GB2323597A - Sealing material for use in a valve for an aerosol inhaler - Google Patents

Sealing material for use in a valve for an aerosol inhaler Download PDF

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Publication number
GB2323597A
GB2323597A GB9706252A GB9706252A GB2323597A GB 2323597 A GB2323597 A GB 2323597A GB 9706252 A GB9706252 A GB 9706252A GB 9706252 A GB9706252 A GB 9706252A GB 2323597 A GB2323597 A GB 2323597A
Authority
GB
United Kingdom
Prior art keywords
rubbers
seal
elastomeric material
valve
thermoplastic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB9706252A
Other versions
GB9706252D0 (en
Inventor
Jonathan Howel Thomas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Consort Medical PLC
Original Assignee
Bespak PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bespak PLC filed Critical Bespak PLC
Priority to GB9706252A priority Critical patent/GB2323597A/en
Publication of GB9706252D0 publication Critical patent/GB9706252D0/en
Publication of GB2323597A publication Critical patent/GB2323597A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D83/00—Containers or packages with special means for dispensing contents
    • B65D83/14—Containers or packages with special means for dispensing contents for delivery of liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant for a product delivered by a propellant
    • B65D83/75—Aerosol containers not provided for in groups B65D83/16 - B65D83/74
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K3/00—Materials not provided for elsewhere
    • C09K3/10—Materials in mouldable or extrudable form for sealing or packing joints or covers
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K2200/00—Chemical nature of materials in mouldable or extrudable form for sealing or packing joints or covers
    • C09K2200/06—Macromolecular organic compounds, e.g. prepolymers

Abstract

The present invention provides a seal for a valve for use in a pharmaceutical metered dose aerosol inhaler device, which seal is formed from a mixture comprising a cross-linked elastomeric material and one or both of a thermoplastic material and a thermoplastic elastomeric material.

Description

Sealina Material The present invention relates to a sealing material and, in particular, to a sealing material for a valve for use in a pharmaceutical metered dose aerosol inhaler device.
Known rubber compounds for sealing pharmaceutical metered dose aerosol inhalers are based on the traditional technology of vulcanising a synthetic or natural rubber polymer. Such rubbers have chemical and physical properties conducive to good valve performance. Seal components have also been manufactured from thermoplastic or thermoplastic elastomer materials. Owing to their relative chemical inertness, these rubbers often have the advantage of low taste and odour. Furthermore, they are generally cheaper to convert into seals and have better quality extractive profiles than vulcanised rubbers.
The present inventor has now developed a mixture which results in an improved extract profile whilst still possessing the material properties necessary for good valve performance, such as chemical compatibility (swell), tensile strength, permanent compression set, stress relaxation and elastic modulus.
Accordingly, the present invention provides a seal for a valve for use in a pharmaceutical metered dose aerosol inhaler device, which seal is formed from a mixture comprising a cross-linked elastomeric material and one or both of a thermoplastic material and a thermoplastic elastomeric material (TPE).
Advantageously the cross-linked elastomeric material is selected from one or more of the following: natural rubber, ethylene-propylene rubbers, such as ethylene-propylene-diene rubber, nitrile rubbers, such as butadiene-acrylonitrile rubber, butadiene-styrene rubbers, butyl rubbers, chlorosulphonated polyethylene rubbers, fluorocarbon rubbers, polychloroprene rubbers, polysulphide rubbers, silicone rubbers, isoprene rubbers, isopreneisobutene rubbers, polypropylene oxide rubbers and fluorosilicone rubbers. The cross-linked elastomeric material is preferably present in the mixture in an amount of from 50 to 97%.
Advantageously the thermoplastic material is selected from one or more of the following polymers: acrylonitrile-butadiene-styrene, acrylic, polyacetal homopolymers or copolymers, polyamides, such as nylon, polycarbonates, polyethylene, polypropylene, polystyrene, polysulphone, polytetrafluoroethylene, vinyl polymers, such as polyvinylchloride and polyvinyl acetate, polyethylene terephthalate, polybutylene terephthalate, cellulosic polymers, such as cellulose acetate and cellulose acetate butyrate and polybutylene. The thermoplastic material is preferably present in the mixture in an amount of from 3 to 50%.
Advantageously the thermoplastic elastomeric material is selected from one or more of the following: polyester rubbers, polyurethane rubbers, ethylene vinyl acetate rubber, styrene butadiene rubber, copolyether ester TPE, olefinic TPE, polyester amide TPE and polyether amide TPE. The thermoplastic elastomeric material is preferably present in the mixture in an amount of from 3 to 50%.
It will be appreciated that the seal may further comprise fillers, reinforcement agents, plasticisers, binders, stabilizers, lubricants and pigments to adjust the material properties and processability.
The present invention also provides a valve for use in a pharmaceutical metered dose aerosol inhaler device having a seal as herein described.
The present invention still further provides a pharmaceutical metered dose aerosol inhaler device having a valve as herein described.
In another aspect of the present invention there is provided the use of a mixture comprising a crosslinked elastomeric material and one or both of a thermoplastic material and a thermoplastic elastomeric material for forming a seal for a valve for a pharmaceutical metered dose aerosol inhaler device.
In yet another aspect of the present invention there is provided a method of making a seal for a valve for use in a pharmaceutical metered dose aerosol inhaler device, which method comprises the step of forming a mixture comprising a cross-linked elastomeric material and one or both of a thermoplastic material and a thermoplastic elastomeric material.
It will be appreciated that the seal may be provided as a separate component or may be formed integrally with the valve.
It has been found that the present invention provides particularly favourable results when used in conjunction with a hydrofluorocarbon propellant in the aerosol device.
The seal of the present invention may be manufactured by any of the processes conventional in the art. For example, the seal may be manufactured by compression moulding, injection moulding or extrusion.
The advantages of the present invention include cost savings, greater control over component quality, reduced extractives, less reliance on externally sourced rubber goods and substantial elimination of an interface which reduces potential leakage paths.

