GB2321853A - Ultrasound Emitting Stent - Google Patents
Ultrasound Emitting Stent Download PDFInfo
- Publication number
- GB2321853A GB2321853A GB9702612A GB9702612A GB2321853A GB 2321853 A GB2321853 A GB 2321853A GB 9702612 A GB9702612 A GB 9702612A GB 9702612 A GB9702612 A GB 9702612A GB 2321853 A GB2321853 A GB 2321853A
- Authority
- GB
- United Kingdom
- Prior art keywords
- stent
- coils
- coil
- patient
- arrangement
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
- A61B2090/3925—Markers, e.g. radio-opaque or breast lesions markers ultrasonic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/88—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure the wire-like elements formed as helical or spiral coils
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F2007/009—Heating or cooling appliances for medical or therapeutic treatment of the human body with a varying magnetic field acting upon the human body, e.g. an implant therein
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Vascular Medicine (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Transplantation (AREA)
- Cardiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Prostheses (AREA)
Abstract
The stent comprises a closed coil 5, a megnetostrictive tubular member with a plurality of slots (7 figure 3) or a laminate of insulation (9 figure 4) and metallic coil (10 figure 4). Emission of ultrasound for destruction of a stenosis is initiated by energisation from external coils 3 and 4 arranged around the body.
Description
MEDICAL ULTRASOUND APPARATUS
The present invention relates to medical ultrasound apparatus and more particularly to the use of so-called stents in the treatment of vascular disorders.
Coronary artery disease is a significant cause of death in the Western World, and a number of methods of treatment have been developed. Surgical treatment in which a vein is grafted to replace the diseased artery, known as coronary artery bypass grafts, are successful, but require the traurna of major surgery with its concomitant risks and long recovery periods, and is limited to a selected patient population.
In more recent years cardiac catheters have been increasingly used to treat the narrowing of coronary arteries, using angioplasty balloons to widen the lumen The lumen widening in many cases is temporary and the vessel relaxes back to its original narrow lumen.
An improved treatment involves implanting metallic stents which act to hinder the remodelling of the opened vessel. A stent is essentially an elongated metallic device which can be introduced into the target area and expanded to as it were shore up the collapsed or partially collapsed arterial wall defining the lumen. A typical method of delivery employs a balloon catheter with the stent carried around the outside of the deflated balloon so that when the balloon is then inflated (at the target area) the stent is caused to expand into its operative position.
Stents do provide a longer lasting treatment for coronary artery stenosis than percutaneous coronary transluminal angioplasty (known as PCTA) but further narrowing or re-stenosis has been observed. The mechanism for this can be the formation of a thrombus around the stent, although this can be minimised by improved stent placement and appropriate use of anti-coagulation therapy. A further mechanism is a longer term proliferation around the foreign body of the stent. termed neo-intimal tissue proliferation.
A new method to reduce this tissue proliferation utilises the well known fact that ionising radiation has greater cytotoxicity on rapidly growing cells and involves radiating the coronary region, either with external radiation or via an intraluminal radiation source implanted into the coronary artery. A further technique provides the radiation to the tissue by implanting stents which are radioactive. However the use of radioactive materials has significant radiation protection implications for clinical and nursing staff, the patient and the general population, and it may be expected that these may hinder this method being more rapidly adopted.
The present invention is concerned with reducing or eliminating this problem of tissue proliferation around a coronary stent.
According to the present invention a stent is provided with means by which it can be made to radiate ultrasonic energy when in an operative position.
The principle behind the invention is to use the stent to radiate ultrasonic energy into the surrounding tissue. It is known that ultrasonic energy can affect the growth of tissue and at certain intensities is cytotoxic.
The advantage of ultrasound radiation is that it is non-ionising and does not couple well to air, so there are no radiation protection issues.
Because of the small size of the stent it is very difficult to provide it with its own internal power source. Therefore the energy is coupled from outside the body via electromagnetic radiation. External coils are excited to produce a radio frequency magnetic field in the coronary area. This couples to the implanted stent and the magnetic field generates an oscillating strain in the metal stent structure. the consequent vibration couples into the tissue in contact with the stent.
The choice of frequency is limited by lower and upper bounds. The frequency has to be higher than the frequencies at which any induced currents can trigger muscle movement, typically 100kHz. At the upper end the frequency must be less than 30-40
MHz for the magnetic fields to penetrate to the coronary artery region.
