number Publication date
AU5861198A (en) 1998-07-31
GB9627115D0 (en) 1997-02-19
WO1998029445A1 (en) 1998-07-09
GB9915067D0 (en) 1999-08-25
GB2335923B (en) 2001-03-14

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Legal Events

Date Code Title Description
732E Amendments to the register in respect of changes of name or changes affecting rights (sect. 32/1977)