Claims (9)

Claims:
1. A seal for a valve for use in a pharmaceutical metered dose aerosol inhaler device, which seal is formed from a mixture comprising a cross-linked elastomeric material and one or both of a thermoplastic material and a thermoplastic elastomeric material.
2. A seal as claimed in claim 1, wherein the cross-linked elastomeric material is selected from one or more of the following: natural rubber, ethylenepropylene rubbers, such as ethylene-propylene-diene rubber, nitrile rubbers, such as butadieneacrylonitrile rubber, butadiene-styrene rubbers, butyl rubbers, chlorosulphonated polyethylene rubbers, fluorocarbon rubbers, polychloroprene rubbers, polysulphide rubbers, silicone rubbers, isoprene rubbers, isoprene-isobutene rubbers, polypropylene oxide rubbers and fluorosilicone rubbers.
3. A seal as claimed in claim 1 or claim 2, wherein the thermoplastic material is selected from one or more of the following polymers: acrylonitrilebutadiene-styrene, acrylic, polyacetated homopolymers or copolymers, polyamides, such as nylon, polycarbonates, polyethylene, polypropylene, polystyrene, polysulphone, polytetrafluoroethylene, vinyl polymers, such as polyvinylchloride and polyvinyl acetate, polyethylene terephthalate, polybutylene terephthalate, cellulosic polymers, such as cellulose acetate and cellulose acetate butyrate and polybutylene.
4. A seal as claimed in any one of the preceding claims, wherein the thermoplastic elastomeric material is selected from one or more of the following: polyester rubbers, polyurethane rubbers, ethylene vinyl acetate rubber, styrene butadiene rubber, copolyether ester TPE, olefinic TPE, polyester amide TPE and polyether amide TPE.
5. A seal as claimed in any one of the preceding claims, further comprising one or more of the following: fillers, reinforcement agents, plasticizers, binders, stabilizers, lubricants and pigments.
6. A valve for use in a pharmaceutical metered dose aerosol inhaler device having a seal as claimed in any one of claims 1 to 5.
7. A pharmaceutical metered dose aerosol inhaler device having a valve as claimed in claim 6.
8. Use of a mixture comprising a cross-linked elastomeric material and one or both of a thermoplastic material and a thermoplastic elastomeric material for forming a seal for a valve for a pharmaceutical metered dose aerosol inhaler device.
9. A method of making a seal for a valve for use in a pharmaceutical metered dose aerosol inhaler device, which method comprises the step of forming a mixture comprising a cross-linked elastomeric material and one or both of a thermoplastic material and a thermoplastic elastomeric material.
GB9706252A 1997-03-26 1997-03-26 Sealing material for use in a valve for an aerosol inhaler Withdrawn GB2323597A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB9706252A GB2323597A (en) 1997-03-26 1997-03-26 Sealing material for use in a valve for an aerosol inhaler