How the invention may be carried out will now be described by way of example only and with reference to the accompanying drawings in which:
Figure 1 is a perspective diagrammatic view of the overall arrangement of the present invention;
Figure 2 is a perspective diagrammatic view of one construction of stent to which the present invention may be applied in the arrangement shown in Figure 1;
Figure 3 is a perspective diagrammatic view of a second construction of stent to which the present invention may be applied in the arrangement shown in Figure 1.
Figure 4 is a perspective diagrammatic view of a third construction of stent may be applied in the arrangement shown in Figure 1.
Figure 5 illustrates one external arrangement generating the magnetic field for energising the stent positioned with the patient;
Figure 6 is a view similar to Figure 5 showing a second external coil arrangement.
Figure 1 illustrates the general arrangement involved in applying the present invention.
A patient 1 is supported in a horizontal position by a known arrangement (not shown).
A metal stent 2 has been inserted into the patient so that the operative part of the stent is located in the appropriate target area within the patient, typically within one of the patients arteries.
A pair of electrical coils 3 and 4 are positioned as indicated so that the patient 1 lies substantially on the common axis X-Y of the two coils 3 and 4.
The stent for use with the present invention can take a number of forms depending on the energisation frequency being used.
Three examples of constructions of stent which could be used by the present invention are shown in Figures 2, 3 and 4.
The stent 2 of Figure 2 comprises a closed coil having a plurality of windings 5 and a return portion 6 joining the two ends of the coil. The windings 5 and portion 6 are electrically insulated from one another preferably by the windings carrying an insulating layer or coating (not shown). Means may be provided to enable the coil to operate as a resonant circuit, e.g. by the incorporation of a capacitor, in order to increase the effectiveness of the coil.
Figure 3 illustrates a second possible construction in which the stent 2 comprises essentially a tubular member 7 having a plurality of slots 8, the tube 7 being made from a material which is magneto-strictive. Examples of appropriate magneto-strictive materials are nickel and stainless steel.
A third example of a possible construction is shown in Figure 4 in which again the stent 2 is of generally cylindrical configuration but each of the conductive paths of the stent comprises metal portions 9 interrupted or separated by insulation portions 10. In other words the stent is of a laminated construction. The insulation portions 10 could be in a number of configurations including helical (as illustrated), mutually parallel and extending longitudinally of the cylindrical surface or even axially spaced apart mutually parallel rings along the length of the cylinder
The stent design shown in Figure 2 is suitable for operation at low frequencies.
With this construction, as indicated earlier, there is a closed coil configuration. When this stent is energised, by means of the coils 3 and 4, shown in Figure 1, currents will be induced in the coils of the stent by means of mutual inductance which in turn will generate an electromotive force in the coil windings. The frequency of the induced force is limited to the self resonant frequency of the windings 5 of the stent.
If higher frequencies of energisation are required then the stent shown in Figure 3 is more suitable. As indicated earlier the stent 2 of Figure 3 is made of a magnetostrictive material, such as nickel or stainless steel, which will change its dimensions when energised, such that the ultrasound generated is twice that imposed by the external coils 3 and 4. Thus for input of 20 MHZ an output of 40 MHZ can be achieved. However with this construction the operating frequency is limited by the reduction in magnetic field caused by eddy currents in the metal forming the cylinder 7.
In order to overcome this limitation a stent could be constructed as indicated in Figure 4. The construction of the stent in Figure 4 is more complicated than that of either
Figure 2 or Figure 3 in that it is essentially a laminated structure having both conducting materials and insulating materials 9 and 10 respectively as described earlier.
As far as the energisation arrangement shown diagramatically in Figure 1 is concerned a number of other arrangements of energisation coils could be employed, two of these being shown in Figures 5 and 6 respectively.
In the arrangement of Figure 5 the radio frequency magnetic field is generated by two coils 11 and 12 which are substantially circular but positioned in a horizontal orientation above and below the patient 1, in contrast to the arrangement shown in
Figure 1 in which the two coils 3 and 4 lie in substantially vertical planes, the patient lying along the common axis X-Y.
In the arrangement of Figure 5 the coils 11 and 12 are again on the same axis but in this arrangement the axis is normal to the axis in which the patient 1 is lying.
The coils 11 and 12 are energised by a radio frequency generator 13.
In the arrangement of Figure 6 there are three radio frequency energisation Helmholtz coils 14, 15 and 16 which are positioned as indicated in relation to patient 1 in order to generate fields in the X, Y and Z directions respectively. In particular the z coil 15 has an axis which lies substantially along the axis along which the patient 1 is lying (as with the coils of Figure 1) the x coil 14 lies substantially horizontally above the patients and the y coil 16 is positioned substantially vertically alongside the patient.
The three coils 14, 15 and 16, set on the three perpendicular axis x, y and z, allow the magnetic field vector to be controlled by sending the ratios of the currents in the coil pairs to be equal to the Cartesian components of the field vector. The coils 14, 15 and 16 are driven by three independent radio frequency generators 17, 18 and 19 respectively which are controlled by a controller 20 so that the amplitude of each generator 17, 18 and 19 is adjusted according to the desired direction of the magnetic field. The coils 14, 15 and 16 could be Helmholtz coils but this is not essential because obtaining an even field is not critical. In fact it may be advantageous to arrange the coils so that the field is concentrated at the position of the stent 2.
Although multi coil arrangements have been described and illustrated, for energising the stent 2, the invention is possible using only one energisation coil. The way in which the arrangement according to the present invention is used will now be briefly described.
In order to prevent or minimise the unwanted tissue proliferation around the coronary stent referred to earlier the stent 2, which is already embedded in the patient and is not intended to be removed, would be energised on a series of occasions in order to prevent the unwanted condition from occurring.
Because this energisation only involves placing an energisation coil or coils outside the patient, the treatment of the patient, in a series of regular doses as indicated earlier can be carried out as an outpatient procedure.
Variations may be made to both the detailed design of the stent and to the coil arrangement for energising it from outside the patient, within the scope of the following claims.
Claims (9)
1. A stent provided with means by which it can be made to radiate ultrasonic energy when in an operative position.
2. A stent as claimed in claiml in which the operative part of the stent comprises a helical elongated coil having its opposite ends interconnected.
3. A stent as claimed in claim 1 in which the operative part of the stent comprises a metallic cylinder provided with a pattern of apertures.
4. A stent as claimed in claim 1 or 3 made from a magnetostrictive material.
5. A stent as claimed in of claim 1 in which the operative part of the stent is made up of a laminated structure comprising metallic segments alternating with insulation segments.
6. A stent substantially as hereinbefore described with reference to and as shown in any one of Figures 2,3 or 4 of the accompanying drawings.
7. Apparatus for use with a stent as claimed in any previous claim which comprises an energisation coil arrangement substantially as hereinbefore described with reference to and as shown in any one of Figures 1, 5 and 6 of the accompanying drawings.
8. A method of operating a stent which comprises inserting the stent into its operating position and then energising it by means of a magnetic coil arrangement external of and separate from the stent to cause the stent to emit ultrasonic energy.
9. A method of operating a stent substantially as hereinbefore described with reference to and as shown in the accompanying drawings.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9702612A GB2321853A (en) | 1997-02-08 | 1997-02-08 | Ultrasound Emitting Stent |
PCT/GB1998/000241 WO1998034564A1 (en) | 1997-02-08 | 1998-02-05 | Medical ultrasound apparatus |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9702612A GB2321853A (en) | 1997-02-08 | 1997-02-08 | Ultrasound Emitting Stent |
GBGB9710548.0A GB9710548D0 (en) | 1997-05-23 | 1997-05-23 | Medical ultrasound apparatus |
Publications (2)
Publication Number | Publication Date |
---|---|
GB9702612D0 GB9702612D0 (en) | 1997-03-26 |
GB2321853A true GB2321853A (en) | 1998-08-12 |
Family
ID=26310956
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB9702612A Withdrawn GB2321853A (en) | 1997-02-08 | 1997-02-08 | Ultrasound Emitting Stent |
Country Status (2)
Country | Link |
---|---|
GB (1) | GB2321853A (en) |
WO (1) | WO1998034564A1 (en) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2352635A (en) * | 1999-07-31 | 2001-02-07 | Martin Terry Rothman | Medical stents |
US6361554B1 (en) * | 1999-06-30 | 2002-03-26 | Pharmasonics, Inc. | Methods and apparatus for the subcutaneous delivery of acoustic vibrations |
WO2001072373A3 (en) * | 2000-03-24 | 2002-05-23 | Transurgical Inc | Apparatus and method for intrabody thermal treatment |