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB9706252A GB2323597A (en) 1997-03-26 1997-03-26 Sealing material for use in a valve for an aerosol inhaler

Publications (2)

Publication Number Publication Date
GB9706252D0 GB9706252D0 (en) 1997-05-14
GB2323597A true GB2323597A (en) 1998-09-30

Family

ID=10809879

Family Applications (1)

Application Number Title Priority Date Filing Date
GB9706252A Withdrawn GB2323597A (en) 1997-03-26 1997-03-26 Sealing material for use in a valve for an aerosol inhaler

Country Status (1)

Country Link
GB (1) GB2323597A (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5408703A (en) * 1991-12-16 1995-04-25 Cicio; William Female urination aid
FR2787424A1 (en) * 1998-12-18 2000-06-23 Valois Sa Valve or pump joint for sealing fluid product dispenser is made from one or more selected elastomer materials
WO2003018432A1 (en) 2001-08-29 2003-03-06 Valois Sas Valve seal
WO2014081746A1 (en) 2012-11-23 2014-05-30 3M Innovative Properties Company Metered dose dispensing valve
US9291274B1 (en) 2001-04-16 2016-03-22 Novatech Holdings Corp. Valve body and seal assembly

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4664275A (en) * 1984-09-07 1987-05-12 Terumo Kabushiki Kaisha Medical container stopper
EP0234468A2 (en) * 1986-02-21 1987-09-02 E.I. Du Pont De Nemours And Company Elastomer blends
WO1987007625A1 (en) * 1986-06-03 1987-12-17 Exxon Research And Engineering Company Dynamically cured thermoplastic olefin polymers (e-76)
US4845145A (en) * 1984-07-11 1989-07-04 Exxon Research & Engineering Company Dynamically cured thermoplastic olefin polymers
US4902745A (en) * 1987-12-22 1990-02-20 Bayer Aktiengesellschaft Rubber-like thermoplastic polymer mixtures
WO1992011190A2 (en) * 1990-12-21 1992-07-09 Minnesota Mining And Manufacturing Company Device for delivering an aerosol
WO1995003984A1 (en) * 1993-07-28 1995-02-09 Minnesota Mining And Manufacturing Company Seals for use in an aerosol delivery device

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4845145A (en) * 1984-07-11 1989-07-04 Exxon Research & Engineering Company Dynamically cured thermoplastic olefin polymers
US4664275A (en) * 1984-09-07 1987-05-12 Terumo Kabushiki Kaisha Medical container stopper
EP0234468A2 (en) * 1986-02-21 1987-09-02 E.I. Du Pont De Nemours And Company Elastomer blends
WO1987007625A1 (en) * 1986-06-03 1987-12-17 Exxon Research And Engineering Company Dynamically cured thermoplastic olefin polymers (e-76)
US4902745A (en) * 1987-12-22 1990-02-20 Bayer Aktiengesellschaft Rubber-like thermoplastic polymer mixtures
WO1992011190A2 (en) * 1990-12-21 1992-07-09 Minnesota Mining And Manufacturing Company Device for delivering an aerosol
WO1995003984A1 (en) * 1993-07-28 1995-02-09 Minnesota Mining And Manufacturing Company Seals for use in an aerosol delivery device

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5408703A (en) * 1991-12-16 1995-04-25 Cicio; William Female urination aid
FR2787424A1 (en) * 1998-12-18 2000-06-23 Valois Sa Valve or pump joint for sealing fluid product dispenser is made from one or more selected elastomer materials
WO2000037582A1 (en) * 1998-12-18 2000-06-29 Valois S.A. Valve or pump joint
US6780929B1 (en) * 1998-12-18 2004-08-24 Valois S.A. Valve or pump joint
US9291274B1 (en) 2001-04-16 2016-03-22 Novatech Holdings Corp. Valve body and seal assembly
WO2003018432A1 (en) 2001-08-29 2003-03-06 Valois Sas Valve seal
FR2829118A1 (en) * 2001-08-29 2003-03-07 Valois Sa VALVE SEAL
US7396019B2 (en) 2001-08-29 2008-07-08 Valois S.A.S Valve gasket
WO2014081746A1 (en) 2012-11-23 2014-05-30 3M Innovative Properties Company Metered dose dispensing valve

Also Published As

Publication number Publication date
GB9706252D0 (en) 1997-05-14

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WAP Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1)