US6755853B2 (en) | 1999-06-30 | 2004-06-29 | Pharmasonics, Inc. | Methods and kits for the inhibition of hyperplasia in vascular fistulas and grafts |
US7674256B2 (en) | 2005-03-17 | 2010-03-09 | Boston Scientific Scimed, Inc. | Treating internal body tissue |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6129705A (en) * | 1997-10-01 | 2000-10-10 | Medtronic Ave, Inc. | Drug delivery and gene therapy delivery system |
WO2001005332A1 (en) * | 1999-07-16 | 2001-01-25 | Sunnanväder, Lars | A device for therapeutic treatment of a blood vessel |
IL131623A0 (en) * | 1999-08-27 | 2001-01-28 | Dan Weiss | Apparatus to couple ultrasonic energy to catheters and other transdermal medical devices |
US6626940B2 (en) | 2001-06-15 | 2003-09-30 | Scimed Life Systems, Inc. | Medical device activation system |
US6895282B2 (en) * | 2002-10-04 | 2005-05-17 | Boston Scientific Scimed, Inc. | Induction heating for the delivery of thermal therapy |
AU2017296039A1 (en) * | 2016-07-14 | 2019-02-21 | The Board Of Regents Of The University Of Texas System | Methods, apparatuses, and systems for inductive heating of foreign metallic implants |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4808153A (en) * | 1986-11-17 | 1989-02-28 | Ultramed Corporation | Device for removing plaque from arteries |
WO1991016864A1 (en) * | 1990-05-04 | 1991-11-14 | Interventional Thermodynamics, Inc. | Method and apparatus for maintaining patency in vivo |
EP0623360A1 (en) * | 1993-02-05 | 1994-11-09 | The Joe W. And Dorothy Dorsett Brown Foundation | Ultrasonic angioplasty balloon catheter |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3570476A (en) * | 1968-11-18 | 1971-03-16 | David Paul Gregg | Magnetostrictive medical instrument |
US4373532A (en) * | 1980-07-07 | 1983-02-15 | Palo Alto Medical Research Foundation | Ultrasonic marker for physiologic diagnosis and method of using same |
DE3741201A1 (en) | 1987-12-02 | 1989-06-15 | Schering Ag | ULTRASONIC PROCESS AND METHOD FOR IMPLEMENTING IT |
US5580575A (en) | 1989-12-22 | 1996-12-03 | Imarx Pharmaceutical Corp. | Therapeutic drug delivery systems |
EP0691841B1 (en) * | 1993-01-08 | 2002-05-29 | Miravant Systems, Inc. | Medicament dispensing stents |
US5405322A (en) * | 1993-08-12 | 1995-04-11 | Boston Scientific Corporation | Method for treating aneurysms with a thermal source |
US5509896A (en) | 1994-09-09 | 1996-04-23 | Coraje, Inc. | Enhancement of thrombolysis with external ultrasound |
US5558092A (en) | 1995-06-06 | 1996-09-24 | Imarx Pharmaceutical Corp. | Methods and apparatus for performing diagnostic and therapeutic ultrasound simultaneously |
-
1997
- 1997-02-08 GB GB9702612A patent/GB2321853A/en not_active Withdrawn
-
1998
- 1998-02-05 WO PCT/GB1998/000241 patent/WO1998034564A1/en active Application Filing
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4808153A (en) * | 1986-11-17 | 1989-02-28 | Ultramed Corporation | Device for removing plaque from arteries |
WO1991016864A1 (en) * | 1990-05-04 | 1991-11-14 | Interventional Thermodynamics, Inc. | Method and apparatus for maintaining patency in vivo |
EP0623360A1 (en) * | 1993-02-05 | 1994-11-09 | The Joe W. And Dorothy Dorsett Brown Foundation | Ultrasonic angioplasty balloon catheter |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6361554B1 (en) * | 1999-06-30 | 2002-03-26 | Pharmasonics, Inc. | Methods and apparatus for the subcutaneous delivery of acoustic vibrations |
US6755853B2 (en) | 1999-06-30 | 2004-06-29 | Pharmasonics, Inc. | Methods and kits for the inhibition of hyperplasia in vascular fistulas and grafts |
GB2352635A (en) * | 1999-07-31 | 2001-02-07 | Martin Terry Rothman | Medical stents |
GB2352635B (en) * | 1999-07-31 | 2002-08-07 | Martin Terry Rothman | Medical stents |
WO2001072373A3 (en) * | 2000-03-24 | 2002-05-23 | Transurgical Inc | Apparatus and method for intrabody thermal treatment |
US6605084B2 (en) | 2000-03-24 | 2003-08-12 | Transurgical, Inc. | Apparatus and methods for intrabody thermal treatment |
US7674256B2 (en) | 2005-03-17 | 2010-03-09 | Boston Scientific Scimed, Inc. | Treating internal body tissue |
US8123741B2 (en) | 2005-03-17 | 2012-02-28 | Boston Scientific Scimed, Inc. | Treating internal body tissue |
Also Published As
Publication number | Publication date |
---|---|
GB9702612D0 (en) | 1997-03-26 |
WO1998034564A1 (en) | 1998-08-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
WAP | Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1) |